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A virtual test of screening technology based on the AGEIA PhysX

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Journal of China University of Mining and Technology 2008年第2期18卷 300-304页

作者： LI Ai-min LV rui-ling LIU chu-sheng School of Mechanical and Electrical Engineering China University of Mining ＆ Technology Xuzhou Jiangsu 221116 China

The authors have created a virtual test of vibration particle-screening using Autodesk's 3ds Max software,the MAXScript scripting language and the AGEIA PhysX physics processing unit(PPU).The affect of various parameters on screening efficiency were *** parameters included vibration amplitude,frequency and *** length and inclination of the vibrating surface were also *** virtual experiment is in basic agreement with results predicted from screening *** shows that the virtual screener can be used for preliminary investigations and the results used to evaluate screen *** addition it can help with theoretical research.

关键词： screening AGEIA PhysX virtual test

Influence of HLA-DRB1 alleles and HBV genotypes on interferon-α therapy for chronic hepatitis B

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World Journal of Gastroenterology 2005年第30期11卷 4753-4757页

作者： rui-Hai chu Li-Xian Ma Gang Wang Li-Hua Shao Department of Infectious Diseases Qilu Hospital of Shandong University Jinan 250012 Shandong Province China

AIM. To investigate the influence of HLA-DRB1 alleles and HBV genotypes on inberferon-α therapy for chronic hepatitis B. METHODS： HLA-DRBI＊03, ＊07, ＊09,＊12, ＊15 alleles were determined using polymerase chain reaction/sequence specific primer （PCR/SSP） technique in 126 patients with chronic hepatitis B and 76 normal control subjects in Shandong Province, and HBV genotypes were determined by nested-PCR analysis using type-specific primers in 126 patients. RESULTS： The positivity of HLA-DRB1＊07 allele in chronic hepatitis B group was significantly higher than that in normal control group （X^2 = 6.33, P〈0.025, RR = 2.37）. Among the 126 patients, genotype B was found in 38 （30.2%）, genotype C in 69 （54.8%）, and mixed genotype （B＋C） in 19 （15.0%）, genotypes D-F were not found. Among the 46 DRB1＊07（＋） patients, 7 were responders and 39 were non-responders among them （X^2 = 6.71, P〈0.05）. The positivity of HLADRB1＊07 and prevalence of HBV genotype C were significantly higher in non-responders than in responders. CONCLUSION： High positivities of HLA-DRB1 ＊07 allele and HBV genotype C are closely associated with the lower response to interferon-α therapy for chronic hepatitis B.

关键词： HLA-DRB1 alleles HBV genotypes Interferon-α therapy Chronic hepatitis B

Some Thoughts on the Protection and Display of Yuanmingyuan Site

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Journal of Landscape Research 2017年第1期9卷 120-122页

作者： chu rui University of Science and Technology Liaoning

Via field survey and analysis,the problems that authenticity of Yuanmingyuan site protection is nibbled by modern garden engineering,and Yuanmingyuan site display has low identification degree,insufficient historical information and improper construction site piece display are elaborated. Meanwhile,it is proposed locating Yuanmingyuan site protection and display into the residual landscape after burnt and looted in 1860. Virtual reality technology is used for full-landscape coverage,to realize the comparison between history and status quo,and the dissemination of Yuanmingyuan information is expanded by"internet+"model,which aims to impel the public joining in heritage awareness and cultural relic preservation.

关键词： Yuanmingyuan site Site protection Authenticity Site display

Fabrication of triple-shelled hollow spheres with optical properties via RAFT polymerization

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Chinese Chemical Letters 2010年第7期21卷 864-867页

作者： Li Ping Wang Li Min Zhao Wen Zhi Li rui Qing chu Long Tan Xiu Xiu Zhao Gang Wang College of Materials Science and Engineering Liaocheng UniversityLiaocheng 252059China

The triple-shelled hollow spheres with optical properties were prepared via reversible addition-fragmentation chain transfer (RAFT) *** removal the core templates of the poly(styrene),the hollow silica spheres were *** coating process of poly(methyl methacrylate)(PMMA) on the hollow silica spheres surface via surface RAFT polymerization was performed *** polymers coated on the hollow spheres surfaces were end-functionalized by trithiocarbonate,and they were used as RAFT agent to proceed the chain extension polymerization using Tb complex as *** samples were characterized by FT-IR,SEM and luminescence spectroscopy *** results indicated that the triple-shelled hollow spheres had been prepared successfully and the average diameter of the hollow core was about 1μm.

