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Effects of dipolar interactions on the magnetic hyperthermia of Zn_(0.3)Fe_(2.7)O_(4) nanoparticles with different sizes

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Chinese Physics B 2021年第1期30卷 497-501页

作者： Xiang Yu Yan Mi Li-Chen Wang zheng-rui Li Di-An Wu Ruo-Shui Liu Shu-Li He Department of Physics Capital Normal UniversityBeijing 100048China

Tumor-targeted magnetic hyperthermia has recently attracted much *** nanoparticles(NPs) are heat mediator nanoprobes in magnetic hyperthermia for cancer *** this paper,single cubic spinel structural Zn_(0.3)Fe_(2.7)O_(4) magnetic NPs with sizes of 14 nm-20 nm were synthesized,followed by coating with SiO_(2) *** SLP value of Zn_(0.3)Fe_(2.7)O_(4)/SiO_(2) NPs below 20 nm changes non-monotonically with the concentration of solution under the alternating current(AC) magnetic field of 430 kHz and 27 kA/*** values of all Zn_(0.3)Fe_(2.7)O_(4)/SiO_(2) NPs appear a peak value with change of solution *** solution concentrations with optimal SLP value decrease with increasing magnetic core *** work can give guidance to the better prediction and control of the magnetic hyperthermia performance of materials in clinical applications.

关键词： magnetic nanoparticles dipolar interaction magnetic hyperthermia

Causal genetic regulation of DNA replication on immune microenvironment in colorectal tumorigenesis: Evidenced by an integrated approach of trans-omics and GWAS

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The Journal of Biomedical Research 2024年第1期38卷 37-50页

作者： Sumeng Wang Silu Chen Huiqin Li Shuai Ben Tingyu Zhao rui zheng Meilin Wang Dongying Gu Lingxiang Liu Department of Oncology the First Affiliated Hospital of Nanjing Medical UniversityNanjingJiangsu 210029China Department of Environmental Genomics Jiangsu Key Laboratory of Cancer BiomarkersPrevention and TreatmentCollaborative Innovation Center for Cancer Personalized MedicineNanjing Medical UniversityNanjingJiangsu 211166China Department of Genetic Toxicology the Key Laboratory of Modern Toxicology of Ministry of EducationCenter for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Biostatistics Center for Global HealthSchool of Public HealthNanjing Medical UniversityNanjingJiangsu 211166China Department of Oncology Nanjing First HospitalNanjing Medical UniversityNanjingJiangsu 210006China.

The interplay between DNA replication stress and immune microenvironment alterations is known to play a crucial role in colorectal tumorigenesis,but a comprehensive understanding of their association with and relevant biomarkers involved in colorectal tumorigenesis is *** address this gap,we conducted a study aiming to investigate this association and identify relevant *** analyzed transcriptomic and proteomic profiles of 904 colorectal tumor tissues and 342 normal tissues to examine pathway enrichment,biological activity,and the immune ***,we evaluated genetic effects of single variants and genes on colorectal cancer susceptibility using data from genome-wide association studies(GWASs)involving both East Asian(7062 cases and 195745 controls)and European(24476 cases and 23073 controls)*** employed mediation analysis to infer the causal pathway,and applied multiplex immunofluorescence to visualize colocalized biomarkers in colorectal tumors and immune *** findings revealed that both DNA replication activity and the flap structure-specific endonuclease 1(FEN1)gene were significantly enriched in colorectal tumor tissues,compared with normal ***,a genetic variant rs4246215 G>T in FEN1 was associated with a decreased risk of colorectal cancer(odds ratio=0.94,95%confidence interval:0.90–0.97,P_(meta)=4.70×10^(-9)).Importantly,we identified basophils and eosinophils that both exhibited a significantly decreased infiltration in colorectal tumors,and were regulated by rs4246215 through causal pathways involving both FEN1 and DNA *** conclusion,this trans-omics incorporating GWAS data provides insights into a plausible pathway connecting DNA replication and immunity,expanding biological knowledge of colorectal tumorigenesis and therapeutic targets.

