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Assessment of wind and photovoltaic power potential in China

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碳中和(英文)

碳中和(英文) 2022年第1期1卷 428-438页

作者： Yang Wang Qingchen Chao Lin Zhao rui chang National Climate Center China Meteorological AdministrationBeijing 100081China China National Offshore Oil Corporation Research Institute Beijing 100028China

Decarbonization of the energy system is the key to China’s goal of achieving carbon neutrality by 2060.However,the potential of wind and photovoltaic(PV)to power China remains unclear,hindering the holistic layout of the renewable energy development plan.Here,we used the wind and PV power generation potential assessment system based on the Geographic Information Systems(GIS)method to investigate the wind and PV power generation potential in China.Firstly,the high spatial-temporal resolution climate data and the mainstream wind turbines and PV modules,were used to assess the theoretical wind and PV power generation.Then,the technical,policy and economic(i.e.,theoretical power generation)constraints for wind and PV energy development were comprehensively considered to evaluate the wind and solar PV power generation potential of China in 2020.The results showed that,under the current technological level,the wind and PV installed capacity potential of China is about 56.55 billion kW,which is approximately 9 times of those required under the carbon neutral scenario.The wind and PV power generation potential of China is about 95.84 PWh,which is approximately 13 times the electricity demand of China in 2020.The rich areas of wind power generation are mainly distributed in the western,northern,and coastal provinces of China.While the rich areas of PV power generation are mainly distributed in western and northern China.Besides,the degree of tapping wind and PV potential in China is not high,and the installed capacity of most provinces in China accounted for no more than 1%of the capacity potential,especially in the wind and PV potential-rich areas.

关键词： Wind Photovoltaic Capacity potential Power potential Carbon neutrality

Disulfiram ameliorates STING/MITA-dependent inflammation and autoimmunity by targeting RNF115

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Cellular & Molecular Immunology 2024年第3期21卷 275-291页

作者： Zhi-Dong Zhang chang-rui Shi Fang-Xu Li Hu Gan Yanhong Wei Qianhui Zhang Xin Shuai Min Chen Yu-Lin Lin Tian-Chen Xiong Xiaoqi Chen Bo Zhong Dandan Lin Department of Gastrointestinal Surgery Medical Research InstituteFrontier Science Center of Immunology and MetabolismZhongnan Hospital of Wuhan UniversityWuhan UniversityWuhan430071China Department of Virology College of Life SciencesWuhan UniversityWuhan430072China TaiKang Center for Life and Medical Sciences Wuhan UniversityWuhan430071China Wuhan Research Center for Infectious Diseases and Cancer Chinese Academy of Medical SciencesWuhan430071China Department of Rheumatology and Immunology Zhongnan Hospital of Wuhan UniversityWuhan430071China Cancer Center Renmin Hospital of Wuhan UniversityWuhan430060China

STING(also known as MITA)is an adaptor protein that mediates cytoplasmic DNA-triggered signaling,and aberrant activation of STING/MITA by cytosolic self-DNA or gain-of-function mutations causes severe inflammation.Here,we show that STING-mediated inflammation and autoimmunity are promoted by RNF115 and alleviated by the RNF115 inhibitor disulfiram(DSF).Knockout of RNF115 or treatment with DSF significantly inhibit systemic inflammation and autoimmune lethality and restore immune cell development in Trex1^(–/–)mice and STING^(N153S/WT) bone marrow chimeric mice.In addition,knockdown or pharmacological inhibition of RNF115 substantially downregulate the expression of IFN-α,IFN-γand proinflammatory cytokines in PBMCs from patients with systemic lupus erythematosus(SLE)who exhibit high concentrations of dsDNA in peripheral blood.Mechanistically,knockout or inhibition of RNF115 impair the oligomerization and Golgi localization of STING in various types of cells transfected with cGAMP and in organs and cells from Trex1^(–/–)mice.Interestingly,knockout of RNF115 inhibits the activation and Golgi localization of STINGN153S as well as the expression of proinflammatory cytokines in myeloid cells but not in endothelial cells or fibroblasts.Taken together,these findings highlight the RNF115-mediated cell type-specific regulation of STING and STINGN153S and provide potential targeted intervention strategies for STING-related autoimmune diseases.

