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Oxidative stress, cardiolipin and mitochondrial dysfunction in nonalcoholic fatty liver disease

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World Journal of Gastroenterology 2014年第39期20卷 14205-14218页

作者： Giuseppe Paradies Valeria Paradies Francesca m ruggiero Giuseppe Petrosillo Department of Biosciences Biotechnologies and Biopharmaceutics University of Bari 70126 Bari Italy Institute of Biomembranes and Bioenergetics National Research Council 70126 Bari Italy

Nonalcoholic fatty liver disease(NAFLD) is today considered the most common form of chronic liver disease, affecting a high proportion of the population worldwide. NAFLD encompasses a large spectrum of liver damage, ranging from simple steatosis to steatohepatitis, advanced fibrosis and cirrhosis. Obesity, hyperglycemia, type 2 diabetes and hypertriglyceridemia are the most important risk factors. The pathogenesis of NAFLD and its progression to fibrosis and chronic liver disease is still unknown. Accumulating evidence indicates that mitochondrial dysfunction plays a key role in the physiopathology of NAFLD, although the mechanisms underlying this dysfunction are still unclear. Oxidative stress is considered an important factor in producing lethal hepatocyte injury associated with NAFLD. mitochondrial respiratory chain is the main subcellular source of reactive oxygen species(ROS), which may damage mitochondrial proteins, lipids and mitochondrial DNA. Cardiolipin, a phospholipid located at the level of the inner mitochondrial membrane, plays an important role in several reactions and processes involved in mitochondrial bioenergetics as well as in mitochondrial dependent steps of apoptosis. This phospholipid is particularly susceptible to ROS attack. Cardiolipin peroxidation has been associated with mitochondrial dysfunction in multiple tissues in several physiopathological conditions, including NAFLD. In this review, we focus on the potential roles played by oxidative stress and cardiolipin alterations in mitochondrial dysfunction associated with NAFLD.

关键词： Oxidative stress Cardiolipin mitochondrial bioenergetics Antioxidants Nonalcoholic fatty liver disease

A global consistent positive effect of urban green area size on bird richness

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Avian Research 2019年第3期10卷 271-284页

作者： Lucas m.Leveau Adriana ruggiero Thomas J.matthews m.Isabel Bellocq Departamento de Ecologia Geneica y EvolucionFacultad de Ciencias Exactas y NaturalesUniversidad de Buenos Aires-IEGEBA(CONICET-UBA) Intendente Guiraldes 2160Ciudad UniversitariaPab 2Piso 4C1428EGA Buenos AiresArgentina Laboratorio Ecotono Centro Regional Universitario Bariloche-Universidad Nacional del ComahueINIBIOMA-CONICET8400 San Carlos de BarilocheRio NegroArgentina GEES (School of Geography Earth and Environmental Sciences) and the Birmingham Institute of Forest ResearchThe University of Birmingham Birmingham B15 2TTUK Departamento de Ciencias e Engenharia do Ambiente CE3C-Centre for EcologyEvolution and Environmental Changes/Azorean Biodiversity Group and Universidade dos Acores9700-042 Angra do HeroismoAcoresPortugal

Background: Although the species-urban green area relationship (SARu) has been analyzed worldwide, the global consistency of its parameters, such as the fit and the slope of models, remains unexplored. moreover,the SARu can be explained by 20 different models. Therefore, our objective was to evaluate which models provide a better explanation of SARus and, focusing on the power model,to evaluate the global heterogeneity in its fit and slope. methods: We tested the performance of multiple statistical models in accounting for the way in which species richness increases with area, and examined whether variability in model form was associated with various methodological and environmental factors. Focusing on the power model, we analyzed the global heterogeneity in the fit and slope of the models through a meta-analysis. Results: Among 20 analyzed models, the linear model provided the best fit to the most datasets, was the top ranked model according to our efficiency criterion, and was the top overall ranked *** Kobayashi and power models were the second and third overall ranked models, *** number of green areas and the minimum number of species within a green area were the only significant variables explaining the variation in model form and performance, accounting for less than 10% of the variation. Based on the power model,there was a consistent overall fit (r2=0.50) and positive slope of 0.20 for the species richness increase with area ***:The good fit of the linear model to our SARu datasets contrasts with the non-linear SAR frequently found in true and non-urban habitat island systems;however, this finding may be a result of the small sample size of many SARu datasets. The overall power model slope of 0.20 suggests low levels of isolation among urban green patches, or alternatively that habitat specialist and area sensitive species have already been extirpated from urban green areas.

