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Effects of bortezomib in sensitizing human prostate ：ancer cell lines to NK-mediated cytotoxicity

Asian Journal of Andrology 2012年第5期14卷 695-702页

作者： Wei Hu rui-rui zheng Hui-Xia Cui Dan Yue Yong Wang You-Hong Jiang Cancer Research Institute First Affiliated HospitalChina Medical UniversityShenyang 110001China Department of Laboratory Medicine Tianjin Medical University Tianjin 300192China Tianjin Institute of Urology Tianjin Medical UniversityTianjin 300192China

The proteasome inhibitor, bortezomib, has been demonstrated to sensitize tumor cells to tumor necrosis factor-related apoptosis-inducing ligand （TRAIL）-mediated apoptosis. Natural killer （NK） cells represent potent antitumor effector cells. They also express TRAIL. Therefore, we investigated whether bortezomib could sensitize tumor cells to NK cell-mediated killing, and have the same effect in human prostate cancer cell lines （LNCaP and DU145）. We found that bortezomib strongly inhibits proliferation in both cell lines. Furthermore, compared with LNCaP cells, DU145 cells are more sensitive to bortezomib-induced apoptosis. However, bortezomib is unable to sensitize these two cell lines to NK cell-mediated killing in short-term assays. In long-term assays, we found that killing mediated by activated NK cells following bortezomib treatment leads to greater antitumor effects than either treatment alone. In addition, treatment with bortezomib causes these cells to upregulate apoptosis-related mRNA as well as death receptors and downregulate the major histocompatibility class （MHC）-I molecule on the cell surface of DU145 cells. In contrast, LNCaP cells are not sensitized by this treatment. Death receptors and the MHC-I molecule did not change in this cell line. These data suggest that bortezomib can be used to sensitize prostate cancer cells to NK cell-mediated killing and improve current cancer therapies. This theral）eutic stratelzv may be more effective in I）atients with androeen-insensitive orostate cancer.

关键词： bortezomib DU145 cells human prostate cancer LNCaP ceils NK cells

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Minimizing pest aluminum in magnesium for the production of high-purity titanium

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Journal of Magnesium and Alloys 2023年第11期11卷 4189-4196页

作者： Bo Yang rui zheng Ge Wu Zhi-Min Chang Zhi-Wei Shan Engineering Research Center for Magnesium-based New Materials Center for Advancing Materials Performance from the Nanoscale(CAMP-Nano)State Key Laboratory for Mechanical Behavior of MaterialsXi’an Jiaotong UniversityXi’an 710049PR China

It is practically difficult to find titanium sponges with low and stable aluminum impurities on the market even though it is the precondition to prepare high-purity titanium. Analysis indicates that almost all the aluminum impurities in the titanium sponge are inherited from the magnesium used to reduce titanium tetrachloride. However, it remains elusive for decades why magnesium produced through the silicothermic reduction method contains a high content of aluminum impurities with large fluctuations. By recourse to thermodynamic calculations and comparative experiments, we demonstrate that fluorite, a material used as a catalyst in the silicothermic reduction method to produce magnesium, is the chief culprit for the pest aluminum and propose a mechanism to rationalize the observed phenomena. Our findings indicate that one practical way to produce qualified magnesium for the production of high-purity titanium is to abandon fluorite during the production of magnesium with the silicothermic reduction method.

关键词： High-purity titanium Titanium sponge Magnesium Aluminum impurity Silicothermic reduction

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A Measurement Study of Economic Growth Transition Based on Quality Index: A Case of Economic Growth in Shenzhen

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当代财经 2013年第S1期 80-93页

作者： XIANG Shu-jian zheng rui-kun Zhongnan University of Economics and Law Hubei University of Technology

How to realize the transition of China’s economic growth from"speed type"to"quality type"is a problem full of exploratory contents;scholars give it wide attention from different theoretical *** it is an indispensable part of the theoretical research to design an index to measure the transition process from speed to quality from the quantitative angle,so as to visually reflect the degree of transition of economic *** drawing on the economic principles and design ideas of the market index,this paper designs the quality index as the quantitative indicator to measure the transition of economic growth model,and quantitatively measures the degree of realization from"Shenzhen speed"to"Shenzhen quality".The results of the empirical evaluation indicate that"Shenzhen speed"has begun to transit to"Shenzhen quality",but the improvement of people’s living standards falls behind substantially the level of economic development of *** this as an opportunity,this paper provides an analytical idea for a quantitative measurement of the economic growth transition in China.

