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3-D observations of a red tide event in the offshore water along the western Guangdong coast

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Acta Oceanologica Sinica 2015年第1期34卷 159-161页

作者： xie Lingling CHEN Qingxiang HU Jianyu ZHANG Shuwen YI Xiaofei CHEN Fajin deng rui deng Xiaodong wang Jing QI Yiquan Guangdong Province Key Laboratory for Coastal Ocean Variation and Disaster Prediction Technologies Guangdong Ocean University State Key Laboratory of Marine Environmental Science Xiamen University Guangdong Key Laboratory for Urbanization and Geo-simulation School of Geography and PlanningSun Yat-sen University State Key Laboratory of Tropic Oceanography South China Sea Institute of OceanologyChinese Academy of Sciences

From November 24 to 26, 2014, a red tide event occurred in the offshore water off the Hailing Island located at the western Guangdong coast. The red tide appeared as pink strips distributed within 3 km in the offshore water and extended for about 10 km along the shoreline. During the flood tide, the pink seawater rushed to the beach with breaking waves, forming foam strips on the beach. Guangdong Province Key Laboratory for Coastal Ocean Variation and Disaster Prediction Technologies, Guangdong Ocean University, emergently responded to the event and organized three-dimensional observations from the air, onboard and on beach. The preliminary analyses of the cruise data and water samples indicate that the event was induced by non- toxic Noctiluca scintillans, of which the concentration reaches as high as 4 200 cells/L near the surface and 2600 cells/L at the bottom.

关键词： red tide Noctiluca scintillans marine pollution Hailing Island South China Sea

Template-free preparation of non-metal(B,P,S)doped g-C_(3)N_(4)tubes with enhanced photocatalytic H_(2)O_(2)generation

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Journal of Materials Science & Technology 2021年第36期95卷 127-135页

作者： Yuanyuan Liu Yanmei Zheng Weijie Zhang Zhengbin Peng Hang xie Yi Xuan wang Xinli Guo Ming Zhang rui Li Ying Huang Jiangsu Key Laboratory of Advanced Metallic Materials School of Materials Science and EngineeringSoutheast UniversityNanjing 211189China School of Energy and Environment Southeast UniversityNanjing 210096China

Developing environmentally friendly methods to produce hydrogen peroxide(H_(2)O_(2))has received increasing *** has been proved to be a sustainable technology for H_(2)O_(2)***,the novel non-metal elements(B,P,and S)doped g-C_(3)N_(4)tubes(B-CNT,P-CNT,and S-CNT)photocatalysts were obtained via a hydrothermal synthesis followed by thermal *** adjusting the precursor,the yield of g-C_(3)N_(4)tubes(CNT)materials has been greatly *** as-prepared B-CNT,P-CNT,and S-CNT photocatalysts show an enhanced photocatalytic H_(2)O_(2)production with the formation rate constants values of 42.31μM min^(-1),24.95μM min^(-1),and 24.22μM min^(-1),respectively,which is higher than that of bulk CN(16.40μM min^(-1)).The doped B,P,S elements significantly enhanced the photocatalytic activity by adjusting their electronic structures and promoting the separation of electronhole *** results have shown great potential for the practical application of CNT photocatalysts.

关键词： Template-free preparation High yield g-C_(3)N_(4)tube(CNT) Non-metal elements doping Photocatalytic H_(2)O_(2)production

Stromal lenticule addition keratoplasty with corneal crosslinking for corneal ectasia secondary to FS-LASIK:a case series

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International Journal of Ophthalmology(English edition) 2024年第3期17卷 596-602页

作者： Li-Xiang wang Ying-Ping deng Meng-Zhen xie Ke Ma Hong-Bo Yin Qiong wang rui Gong Jing Tang Department of Ophthalmology West China HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina West China School of Medicine Sichuan UniversityChengdu 610041Sichuan ProvinceChina