关键词： Birds Conservation macroecology Habitat islands Species-area relationships Species-urban green area relationship Urban parks Urbanization

Exploring building's envelope thermal behavior of the neo-vernacular residential architecture in a hot and dry climate region of Algeria

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Building Simulation 2021年第5期14卷 1567-1584页

作者： Khaoula Amraoui Leila Sriti Silvia Di Turi Francesco ruggiero Ahmed Kaihoul Department of Architecture LACOMOFA LaboratoryMohamed khider University of BiskraAlgeria Energy Efficiency Unit Department(DUEE) Italian National Agency for New TechnologiesEnergy and Sustainable Economic Development(ENEA)RomeItaly Department of Civil Engineering and Architecture Sciences(DICAR) Polytechnic University of BariItaly Department of Architecture Larbi Ben M'hidi University of Oum El-BouaghiAlgeria

It is well known that the passive strategies applying in traditional buildings respond satisfactory to climatic requirements and succeed to provide maximum indoor comfort with minimum energy *** this point of view,it is interesting to quantitatively assess the effectiveness of the vernacular strategies to improve the environmental performance of the building's envelope under desert climate *** research tries to address this issue and was undertaken in southern Algeria where a very hot and arid climate *** effect of some selected passive cooling strategies on enhancing the building's envelope climate performance was *** strategies are inspired from the local vernacular architecture,and they are expected to provide satisfactory indoor thermal comfort for users and to reduce the energy cooling demand from residential *** field and computational investigations,two existing residential buildings were tested:a typical residential unit and a contemporary vernacular(neo-vernacular)*** the latter,climate responsive strategies inspired from vernacular architecture were applied.A comparison based on site measurements was carried out on the two selected buildings which differ from their envelope design properties and components.

关键词： architectural envelope neo-vernacular architecture cooling passive strategies thermal comfort in hot dry climate computer simulation residential sector

Role of rumination in the relationship between metacognition and shyness

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World Journal of Psychiatry 2018年第4期8卷 108-113页

作者： Sara Palmieri Giovanni mansueto Simona Scaini Francesca Fiore Sandra Sassaroli Giovanni m ruggiero Rosita Borlimi Bernardo J Carducci Studi Cognitivi Cognitive Psychotherapy School and Research Center Department of Psychology Sigmund Freud University Psicoterapia Cognitiva e Ricerca Cognitive Psychotherapy School Shyness Research Institute Indiana University Southeast

AIm To explore the association between metacognitive beliefs, rumination and shyness in a non-clinical sample of adults. mETHODS One hundred and three healthy subjects from the general population were enrolled in the study. Shyness was evaluated using the Revised Cheek and Buss Shyness Scale, rumination was assessed using the Ruminative Response Scale, metacognition was evaluated using the metaCognitions Questionnaire 30, and anxiety levels were measured using the State Trait Anxiety Inventory form Y. Correlation analyses, mediation models and 95% bias-corrected and accelerated(BCaCI) bootstrapped analyses were performed. mediation analyses were adjusted for sex and anxiety. RESULTS Shyness, rumination and metacognition were significantly correlated(P metacognition and shyness was fully mediated by rumination(Indirect effect: 0.20; 95% BCaCI: 0.08-0.33).CONCLUSION These findings suggest an association between metacognition and shyness. Rumination mediated the relationship between metacognition and shyness, suggesting that rumination could be a cognitive strategy for shy people. Future research should explore the relationship between these constructs in more depth.

关键词： Social anxiety Shyness Rumination Postevent metacognitive beliefs

Percutaneous coronary intervention of totally occluded coronary venous bypass grafts:An exercise in futility?

