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Dynamic changes of estimated glomerular filtration rate are conversely related to triglyceride in non-overweight patients

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World Journal of Clinical Cases 2022年第31期10卷 11371-11380页

作者： Si-Qi Liu Xiu-Jun Zhang Yuan Xue rui huang Jian Wang Chao Wu Yi-Shan He Ya-Ru Pan Long-Gen Liu Changzhou Clinical Medical College Nanjing Medical UniversityChangzhou 213000Jiangsu ProvinceChina Institute of Hepatology The Third People’s Hospital of ChangzhouChangzhou 213000Jiangsu ProvinceChina Department of Infectious Diseases Nanjing Drum Tower HospitalNanjing 210008Jiangsu ProvinceChina

BACKGROUND Correlation between Triglyceride(TG)and estimated glomerular filtration rate(eGFR)remains largely unknown in overweight and non-overweight patients.AIM To investigated the dynamic changes of eGFR and lipid profiles during 3-year tenofovir disoproxil fumarate(TDF)treatment in patients with chronic hepatitis B(CHB)and overweight.METHODS A total of 202 CHB patients who received TDF treatment at the Third People's Hospital of Changzhou(Changzhou,China)and Nanjing Drum Tower Hospital(Nanjing,China)between January 2016 and May 2018 were retrospectively enrolled.According to the body mass index(BMI)at the initiation of TDF treatment,CHB patients were divided into overweight(BMI≥25 kg/m^(2))and nonoverweight(BMI0.05).More patients in non-overweight group achieved alanine aminotransferase normalization compared with those in overweight group(χ^(2)=11.036,P<0.01).In non-overweight patients,the eGFR significantly declined in the 1^(st) year(P<0.01),then remained at a relatively lower level.TG significantly declined in the 2^(nd) year(P=0.02)and increased in the 3^(rd) year.Moreover,TG was negatively correlated with GFR at the four-time points(P=0.002,0.030,0.007,0.008,respectively).In overweight patients,eGFR and TG remained relatively stable during the 3-year treatment,and eGFR showed no significant relationship with TG.Moreover,multivariate analysis showed that age[P<0.01,95%CI(0.97-1.005)]and baseline eGFR[P<0.01,95%CI(5.056-33.668)]were independent risk factors for eGFR<90 mL/(min·1.73 m^(2))at the 3^(rd) year.CONCLUSION Dynamic changes in renal function were conversely related to TG during TDF treatment in patients with CHB and normal BMI,but not with overweight.

关键词： Tenofovir disoproxil fumarate Hepatitis B virus Glomerular filtration rate Overweight Body mass index

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基于不变图卷积神经网络的文本分类

计算机科学 2024年第S1期51卷 108-112页

作者：黄瑞徐计贵州大学计算机科学与技术学院贵阳550025 贵州大学省部共建公共大数据国家重点实验室贵阳550025

文本分类是自然语言处理中一个基本而又重要的任务,近年来,图神经网络被越来越多地应用于文本分类中。然而,使用图神经网络的图表示学习在涉及文本分类的任务中不能很好地满足新词的归纳学习,其一般假设训练和测试数据来自相同的分布,... 详细信息

文本分类是自然语言处理中一个基本而又重要的任务,近年来,图神经网络被越来越多地应用于文本分类中。然而,使用图神经网络的图表示学习在涉及文本分类的任务中不能很好地满足新词的归纳学习,其一般假设训练和测试数据来自相同的分布,但现实中这个假设经常不成立。为了克服这些问题,文中提出了Invariant-GCN,用于通过GCN进行归纳文本分类。首先为每个文档构建单个图,使用GCN根据其局部结构学习细粒度的单词表示,这可以有效地为新文档中没见过的单词生成嵌入进而将单词节点作为文档嵌入合并;然后提取最大限度地保留不变类内信息的期望子图,使用这些子图进行学习不受分布变化的影响;最后通过图分类方法完成文本分类。在4个基准数据集上与5种分类方法进行了比较,实验结果表明Invariant-GCN具有良好的文本分类效果。

