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A pH-responsive nanoparticle delivery system containing dihydralazine and doxorubicin-based prodrug for enhancing antitumor efficacy

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Aggregate 2024年第1期5卷 436-450页

作者： Lianxue Zhang Jianxiang Huang Damiano Buratto Panli Han Zaixing Yang ruhong zhou Institute of Quantitative Biology Shanghai Institute for Advanced StudyCollege of Life SciencesZhejiang UniversityHangzhouChina State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences(RAD-X)Soochow UniversitySuzhouChina Cancer Center Zhejiang UniversityHangzhouChina Department of Chemistry Columbia UniversityNew YorkNew YorkUSA

The efficacy of nanoparticle(NP)-based drug delivery technology is hampered by aberrant tumor stromal microenvironments(TSMs)that hinder NP ***,the promotion of NP permeation into deep tumor sites via the regulation of tumor microenvironments is of critical ***,we propose a potential solution using a dihydralazine(HDZ)-loaded nanoparticle drug delivery system containing a pH-responsive,cyclic RGD peptide-modified prodrug based on doxorubicin(cRGD-Dex-DOX).With a combined experimental and theoretical approach,we find that the designed NP system can recognize the acid tumor environments and precisely release the encapsulated HDZ into tumor *** can notably downregulate the expression levels of hypoxia-inducible factor 1α(HIF1α),α-smooth muscle actin,and fibronectin through the dilation of tumor blood *** changes in the TSMs enhance the enrichment and penetration of NPs and also unexpectedly promote the infiltration of activated T cells into tumors,suggesting that such a system may offer an effective“multifunctional therapy”through both improving the chemotherapeutic effect and enhancing the immune response to *** vivo experiments on 4T1 breast cancer bearing mice indeed validate that this therapy has the most outstanding antitumor effects over all the other tested control regimens,with the lowest side effects as well.

关键词： antitumor dihydralazine drug delivery system tumor stromal microenvironment vasculature

Theoretical Investigation of the Ammonia Adsorption Process on Si(100)-2×1 Surface

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Chinese Physics Letters 1991年第2期8卷 94-97页

作者： zhou ruhong CAO Peilin Physics Department of Zhejiang University Hangzhou 310027

The nature of the NH_(3) adsorption process on Si(100)-2×1 surface has been studied by DV-Xα(discrete variational Xαmethod)and ASED-MO(atom superposition and electron delocalization molecular orbital theory)*** calculated results show that NH3 is dissociatively adsorbed on the surface dangling bonds as NH_(2)(a)and H(a)un'th no activation *** the further decomposion of NH_(2)(a)to NH(a)and N(a)has been found to have activation barriers of 0.87 and 1.65eV *** bond geometries and electronic structures of these NH3-derived adsorbed species are described in detail.

关键词： methods adsorbed activation

Probing the electrostatic aggregation of nanoparticles with oppositely charged molecular ions

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聚集体(英文)

聚集体(英文) 2023年第4期4卷 185-194页

作者： Jianxiang Huang Damiano Buratto ruhong zhou Institute of Quantitative Biology College of Life SciencesHangzhouChina Department of Chemistry Columbia UniversityNew YorkNew YorkUSA

The co-assembly of charged nanoparticles with oppositely charged molecular ions has emerged as a promising technique in the fabrication of nanoparticle ***,the underlying mechanism behind these molecular ions in mediating the repulsion between these charged nanoparticles remains ***,coarsegrained molecular dynamics simulations are used to elucidate the effects of valency,shape,and size of molecular anions on their co-assembly with gold nanoparticles coated with positively charged *** findings suggest that the valency,shape,and size of molecular anions significantly influence the repulsion and aggregating dynamics among these positively charged ***,the free energy calculations reveal that ring-shaped molecular anions with higher valences and larger sizes are more effective at reducing the repulsion between these gold nanoparticles and thus enhance the stability of the *** study contributes to a better understanding of the critical roles of valence,shape,and size of ions in mediating the electrostatic co-assembly of nanoparticles with oppositely charged ions,and it also guides the future design of DNA templates and DNA origami in co-assembly with oppositely charged nanoparticles.

关键词： aggregation coarse-grained molecular dynamics simulation co-assembly electrostatic interaction nanoparticle

Five-Stage Model of the Palaeozoic Crustal Evolution in Xinjiang

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Acta Geologica Sinica(English Edition) 1998年第4期72卷 339-349页

作者： LIU Dequan TANG Yanling zhou ruhong Xinjiang Bureau of Geology and Mineral Exploration and Development No. 2 W. Karamay Rd Urumqi Xinjiang 830000

Abstract: The great majority of the Palaeozoic orogenic belts of Central Asia are of the intercontinental type, whose evolution always follows a five-stage model, i.e. the basal continental crust-extensional transitional crust-oceanic crust-convergent transitional crust-new continental crust model. The stage for the extensional transitional crust is a pretty long, independent and inevitable phase. The dismembering mechanism of the basal continental crust becoming an extensional continental crust is delineated by the simple shear model put forward by Wernike (1981). The continental margins on the sides of a gently dipping detachment zone and moving along it are asymmetric: one side is of the nonmagmatic type and the other of the magmatic type with a typical bimodal volcanic formation. In the latter case, however, they were often confused with island arcs. This paper discusses the five-stage process of the crustal evolution of some typical orogenic belts in Xinjiang.