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World Journal of Cardiology 2021年第9期13卷 493-502页

作者： Evan W Nardone Brandon m madsen melissa m mcCarey David L Fischman Nicholas J ruggiero Paul Walinsky Alec Vishnevsky michael P Savage Department of medicine Thomas Jefferson UniversityPhiladelphiaPA 19107United States Department of Anesthesiology Medstar Georgetown University HospitalWashingtonDC 20007United States Jefferson Clinical Research Institue Thomas Jefferson UniversityPhiladelphiaPA 19107United States

BACKGROUND Percutaneous coronary intervention(PCI)of diseased saphenous vein grafts(SVG)continues to pose a clinical *** PCI guidelines give a class III recommendation against performing PCI on chronically occluded ***,contemporary outcomes after SVG intervention have incrementally improved with distal protection devices,intracoronary vasodilators,drug-eluting stents,and prolonged dual antiplatelet *** To reassess the procedural and long-term outcomes of PCI for totally occluded SVG with contemporary *** This was a retrospective observational study conducted at a single university *** study population consisted of 35 consecutive patients undergoing PCI of totally occluded ***-procedure dual antiplatelet therapy was continued for a minimum of one year and aspirin was continued *** outcomes were assessed at a mean follow-up of 1221±1038 *** primary outcome was freedom from a major adverse cardiac event(mACE)defined as the occurrence of any of the following:death,myocardial infarction,stroke,repeat bypass surgery,repeat PCI,or graft *** The study group included 29 men and 6 women with a mean age of 69±12 *** was present in 14(40%)*** patients had Canadian Heart Classification class III or IV *** presentation was an acute coronary syndrome in 34(97%)*** SVG age was 12±5 *** duration of occlusion was acute(24 h to 30 d)in 26%,and late(>30 d)in 40%.PCI was initially successful in 29/35 SVG occlusions(83%).Total stent length was 52±35 *** complications of distal embolization or no-reflow occurred in 6(17%)*** longer term follow-up,mACE-free survival was only 30%at 3 years and 17%at 5 *** PCI of totally occluded SVG can be performed with a high procedural success ***,its clinical utility remains limited by poor follow-up outcomes.

关键词： Coronary artery bypass grafting Coronary stents Chronic total occlusion Percutaneous coronary intervention Restenosis Saphenous vein grafts

Exercise and children's cognition:The role of exercise characteristics and a place for metacognition

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Journal of Sport and Health Science 2015年第1期4卷 47-55页

作者： Phillip D.Tomporowski Bryan mc Cullick Daniel m.Pendleton Caterina pesce Department of Kinesiology University of Georgia Department of Human motion and Sport Science Italian University Sport and Movement

Definitive conclusions concerning the impact of exercise interventions on children＇s mental functioning are difficult to ascertain because of procedural differences among studies. A narrative review of studies was conducted to evaluate the role of two types of exercise interventions on children＇s cognition. Acute and chronic exercise interventions were classified as quantitative or qualitative on the basis of manipulations of task complexity and, by inference, mental engagement. Both types of interventions enhance aspects of children＇s cognition; however, their effects on metacognitive processes are unknown. The role of metacognitive processes and their regulation of children＇s behavior and academic performance are highlighted.

关键词： Academic achievement Child development Executive function Intelligence memory mental engagement

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以微处理器为基础的虚拟存储系统

计算机研究与发展 1981年第10期 27-32页

作者： m. D. ruggiero S. G. Zaky 李树贻

本文提出了一种可接在主机存储总线上的虚拟存储系统。此系统采用了一个能与后援存储器连接并完成全部虚存管理过程的独立处理器。主机不受虚存执行时间的影响。后援存储器采用磁泡,其优点在文中作了讨论。

关键词：存储器磁泡总线存贮器计算机虚拟存储系统微处理器

Performance and calibration of quark/gluon-jet taggers using 140 fb^(-1) of pp collisions at √s=13 TeV with the ATLAS detector

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Chinese Physics C 2024年第2期48卷 1-25页