关键词： STING/MITA Disulfiram RNF115 SLE Autoimmunity

Intralesional corticosteroid injections for infantile hemangioma

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Chinese Journal Of Plastic and Reconstructive Surgery 2023年第2期5卷 80-85页

作者： rui chang Yajing Qiu Xiaoxi Lin Department of Plastic and Reconstructive Surgery Shanghai Ninth People’s HospitalShanghai Jiaotong University School of MedicineShanghai 200011China

Infantile hemangiomas(IHs) are the most common benign soft-tissue tumors in infancy;about 10%–15% of them may result in various complications that require active management. The current first-line treatment for IH is oral propranolol;however, some studies recommend intralesional corticosteroid injections for small, limited, deep, or prominent tumors because of concern regarding serious systemic complications related to propranolol. This review summarizes and analyzes the current clinical studies on corticosteroid injections in IHs, discusses treatment norms, and explores future research directions.

关键词： Infantile hemangioma Intralesional injections Corticosteroids Clinical norms Bleomycin Propranolol Lauromacrogol Bevacizumab

Enzymatic properties and inhibition tolerance analysis of key enzymes inβ-phenylethanol anabolic pathway of Saccharomyces cerevisiae HJ

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Synthetic and Systems Biotechnology 2023年第4期8卷 772-783页

作者： Qilin Yang Shuangping Liu Yuzong Zhao Xiao Han rui chang Jian Mao National Engineering Research Center of Cereal Fermentation and Food Biomanufacturing State Key Laboratory of Food Science and TechnologySchool of Food Science and TechnologyJiangnan UniversityWuxiJiangsu214122China Shaoxing Key Laboratory of Traditional Fermentation Food and Human Health Jiangnan University(Shaoxing)Industrial Technology Research InstituteShaoxingZhejiang312000China National Engineering Research Center of Huangjiu Zhejiang Guyuelongshan Shaoxing Wine Co.Ltd.ShaoxingZhejiang312000China Jiangsu Provincial Engineering Research Center for Bioactive Product Processing Technology Jiangnan UniversityWuxiJiangsu214122China

Huangjiu is known for its unique aroma,primarily attributed to its high concentration ofβ-phenylethanol(ranging from 40 to 130 mg/L).Phenylalanine aminotransferase Aro9p and phenylpyruvate decarboxylase Aro10p are key enzymes in theβ-phenylethanol synthetic pathway of Saccharomyces cerevisiae^(HJ).This study examined the enzymatic properties of these two enzymes derived from S.cerevisiae^(HJ)and^(S288C).After substrate docking,Aro9p^(HJ)(-24.05 kJ/mol)and Aro10p^(HJ)(-14.33 kJ/mol)exhibited lower binding free energies compared to Aro9p^(S288C)(-21.93 kJ/mol)and Aro10p^(S288C)(-12.84 kJ/mol).ARO9 and ARO10 genes were heterologously expressed in E.coli BL21.Aro9p,which was purified via affinity chromatography,showed inhibition by L-phenylalanine(L-PHE),but the reaction rate Vmax(Aro9p^(HJ):23.89μmol⋅(min·g)^(-1)>Aro9p^(S288C):21.3μmol⋅(min·g)^(-1))and inhibition constant Ki values(Aro9p^(HJ):0.28 mol L^(-1)>Aro9p^(S288C)0.26 mol L^(-1))indicated that Aro9p from S.cerevisiae^(HJ)was more tolerant to substrate stress during Huangjiu fermentation.In the presence of the same substrate phenylpyruvate(PPY),Aro10p^(HJ)exhibited a stronger affinity than Aro10p^(S288C).Furthermore,Aro9p^(HJ)and Aro10p^(HJ)were slightly more tolerant to the final metabolitesβ-phenylethanol and ethanol,respectively,compared to those from^(S288C).The study suggests that the mutations in Aro9p^(HJ)and Aro10p^(HJ)may contribute to the increasedβ-phenylethanol concentration in Huangjiu.This is the first study investigating enzyme tolerance mechanisms in terms of substrate and product,providing a theoretical basis for the regulation of theβ-phenylethanol metabolic pathway.