关键词： economic growth transition quality index quantitative measurement

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Four-Parameter Scheme for Ground Level of Helium Atom

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Communications in Theoretical Physics 2006年第5期45卷 906-910页

作者： HU Xian-Quan XU Jie MA Yong zheng rui-Lun College of Physics and Information Technology Chongqing Normal University Chongqing 400047 China School of Physics Southwest Normal University Chongqing 400715 China

In this paper,the ground state wave function of four parameters is developed and expression of the ground state level is derived for the helium atom when the radial Schrodinger equation of the helium atom is solved. The ground energy is respectively computed by the optimized aJgorithms of Matlab 7.0 and the Monte Carlo methods. Furthermore, the ground state wave function is obtained. Compared with the experiment value and the value with the variation calculus in reference, the results of this paper show that in the four-parameter scheme, not only the calculations become more simplified and precise, but also the radial wave function of the helium atom meets the space symmetry automatically in ground state.

关键词： helium atom ground state level variation calculus wave function

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Reconceptualizing kinesin＇s working cycle as separate chemical and mechanical processes

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Frontiers of physics 2018年第5期13卷 153-163页

作者： Hui-Juan Xu Tong Tong rui-zheng Hou Hong-Rong Li School of Science Xi'an Jiaotong University Xi'an 710049 China Institute of Quantum Optics and Quantum Information Xi'an Jiaotong University Xi'an 710049 China

The biomolecular motor kinesin uses chemical energy released from a fuel reaction to generate di- rectional movement and produce mechanical work. The underlying physical mechanism is not fully understood yet. To analyze the energetics of the motor, we reconceptualize its chemomechanical cy- cle in terms of separate fuel reaction and work production processes and introduce a thermodynamic constraint to optimize the cycle. The model predicts that the load dependences of the motor＇s veloc- ity, stepping ratio, and dwell time are determined by the mechanical parameters of the motor-track system rather than the fuel reaction rate. This behavior is verified using reported experimental data from wild-type and elongated kinesins. The fuel reaction and work production processes indicate that kinesin is driven by switching between two chemical states, probably following a general pattern for molecular motors. The comparison with experimental data indicates that the fuel reaction processes are close to adiabatic, which is important for efficient operation of the motor. The model also suggests that a soft, short neck linker is important for the motor to maintain its load transport velocity.

关键词： kinesin chemomechanical coupling thermodynamics entropy production

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Photo-reduction of NO by g-C3N4@foamed ceramic

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Chinese Journal of Chemical Engineering 2020年第7期28卷 1840-1846页

作者： rui zheng Chunhu Li Chengzhen Zhang Wentai Wang Liang Wang Lijuan Feng Junjie Bian Key Laboratory of Marine Chemistry Theory and Technology Ministry of EducationCollege of Chemistry and Chemical EngineeringOcean University of ChinaQingdao 266100China

G-C3N4 was supported on the surface of foamed ceramic,and the g-C3N4@foamed ceramic was packed in the photocatalytic reactor in a layered *** of urea and H2O2 concentration on NO conversion were *** experiments were carried out to investigate the change of NO conversion with time under different concentrations of *** contribution of each route that NO converted and the selectivities of products were *** showed that the photo-reduction of NO accounted for 2%,and the photo-oxidation of NO accounted for 14%,and the rest was absorbed by the *** include ammonia(NH+4-N),nitrogen(N2),nitrite(NO-2-N)and nitrate(NO-3-N),of which N2 accounted for 9%.

关键词： deNOX Photocatalysis g-C3N4@foamed ceramic Photo-reduction

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Multiphase-field simulation of austenite reversion in medium-Mn steels

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International Journal of Minerals,Metallurgy and Materials 2021年第5期28卷 847-853页

作者： Yan Ma rui zheng Ziyuan Gao Ulrich Krupp Hai-wen Luo Wenwen Song olfgang Bleck Steel Institute(IEHK) RWTH Aachen UniversityIntzestraße 152072 AachenGermany Department of Ferrous Metallurgy University of Science and Technology BeijingBeijing 100083China Max-Planck-Institut für Eisenforschung GmbH(MPIE) Max-Planck-Straße 140237 DüsseldorfGermany

Medium-Mn steels have attracted immense attention for automotive applications owing to their outstanding combination of high strength and superior *** steel class is generally characterized by an ultrafine-grained duplex microstructure consisting of ferrite and a large amount of *** a unique microstructure is processed by intercritical annealing,where austenite reversion occurs in a fine martensitic *** the present study,austenite reversion in a medium-Mn alloy was simulated by the multiphase-field approach using the commercial software MICRESS®coupled with the thermodynamic database TCFE8 and the kinetic database *** particular,a faceted anisotropy model was incorporated to replicate the lamellar morphology of reversed *** simulated microstructural morphology and phase transformation kinetics(indicated by the amount of phase)concurred well with experimental observations by scanning electron microscopy and in situ synchrotron high-energy X-ray diffraction,respectively.