作者： G. Aad B. Abbott K. Abeling N.J. Abicht S.H. Abidi A. Aboulhorma H. Abramowicz H. Abreu Y. Abulaiti B.S. Acharya C. Adam Bourdarios L. Adamczyk S.V. Addepalli m.J. Addison J. Adelman A. Adiguzel T. Adye A.A. Affolder Y. Afik m.N. Agaras J. Agarwala A. Aggarwal C. Agheorghiesei A. Ahmad F. Ahmadov W.S. Ahmed S. Ahuja X. Ai G. Aielli A. Aikot m. Ait Tamlihat B. Aitbenchikh I. Aizenberg m. Akbiyik T.P.A. Åkesson A.V. Akimov D. Akiyama N.N. Akolkar K. Al Khoury G.L. Alberghi J. Albert P. Albicocco G.L. Albouy S. Alderweireldt m. Aleksa I.N. Aleksandrov C. Alexa T. Alexopoulos F. Alfonsi m. Algren m. Alhroob B. Ali H.m.J. Ali S. Ali S.W. Alibocus m. Aliev G. Alimonti W. Alkakhi C. Allaire B.m.m. Allbrooke J.F. Allen C.A. Allendes Flores P.P. Allport A. Aloisio F. Alonso C. Alpigiani m. Alvarez Estevez A. Alvarez Fernandez m. Alves Cardoso m.G. Alviggi m. Aly Y. Amaral Coutinho A. Ambler C. Amelung m. Amerl C.G. Ames D. Amidei S.P. Amor Dos Santos K.R. Amos V. Ananiev C. Anastopoulos T. Andeen J.K. Anders S.Y. Andrean A. Andreazza S. Angelidakis A. Angerami A.V. Anisenkov A. Annovi C. Antel m.T. Anthony E. Antipov m. Antonelli F. Anulli m. Aoki T. Aoki J.A. Aparisi Pozo m.A. Aparo L. Aperio Bella C. Appelt A. Apyan N. Aranzabal S.J. Arbiol Val C. Arcangeletti A.T.H. Arce E. Arena J-F. Arguin S. Argyropoulos J.-H. Arling O. Arnaez H. Arnold G. Artoni H. Asada K. Asai S. Asai N.A. Asbah J. Assahsah K. Assamagan R. Astalos S. Atashi R.J. Atkin m. Atkinson H. Atmani P.A. Atmasiddha K. Augsten S. Auricchio A.D. Auriol V.A. Austrup G. Avolio K. Axiotis G. Azuelos D. Babal H. Bachacou K. Bachas A. Bachiu F. Backman A. Badea P. Bagnaia m. Bahmani A.J. Bailey V.R. Bailey J.T. Baines L. Baines O.K. Baker E. Bakos D. Bakshi Gupta V. Balakrishnan R. Balasubramanian E.m. Baldin P. Balek E. Ballabene F. Balli L.m. Baltes W.K. Balunas J. Balz E. Banas m. Bandieramonte A. Bandyopadhyay S. Bansal L. Barak m. Barakat E.L. Barberio D. Barberis m. Barbero m.Z. Barel K.N. Barends T. Barillari m-S. Barisits T. Barklow P. Baron D.A. Baron mo The ATLAS Collaboration

The identification of jets originating from quarks and gluons,often referred to as quark/gluon tagging,plays an important role in various analyses performed at the Large Hadron Collider,as Standard model measurements and searches for new particles decaying to quarks often rely on suppressing a large gluon-induced *** paper describes the measurement of the efficiencies of quark/gluon taggers developed within the ATLAS Collaboration,using √s=13 TeV proton–proton collision data with an integrated luminosity of 140 fb^(-1) collected by the ATLAS *** taggers with high performances in rejecting jets from gluon over jets from quarks are studied:one tagger is based on requirements on the number of inner-detector tracks associated with the jet,and the other combines several jet substructure observables using a boosted decision tree.A method is established to determine the quark/gluon fraction in data,by using quark/gluon-enriched subsamples defined by the jet *** in tagging efficiency between data and simulation are provided for jets with transverse momentum between 500 GeV and 2 TeV and for multiple tagger working points.

关键词： ATLAS JET QUARK GLUON TAGGING

Role of genomics in cardiovascular medicine

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World Journal of Cardiology 2010年第12期2卷 428-436页

作者： Giuseppe Novelli Irene m Predazzi ruggiero mango Francesco Romeo Jawahar L mehta Department of Biopathology and Diagnostic Imaging Section of Medical Genetics School of MedicineTor Vergata University Department of Internal medicine University of Arkansas for Medical Sciences Centro Neurolesi"Bonino Pulejo" 98100 messina Italy Department of Internal medicine University of Rome Tor Vergata

As all branches of science grow and new experimental techniques become readily accessible,our knowledge of medicine is likely to increase exponentially in the coming *** developed technologies have revolutionized our analytical capacities,leading to vast knowledge of many genes or genomic regions involved in the pathogenesis of congenital heart diseases,which are often associated with other genetic syndromes,coronary artery disease and non-ischemic cardiomyopathies and *** knowledge-base of the genesis of cardiovascular diseases is likely going to be further revolutionized in this new era of genomic ***,we review the advances that have been made over the last several years in this field and discuss different genetic mechanisms that have been shown to underlie a variety of cardiovascular diseases.

关键词： Genomics Polymorphisms mutations Complex diseases Atherosclerosis