●AIM:To explore the clinical efficacy and safety of stromal lenticule addition keratoplasty(SLAK)with corneal crosslinking(CXL)on patients with corneal ectasia secondary to femtosecond laser-assisted in situ keratomileusis(FS-LASIK).●METHODS:A series of 5 patients undertaking SLAK with CXL for the treatment of corneal ectasia secondary to FS-LASIK were followed for *** lenticules were collected from patients undertaking small incision lenticule extraction(SMILE)for the correction of *** a stromal lenticule was aimed at improving the corneal thickness for the safe application of crosslinking and compensating for the thin cornea to improve its mechanical strength.●RESULTS:All surgeries were conducted successfully with no significant *** best corrected visual acuity(BCVA)ranged from 0.05 to 0.8-2 before *** pre-operational total corneal thickness ranged from 345-404μm and maximum keratometry(Kmax)ranged from 50.8 to *** the combination surgery,both the corneal keratometry(range 55.9 to 92.8)and total corneal thickness(range 413-482μm)significantly *** out of 5 patients had improvement of corneal biomechanical parameters(reflected by stiffness parameter A1 in Corvis ST).However,3 patients showed decreased BCVA after surgery due to the development of irregular astigmatism and transient *** the onset of corneal edema right after SLAK,the corneal topography and thickness generally stabilized after 3mo.●CONCLUSION:SLAK with CXL is a potentially beneficial and safe therapy for advanced corneal *** work needs to address the poor predictability of corneal refractometry and compare the outcomes of different surgical modes.

关键词： corneal ectasia femtosecond laserassisted in situ keratomileusis stromal lenticule addition keratoplasty corneal crosslinking corneal thickness corneal biomechanics

The burgeoning importance of PIWI-interacting RNAs in cancer progression

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Science China(Life Sciences) 2024年第4期67卷 653-662页

作者： Xinpei deng Tianle Liao Jindong xie Da Kang Yiwei He Yuying Sun Zhangling wang Yongluo Jiang Xuan Miao yixuan Yan Hailin Tang Lewei Zhu Yutian Zou Peng Liu State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for CancerSun Yat-sen University Cancer CenterGuangzhou 510060China School of Medicine Sun Yat-sen UniversityShenzhen 518107China Key Laboratory of Cardiovascular and Cerebrovascular Medicine Nanjing Medical UniversityNanjing 211166China Guanghua School of Stomatology Sun Yat-sen UniversityGuangzhou 510062China The First People’s Hospital of Foshan Foshan 528000China

PIWI-interacting RNAs(pi RNAs)are a class of small noncoding RNA molecules that specifically bind to piwi protein family members to exert regulatory functions in germ *** studies have found that pi RNAs,as tissue-specific molecules,both play oncogenic and tumor suppressive roles in cancer progression,including cancer cell proliferation,metastasis,chemoresistance and ***,the atypical manifestation of pi RNAs and PIWI proteins in various malignancies presents a promising strategy for the identification of novel biomarkers and therapeutic targets in the diagnosis and management of ***,the precise functions of pi RNAs in cancer progression and their underlying mechanisms have yet to be fully *** review aims to examine current research on the biogenesis and functions of pi RNA and its burgeoning importance in cancer progression,thereby offering novel perspectives on the potential utilization of pi RNAs and piwi proteins in the management and treatment of advanced cancer.

关键词： PIWI-interacting RNAs/piRNAs cancer progression metastasis chemoresistance stemness

shinyTempSignal:an R shiny application for exploring temporal and other phylogenetic signals

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Journal of Genetics and Genomics 2024年第7期51卷 762-768页

作者： Li Zhan Xiao Luo Wenqin xie Xuan-An Zhu Zijing xie Jianfeng Lin Lin Li Wenli Tang rui wang Lin deng Yufan Liao Bingdong Liu Yantong Cai Qianwen wang Shuangbin Xu Guangchuang Yu Department of Bioinformatics School of Basic Medical SciencesSouthern Medical UniversityGuangzhouGuangdong 510515China Faculty of Computers Guangdong University of TechnologyGuangzhouGuangdong 510006China Ubigene Biosciences Co. Ltd.GuangzhouGuangdong 510530China State Key Laboratory of Applied Microbiology Southern China Guangdong Provincial Key Laboratory of Microbial Culture Collection and ApplicationGuangdong Open Laboratory of Applied MicrobiologyGuangdong Institute of MicrobiologyGuangdong Academy of SciencesGuangzhouGuangdong 510070China