关键词：文本分类图卷积神经网络因果学习文本图构建

外部性视角下环境关心对公众低碳消费行为的影响研究

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干旱区资源与环境 2024年第4期38卷 13-20页

作者：芮韦青黄涛珍河海大学公共管理学院南京211100 江苏水安全与生态共富研究基地(江苏省决策咨询基地) 南京211100

低碳消费的广泛推行是应对全球气候变化和实现“双碳”目标的重要举措。文章从环境关心、结果意识和消费外部性政策反应三个层面出发,构建低碳消费行为影响因素的理论模型,通过江苏省803名消费者的问卷调查数据,利用验证性因子分析和Boo... 详细信息

低碳消费的广泛推行是应对全球气候变化和实现“双碳”目标的重要举措。文章从环境关心、结果意识和消费外部性政策反应三个层面出发,构建低碳消费行为影响因素的理论模型,通过江苏省803名消费者的问卷调查数据,利用验证性因子分析和Bootstrap方法进行假设检验。研究表明:环境关心不仅对低碳消费行为具有显著正向影响,也能通过结果意识的中介作用正向影响低碳消费行为;消费外部性政策反应在“环境关心-低碳消费行为”的影响路径中具有正向调节作用。研究结果有助于揭示环境关心对低碳消费行为影响的作用机制,为相关部门减排政策的设计与实施提供有益启示。

关键词：低碳消费行为环境关心消费外部性结果意识

Multiomics analysis reveals metabolic subtypes and identifies diacylglycerol kinase α (DGKA) as a potential therapeutic target for intrahepatic cholangiocarcinoma

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Cancer Communications 2024年第2期44卷 226-250页

作者： Weiren Liu Huqiang Wang Qianfu Zhao Chenyang Tao Weifeng Qu Yushan Hou Run huang Zimei Sun Guiqi Zhu Xifei Jiang Yuan Fang Jun Gao Xiaoling Wu Zhixiang Yang Rongyu Ping Jiafeng Chen rui Yang Tianhao Chu Jian Zhou Jia Fan Zheng Tang Dong Yang Yinghong Shi Department of Liver Surgery and Transplantation Liver Cancer InstituteZhongshan HospitalFudan UniversityKey Laboratory of Carcinogenesis and Cancer Invasion of Ministry of EducationShanghaiP.R.China Research Unit of Liver cancer Recurrence and Metastasis Chinese Academy of Medical SciencesBeijingP.R.China State Key Laboratory of Medical Proteomics Beijing Proteome Research CenterNational Center for Protein Sciences(Beijing)Beijing Institute of LifeomicsBeijingP.R.China

Background:Intrahepatic cholangiocarcinoma(iCCA)is a highly heteroge-neous and lethal hepatobiliary tumor with few therapeutic strategies.The metabolic reprogramming of tumor cells plays an essential role in the develop-ment of tumors,while the metabolic molecular classification of iCCA is largely unknown.Here,we performed an integrated multiomics analysis and metabolic classification to depict differences in metabolic characteristics of iCCA patients,hoping to provide a novel perspective to understand and treat iCCA.Methods:We performed integrated multiomics analysis in 116 iCCA samples,including whole-exome sequencing,bulk RNA-sequencing and proteome anal-ysis.Based on the non-negative matrix factorization method and the protein abundance of metabolic genes in human genome-scale metabolic models,the metabolic subtype of iCCA was determined.Survival and prognostic gene analy-ses were used to compare overall survival(OS)differences between metabolic subtypes.Cell proliferation analysis,5-ethynyl-2’-deoxyuridine(EdU)assay,colony formation assay,RNA-sequencing and Western blotting were performed to investigate the molecular mechanisms of diacylglycerol kinaseα(DGKA)in iCCA cells.Results:Three metabolic subtypes(S1-S3)with subtype-specific biomarkers of iCCA were identified.These metabolic subtypes presented with distinct prog-noses,metabolic features,immune microenvironments,and genetic alterations.The S2 subtype with the worst survival showed the activation of some special metabolic processes,immune-suppressed microenvironment and Kirsten ratsar-coma viral oncogene homolog(KRAS)/AT-rich interactive domain 1A(ARID1A)mutations.Among the S2 subtype-specific upregulated proteins,DGKA was further identified as a potential drug target for iCCA,which promoted cell proliferation by enhancing phosphatidic acid(PA)metabolism and activating mitogen-activated protein kinase(MAPK)signaling.Conclusion:Viamultiomics analyses,we identified three metabolic subtypes of iCCA,revealing that the S2 subtype exhibited the poorest surviv