关键词： crustal evolution extensional transitional crust oceanic crust new continental crust five-stage model Xinjiang

De novo design of transmembrane nanopores

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Science China Chemistry 2022年第11期65卷 2122-2143页

作者： Dan Qiao Yuang Chen Haojing Tan ruhong zhou Jiandong Feng Laboratory of Experimental Physical Biology Department of ChemistryZhejiang UniversityHangzhou 310027China Institute of Quantitative Biology College of Life SciencesZhejiang UniversityHangzhou 310058China Zhejiang Lab Hangzhou 31000China

Transmembrane nanopores are structurally stable and biocompatible, and have various applications in molecular sensing and selective transport. The relationship between the function and structure is crucial for transmembrane nanopores, but it is still challenging to design and precisely tune the structure of conventional protein nanopores from scratch, albeit of abundant previous work on natural and bioengineered transmembrane protein nanopores. Therefore, numerous types of artificial transmembrane nanopores that can be de novo designed are rapidly under development, such as molecular nanopores, peptide nanopores, and DNA origami nanopores. In this review, we compare different building blocks of “bottom-up” built nanopores in terms of construction methods, structures and applications, and also describe important advances in de novo designed proteins from the perspective of theoretical simulations as well as an outlook for artificial intelligence-assisted nanopore design.

关键词： nanopores de novo design macrocycle DNA origami protein design

High-resolution anatomical and spatial transcriptome analyses reveal two types of meristematic cell pools within the secondary vascular tissue of poplar stem

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Molecular Plant 2023年第5期16卷 809-828页

作者： Juan Du Yichen Wang Wenfan Chen Mingling Xu ruhong zhou Huixia Shou Jun Chen State Key Laboratory of Plant Physiology and Biochemistry College of Life SciencesZhejang University866Yu Hangtang RoadHangzhouZhejiang 310058China MOE Key Laboratory of Biosystems Homeostasis&Protection College of Life SciencesZhejang University866 Yu Hangtang RoadHangzhouZhejang 310058China Institute of Quantitative Biology College of Life SciencesZhejiang UniversityHangzhouZhejiang 310058China Hangzhou Botanical Garden Taoyuanling RoadHangzhouZhejiang 310013China

The secondary vascular tissue emanating from meristems is central to understanding how vascular plants such as forest trees evolve,grow,and regulate secondary radial ***,the overall molecular characterization of meristem origins and developmental trajectories from primary to secondary vascular tissues in woody tree stems is technically *** this study,we combined high-resolution anatomic analysis with a spatial transcriptome(ST)technique to define features of meristematic cells in a developmental gradient from primary to secondary vascular tissues in poplar *** tissue-specific gene expression of meristems and derived vascular tissue types were accordingly mapped to specific anatomical *** analyses were used to track the origins and changes of meristems throughout the development from primary to secondary vascular ***,two types of meristematic-like cell pools within secondary vascular tissues were inferred based on high-resolution microscopy combined with ST,and the results were confirmed by in situ hybridization of,transgenic trees,and single-cell *** rectangle shape procambium-like(PCL)cells develop from procambium meristematic cells and are located within the phloem domain to produce phloem cells,whereas fusiform shape cambium zone(CZ)meristematic cells develop from fusiform metacambium meristematic cells and are located inside the CZ to produce xylem *** gene expression atlas and transcriptional networks spanning the primary transition to secondary vascular tissues generated in this work provide new resources for studying the regulation of meristem activities and the evolution of vascular plants.A web server(https://***/stRNAPal/)was also established to facilitate the use of ST RNA-seq data.

关键词： poplar stem primary and secondary meristem primary and secondary vascular tissue spatial transcriptome single-cell sequencing

Ultralong excimer phosphorescence by the self-assembly and confinement of terpyridine derivatives in polymeric matrices

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聚集体(英文)

聚集体(英文) 2023年第4期4卷 230-238页

作者： Guangqiang Yin Wei Lu Jianxiang Huang Rui Li Depeng Liu Longqiang Li ruhong zhou Guifei Huo Tao Chen Key Laboratory of Marine Materials and Related Technologies Zhejiang Key Laboratory of Marine Materials and Protective TechnologiesNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingboChina School of Chemical Sciences University of Chinese Academy of SciencesBeijingChina Institute of Quantitative Biology College of Life SciencesZhejiang UniversityHangzhouChina Department of Chemistry National University of SingaporeSingaporeSingapore