The molecular clock model is fundamental for inferring species divergence times from molecular ***,its direct application may introduce significant biases due to sequencing errors,recombination events,and inaccurately labeled sampling *** accuracy necessitates rigorous quality control measures to identify and remove potentially erroneous ***,while not all branches of a phylogenetic tree may exhibit a clear temporal signal,specific branches may still adhere to the assumptions,with varying evolutionary *** a relaxed molecular clock model better aligns with the complexities of *** root-to-tip regression method has been widely used to analyze the temporal signal in phylogenetic studies and can be generalized for detecting other phylogenetic *** its utility,there remains a lack of corresponding software implementations for broader *** address this gap,we present shinyTempSignal,an interactive web application implemented with the shiny framework,available as an R package and publicly accessible at https://***/YuLab-SMU/*** tool facilitates the analysis of temporal and other phylogenetic signals under both strict and relaxed *** extending the root-to-tip regression method to diverse signals,shinyTempSignal helps in the detection of evolving features or traits,thereby laying the foundation for deeper insights and subsequent analyses.

关键词： Molecular clock Root-to-tip regression Temporal signal Phylogenetic signal

Age-specific differences in the association between prediabetes and cardiovascular diseases in China:A national cross-sectional study

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World Journal of Diabetes 2024年第2期15卷 240-250页

作者： Shuo xie Li-Ping Yu Fei Chen Yao wang rui-Fen deng Xue-Lian Zhang Bo Zhang Department of Endocrinology Chinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100730China Department of Endocrinology China-Japan Friendship HospitalBeijing 100029China

BACKGROUND Cardiovascular disease(CVD)is a leading cause of morbidity and mortality worldwide,the global burden of which is *** is still unclear the extent to which prediabetes contributes to the risk of CVD in various age brackets among *** develop a focused screening plan and treatment for Chinese adults with prediabetes,it is crucial to identify variations in the connection between prediabetes and the risk of CVD based on *** To examine the clinical features of prediabetes and identify risk factors for CVD in different age groups in *** The cross-sectional study involved a total of 46239 participants from June 2007 through May 2008.A thorough evaluation was *** with prediabetes were categorized into two groups based on *** atherosclerotic CVD risk prediction model was employed to evaluate the risk of developing CVD over 10 *** forest was established in both age *** Additive exPlanation method prioritized the importance of features from the perspective of assessment *** In total,6948 people were diagnosed with prediabetes in this *** prediabetes,prevalences of CVD were 5(0.29%)in the younger group and 148(2.85%)in the older ***,11.11%of the younger group and 29.59% of the older group were intermediate/high-risk of CVD for prediabetes without CVD based on the Prediction for ASCVD Risk in China equation in ten *** the younger age group,the 10-year risk of CVD was found to be more closely linked to family history of CVD rather than lifestyle,whereas in the older age group,resident status was more closely *** The susceptibility to CVD is age-specific in newly diagnosed *** is necessary to develop targeted approaches for the prevention and management of CVD in adults across various age brackets.

关键词： Age Cardiovascular diseases Prediabetes Risk factors Differences

A novel and low-toxic peptide DR3penA alleviates pulmonary fibrosis by regulating the MAPK/miR-23b-5p/AQP5 signaling axis

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Acta Pharmaceutica Sinica B 2023年第2期13卷 722-738页

作者： Dan wang Bochuan deng Lu Cheng Jieru Li Jiao Zhang Xiang Zhang Xiaomin Guo Tiantian Yan Xin Yue Yingying An Bangzhi Zhang Wenle Yang Junqiu xie rui wang Institute of Materia Medica and Research Unit of Peptide Science Chinese Academy of Medical SciencesPeking Union Medical CollegeBeijing 100050China Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical SciencesLanzhou UniversityLanzhou 730000China