关键词： diacylglycerol kinaseα intrahepatic cholangiocarcinoma MAPK signaling metabolic classifi-cation multiomics analysis phosphatidic acid metabolism

田野—历史—国家:田野政治学的概念建构逻辑——以“家户制”概念为例

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学海 2024年第1期 120-129,215,216页

作者：黄振华杨瑞华中师范大学政治学部、中国农村研究院武汉430079

概念建构是构建中国自主知识体系的基础性工作。田野政治学是推进中国政治学自主知识体系建设的积极探索,并以一系列原创性概念建构为路径。以“家户制”概念为例,田野政治学概念建构内含三重逻辑:一是基于田野调查的概念建构,注重从丰... 详细信息

概念建构是构建中国自主知识体系的基础性工作。田野政治学是推进中国政治学自主知识体系建设的积极探索,并以一系列原创性概念建构为路径。以“家户制”概念为例,田野政治学概念建构内含三重逻辑:一是基于田野调查的概念建构,注重从丰富的田野事实中提炼概念;二是基于历史根基的概念建构,强调从深厚的历史传统中生成概念;三是基于国家治理的概念建构,侧重于从国家的微观基础视角产生概念。田野政治学的概念建构以立足中国场景为前提,其既是构建中国自主知识体系的有效路径,也是一个需要持续努力的渐进发展过程。未来,田野政治学的概念建构还需在发展概念家族、强化现实取向、构建理论体系方面继续深化和拓展。

关键词：自主知识体系田野政治学概念建构家户制

Comprehensive analysis of gene mutations and mismatch repair in Chinese colorectal cancer patients

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World Journal of Gastrointestinal Oncology 2024年第6期16卷 2673-2682页

作者： huang Chen rui-Ying Jiang Zhan Hua Xiao-Wei Wang Xiao-Li Shi Ye Wang Qian-Qian Feng Jie Luo Wu Ning Yan-Fen Shi Da-Kui Zhang Bei Wang Jian-Zheng Jie Ding-Rong Zhong Department of Pathology China-Japan Friendship HospitalBeijing 100029China Department of Gastrointestinal Surgery China-Japan Friendship HospitalBeijing 100029China Department of Scientific Research GeneisBeijing 100012China

BACKGROUND RAS,BRAF,and mismatch repair(MMR)/microsatellite instability(MSI)are crucial biomarkers recommended by clinical practice guidelines for colorectal cancer(CRC).However,their characteristics and influencing factors in Chinese patients have not been thoroughly described.AIM To analyze the clinicopathological features of KRAS,NRAS,BRAF,and PIK3CA mutations and the DNA MMR status in CRC.METHODS We enrolled 2271 Chinese CRC patients at the China-Japan Friendship Hospital.MMR proteins were tested using immunohistochemical analysis,and the KRAS/NRAS/BRAF/PIK3CA mutations were determined using quantitative polymerase chain reaction.Microsatellite status was determined using an MSI detection kit.Statistical analyses were conducted using SPSS software and logistic regression.RESULTS The KRAS,NRAS,BRAF,and PIK3CA mutations were detected in 44.6%,3.4%,3.7%,and 3.9% of CRC patients,respectively.KRAS mutations were more likely to occur in patients with moderate-to-high differentiation.BRAF mutations were more likely to occur in patients with right-sided CRC,poorly differentiated,or no perineural invasion.Deficient MMR(dMMR)was detected in 7.9% of all patients and 16.8% of those with mucinous adenocarcinomas.KRAS,NRAS,BRAF,and PIK3CA mutations were detected in 29.6%,1.1%,8.1%,and 22.3% of patients with dMMR,respectively.The dMMR was more likely to occur in patients with a family history of CRC,aged<50 years,right-sided CRC,poorly differentiated histology,no perineural invasion,and with carcinoma in situ,stage I,or stage II tumors.CONCLUSION This study analyzed the molecular profiles of KRAS,NRAS,BRAF,PIK3CA,and MMR/MSI in CRC,identifying key influencing factors,with implications for clinical management of CRC.