关键词： trans-omics DNA replication tumor immune microenvironment causal mediation colorectal tumorigenesis

Capability of TCSC on SSR Mitigation

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Journal of Power and Energy Engineering 2015年第4期3卷 232-239页

作者： rui zheng Gen Li Jun Liang School of Engineering Cardiff University Cardiff UK

TCSC (Thyristor-Controlled Series Compensator) has been used in modern power systems to increase power transfer and system stability. Besides, due to its controllable feature, TCSC has been used to work as a solution to sub-synchronous resonance (SSR) problems. However, it is not clear so far whether TCSC’s inherent characteristic can avoid SSR and its effectiveness for SSR damping. In this paper, an equivalent circuit of TCSC is used to better understand how TCSC performs at sub-synchronous frequency ranges. Therefore, interactions of TCSC behaviors and SSR components can be viewed individually. The effects of TCSC operation interfered by sub-synchronous components are discussed. Results show that TCSC has the capability to damp SSR, but this capability can be deteriorated if TCSC firing logic cannot be effectively maintained.

关键词： TCSC SSR Frequency Response

Creating nitrogen-vacancy ensembles in diamond for coupling with flux qubit

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Chinese Physics B 2017年第2期26卷 75-79页

作者： Ya-rui zheng Jian Xing Yan-Chun Chang Zhi-Guang Yan Hui Deng Yu-Lin Wu Li Lu Xin-Yu Pan Xiao-Bo Zhu Dong-Ning zheng Institute of Physics Chinese Academy of Sciences Beijing 100190 China

Hybrid quantum system of negatively charged nitrogen–vacancy（NV^-） centers in diamond and superconducting qubits provide the possibility to extend the performances of both systems. In this work, we numerically simulate the coupling strength between NV^-ensembles and superconducting flux qubits and obtain a lower bound of 1016cm^（-3） for NV^-concentration to achieve a sufficiently strong coupling of 10 MHz when the gap between NV^-ensemble and flux qubit is 0. Moreover, we create NV^-ensembles in different types of diamonds by14^（N＋）and12（C＋）ion implantation, electron irradiation, and high temperature annealing. We obtain an NV^-concentration of 1.05 × 1016cm^（-3） in the diamond with1-ppm nitrogen impurity, which is expected to have a long coherence time for the low nitrogen impurity concentration. This shows a step toward performance improvement of flux qubit-NV^-hybrid system.

关键词： flux qubit nitrogen–vacancy center hybrid quantum system

非简谐振动对石墨烯杨氏模量与声子频率的影响

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物理学报 2016年第10期65卷 177-184页

作者：程正富郑瑞伦重庆文理学院电子电气工程学院重庆402160

在哈里森键联轨道法框架下,考虑到原子的短程相互作用和原子的非简谐振动,应用固体物理理论和方法,得到了石墨烯的力常数、杨氏模量、扭曲模量、泊松系数以及声子频率随温度的变化关系,探讨了非简谐振动对它们的影响.结果表明:1)杨氏模... 详细信息

在哈里森键联轨道法框架下,考虑到原子的短程相互作用和原子的非简谐振动,应用固体物理理论和方法,得到了石墨烯的力常数、杨氏模量、扭曲模量、泊松系数以及声子频率随温度的变化关系,探讨了非简谐振动对它们的影响.结果表明:1)杨氏模量与声子频率等随温度变化并遵从一定的规律,其中力常数、杨氏模量、扭曲模量随温度升高而增大,但变化较小;声子频率随温度升高而增大但变化较快;泊松系数随温度升高而较快地减小;2)石墨烯原子具有沿键长方向的纵振动和垂直键长方向的横振动,但以纵振动为主,纵振动的非简谐效应远大于横振动,横振动的简谐系数ε′0和第二非谐系数ε′2均小于纵振动的相应值ε_0,ε_2;比值为ε_0/ε′_0≈8.477,ε_2/ε′_2≈156;3)若不考虑非简谐振动项,则石墨烯的力常数、杨氏模量和扭曲模量、泊松系数、声子频率均为常量,与实验不符合;同时考虑到原子的第一、二非简谐振动项后,它们均随温度升高而变化,而且温度愈高,原子振动的非简谐效应愈显著.本文的结果与文献的实验结果符合较好.