关键词： Ehrlich pathway Phenylalanine aminotransferase and phenylpyruvate decarboxylase Saccharomyces cerevisiae Metabolic engineering Escherichia coli

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数智技术赋能理想信念教育常态化探赜

兰州大学学报（社会科学版） 2024年第2期52卷 88-97页

作者：宫长瑞兰州大学马克思主义学院/教育部高校思想政治工作创新发展中心甘肃兰州730000

以互联网、大数据、人工智能为核心依托的数智技术赋能理想信念教育常态化,是科学技术日益精进和教育与时俱进的应有之义。数智技术所支撑的“数智化内容”“数智化表达”“数智化平台”和“数智化场景”能够极大提升理想信念教育的及... 详细信息

以互联网、大数据、人工智能为核心依托的数智技术赋能理想信念教育常态化,是科学技术日益精进和教育与时俱进的应有之义。数智技术所支撑的“数智化内容”“数智化表达”“数智化平台”和“数智化场景”能够极大提升理想信念教育的及时性、日常性、持续性、实践性,推动理想信念教育常态化开展。但值得注意的是数智技术环境的复杂性干扰常态化输出信度,数智技术主体的消解性降低常态化传播温度,数智技术素养的差异性影响常态化接受深度,数智技术风险的隐匿性妨碍常态化育人效度。为此,既要采取行之有效的措施积极应对数智技术赋能理想信念教育常态化的现实挑战,也要充分发挥数智技术的赋能优势促进数智技术与理想信念教育常态化的深度融合,以切实提升数智技术赋能理想信念教育常态化成效。

关键词：数智技术理想信念教育常态化

氧化型光电催化促进的C—H键官能团化反应研究进展

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有机化学 2024年第3期44卷 728-747页

作者： Hasil Aman 常瑞叶俊涛上海交通大学化学化工学院、上海市手性药物分子工程重点实验室上海200240

惰性C—H键直接选择性官能团化反应是有机合成领域长久以来的挑战之一.虽然已经发展了多种策略,但仍亟待发展无需添加过渡金属和氧化剂的新方法.近年来,光电催化作为一种新兴策略,能够在温和条件下实现包括直接C—H键官能团化在内的多... 详细信息

惰性C—H键直接选择性官能团化反应是有机合成领域长久以来的挑战之一.虽然已经发展了多种策略,但仍亟待发展无需添加过渡金属和氧化剂的新方法.近年来,光电催化作为一种新兴策略,能够在温和条件下实现包括直接C—H键官能团化在内的多种挑战性转化反应,表现出强大的潜力.从机理的角度出发,总结了通过阳极氧化的光电催化策略实现C—H键官能团化反应的最新研究进展,并简单讨论了这个新兴领域所面临的挑战和机遇.

关键词：光电催化电化学 C—H键官能团化氧化反应

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中国典型复杂地形风能资源特性及其形成机制

太阳能学报 2024年第4期45卷 226-237页

作者：朱蓉向洋孙朝阳常蕊国家气候中心北京100081

为提高对复杂地形风资源特性及其形成机制的认识,改进复杂地形风场数值模拟方法,分别选取代表极大起伏山地与宽谷地形的藏南谷地、代表极大起伏山地与深谷地形的横断山区以及代表中、小起伏丘陵山地的山西高原开展风资源特性观测实验,... 详细信息