Pulmonary fibrosis(PF)is a pathological change caused by repeated injuries and repair dysfunction of the alveolar *** previous study revealed that the residues Asn3 and Asn4 of peptide DR8(DHNNPQIR-NH_(2))could be modified to improve stability and antifibrotic activity,and the unnatural hydrophobic amino acids a-(4-pentenyl)-Ala and D-Ala were considered in this ***3penA(DHa-(4-pentenyl)-ANPQIR-NH_(2))was verified to have a longer half-life in serum and to significantly inhibit oxidative damage,epithelial-mesenchymal transition(EMT)and fibrogenesis in vitro and in ***,DR3penA has a dosage advantage over pirfenidone through the conversion of drug bioavailability under different routes of administration.A mechanistic study revealed that DR3penA increased the expression of aquaporin 5(AQP5)by inhibiting the upregulation of miR-23b-5p and the mitogen-activated protein kinase(MAPK)pathway,indicating that DR3penA may alleviate PF by regulating MAPK/miR-23b-5p/*** evaluation showed that DR3penA is a peptide drug without obvious toxicity or acute side effects and has significantly improved safety compared to ***,our findings suggest that DR3penA,as a novel and low-toxic peptide,has the potential to be a leading compound for PF therapy,which provides a foundation for the development of peptide drugs for fibrosis-related diseases.

关键词： Peptide Structure modification Pulmonary fibrosis miR-23b-5p AQP5

Protective effects of curcumin against human immunodeficiency virus 1 gp120 V3 loop-induced neuronal injury in rats

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Neural Regeneration Research 2012年第3期7卷 171-175页

作者： Zheng Gong Lijuan Yang Hongmei Tang rui Pan Sai xie Luyan Guo Junbin wang Qinyin deng Guoyin Xiong Yanyan Xing Jun Dong Department of Pathophysiology Key Laboratory of State Administration of Traditional Chinese Medicine Medical College of Jinan UniversityGuangzhou 510632 Guangdong Province China Institute of Brain Research Medical College of Jinan University Guangzhou 510632 Guangdong Province China Joint Laboratory for Brain Function and Health of Jinan University and the University of Hongkong Guangzhou 510632 GuangdongProvince China Department of Orthopedics First Affiliated Hospital Medical College of Jinan University Guangzhou 510632 Guangdong Province China

Curcumin improves the learning and memory deficits in rats induced by the gp120 V3 loop. The present study cultured rat hippocampal neurons with 1 nM gp120 V3 loop and 1 μM curcumin for 24 hours. The results showed that curcumin inhibited the gp120 V3 loop-induced mitochondrial membrane potential decrease, reduced the mRNA expression of the pro-apoptotic gene caspase-3, and attenuated hippocampal neuronal injury.

关键词： curcumin gp120 V3 loop hippocampal neurons mitochondrial membrane potential caspase-3 human immunodeficiency virus-associated neurocognitive function neural regeneration

Targeted core-shell nanoparticles for precise CTCF gene insert in treatment of metastatic breast cancer

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Bioactive Materials 2022年第5期7卷 1-14页

作者： Jialun Duan Chunjie Bao Ying xie Haitao Guo yixuan Liu Jianwei Li rui Liu Peishan Li Jing Bai Yan Yan Limin Mu Xueqi Li Guiling wang Wanliang Lu State Key Laboratory of Natural and Biomimetic Drugs Beijing Key Laboratory of Molecular Pharmaceutics and New Drug Delivery SystemsAnd School of Pharmaceutical SciencesPeking UniversityBeijing100191China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing100875China

Clustered regularly interspaced short palindromic repeats(CRISPR)technology emerges a remarkable potential for cure of refractory cancer like metastatic breast ***,how to efficiently deliver the CRISPR system with non-viral carrier remains a major issue to be ***,we report a kind of targeted core-shell nanoparticles(NPs)carrying dual plasmids(pHR-pCas9)for precise CCCTC-binding factor(CTCF)gene insert to circumvent metastatic breast *** targeted core-shell NPs carrying pHR-pCas9 can accomplishγGTP-mediated cellular uptake and endosomal escape,facilitate the precise insert and stable expression of CTCF gene,inhibit the migration,metastasis,and colonization of metastatic breast cancer ***,the finding further reveals that the inhibitory mechanism of metastasis could be associated with up-regulating CTCF protein,followed by down-regulating stomatin(STOM)*** study offers a universal nanostrategy enabling the robust non-viral delivery of gene-editing system for treatment of severe illness.

关键词： Core-shell nanoparticles Non-viral gene delivery Precise gene editing CTCF Metastatic breast cancer