关键词： medium-Mn steels intercritical annealing austenite reversion phase-field simulation faceted anisotropy model

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The role of synphilin-1 in the pathogenesis of Parkinson’s disease

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Neuroscience Bulletin 2006年第4期22卷 239-243页

作者： rui zheng Hai-Yan ZHOU Sheng-Di CHEN Department of Neurology and Institute of Neurology Shanghai Jiaotong University School of Medicine Shanghai 200025China

Parkinson’s disease (PD) is one of the commonest neurodegenerative disorders characterized by the loss of dopaminergic (DAergic) neurons in the substantia nigra and the appearance of Lewy bodies (LBs), whose cytoplasmic inclusions are highly enriched with ubiquitin, synphilin-1, α-synuclein and parkin. Synphilin-1 is an α-synuclein-binding protein and a major component of LBs. It is widely accepted that synphilin-1 is involved in the pathogenic process of PD. This review will provide an overall view of the role of synphilin-1 in the pathogenesis of Parkinson’s disease and the latest findings in this field.

关键词： synphlin- 1 Parkinson's disease α-synuclein

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An Ideal Hallmark Closest to Complete Cure of Chronic Hepatitis B Patients:High-sensitivity Quantitative HBsAg Loss

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Journal of Clinical and Translational Hepatology 2023年第1期11卷 197-206页

作者： Zi-Long Wang Jia-rui zheng rui-Feng Yang Lin-Xiang Huang Hong-Song Chen Bo Feng Peking University People’s Hospital Peking University Hepatology InstituteBeijing Key Laboratory of Hepatitis C and Immunotherapy for Liver DiseasesBeijingChina

In the era of antiviral therapy,the main goal of treatment has shifted from the persistent inhibition of hepatitis B virus(HBV)replication to the pursuit of serological clearance of HBs surface antigen(HBsAg).Based on the life cycle of HBV,HBsAg originates from covalently closed circular DNA(cccDNA)and integrated HBV DNA,thus reflecting their transcriptional *** HBsAg loss may mean elimination or persistent inactivity of the HBV genome including cccDNA and integrated HBV *** loss improves the recovery of abnormal immune function,which in turn,may further promote the clearance of residual *** with functional cure and the great improvement of clinical outcomes,the continuous seroclearance of high-sensitivity quantitative HBsAg may represent the complete cure of chronic hepatitis B(CHB).For many other risk factors besides HBV itself,patients with HBsAg loss still need regular *** this review,we summarized the evolution of CHB treatment,the origin of serum HBsAg,the pattern of HBsAg seroclearance,and the effect of HBsAg loss on immune function and disease *** addition,we discuss the significance of high-sensitivity HBsAg detection and its possibility as a surrogate of complete cure.

关键词： Hepatitis B virus Chronic hepatitis B HBsAg Immunoassay Functional cure Complete cure Biomarker

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Magnetic interactions during sympathetic solar eruptions

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Chinese Journal of Astronomy and Astrophysics 2009年第5期9卷 603-612页

作者： Yun-Chun Jiang Yi Bi Jia-Yan Yang rui-Sheng zheng Jing-Xiu Wang National Astronomical Observatories/Yunnan Observatory Chinese Academy of Sciences Kunming 650011 China National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China

We present the first evidence for occurrences of magnetic interactions between a jet, a filament and coronal loops during a complex event, in which two flares sequentially occurred at different positions of the same active region and were closely associated with two successive coronal mass ejections （CMEs）, respectively. The coronal loops were located outside but nearby the filament channel before the flares. The jet, originating from the first flare during its rise phase, not only hit the filament body but also met one of the ends of the loops. The filament then underwent an inclined eruption followed by the second flare and met the same loop end once more. Both the jet and the filament eruption were accompanied by the development of loop disturbances and the appearances of brightenings around the meeting site. In particular, the erupting filament showed clear manifestations of interactions with the loops. After a short holdup, only its portion passed through this site, while the other portion remained at the same place. Following the filament eruption and the loop disappearance, four dimmings were formed and located near their four ends. This is a situation that we define as ＂quadrupolar dimmings.＂ It appears that the two flares consisted of a sympathetic pair physically linked by the interaction between the jet and the filament, and their sympathy indicated that of the two CMEs. Moreover, it is very likely that the two sympathetic CMEs were simultaneously associated with the disappearing loops and the quadrupole dimmings.

关键词： Sun activity - Sun coronal mass ejections (CMEs) - Sun filaments - Sun flares - Sun magnetic fields - Sun corona

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