关键词： Colorectal cancer Deficient mismatch repair Microsatellite instability Gene mutation Comprehensive analysis

基于逻辑-物理框架的智慧机场评价指标量化方法

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航空学报 2024年第10期45卷 35-47页

作者：张锐黄卫马涛东南大学智能运输系统研究中心南京211189 综合交通运输理论交通运输行业重点实验室(南京现代综合交通实验室) 南京211100 东南大学交通学院南京211189

为了解决机场在进行智能化程度评价过程中基础业务流指标无法定量表达的问题,通过对比分析现有评价体系方法,采用面向过程的方法对智慧机场体系框架进行构建,搭建了基于逻辑-物理框架的智慧机场评价体系;在此基础上,对框架内的各个基础... 详细信息

为了解决机场在进行智能化程度评价过程中基础业务流指标无法定量表达的问题,通过对比分析现有评价体系方法,采用面向过程的方法对智慧机场体系框架进行构建,搭建了基于逻辑-物理框架的智慧机场评价体系;在此基础上,对框架内的各个基础指标按定性指标和定量指标2个不同的类别进行了数学上的定义与定量描述。研究结果表明:面向过程的评价体系同样也适用于机场的智能化评价体系构建,且能够从逻辑框架到物理框架对智慧机场的各个业务流和子系统进行全面的反映。对基础指标根据其数学描述采用不同的分类量化有助于对机场的智慧化程度刻画更加精确和全面。对A机场基础指标的量化发现飞行区管理基础指标中百分比型指标占20%,数值型指标占34.3%,是否型指标占45.7%,陆侧交通管理基础指标中百分比型指标占13.3%,数值型指标占13.3%,是否型指标占73.4%,且各个指标能够展现具体的量化分值,说明提出的量化方法能够适用于机场全部业务流的量化处理。

关键词：智慧机场面向过程评价法逻辑框架物理框架量化方法

Simulation, experimentation, and collaborative analysis of adjacent heat exchange modules in a vehicular cooling system

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2013年第6期14卷 417-426页

作者： Yu-qi huang rui huang Xiao-li YU Feng LV Power Machinery and Vehicular Engineering Institute Zhejiang University Department of Mechanical and Aerospace Engineering Monash University-Clayton

A cooling system consisting of several heat exchange modules is a necessary part of an automobile, and its performance has a direct effect on a vehicle's energy consumption. Heat exchangers, such as a charged air cooler (CAC), radiator, oil cooler, or condenser have different structures and can be arranged in various orders, and each combination may produce different effects because of interactions among them. In this study, we aimed to explore the principles governing interactions among adjacent heat exchangers in a cooling system, using numerical simulation and experimental technology. 3D models with different combinations were developed, compared, and analyzed comprehensively. A wind tunnel test platform was constructed to validate the computational results. We found that the heat dissipation of the modules was affected slightly by their relative position (the rules basically comply with the field synergy principle), but was independent of the modules' spacing within a certain distance range. The heat dissipation of one module could be effectively improved by restructuring, but with a penalty of higher resistance. However, the negative effect on the downstream module was much less than expected. The results indicated that the intensity of heat transfer depends not only on the average temperature difference between cold and hot mediums, but also on the temperature distribution.

