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Molecular and cellular mechanisms of neuroprotection by oligopeptides from snake venoms

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BIOCELL 2024年第6期48卷 897-904页

作者： CARLOS ALBERTO-SILVA BRENDA rufino DA SILVA Natural and Humanities Sciences Center Experimental Morphophysiology LaboratoryFederal University of ABC(UFABC)São Bernardo do CampoSão PauloBrazil

Venom snake-derived peptides have multiple biochemical,pharmacological,and toxicological proﬁles,allowing for the discovery of new medicinal products and therapeutic *** review speciﬁcally examines the fundamental elements of neuroprotection offered by different oligopeptides derived from snake *** also includes a brief evaluation of short peptides that are being considered as potential therapeutic ***-rich peptides and tryptophyllin family peptides isolated from the crude venom of Viperidae family snakes,speciﬁcally Bothrops atrox,Bothrops jararaca,and Bothrops moojeni,have been shown to have pro-survival properties,the ability to reduce oxidative stress,and the ability to promote cell viability and mitochondrial *** signiﬁcant mechanisms are related to the neuroprotection mediated by snake venom oligopeptides:(1)Activation of the L-arginine metabolite pathway,such as polyamines from ornithine metabolism,which reduces N-methyl-D-aspartate(NMDA)-type glutamate receptor activity;(2)Enhancement of cell viability by activating the nerve growth factor-signaling pathway;and(3)Activation of the Muscarinic acetylcholine receptor subtype M1(mAChR-M1).These small peptides show promise as neuroprotective agents against a variety of neurodegenerative disorders.

关键词： Neuroprotective peptides Neurodegenerative disease Oxidative stress Reactive oxygen species Biopeptides

Corrigendum to“Towards a business model for second-life batteries:Barriers,opportunities,uncertainties,and technologies”[*** Chem.78(2023)507–525]

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Journal of Energy Chemistry 2024年第4期91卷 684-684页

作者： Carlos Antônio rufino Júnior Eleonora Riva Sanseverino Pierluigi Gallo Daniel Koch Yash Kotak Hans-Georg Schweiger Hudson Zanin Advanced Energy Storage Division New Energy Innovation CenterUniversity of Campinas(UNICAMP)Campinas 13083-852Brazil Engineering Department University of Palermo(UNIPA)Palermo 90128Italy Consorzio Nazionale Interuniversitario per le Telecomunicazioni(CNIT) Parma 43124Italy Technische Hochschule Ingolstadt Institute for ElectricConnected and Safe Mobility(C-ECOS)Ingolstadt 85049Germany

In the Acknowledgments Section,please replace“Shell oil”for“TotalEnergies”.The authors would like to apologise for any inconvenience *** the sake of clarity(“Shell oil”should be removed and in boldblack“TotalEn... 详细信息

关键词： please replace removed

Epidemiology and Clinical Features of Mycobacterium avium Complex Pulmonary Disease in a Brazilian Amazon Cohort

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Advances in Microbiology 2024年第6期14卷 287-302页

作者： Jose Tadeu Colares Monteiro Adriana Rodrigues Barretto Ruan Seguin Azevedo Quaresma Bianca Miranda Gouveia Ismari Perini Furlaneto Victória Menezes da Costa Yan Corrêa Rodrigues Layana rufino Ribeiro Ricardo J. de Paula Souza e Guimarães Alex Brito Souza Ana Roberta Fusco da Costa Karla Valéria Batista Lima Joao de Barros Barreto University Hospital Federal University of Par Belm Brazil Center for Biological and Health Sciences Ph.D. Program in Parasitic Biology in the Amazon Region (PPGBPA) State University of Par (UEPA) Belm Brazil Department of Medicine Centro Universitrio do Par CESUPA Belm Brazil Bacteriology and Mycology Section Evandro Chagas Institute (SABMI/IEC) Ministry of Health Ananindeua Brazil Geoprocessing Laboratory Evandro Chagas Institute/SVSA/MS Ananineua Brazil

