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融合思政元素:大学生心理健康教育课程创新与实践

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湖北开放职业学院学报 2024年第16期37卷 17-19页

作者：于丹丹周芳蕊田来吉林省经济管理干部学院吉林长春130012

以课程思政为背景,分析大学生心理健康教育课程开展课程思政的优势与必要性,从而探索心理健康教育课程思政实践路径。从思政育人目标出发,深度挖掘思政元素;从课程内容出发,设计课程思政切入点;从课程思政案例出发,实践思政元素渗透;从... 详细信息

以课程思政为背景,分析大学生心理健康教育课程开展课程思政的优势与必要性,从而探索心理健康教育课程思政实践路径。从思政育人目标出发,深度挖掘思政元素;从课程内容出发,设计课程思政切入点;从课程思政案例出发,实践思政元素渗透;从教学方法出发,采用任务驱动、角色扮演、案例教学等方式,探索思政融合载体路径。将思政教育融入大学生的心理健康教育课程中,有利于创新高校心理健康教育模式,验证融合思政元素的大学生心理健康教育课程的有效性和可行性,使心理课程与思政课程同向同行,将显性教育和隐性教育相统一。

关键词：课程思政大学生心理健康教育思政元素

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微量不对称催化实验教学:手性半酯的合成

化学教育（中英文） 2024年第4期45卷 54-59页

作者：熊非朱依仁孙宸方睿靖何一扬李烨基上海理工大学化学系上海200093

采用“有机酸-有机碱”协同共催化合成策略,实现了在温和反应条件下催化内消旋环状酸酐的不对称醇解,并通过柱前衍生化高效液相色谱法对所得手性半酯产物的对映体过量百分数(ee值)进行了测定。在该实验中融合了绿色化学发展理念等思政... 详细信息

采用“有机酸-有机碱”协同共催化合成策略,实现了在温和反应条件下催化内消旋环状酸酐的不对称醇解,并通过柱前衍生化高效液相色谱法对所得手性半酯产物的对映体过量百分数(ee值)进行了测定。在该实验中融合了绿色化学发展理念等思政元素、无水无氧操作技术、薄层色谱喷雾显色、柱前衍生化、手性HPLC等多种教学理念、现代实验技术和测试表征方法,将一个涉及光学活性物质合成与ee值检测的前沿科研实验开发成为了一个适合本科教学环境的微型有机合成综合实验,同时还可以进行模块化拆分教学,满足于不同内容和不同学时的实验教学要求。

关键词：手性半酯有机合成实验立体化学不对称催化

Medical care and clinical practice for disabled elderly

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Frontiers of Nursing 2018年第1期5卷 7-16页

作者： rui-fang Zhu Shi-Fan Han School of Nursing Shanxi Medical UniversityTaiyuanShanxi 030001China First Hospital of Shanxi Medical University TaiyuanShanxi 030001China

At preasent,with the continuous development of the trend of population aging worldwide,more elderiy people are increasingly facing s-erious life disorders caused by physical and mental *** this study,the common symptoms and the nursing practice related to diseases of the disabled elderly are reviewed with reference to the basic concepts of disability care and the current situation of domestic and foreign research,which is expected to provide the basis for the construction of a new model of disability nursing.

关键词： disability elderly disability care clinical practice symptoms disease

Contragestazol (DL111-IT) inhibits proliferation of human androgen-independent prostate cancer cell line PC3 in vitro and in vivo

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Asian Journal of Andrology 2005年第4期7卷 389-393,页

作者： Qiao-Jun He Bo Yang Yi-Jia Lou rui-Ying fang Department of Pharmacology College of Pharmaceutical Science Zhejiang University Hangzhou 310031 China

