检索结果-南通市图书馆

Acta Biochimica et Biophysica Sinica 2006年第3期38卷 151-156页

作者： Catherine CHANG ruhong dong Akira MIYAZAKI Naomi SAKASHITASecond Department of Pathology,Kumamoto University School of Medicine,Kumamoto,Japan Jay LIU Michael GUO Department of Biochemistry Dartmouth Medical SchoolHanoverNew Hampshire 03755 USA Department of Biochemistry Showa University School of MedicineTokyoJapan

Acyl-CoA:cholesterol acyltransferase (ACAT) catalyzes the formation of cholesteryl estersfrom cholesterol and long-chain fatty-acyl-coenzyme *** the single-cell level,ACAT serves as a regulatorof intracellular cholesterol *** addition,ACAT supplies cholesteryl esters for lipoproteinassembly in the liver and small *** pathological conditions,the accumulation of cholesterylesters produced by ACAT in macrophages contributes to foam cell formation,a hallmark of the earlystage of *** reviews addressing various aspects of ACAT and ACAT inhibitors areavailable [1-8].This review briefly outlines the current knowledge on the biochemical properties of humanACATs,and then focuses on discussing the merit of ACAT as a drug target for pharmaceutical interventionsagainst atherosclerosis.

关键词： acyl-CoA cholesterol acyltransferase cholesterol cholesteryl ester atherosclerosis

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

BF公司L6生产线快速换型效率改善分析

盐城工学院学报（自然科学版） 2017年第3期30卷 41-47页

作者：马如宏董晓慧张溪红孙凯南盐城工学院机械工程学院江苏盐城224002

针对BF公司L6生产线快速换型流程中的换料效率低、预装工位待料频繁问题,基于精益生产思想中的快速换型理论,采用价值流图析、意大利面条图等方法,通过设计工位物料清单来缩减换料时间,提升换料效率;通过设计换型信息提示灯来优化换型... 详细信息

针对BF公司L6生产线快速换型流程中的换料效率低、预装工位待料频繁问题,基于精益生产思想中的快速换型理论,采用价值流图析、意大利面条图等方法,通过设计工位物料清单来缩减换料时间,提升换料效率;通过设计换型信息提示灯来优化换型信息流;通过设计新的料架,减少工序调整的换型时间,并对现有快速换型流程进行优化,使整个换型效率得到很大提升。L6生产线评价结果显示,采用新的方法,不同系列产品175D0、38100的换型时间从17.9min缩减至6.2 min,换型效率提升了65.4%。

关键词：快速换型精益生产价值流图析

Tribological behavior of thermal- and pH-sensitive microgels under steel/CoCrMo alloy contacts

在线全文

学校读者我要写书评

暂无评论

Friction 2023年第4期11卷 602-616页

作者： Kequn SUN Yuanhua HU Yinghui dong Lulu YAO ruhong SONG Yufu XU Institute of Tribology School of Mechanical EngineeringHefei University of TechnologyHefei 230009China School of Chemistry and Chemical Engineering Hefei University of TechnologyHefei 230009China

The tribological behavior of 316L stainless steel/CoCrMo alloy contacts under aqueous lubrication was investigated in this *** types of microgels including poly(N-isopropylacrylamide)(PNIPAM),polyacrylic acid(PAA),and poly(N-isopropylacrylamide-co-acrylic acid)(PNIPAM-co-PAA)were prepared and used as lubricant additives in aqueous *** tests were conducted using a ball-on-disk reciprocating tribometer,over a range of temperatures,pH,and concentrations of the *** PNIPAM-co-PAA microgels were proven to have excellent anti-friction and anti-wear properties,depending on the temperature and pH values of the *** maximum friction coefficient coincided with the lower critical solution temperature of the PNIPAM-co-PAA microgels at 32°*** the same time,the friction coefficient increased with the increase in pH value of the lubricant solution with the PNIPAM-co-PAA *** unique thermal-and pH-sensitive properties of the PNIPAM-co-PAA microgels provided a new strategy for controlling the friction and wear of steel/CoCrMo alloy contacts under aqueous lubrication.