The incidence of Mycobacterium avium complex pulmonary disease (MACPD) has been globally increasing. The present study aims to provide a comprehensive analysis of clinical characteristics and treatment response among patients in the Amazon region of Brazil and conduct a retrospective cohort study at a prominent referral hospital in the State of Par, Brazil, from 2012 to 2020. The M. avium group represented 58.9% of cases, followed by M. intracellulare (35.7%), M. colombiense (3.6%), and M. chimaera (1.8%). The majority of patients (73.2%) were female and with an average age of 63 years. Primary clinical manifestations included persistent cough and sputum production. The Charlson comorbidity index (CCI) averaged 2.47, with 36.3% of patients having a CCI score equal to higher than 3. Notably, over 70% of patients had received treatment for pulmonary tuberculosis before initiating treatment for MAC infection. The fibrocavitary radiologic form was the most prevalent (55.4%), frequently exhibiting a bilateral distribution (53.6%). Antimicrobial susceptibility revealed a significant prevalence of MAC resistance to drugs in the therapeutic regimen. Despite this, most of the patients experienced clinical improvement (50%). In conclusion, this study highlights a higher prevalence of MAC infections among middle-aged women, with a history of pulmonary tuberculosis treatment and presenting the fibrocavitary radiological form was predominant.

关键词： MACDP Nontuberculous Mycobacteria Mycobacterium avium Lung Disease

Forensic odontology identification response to terrorist attacks in Paris November 2015

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Forensic Sciences Research 2020年第3期5卷 214-222页

作者： Steve Toupenay Aida Ben Cheikh Bertrand Ludes rufino Felizardo UFR Odontologie Universite de ParisParisFrance Universite de Paris BABELCNRSInstitut Medico-Legal de ParisParisFrance

The terrorist attacks of November 2015 led to the immediate death of 129 victims admitted to the Legal and Forensic Medicine Institute of Paris,including 41 *** the Disaster Victim Identification(DVI)operations,22 bodies were examined by the postmortem(PM)dental team with the aim of establishing PM *** the same time,the dental expert in the antemortem(AM)unit collected a large number of dental files,progressively filtered as the list of missing persons became *** from these events has highlighted the difficulties of implementing the DVI chain principles in a legal framework,published the day before the attacks,and also the technical complexity of collecting dental data on a week end of *** return on experience after this event has represented a paradigm shift on previous methods of DVI in Paris and even more in ***,the victim identification procedure was redesigned,integrating new technical means such as a CT scan directly on spot,allowing the extraction of maxillofacial data as soon as possible in order to support the PM dental examination ***,the National Dental Council proceeded to the overall remodeling of the dental identification unit,which is composed of trained members,from local,regional and national *** forensic experts are dedicated,at the request of the legal authorities,to DVI operations and deployed throughout the country capable of managing AM and PM *** unit aims also to share experiences and awarenessraising among health professionals and investigators in order to optimize a better submission of AM elements and also to enhance the major interest of odontology as a primary identifier in disaster.

关键词： Forensic sciences forensic odontology terrorist attack forensic identification disaster victim identification

Towards a business model for second-life batteries: Barriers,opportunities, uncertainties, and technologies

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Journal of Energy Chemistry 2023年第3期78卷 507-525,I0014页

Electric vehicles(EVs) and the recent pandemic outbreak give cities a new trend to primarily private and shared mobility with low noise and less air *** factors for the widespread of EVs are the electrical charging infrastructure,driving range,and the reduction of the cost of battery *** this reason,there is a massive effort from manufacturers,governments,and the scientific community to reduce battery costs and boost sustainable electrical production and *** reuse is an alternative to reduce batteries’ costs and environmental ***-life batteries can be used in a wide variety of secondary ***-life batteries can be connected with off-grid or on-grid photovoltaic and wind systems,vehicle charging stations,forklifts,and frequency *** present work aims to analyze the main challenges imposed on the reuse of batteries,the leading technologies for their reuse,and the different types of batteries in terms of their feasibility for second-life *** main novelty of this work is the discussion about the barriers,opportunities,uncertainties,and technologies for the second life *** we summarize the present state of the art in reusing lithium-ion batteries discussing technical and economic feasibility,environmental impacts,and *** results show five business models that have been proposed in the literature,three types of markets for trading second-life batteries,and the main opportunities and barriers for each actor in the battery supply chain.