为提高对复杂地形风资源特性及其形成机制的认识,改进复杂地形风场数值模拟方法,分别选取代表极大起伏山地与宽谷地形的藏南谷地、代表极大起伏山地与深谷地形的横断山区以及代表中、小起伏丘陵山地的山西高原开展风资源特性观测实验,分析不同典型复杂地形条件下天气背景风场、局地大气环流、地形动力强迫、地表摩擦与热力作用对风资源特性形成的贡献,结果表明:山西高原局地大气环流的作用较小;藏南谷地和横断山区的山谷风环流对其风能资源特性的形成起主要作用,尤其是横断山区还存在多尺度的局地大气环流,传统的风电场风资源CFD数值模拟不足以描述如此复杂的风场。因此,在局地大气环流作用明显的复杂地形地区,需要采用中尺度与CFD结合的风电场选址风资源数值模拟方法。

关键词：风电场复杂地形激光雷达声雷达数值模拟山谷风环流

A TrustEnclave-Based Architecture for Ensuring Run-Time Security in Embedded Terminals

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Tsinghua Science and Technology 2017年第5期22卷 447-457页

作者： rui chang Liehui Jiang Wenzhi Chen Yaobin Xie Zhongyong Lu the State Key Laboratory of Mathematic Engineering and Advanced Computing the Department of Computer Zhejiang University

The run-time security guarantee is a hotspot in current cyberspace security research, especially on embedded terminals, such as smart hardware as well as wearable and mobile devices. Typically, these devices use universal hardware and software to connect with public networks via the Internet, and are probably open to security threats from Trojan viruses and other malware. As a result, the security of sensitive personal data is threatened and economic interests in the industry are compromised. To address the run-time security problems efficiently, first, a TrustEnclave-based secure architecture is proposed, and the trusted execution environment is constructed by hardware isolation technology. Then the prototype system is implemented on real TrustZone-enabled hardware devices. Finally, both analytical and experimental evaluations are provided. The experimental results demonstrate the effectiveness and feasibility of the proposed security scheme.

关键词： run-time security trusted execution environment hardware isolation TrustZone

Lymphovenous anastomosis and complex decongestive therapy for severe deformed lymphedema with recurrent infection:A case report

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World Journal of Clinical Cases 2024年第22期12卷 5159-5167页

作者： He-Jun Wang Qing-Qing He chang-rui Liu Ying-Ying Wang Xun-Wei Liu Department of Thyroid and Breast Surgery The 960th Hospital of People’s Liberation ArmyJinan 250000Shandong ProvinceChina Department of Oncology The 960th Hospital of People’s Liberation ArmyJinan 250000Shandong ProvinceChina

BACKGROUND Lower extremity lymphedema is a common complication following treatment for gynecological malignancies.Its incidence rate can reach up to 70%,affecting~20 million people worldwide.However,specialized treatment centers are scarce,and there is a lack of consensus on treatment approaches.Furthermore,there are even fewer reports on the systematic and effective treatment of severe lymphedema with malformations.Effective management of this condition remains a significant challenge for clinicians.CASE SUMMARY A 40-year-old woman developed bilateral leg swelling 6 years after receiving treatment for endometrial cancer.Since August 2018,she experienced>30 episodes of lymphangitis.Upon presentation,she exhibited bilateral leg swelling and deformation,with four large swellings in the posterior thigh that impeded movement,and pain in the limbs.Skin manifestations included lichenoid lesions and features of deep sclerosis.Radionuclide lymphoscintigraphy confirmed the diagnosis of lower limb lymphedema.After 6 mo of complex decongestive therapy(CDT)and three lymphaticovenous anastomosis(LVA)treatments,the patient lost 49 kg in weight.She also experienced a maximum circumference reduction of 35.2 cm in the left lower limb and 37.5 cm in the right lower limb.The leg pain disappeared,her swelling significantly decreased,and she regained the ability to walk,cycle,and run normally.CONCLUSION The combined application of CDT and LVA therapy demonstrates significant positive effects in the treatment of severe,deformed stage III lymphedema.

关键词： Lower extremity lymphedema Endometrial cancer Lymphaticovenous anastomosis Complex decongestive therapy Gynecological malignancies Recurrent infection Case report