关键词： poly(N-isopropylacrylamide-co-acrylic acid)(PNIPAM-co-PAA) microgel aqueous lubrication thermal-sensitive pH-sensitive

DeST 3.0:A new-generation building performance simulation platform

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Building Simulation 2022年第11期15卷 1849-1868页

作者： Da Yan Xin Zhou Jingjing An Xuyuan Kang Fan Bu Youming Chen Yiqun Pan Yan Gao Qunli Zhang Hui Zhou Kuining Qiu Jing Liu Yan Liu Honglian Li Lei Zhang Hong dong Lixin Sun Song Pan Xiang Zhou Zhe Tian Wenjie Zhang ruhong Wu Hongsan Sun Yu Huang Xiaohong Su Yongwei Zhang Rui Shen Diankun Chen Guangyuan Wei Yixing Chen Jinqing Peng Building Energy Research Center School of ArchitectureTsinghua UniversityBeijing 100084China School of Architecture Southeast UniversityNanjingJiangsu 210096China School of Environment and Energy Engineering Beijing University of Civil Engineering and ArchitectureBeijing 100044China College of Civil Engineering Hunan UniversityChangshaHunan 410082China School of Mechanical Engineering Tongji UniversityShanghai200092China Beijing Key Lab of Heating Gas SupplyVentilating and Air Conditioning EngineeringBeijing University of Civil Engineering and ArchitectureBeijing 100044China China State Construction Technology Center Beijing 101320China School of Architecture Harbin Institute of TechnologyHarbinHeilongjiang 150090China School of Architecture Xi'an University of Architecture and TechnologyXi'anShaanxi 710055China School of Architecture South China University of TechnologyGuangzhouGuangdong 510641China Institute of Building Environment and Energy China Academy of Building ResearchBeijing 100013China Beijing Key Laboratory of Green Built Environment and Energy Efficient Technology Beijing University of TechnologyBeijing 100124China Key Lab of Built Environment and Energy of Tianjin School of Environmental Science and EngineeringTianjin UniversityTianjin 300350China School of Energy and Power Engineering Nanjing University of Science and TechnologyNanjing 210094China School of Civil Engineering Guangzhou UniversityGuangzhou 510006China Faculty of Computing Harbin Institute of TechnologyHarbinHeilongjiang 150001China Beijing Glory PKPM Technology Co. Ltd.Beijing 100013China Beijing Tangent Software Co. LtdBeijing 100081China Shanghai Huadianyuan Information Technology Co. LtdShanghai200092China Luoyang Hongye Information Technology Co. Ltd.LuoyangHenan 471822China

Buildings contribute to almost 30%of total energy consumption *** building energy modeling programs is of great significance for lifecycle building performance assessment and *** in novel building technologies,the requirements of high-performance computation,and the demands for multi-objective models have brought new challenges for building energy modeling software and *** meet the increasing simulation demands,DeST 3.0,a new-generation building performance simulation platform,was developed and *** structure of DeST 3.0 incorporates four simulation engines,including building analysis and simulation(BAS)engine,HVAC system engine,combined plant simulation(CPS)engine,and energy system(ES)engine,connected by air loop and water loop balancing *** 3.0 offers numerous new simulation features,such as advanced simulation modules for building envelopes,occupant behavior and energy systems,cross-platform and compatible simulation kernel,FMI/FMU-based co-simulation functionalities,and high-performance parallel simulation *** 3.0 has been thoroughly evaluated and validated using code verification,inter-program comparison,and case-study *** 3.0 has been applied in various aspects throughout the building lifecycle,supporting building design,operation,retrofit analysis,code appliance,technology adaptability evaluation as well as research and *** new generation building simulation platform DeST 3.0 provides an efficient tool and comprehensive simulation platform for lifecycle building performance analysis and optimization.