Aim： To evaluate the antiproliferative activity of contragestazol （DL111-IT） on the human prostate cancer cell line PC3 in vitro and in vivo and to elucidate its potential molecular mechanisms. Methods： The cell killing ability of DL111-IT was measured by the 3-（4,5-dimethylthia-zol,2-yl）-2,5-diphenyltetrazolium bromide （MTT） reagent assay method and the tumor xenograft model. The cell cycle was analyzed by flow cytometry and protein expression, including retinoblastoma （pRb）, cyclin-dependent kinase 4 （CDK4） and cyclin D 1, was detected by Western blotting. Results： DL111-IT exhibited high efficiency on cell growth inhibition of the human androgen-independent prostate cancer cell line PC3. The drug concentration that yielded 50 % cell inhibition （IC50 value） was 9.9 mg/mL. In the PC3 tumor xenograft study, DL111-IT （1.25 mg/kg-20.0 mg/kg） given once a day for 10 days significantly inhibited tumor growth, with the inhibition rate ranging from 21% to 50 %. Flow cytometric analysis indicated that DL111-IT could cause GI arrest in the PC3 cell line, but not apoptosis. DL111-IT enhanced pRb expression and down-regulated CDK4 and cyclin D 1 expression, suggesting that cell cycle regulation might contribute to the anticancer property of DL 111- IT. Conclusion： DL111-1T inhibits the proliferation of human androgen-independent prostate cancer cell line PC3 in vitro and in vivo by a cell cycle regulation pathway.

关键词： DL111-IT prostate cancer pRb cyclin-dependent kinase 4 cyclin D 1 PC3 cell line

Estimating coal reserves using a support vector machine

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Journal of China University of Mining and Technology 2008年第1期18卷 103-106页

作者： LIU Wen-kai WANG rui-fang ZHENG Xiao-juan Jiaozuo Teacher＇s College Jiaozuo Henan 454000 China Department of Surveying Engineering Henan Polytechnic University Jiaozuo Henan 454000 China

The basic principles of the Support Vector Machine (SVM) are introduced in this paper. A specific process to establish an SVM prediction model is given. To improve the precision of coal reserve estimation, a support vector machine method, based on statistical learning theory, is put forward. The SVM model was trained and tested by using the existing exploration and exploitation data of Chencun mine of Yima bureau’s as the input data. Then coal reserves within a particular region were calculated. These calculated results and the actual results of the exploration block were compared. The maximum relative error was 10.85%, within the scope of acceptable error limits. The results show that the SVM coal reserve calculation method is reliable. This method is simple, practical and valuable.

关键词： support vector machine statistical learning theory coal reserve

A Novel Method for Synthesis of 2,3,4-Trisubstituted Furans

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Chinese Chemical Letters 2006年第11期17卷 1421-1422页

作者： Lu Bin XU fang rui ZHONG Lu Ling WU Xian HUANG Department of Chemistry Zhejiang University （Xixi Campus） Hangzhou 310028

Intermolecular addition-cyclization of 1, 3-dicarbonyl compounds with arylbromo- allenes in K2CO3 mediated condition afforded 2, 3, 4-trisubstituted furans in good yield.

关键词： Bromoallene polysubstituted furans allyl dication equivalent.

Inverted Internal Limiting Membrane Flap Technique for Repair of Large Macular Holes： A Short-term Follow-up of Anatomical and Functional Outcomes

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Chinese Medical Journal 2016年第5期129卷 511-517页

作者： Zhe Chen Chan Zhao Jun-Jie Ye Xu-Qian Wang rui-fang Sui Department of Ophthalmology Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College geijing 100005 China

Background：Inverted internal limiting membrane （ILM） flap technique has recently been reported in a limited number of studies as an effective surgical technique for the management of large macular holes （MHs） with fair MH closure rates as well as gains in visual *** the current study,longitudinal changes in multi-focal electroretinogram （mfERG） responses,best-corrected visual acuity （BCVA） and spectral-domain optical coherence tomography （SD-OCT） were evaluated in eyes with large MHs managed by this ***：A prospective noncontrolled interventional study of eight patients （eight eyes） with large MHs （minimum diameter 〉400 μm） was *** MHs were treated with pars plana vitrectomy and indocyanine green-assisted inverted ILM flap ***-OCT images were used to assess the anatomical outcomes of surgery while BCVA and mfERG were used to evaluate the functional outcomes during a 3-month ***：All patients underwent successful intended manipulation and translocation of the ILM flap without flap dislocation and achieved complete anatomical *** microstructural reconstruction,demonstrated on SD-OCT as restoration of the external limiting membrane and the ellipsoid zone,was observed in all cases as early as 1 month after ***,as compared to baseline,all patients showed improvements in BCVA and all but one in mfERG response during ***,Pearson＇s test revealed no significant correlations between BCVA and mfERG responses of the fovea and of the macular area at each evaluation time ***：Inverted ILM flap technique appeares to be a safe and effective approach for the management of large idiopathic MHs with favorable short-term anatomical and functional *** reconstruction of the microstructure generally shows good consistency with improvements in both BCVA and mfERG response,of which the latter might be a supplement for the former in postoperative functional follow-up.