关键词： Collaborative analysis Heat exchangers Field synergy principle Computational fluid dynamics (CFD) Wind tunnel

An overview for monitoring and prediction of pathogenic microorganisms in the atmosphere

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Fundamental Research 2024年第3期4卷 430-441页

作者： Jianping huang Danfeng Wang Yongguan Zhu Zifeng Yang Maosheng Yao Xiaoming Shi Taicheng An Qiang Zhang Cunrui huang Xinhui Bi Jiang Li Zifa Wang Yongqin Liu Guibing Zhu Siyu Chen Jian Hang Xinghua Qiu Weiwei Deng Huaiyu Tian Tengfei Zhang Tianmu Chen Sijin Liu Xinbo Lian Bin Chen Beidou Zhang Yingjie Zhao rui Wang Han Li Collaborative Innovation Center for Western Ecological Safety College of Atmospheric SciencesLanzhou UniversityLanzhou 730000China Research Center for Eco-Environmental Sciences Chinese Academy of SciencesBeijing 100085China National Clinical Research Center for Respiratory Disease Guangzhou Institute of Respiratory HealthFirst Affiliated Hospital of Guangzhou Medical UniversityState Key Laboratory of Respiratory Disease(Guangzhou Medical University)Guangzhou 510230China College of Environmental Sciences and Engineering Peking UniversityBeijing 100871China China CDC Key Laboratory of Environment and Population Health National Institute of Environmental HealthChinese Center for Disease Control and PreventionBeijing 100021China Guangdong-Hong Kong-Macao Joint Laboratory for Contaminants Exposure and Health School of Environmental Science and EngineeringInstitute of Environmental Health and Pollution ControlGuangdong University of TechnologyGuangzhou 510006China Ministry of Education Key Laboratory for Earth System Modeling Department of Earth System ScienceTsinghua UniversityBeijing 100084China Vanke School of Public Health Tsinghua UniversityBeijing 100084China State Key Laboratory of Organic Geochemistry and Guangdong Key Laboratory of Environmental Protection and Resources Utilization Guangzhou Institute of GeochemistryChinese Academy of SciencesGuangzhou 510640China National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of Atmospheric Boundary Layer Physics and Atmospheric Chemistry Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China Center for Pan-third Pole Environment Lanzhou UniversityLanzhou 730000China College of Atmospheric Sciences Lanzhou UniversityLanzhou 730000China School of Atmospheric Sciences Sun Yat-sen Universityand Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai)Zhuhai 510640

Corona virus disease 2019(COVID-19)has exerted a profound adverse impact on human health.Studies have demonstrated that aerosol transmission is one of the major transmission routes of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Pathogenic microorganisms such as SARS-CoV-2 can survive in the air and cause widespread infection among people.Early monitoring of pathogenic microorganism transmission in the atmosphere and accurate epidemic prediction are the frontier guarantee for preventing large-scale epidemic outbreaks.Monitoring of pathogenic microorganisms in the air,especially in densely populated areas,may raise the possibility to detect viruses before people are widely infected and contain the epidemic at an earlier stage.The multi-scale coupled accurate epidemic prediction system can provide support for governments to analyze the epidemic situation,allocate health resources,and formulate epidemic response policies.This review first elaborates on the effects of the atmospheric environment on pathogenic microorganism transmission,which lays a theoretical foundation for the monitoring and prediction of epidemic development.Secondly,the monitoring technique development and the necessity of monitoring pathogenic microorganisms in the atmosphere are summarized and emphasized.Subsequently,this review introduces the major epidemic prediction methods and highlights the significance to realize a multi-scale coupled epidemic prediction system by strengthening the multidisciplinary cooperation of epidemiology,atmospheric sciences,environmental sciences,sociology,demography,etc.By summarizing the achievements and challenges in monitoring and prediction of pathogenic microorganism transmission in the atmosphere,this review proposes suggestions for epidemic response,namely,the establishment of an integrated monitoring and prediction platform for pathogenic microorganism transmission in the atmosphere.

关键词： Aerosol transmission Epidemic monitoring methods Epidemic prediction modelsEpidemic response Multidisciplinary cooperation