关键词： DeST building performance simulation building energy modeling

Effect of visceral obesity on outcomes of fluorescence-guided lymphadenectomy during laparoscopic gastrectomy for gastric cancer:Post hoc analysis of a randomized phase 3 trial

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Cancer Research 2024年第5期36卷 503-516页

作者： Yihui Tang Zening Huang Xingqi Zhang Ping Li Jianwei Xie Jiabin Wang Qiyue Chen Longlong Cao Mi Lin ruhong Tu Guangtan Lin Hualong Zheng Qing Zhong Juli Lin Zihao Yao dong Wu Chaohui Zheng Jianxian Lin Changming Huang Department of Gastric Surgery Fujian Medical University Union HospitalFuzhou 350001China Department of General Surgery Fujian Medical University Union HospitalFuzhou 350001China Fujian Province Minimally Invasive Medical Center Fuzhou 350001China Key Laboratory of Gastrointestinal Cancer(Fujian Medical University) Ministry of EducationFuzhou 350108China

Objective:To explore the impact of visceral fat area(VFA)on the short-and long-term efficacy of indocyanine green(ICG)-guided D2 lymphadenectomy for gastric cancer(GC).Methods:A post hoc analysis was performed in patients who participated in a phase 3 randomized clinical trial of ICG-guided laparoscopic radical gastrectomy *** laparoscopic radical gastrectomy from November 2018 to July *** VFA was calculated based on preoperative computed tomography ***-term efficacy included the quality of lymph node(LN)dissection and surgical outcomes,while long-term efficacy included overall survival(OS)and recurrence-free survival(RFS).Results:This study included 126 patients each in the ICG(high-VFA,n=43)and non-ICG groups(high-VFA,n=38).Compared with the non-ICG group,the ICG group had significantly more retrieved LNs(low-VFA:50.1 vs.43.9,P=0.001;high-VFA:49.6 vs.37.5,P<0.001)and a significantly lower LN noncompliance rate(low-VFA:32.5%vs.50.0%,P=0.020;high-VFA:32.6%vs.73.7%,P<0.001),regardless of the *** ICG group had a shorter postoperative hospital stay and fewer intra-abdominal infections than the ICG group in the high-VFA patients(P=0.025 and P=0.020,respectively)but not in the low-VFA *** of the VFA,the 3-year OS(RFS)was better in the ICG group than in the non-ICG group[low-VFA:83.1%(76.9%)vs.73.9%(67.0%);high-VFA:90.7%(90.7%)vs.73.7%(73.5%);P for interaction=0.474(0.547)].Conclusions:The short-and long-term efficacies of ICG tracing were not influenced by visceral obesity.

关键词： Gastric cancer laparoscopic gastrectomy indocyanine green visceral obesity lymph node dissection survival

在线全文

学校读者我要写书评

暂无评论

风力机塔架螺栓连接状态监测与辨识研究进展

现代制造工程 2013年第3期 129-133页

作者：董晓慧马如宏詹月林盐城工学院机械工程学院盐城224051

螺栓连接是大型风力机塔架各段塔筒及塔架与塔基之间的唯一连接方式,若其连接状态失效,将会造成灾难性的破坏。为了预防螺栓松动,甚至断裂,对风力机塔架螺栓连接状态进行监测与辨识至关重要。综述了螺栓连接结构动特性分析方法和螺栓连... 详细信息

螺栓连接是大型风力机塔架各段塔筒及塔架与塔基之间的唯一连接方式,若其连接状态失效,将会造成灾难性的破坏。为了预防螺栓松动,甚至断裂,对风力机塔架螺栓连接状态进行监测与辨识至关重要。综述了螺栓连接结构动特性分析方法和螺栓连接状态监测与辨识方法,并对基于动力学模型和基于信号分析的无模型状态监测与辨识方法能否应用于风力机塔架螺栓连接状态的监测与辨识进行了述评,重点论述了波传播非线性动力学模型和应用非线性动力学理论进行信号分析的无模型状态监测与辨识方法,综述了风力机塔架螺栓连接状态监测与辨识的发展动态。

关键词：风力发电机塔架螺栓连接状态监测非线性动力学

近海风力机塔架塔基的动力特性及稳固性分析方法研究

在线全文

学校读者我要写书评

暂无评论

机床与液压 2012年第17期40卷 46-49页

作者：董晓慧马如宏詹月林盐城工学院江苏盐城224051

根据近海风力机塔架塔基的动力特性及稳固性分析的研究状况,提出近海风力机塔架塔基的动力特性及稳固性分析需要解决的关键技术及相应的解决方案。该方案可用来模拟作用在风力机塔架塔基上的载荷变化特性,推求作用在塔架塔基上的气动载... 详细信息