关键词： Hollow spheres Optical properties Polymers Surfaces Luminescence

GRK2 mediated degradation of SAV1 initiates hyperplasia of fibroblast-like synoviocytes in rheumatoid arthritis

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Acta Pharmaceutica Sinica B 2024年第3期14卷 1222-1240页

作者： Paipai Guo Ji Jiang rui chu Feng He Mingli Ge Ruhong Fang Qiuyun Guan Huijuan Cheng chunru Jiang Tiantian Su Zhenduo Zhu Hao Liu Wei Wei Shihao Zhang Qingtong Wang Institute of Clinical Pharmacology Anhui Medical UniversityKey Laboratory of Anti-inflammatory and Immune MedicineMinistry of EducationCollaborative Innovation Center of Anti-inflammatory and Immune MedicinesHefei 230032China School of Pharmacy Bengbu Medical CollegeBengbu 233030China The Third Affiliated Hospital of Anhui Medical University(the First People’s Hospital of Hefei) Hefei 230061China

Hyperplasia and migration of fibroblast-like synoviocytes(FLSs)are the key drivers in the pathogenesis of rheumatoid arthritis(RA)and joint *** Yes-associated protein(YAP),which is a powerful transcription co-activator for proliferative genes,was observed in the nucleus of inflammatory FLSs with unknown upstream *** Gene Expression Omnibus database analysis,it was found that Salvador homolog-1(SAV1),the pivotal negative regulator of the Hippo-YAP pathway,was slightly downregulated in RA ***,SAV1 protein expression is extremely ***,it was revealed that SAV1 is phosphorylated,ubiquitinated,and degraded by interacting with an important serine-threonine kinase,G protein-coupled receptor(GPCR)kinase 2(GRK2),which was predominately upregulated by GPCR activation induced by ligands such as prostaglandin E2(PGE2)in *** process further contributes to the decreased phosphorylation,nuclear translocation,and transcriptional potency of YAP,and leads to aberrant FLSs *** depletion of GRK2 or inhibition of GRK2 by paroxetine rescued SAV1 expression and restored YAP phosphorylation and finally inhibited RA FLSs proliferation and ***,paroxetine treatment effectively reduced the abnormal proliferation of FLSs in a rat model of collagen-induced arthritis which was accompanied by a significant improvement in clinical ***,these results elucidate the significance of GRK2 regulation of Hippo-YAP signaling in FLSs proliferation and migration and the potential application of GRK2 inhibition in the treatment of FLSs-driven joint destruction in RA.

关键词： Rheumatoid arthritis Fibroblast-like synoviocytes G protein-coupled receptor kinase 2 Salvador homolog-1 Yes-associated protein

Organic Phosphorus in Shallow Lake Sediments in Middle and Lower Reaches of the Yangtze River Area in China

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Pedosphere 2008年第3期18卷 394-400页

作者： JIN Xiang-Can WANG Sheng-rui chu Jian-Zhou WU Feng-Chang State Environmental Protection Key Laboratory for Lake Pollution Control Research Center of Lake Eco-EnvironmentChinese Research Academy of Environmental Sciences Beijing 100012 （China） Colleges of Resource and Environment Hebei Agriculture University Baoding 071001 （China） State Key Laboratory of Environmental Geochemistry Institute of Geochemistry Chinese Academy of Sciences Guiyang550002 （China）

Thirteen sediment core samples(0-10 cm) were taken from the seven lakes in the middle and lower reaches of the Yangtze River to determine the contents and distributions of organic phosphorus(P) fractions in the sediments of the shallow lakes in the *** organic P fractions in the sediments were in the order of moderately labile organic P(MLOP) > moderately resistant organic P(MROP) > highly resistant organic P(HROP) > labile organic P(LOP),with average proportional ratios of 13.2:2.8:1.3:***,MLOP,and MROP were significantly related to the contents of total organic carbon(TOC),water-soluble P(WSP),algal-available P(AAP),NaHCO3-extractable P(Olsen-P),total P(TP),organic P(OP),and inorganic P(IP).However,HROP was significantly related to OP and weakly correlated with TOC,WSP,AAP,Olsen-P,TP or *** suggested that organic P,especially LOP and MLOP in sediments,deserved even greater attention than IP in regards to lake *** terms of organic P,sediments were more hazardous than soils in lake *** OP concentrations were higher in moderately polluted sediment than those in heavily polluted sediment,LOP and MLOP were higher in the heavily polluted sediment,which indicated that heavily polluted sediment was more hazardous than moderately polluted sediment in lake eutrophication.