关键词： Inverted Internal Limiting Membrane Flap Technique Large Macular Hole Multi-focal Electroretinogram:Spectral-domain Optical Coherence Tomography

Role of gut microbiota in the pathogenesis and therapeutics of minimal hepatic encephalopathy via the gut-liver-brain axis

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World Journal of Gastroenterology 2023年第1期29卷 144-156页

作者： Ming Luo rui-Juan Xin fang-rui Hu Li Yao Sheng-Juan Hu Fei-Hu Bai Department of Gastroenterology People’s Hospital of Ningxia Hui Autonomous RegionYinchuan 750021Ningxia Hui Autonomous RegionChina

Minimal hepatic encephalopathy(MHE) is a frequent neurological and psychiatric complication of liver cirrhosis. The precise pathogenesis of MHE is complicated and has yet to be fully elucidated. Studies in cirrhotic patients and experimental animals with MHE have indicated that gut microbiota dysbiosis induces systemic inflammation, hyperammonemia, and endotoxemia, subsequently leading to neuroinflammation in the brain via the gut-liver-brain axis. Related mechanisms initiated by gut microbiota dysbiosis have significant roles in MHE pathogenesis. The currently available therapeutic strategies for MHE in clinical practice, including lactulose, rifaximin, probiotics, synbiotics, and fecal microbiota transplantation, exert their effects mainly by modulating gut microbiota dysbiosis. Microbiome therapies for MHE have shown promised efficacy and safety;however, several controversies and challenges regarding their clinical use deserve to be intensively discussed. We have summarized the latest research findings concerning the roles of gut microbiota dysbiosis in the pathogenesis of MHE via the gut-liver-brain axis as well as the potential mechanisms by which microbiome therapies regulate gut microbiota dysbiosis in MHE patients.

关键词： Gut microbiota Minimal hepatic encephalopathy Gut-liver-brain axis Pathogenesis Therapeutics

基于电容耦合法的环网柜局部放电在线监测技术研究

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仪表技术 2024年第2期 55-59页

作者：方锐梁馨予管婵波江悦国网江苏省电力有限公司常州供电分公司江苏常州213003

环网柜绝缘放电击穿故障占比较高,供电公司每年须定期巡检检测环网柜局部放电情况,但仍然存在漏检和误判现象,为了实时了解环网柜局部放电情况,提出借助环网柜带电显示器配置的电容传感器直接从环网柜内部获取放电信息,无需安装昂贵的... 详细信息

环网柜绝缘放电击穿故障占比较高,供电公司每年须定期巡检检测环网柜局部放电情况,但仍然存在漏检和误判现象,为了实时了解环网柜局部放电情况,提出借助环网柜带电显示器配置的电容传感器直接从环网柜内部获取放电信息,无需安装昂贵的超高频和超声波探头;提出利用无源型网络变压器滤除幅值较高的低频信号,采用50 MHz采样频率的高速A/D和FPGA快速采集局部放电信号,基于STM32嵌入式技术开发了局部放电在线监测装置,编制了相应软件对局部放电波形和频谱进行绘制。搭建局部放电实验平台对局部放电进行了对比测试,结果表明,研制的在线监测装置对局部放电监测满足设计要求,该监测装置可替代传统带电显示器,具有安装简便的优势,对保障供电安全具有重要的意义。

关键词：电容耦合法环网柜局部放电在线监测