根据近海风力机塔架塔基的动力特性及稳固性分析的研究状况,提出近海风力机塔架塔基的动力特性及稳固性分析需要解决的关键技术及相应的解决方案。该方案可用来模拟作用在风力机塔架塔基上的载荷变化特性,推求作用在塔架塔基上的气动载荷、流体动力载荷和海床阻抗载荷,分析在风波海床耦合作用下塔架塔基的固有频率和振型,计算塔架塔基结构节点的位移、速度、加速度和应力响应谱,在此基础上进行海床失稳破坏和塔架塔基结构屈曲失稳破坏分析,为揭示风力机塔架塔基稳固破坏演变规律及机制提供参考。

关键词：近海风力机塔架塔基动力特性稳固性

新疆北阿尔泰造山带早古生代花岗岩类侵入序列及其构造意义

在线全文

学校读者我要写书评

暂无评论

岩石学报 2012年第8期28卷 2307-2316页

作者：董连慧屈迅赵同阳徐仕琪周汝洪王克卓朱志新新疆地质矿产开发局乌鲁木齐830000 新疆地质调查院乌鲁木齐830000

新疆阿尔泰早古生代造山带侵入岩占构造带面积50%以上,近年大量高精度SHRIMP和LA-ICP-MS锆石U-Pb年代学资料反映其构造属性为奥陶纪碰撞前序列和中志留-早泥盆世后碰撞序列。碰撞前序列岩石组合为(石英)闪长岩-英云闪长岩/奥长花岗岩/... 详细信息

新疆阿尔泰早古生代造山带侵入岩占构造带面积50%以上,近年大量高精度SHRIMP和LA-ICP-MS锆石U-Pb年代学资料反映其构造属性为奥陶纪碰撞前序列和中志留-早泥盆世后碰撞序列。碰撞前序列岩石组合为(石英)闪长岩-英云闪长岩/奥长花岗岩/花岗闪长岩-二长花岗岩序列,类似TTG组合,锆石U-Pb同位素年龄峰值为450～465Ma。后碰撞由二长花岗岩-正长花岗岩及少量碱长花岗岩组成,属于广义的GG组合,同位素年龄峰值390～415Ma。前者主要分布在中南部,后者主要分布中北部,分布的极性显示俯冲带在南侧。而区域南侧的阿尔曼太蛇绿岩带同位素年龄与北阿尔泰奥陶纪碰撞前序列时代相同,本文推测该蛇绿岩带与北阿尔泰岩浆链带构成洋脊俯冲带模式;其间的南阿尔泰晚古生代增生带、额尔齐斯强变形带、北准噶尔晚古生代洋内弧带都是后来的上叠产物。

关键词：花岗岩 TTG组合洋脊俯冲早古生代阿尔泰新疆

动态对比增强MRI纹理分析预测高级别胶质瘤IDH基因表型的价值

在线全文

学校读者我要写书评

暂无评论

中华放射学杂志 2020年第5期54卷 450-455页

作者：卢海涛邢伟张艳文董博吴汝洪顾正章江苏省常州市第一人民影像科 213003 江苏省常州市第一人民医院神经外科 213003

目的探讨动态对比增强(DCE)-MRI纹理分析术前鉴别脑高级别胶质瘤异柠檬酸脱氢酶(IDH)基因表型的价值。方法回顾性分析常州市第一人民医院院2016年4月至2019年12月经手术病理证实的、IDH基因型明确的29例高级别胶质瘤,其中IDH突变型10例,... 详细信息