Ultralong organic room temperature phosphorescence(RTP)is attracting increas-ing attention due to its fascinating optical phenomena and wide *** various RTP,excimer phosphorescence is of fundamental significance,but it remains a considerable challenge to achieveflexible,multicolor and large-area excimer RTP materials,which should greatly advance the understanding and devel-opment of organic light-emitting ***,we present ultralong excimer RTPfilms by the self-assembly and confinement of terpyridine(Tpy)derivatives in polymeric ***,the self-assembly of Tpy derivatives induces the formation of excimer complexes,thus immensely minimizing singlet-triplet split-ting energy(ΔEST)to promote the intersystem crossing ***,the confinement by multiple hydrogen bonding interactions as well as the compact aggregation of phosphors jointly suppresses the nonradiative transitions,leading to long-lived excimer RTP(τ543.9 ms,19,000-fold improvements over the pow-=der).On account of the outstanding afterglow performance and color-tunability of RTP materials,flexible and large-areafilms were fabricated for intelligent display,anticounterfeiting,and time-resolved information encryption.

关键词： aggregation excimer information encryption room temperature phosphorescence terpyridine

Physical and toxicological profiles of human IAPP amyloids and plaques

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Science Bulletin 2019年第1期64卷 26-35页

作者： Aleksandr Kakinen Yunxiang Sun Ibrahim Javed Ava Faridi Emily H.Pilkington Pouya Faridi Anthony W.Purcell ruhong zhou Feng Ding Sijie Lin Pu Chun Ke Thomas P.Davis ARC Centre of Excellence in Convergent Bio-Nano Science and Technology Monash Institute of Pharmaceutical Sciences Monash University Department of Physics and Astronomy Clemson University College of Environmental Science and Engineering Shanghai Institute of Pollution Control and Ecological Security Biomedical Multidisciplinary Innovation Research Institute Shanghai East Hospital Tongji University Infection and Immunity Program & Department of Biochemistry and Molecular Biology Biomedicine Discovery Institute Monash University IBM Thomas J.Watson Research Center Department of Chemistry Columbia University

Although much has been learned about the fibrillization kinetics, structure and toxicity of amyloid proteins, the properties of amyloid fibrils beyond the saturation phase are often perceived as chemically and biologically inert, despite evidence suggesting otherwise. To fill this knowledge gap, we examined the physical and biological characteristics of human islet amyloid polypeptide(IAPP) fibrils that were aged up to two months. Not only did aging decrease the toxicity of IAPP fibrils, but the fibrils also sequestered fresh IAPP and suppressed their toxicity in an embryonic zebrafish model. The mechanical properties of IAPP fibrils in different aging stages were probed by atomic force microscopy and sonication, which displayed comparable stiffness but age-dependent fragmentation, followed by self-assembly of such fragments into the largest lamellar amyloid structures reported to date. The dynamic structural and toxicity profiles of amyloid fibrils and plaques suggest that they play active, long-term roles in cell degeneration and may be a therapeutic target for amyloid diseases.

关键词： IAPP Amyloid Plaque Self assembly Toxicity

Mechanochemical transformation of fluorescent hydrogel based on dynamic lanthanide-terpyridine coordination

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Chinese Chemical Letters 2023年第3期34卷 430-433页

作者： Guangqiang Yin Jianxiang Huang Depeng Liu Rui Li Shuxin Wei Muqing Si Feng Ni Yinfei Zheng Qiu Yang ruhong zhou Xiaoxia Le Wei Lu Tao Chen Key Laboratory for Biomedical Engineering of Ministry of Education Ministry of China College of Biomedical Engineering and Instrument ScienceZhejiang UniversityHangzhou 310027China Key Laboratory of Marine Materials and Related Technologies Zhejiang Key Laboratory of Marine Materials and Protective TechnologiesNingbo Institute of Materials Technology and EngineeringChinese Academy of SciencesNingbo 315201China School of Chemical Sciences University of Chinese Academy of SciencesBeijing 100049China Institute of Quantitative Biology Zhejiang UniversityHangzhou 310027China Research Center for Intelligent Sensing Zhejiang LabHangzhou 311100China Ningbo New Material Testing and Evaluation Center Co. Ltd.Ningbo 315000China

As a burgeoning research field, ultrasound-responsive materials have attracted intense interest in healthcare research. However, the basic mechanism of sonochemical effect in the quasi-solid state is far from being well understood than those in the solution. Herein, we showcase mechanochemical transformations of europium(Ⅲ) complexes in a supramolecular hydrogel matrix. With the combination of labile terpyridine-europium complexes(TPY-Eu^(3+)) as mechanochromic moieties and an ultrasound-responsive fluorogen(URF) as a molecular tweezer, the hydrogel produces a notable fluorescence change in response to ultrasound. The mechanochemical transformation was elucidated by molecular dynamics(MD) simulations, and fully probed and evidenced by electrochemical experiments, X-ray photoelectron spectroscopy(XPS), and attenuated total reflectance-Fourier transform infrared(ATR-FTIR) spectroscopy.

关键词： Supramolecular hydrogel Ultrasound-responsive Mechanochemical transformation Terpyridine-europium coordination Dynamic interaction