关键词：石墨烯非简谐效应杨氏模量声子频率

Expression and role of calcitonin gene-related peptide in mouse Aspergillus fumigatus keratitis

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International Journal of Ophthalmology(English edition) 2019年第5期12卷 697-704页

作者： Min Yin Cui Li Xu-Dong Peng Gui-Qiu Zhao Yuan Wu Heng-rui zheng Qian Wang Qiang Xu Nan Jiang Department of Ophthalmology the Affiliated Hospital of Qingdao University

AIM: To investigate the expression and role of calcitonin gene-related peptide(CGRP) in the mouse models induced by Aspergillus fumigatus(A. fumigatus). METHODS: C57 BL/6 mice were randomized into a control group and A. fumigatus keratitis group. The cornea photography was assessed under the slit lamp and the clinical score was recorded after infection. Western blot, real-time polymerase chain reaction(PCR) and immunohistofluorescence analysis were applied to detect CGRP expression in cornea of both groups. In vitro, tests were conducted with C57 BL/6 mice macrophages to investigate CGRP expression after interaction with A. fumigatus. Cytokines expression induced by exogenous CGRP and the antagonist CGRP8-37 in A. fumigatus-exposed macrophages was evaluated by real-time PCR and ***: The cornea expression of CGRP was significantly elevated in C57 BL/6 mice corneas and macrophages after A. fumigatus infection. After treatment with exogenous CGRP, the levels of interleukin-1β(IL-1β), tumor necrosis factor-α(TNF-α) and IL-6 were reduced, and IL-10 level was increased in the A. fumigatus stimulatedmacrophages. However, IL-1β, TNF-α and IL-6 levels were upregulated after pretreatment of CGRP8-37. But the m RNA levels of MIP-2, TGF-β and IL-10 were not changed. CONCLUSION: This study provides evidence that A. fumigatus increased CGRP expression. CGRP may play a protective role against inflammation in A. fumigatus keratitis.

关键词： calcitonin gene-related peptide fungal keratitis macrophages inflammation mice

一种新型宽频带低损耗小单元左手材料的设计与实现

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物理学报 2016年第9期65卷 55-60页

作者：何政蕊耿友林杭州电子科技大学天线与微波研究所杭州310018

设计了一种结构简单、可在电路板单面上印刷的新型左手材料.该结构由周期性排列的"Ⅱ"组成,具有频带宽、损耗低、尺寸小等优点.该材料在一定频段内具有介电常数和磁导率同时为负的特性.仿真结果表明:在8.79—15.57 GHz频率范围内,折射... 详细信息

设计了一种结构简单、可在电路板单面上印刷的新型左手材料.该结构由周期性排列的"Ⅱ"组成,具有频带宽、损耗低、尺寸小等优点.该材料在一定频段内具有介电常数和磁导率同时为负的特性.仿真结果表明:在8.79—15.57 GHz频率范围内,折射率实部为负,而虚部接近于零;同时在该频段内的波阻抗实部大于零.从而说明该材料具有左手特性,在此基础上对该结构进行了制作、加工、并通过矩形波导法进行了验证.同时,该左手材料的相对带宽达到55.74%,而最大单元损耗仅是0.27 d B,远远优于传统的左手材料.

关键词： “Ⅱ”形结构左手材料宽频带低损耗

Metabolic Disorders Combined with Noninvasive Tests to Screen Advanced Fibrosis in Nonalcoholic Fatty Liver Disease

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Journal of Clinical and Translational Hepatology 2021年第5期9卷 607-614页

作者： Yi-Wen Shi Fang-Ping He Jin-Jun Chen Hong Deng Jun-Ping Shi Cai-Yan Zhao Yu-Qiang Mi zheng-Sheng Zou Yong-Jian Zhou Fu-Sheng Di rui-Dan zheng Qin Du Jia Shang rui-Xu Yang Branko Popovic Bi-Hui Zhong Jian-Gao Fan Center for Fatty Liver Department of GastroenterologyXinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai Key Lab of Pediatric Gastroenterology and NutritionShanghaiChina Department of Gastroenterology II The First Affiliated Hospital of Xinjiang Medical UniversityXinjiang Uygur Autonomous RegionsÜrümqiChina Hepatology Unit Department of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhouChina Department of Infectious Diseases the Third Affiliated HospitalSun Yat-Sen UniversityGuangzhouChina The Affiliated Hospital of Hangzhou Normal University HangzhouChina Department of Infectious Disease The Third Hospital of Hebei Medical UniversityShijiazhuangChina Department of Infectious Diseases Tianjin Second People’s HospitalTianjinChina Department of Liver Disease Chinese PLA General Hospitalthe Fifth Medical Center of Chinese PLA General HospitalBeijingChina Department of Gastroenterology and Hepatology Guangzhou First People’s HospitalSchool of MedicineSouth China University of TechnologyGuangzhouChina Department of Endocrinology and Metabolism The Third Central Hospital of TianjinTianjinChina Diagnosis and Treatment Center for Liver Diseases Zhengxing HospitalZhangzhouChina Department of Gastroenterology the Second Affiliated HospitalSchool of MedicineZhejiang UniversityHangzhouChina Department of Infectious Diseases Henan Provincial Peoples’Hospital Zhengzhou ZhengzhouChina Sanofi-Aventis Deutschland GmbH FrankfurtGermany Department of Gastroenterology The First Affiliated HospitalSun Yat-Sen UniversityGuangzhouChina