目的探讨动态对比增强(DCE)-MRI纹理分析术前鉴别脑高级别胶质瘤异柠檬酸脱氢酶(IDH)基因表型的价值。方法回顾性分析常州市第一人民医院院2016年4月至2019年12月经手术病理证实的、IDH基因型明确的29例高级别胶质瘤,其中IDH突变型10例,IDH野生型19例。采用荷兰飞利浦Achieve 3.0 T超导MR扫描仪进行数据采集,扫描序列包括常规MRI平扫、增强及动态对比增强(DCE)。采用Omni Kinetics软件进行DCE数据分析及纹理分析,生成全脑容积转运常数(Ktrans)、速率常数(Kep)、血管外细胞外容积分数(Ve)、血浆容积分数(Vp)及信号强度-时间曲线下面积(AUC)参数图;采用灰度共生矩阵法提取各参数图ROI内5个常用纹理特征(能量、熵、惯性、相关性、逆差矩)。采用独立样本t检验(满足正态分布和方差齐性)或Mann-Whitney秩和检验(不满足正态分布或方差不齐)比较IDH突变组与IDH野生组各参数图纹理特征的差异。对差异有统计学意义的纹理特征绘制受试者操作特征(ROC)曲线,评价其鉴别IDH突变型与IDH野生型高级别胶质瘤的效能。结果IDH突变型高级别胶质瘤Ktrans、Ve的熵分别为5.368±1.458、6.698±1.081,IDH野生型高级别胶质瘤Ktrans、Ve的熵分别为7.334±1.385、8.213±1.320,两组间差异具有统计学意义(t值分别为-3.570、-3.113,P值分别为0.001、0.004)。IDH突变型高级别胶质瘤Ktrans、Ve的逆差距分别为0.567±0.147、0.417±0.106,IDH野生型高级别胶质瘤Ktrans、Ve的逆差距分别为0.393±0.119、0.296±0.101,两组间差异具有统计学意义(t值分别为3.452、3.014,P值分别为0.002、0.006)。Ktrans的熵鉴别IDH突变型与IDH野生型高级别胶质瘤的ROC曲线下面积最大(0.874),对鉴别诊断的灵敏度也最高(100%);Ve的逆差距对鉴别诊断的特异度最高(94.7%)。结论DCE-MRI纹理分析有助于术前高级别胶质瘤IDH基因表型的鉴别。

关键词：神经胶质瘤磁共振成像 IDH基因突变

‘贵紫麦1号’GzA BI5-3A3基因的克隆及在烟草中的功能分析

在线全文

学校读者我要写书评

暂无评论

分子植物育种 2021年第1期19卷 41-49页

作者：彭亚姝李鲁华董亚兵徐如宏任明见贵州大学农学院贵阳550025 国家小麦改良中心贵州分中心贵阳550025

ABI5在植物种子休眠与萌发、生长发育、花青素合成以及对逆境胁迫的响应等诸多生物学过程中起着重要作用。而大量研究表明ABI5参与种子休眠与萌发,少有研究表明ABI5参与花青素合成。为了探究ABI5转录因子参与调控小麦花青素合成,本研究... 详细信息

ABI5在植物种子休眠与萌发、生长发育、花青素合成以及对逆境胁迫的响应等诸多生物学过程中起着重要作用。而大量研究表明ABI5参与种子休眠与萌发,少有研究表明ABI5参与花青素合成。为了探究ABI5转录因子参与调控小麦花青素合成,本研究从‘贵紫麦1号’中扩增得到Gz ABI5-3A3的c DNA全长。其启动子顺式元件分析结果表明Gz ABI5-3A3可能参与调控植物生长、光合作用、开花及种子萌发和花青素累积的生物学过程。蛋白质系统进化树分析表明,Gz ABI5-3A3与小麦中Ta ABI5D-SH-31、Ta ABI5D-SH-23和Ta ABI5D-SW-23同源。本研究进一步构建Gz ABI5-3A3基因的过表达载体PBI121-Gz ABI5-3A3,用于烟草遗传转化,共获得8个烟草转基因株系。本研究对Gz ABI5-3A3过表达转基因株系进行研究发现,转基因烟草株系L4、L7和L15苗期叶片中花青素含量显著低于野生型,其花青素合成途径的结构基因Nt PAL、Nt DFR、Nt ANS和Nt CHS的表达量显著下降。研究结果表明Gz ABI5-3A3能够通过调控花青素合成途径结构基因的表达来负向调控植物花青素的合成,为后续研究Gz ABI5-3A3调控花青素合成的分子机制提供研究基础。

关键词： ‘贵紫麦1号’ GzA BI5-3A3 基因克隆烟草遗传转化