关键词： Business models Batteries Sustainability Electric vehicles Challenges Opportunities Lithium-ion batteries Reuse

Optical coherence tomography angiography in wet age-related macular degeneration(AMD)

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Eye Science 2016年第1期31卷 1-3页

作者： Joao Pedro Marques rufino Silva Department of Ophthalmology Centro Hospitalar e Universitairio de Coimbra(CHUC)3000-075 CoimbraPortugal Association for Innovation and Biomedical Research on Light and Image(MBILI) 3000-548 CoimbraPortugal Faculty of Medicine University of Coimbra(FMUC)CoimbraPortugal

Over the last decades,substantial developments in retinal imaging offered a paradigmatic change in the understanding of the pathophysiology of wet age-related macular degeneration(AMD).We have reached a point of sophi... 详细信息

关键词：年龄相关 AMD 血管造影断层扫描光学相干变性黄斑病理生理学

Best practices for electrochemical characterization of supercapacitors

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Journal of Energy Chemistry 2023年第5期80卷 265-283,I0007页

作者： João Pedro Aguiar dos Santos Fernando Cesar rufino Joǎo IYutaka Ota Rodolfo CFernandes Rafael Vicentini Cesar JBPagan Leonardo Morais Da Silva Hudson Zanin Brazilian Renewable Energies Center for Innovation on New EnergiesSchool of Electrical and Computer EngineeringUniversity of CampinasSP 13083-852Brazil School of Electrical and Computer Engineering University of CampinasSP 13083-852Brazil Department of Chemistry Laboratory of Fundamental and Applied ElectrochemistryFederal University of Jequitinhonha e Mucuri's ValleyRodovia MGT 367km 5835000Alto da Jacuba39100-000 DiamantinaMGBrazil

We discuss here essential aspects of the experimental supercapacitors characterization by a series of well-known electrochemical *** are motivated by a considerable number of publications that misreport procedures and *** often conceal or neglect essential information about the electrochemical analytical apparatus used and its *** lack of such information may lead researchers,especially inexperienced ones,to misunderstand the procedures and ***,the misled electrochemical equipment configuration favors misinterpretation of data and low reproducibility *** paper aims to highlight these issues and clarify *** explain fundamental concepts of some electrochemical analytical methods,such as cyclic voltammetry,galvanostatic charge-discharge,single potential step chronoamperometry,and electrochemical impedance spectroscopy,focusing on the supercapacitor *** configurations of electrical parameters are presented and discussed to highlight the effects of incorrect setup and uncover misleading *** discuss how the electrochemical setup and data analyses matter in reliable data results for the supercapacitor.

关键词： Supercapacitor Electrochemical instrumentation Electrochemical methods Electrochemistry

Intake,digestibility and nitrogen utilization in cattle fed tropical forage and supplemented with protein in the rumen,abomasum,or both

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Journal of Animal Science and Biotechnology 2016年第4期7卷 544-553页

作者： Luana Marta de Almeida rufino Edenio Detmann Daianyíris Gomes William Lima Santiago dos Reis Erick Darlisson Batista Sebastiao de Campos Valadares Filho Mário Fonseca Paulino Department of Animal Science Universidade Federal de Viaosa Department of Animal Science Universidade Federal Rural da Amaznia