Background and Aims:Nonalcoholic fatty liver disease(NAFLD)is associated with metabolic *** study aimed to explore the role of metabolic disorders in screening advanced fibrosis in NAFLD ***:A total of 246 histologically-proven NAFLD patients were enrolled across 14 *** compared the severity of fibrosis in patients with different components of metabolic *** on standard noninvasive tests and metabolic disorders,we developed new algorithms to identify advanced ***:Metabolic syndrome(MetS)was frequent in NAFLD patients(133/246,54%).Patients with MetS had a higher proportion of significant fibrosis(p=0.014)and higher LSM values(9.2 kPa,vs.7.4 kPa,p=0.002)than those without *** with more metabolic disorders had higher fibrosis stages(p=0.017).Reduced highdensity lipoprotein cholesterol(odds ratio[OR]:2.241,95%confidence interval[CI]:1.004–5.002,p=0.049)and raised fasting glucose(OR:4.500,95%CI:2.083–9.725,p<0.001)were significantly associated with advanced *** these two metabolic disorders as a screening tool,a sensitivity,specificity and accuracy of 92%,81%and 83%was achieved,*** the new algorithms combining metabolic disorders with noninvasive measurements,the number of patients requiring liver biopsy was reduced,especially in combination with the Fibrosis-4 score and metabolic disorders(36%to 17%,p<0.001).In addition,this stepwise algorithm could achieve a high accuracy(85%)and high negative predictive value(93%).Conclusions:Metabolic disorders should be taken into consideration in the diagnosis of advanced *** further validation and investigation,new algorithms could be recommended in primary care units to spare patients from unnecessary referral and liver biopsies.

关键词： Nonalcoholic fatty liver disease Liver fibrosis Metabolic syndrome Noninvasive measurement

Prevalence and modifiable risk factors of degenerative valvular heart disease among elderly population in southern China

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Journal of Geriatric Cardiology 2021年第7期18卷 523-533页

作者： Shang-Fei HE Jun-Rong JIANG Fang-Zhou LIU Hong-Tao LIAO Yu-Mei XUE Mu-rui zheng Huo-Xing LI Hai DENG Shu-Lin WU South China University of Technology School of Medicine GuangzhouChina Department of Cardiology Guangdong Provincial People’s HospitalGuangzhouChina Guangzhou Center for Disease Control and Prevention GuangzhouChina Qinghai Province Cardio Cerebrovascular Disease Specialist Hospital XiningChina

Objective To investigate the prevalence and modifiable risk factors of degenerative valvular heart disease(DVHD)among elderly population in southern *** A stratified multistage sampling method was used to recruit *** contents of the survey included the questionnaire,laboratory examination,echocardiography,and other auxiliary *** possible risk factors of DVHD were analyzed by logistic regression *** A total of 3538 subjects≥65 years of age were *** thousand three hundred and seven subjects(36.9%)were diagnosed with *** was the most common etiology of *** of DVHD increased with advancing *** prevalence of DVHD differed by living region(χ^(2)=45.594,P<0.001),educational level(χ^(2)=50.557,P<0.001),and occupation(χ^(2)=36.961,P<0.001).Risk factors associated with DVHD included age(two-fold increased risk for each 10-year increase in age),elevated level C-reactive protein(OR=1.346,95%CI:1.100-1.646),elevated level low density lipoprotein(OR=1.243,95%CI:1.064-1.451),coronary artery disease(OR=1.651,95%CI:1.085-2.513),smoking(OR=1.341,95%CI:1.132-1.589),and hypertension(OR=1.414,95%CI:1.221-1.638).Other significant risk factors included reduced or elevated level red blood cell(OR=1.347,95%CI:1.031-1.761;OR=1.599,95%CI:1.097-2.331;respectively),elevated level platelets(OR=1.891,95%CI:1.118-3.198),elevated level uric acid(OR=1.282,95%CI:1.112-1.479),and stroke(OR:1.738,95%CI=1.085-2.513).Conclusions The survey characterized the baseline conditions of DVHD cohort of elderly population in Guangzhou *** established and emerging risk factors for DVHD may represent challenges and opportunities for therapy.

关键词： elevated degenerative occupation