关键词： bioavailability chemical extracted phosphorus lake sediment middle and lower reaches of the Yangtze River area organic phosphorus fractions

一种基于GMA结构的开放式网格资源信息服务

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计算机研究与发展 2004年第12期41卷 2114-2122页

作者：褚瑞肖侬卢锡城并行与分布处理国家重点实验室长沙410073

网格是把广域网上大量分布、异构资源进行整合 ,实现统一视图和统一访问接口的基础设施资源信息服务在网格中具有重要地位 ,其作用是感知和监控异构资源 ,并为上层应用提供资源信息 ,从而为资源调度和选择系统策略提供依据传统的主机... 详细信息

网格是把广域网上大量分布、异构资源进行整合 ,实现统一视图和统一访问接口的基础设施资源信息服务在网格中具有重要地位 ,其作用是感知和监控异构资源 ,并为上层应用提供资源信息 ,从而为资源调度和选择系统策略提供依据传统的主机监控不能适用于网格 ,现有的网格资源信息服务也存在一定缺点通过分析网格资源信息服务的一般要求 ,针对现有系统的不足 ,基于GGF提出的GMA体系结构 ,从几个不同方面提出了更适合网格特点 ,开放性和互操作性较好的改进方案 ,最后 ,一方面对资源信息服务的性能策略进行了讨论和理论分析 ,另一方面以目前实现的原型系统GridEye为基础 ,进行了资源信息服务的性能测试实验。

关键词：网格资源信息服务 GMA GridEye

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一种基于聚类的虚拟计算环境资源聚合方法

软件学报 2007年第8期18卷 1858-1869页

作者：褚瑞卢锡城肖侬并行与分布处理国家重点实验室(国防科学技术大学) 湖南长沙410073

作为面向互联网资源共享的虚拟计算环境的实例,iVCE(Internet based virtual computing environment)for Memory致力于解决广域分布的内存资源的共享与综合利用问题.由于内存资源的特殊性,传统的资源管理方法很难适用.以iVCE for Memor... 详细信息

作为面向互联网资源共享的虚拟计算环境的实例,iVCE(Internet based virtual computing environment)for Memory致力于解决广域分布的内存资源的共享与综合利用问题.由于内存资源的特殊性,传统的资源管理方法很难适用.以iVCE for Memory作为背景,提出一种基于聚类的虚拟计算环境资源聚合方法,有效降低了资源聚合的问题规模;借鉴物理学中的力场和势能理论,建立了实现资源聚合的基本模型和力场-势能模型以及相应的分布式算法;通过基于真实网络拓扑的模拟,对两种模型和算法分别进行了评估和验证.

关键词：虚拟计算环境 iVCE(Internet based virtual computing environment)for Memory 资源聚合聚类力场-势能模型

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一种内存网格的数据预取算法

软件学报 2006年第11期17卷 2234-2244页

作者：褚瑞卢锡城肖侬并行与分布处理国家重点实验室湖南长沙410073

内存网格(RAM(random access memory)grid)是一种面向广域网上内存资源共享的新型网格系统.它的主要目标是在物理内存不足的情况下,提高内存密集型应用或IO密集型应用的系统性能.内存网格的应用效果取决于网络通信开销.在减少或隐藏网... 详细信息

内存网格(RAM(random access memory)grid)是一种面向广域网上内存资源共享的新型网格系统.它的主要目标是在物理内存不足的情况下,提高内存密集型应用或IO密集型应用的系统性能.内存网格的应用效果取决于网络通信开销.在减少或隐藏网络通信开销的情况下,其性能可以进一步提高.通过对内存网格的分析,设计了一种基于“推”数据的内存网格预取机制.借助数据挖掘领域中序列模式挖掘的方法,提出了相应的预取算法.通过基于真实运行状态的模拟,对预取算法进行了评估和验证.

关键词：内存网格预取算法序列模式挖掘 IO密集型磁盘缓存