Background： There is little information in the tropics with regard the comparative understanding of how an increased nitrogen supply in the rumen or in the intestines affects efficiency of nitrogen utilization in cattle. This study evaluated the effects of supplementation with nitrogenous compounds in the rumen, abomasum, or both on intake, digestibility and the characteristics of nitrogen utilization in cattle fed tropical forage. Four rumen- and abomasum-fistulated Nellore bulls （227 ± 11 kg） were used. Four treatments were evaluated： control, ruminal supplementation （230 g/d of supplemental protein in the rumen）, abomasal supplementation （230 g/d of supplemental protein in the abomasum）, and ruminal and abomasal supplementation （115 g/d protein in both the rumen and the abomasum）. The basal forage diet consisted of Tifton 85 hay with a crude protein （CP） level of 78.4 g/kg dry matter. Casein was used as a supplement. The experiment was conducted using a 4 x 4 Latin square. Results： There were no differences between the treatments （P 〉 0.10） with regard to forage intake. The intake and tota digestibility of CP increased （P 〈 0.01） with supplementation. The nitrogen balance in the body increased （P 〈 0.01） and muscle protein mobilization decreased （P 〈 0.01） with supplementation, regardless of the supplementation site. The efficiency of nitrogen utilization did not differ among the treatments （P 〉 0.10）. Conclusions： The supplementation of cattle fed tropical forage with protein in the rumen, abomasum, or both similarly increased the nitrogen accretion in animal, which reflects improvements on nitrogen status in animal body.

关键词： Casein Nitrogen balance Rumen ammonia nitrogen Supplementation 3-methylhistidine

Groundwater recharge rates and surface runoff response to land use and land cover changes in semi-arid environments

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Ecological Processes 2016年第1期5卷 195-215页

作者： S.O.Owuor K.Butterbach-Bahl A.C.Guzha M.C.rufino D.E.Pelster E.Diaz-Pines L.Breuer Institute of Meteorology and Climate Research Atmospheric Environmental Research(IMK-IFU)Karlsruhe Institute of Technology(KIT)Kreuzeckbahnstr.1982467 Garmisch-PartenkirchenGermany International Livestock Research Institute(ILRI) Old Naivasha Rd.P.O.Box 30709-00100NairobiKenya United States Forest Service c/o CIFORWorld Agroforestry CentreUnited Nations Avenue GigiriP.O.Box 30677-00100NairobiKenya Center for International Forestry Research(CIFOR) C/o World Agroforestry CentreUnited Nations Avenue GigiriP.O.Box 30677-00100NairobiKenya Institute for Landscape Ecology and Resources Management(ILR) Research Centre for BioSystemsLand Use and Nutrition(iFZ)Justus Liebig University GiessenHeinrich-Buff-Ring 2635392 GiessenGermany Centre for International Development and Environmental Research(ZEU) Justus Liebig University GiessenGiessenGermany

The effects of land use and land cover(LULC)on groundwater recharge and surface runoff and how these are affected by LULC changes are of interest for sustainable water resources ***,there is limited quantitative evidence on how changes to LULC in semi-arid tropical and subtropical regions affect the subsurface components of the hydrologic cycle,particularly groundwater *** water resource management in these regions requires conclusive evidence and understanding of the effects of LULC changes on groundwater recharge and surface *** reviewed a total of 27 studies(2 modeling and 25 experimental),which reported on pre-and post land use change groundwater recharge or surface runoff magnitude,and thus allowed to quantify the response of groundwater recharge rates and runoff to *** between initial and subsequent LULC indicate that forests have lower groundwater recharge rates and runoff than the other investigated land uses in semi-arid tropical/subtropical *** of bare land induces a decrease in groundwater recharge from 42% of precipitation to between 6 and 12% depending on the final *** forests are cleared for rangelands,groundwater recharge increases by 7.8±12.6%,while conversion to cropland or grassland results in increases of 3.4±2.5 and 4.4±3.3%,*** of bare land to cropland results in surface runoff reductions of between 5.2 and 7.3%.The conversion of forest vegetation to managed LULC shows an increase in surface runoff from 1 to 14.1% depending on the final *** runoff was reduced from 2.5 to 1.1% when grassland is converted to forest *** there is general consistency in the results from the selected case studies,we conclude that there are few experimental studies that have been conducted in tropical and subtropical semi-arid regions,despite that many people rely heavily on groundwater for their ***,there is an urgent need to increase th

关键词： Groundwater recharge rate Infiltration Surface runoff Semi-arid Land use change Land cover change