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Analysis of sensitivity and specificity:precise recognition of neutrophils during regeneration of contused skeletal muscle in rats

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Forensic Sciences Research 2022年第2期7卷 228-237页

作者： Jiajia Niu Guoshuai An Zhen Gu Peng Li Qiqing Liu rufeng bai Junhong Sun Qiuxiang Du School of Forensic Medicine Shanxi Medical UniversityJinzhongChina Criminal Investigation Brigade Zhuji Public Security BureauZhujiChina 2011 Cooperative Innovation Center of Judicial Civilization BeijingChina Key Laboratory of Evidence Science China University of Political Science and LawMinistry of EducationBeijingChina

In this report,we applied the TissueFAXS 200 digital pathological analysis system to rapidly and accurately identify neutrophils during regeneration of contused skeletal muscle,and to provide information for follow-up studies on neutrophils to estimate wound *** injury model was established,and skeletal muscle samples were obtained from the control group and contusion groups at 1,1.5,2,3,4,and 6 h,as well as at 1,3,5,and 15 d post-injury(n紏5 per group).The expression of nuclei and neutrophils was detected by hematoxylin and eosin(HE)staining and immunohistochemical(IHC)staining.A total of 20 injury site areas of 0.25mm^(2)(0.5mm0.5mm)were then randomly selected at all time points.A TissueFAXS 200 digital pathological analysis system was used to identify the positive and negative *** of five professional medical workers were considered the gold standard to measure the false positive rate(FPR),false negative rate(FNR),sensitivity,specificity,and area under the curve(AUC)of receiver operating characteristic(ROC)*** a result,with a staining area of neutrophils from 8 μm^(2) to 15 μm^(2),the FPR was 4.28%–12.14%,the FNR was 12.42%–64.08%,the sensitivity was 35.92%–87.58%,the specificity was 87.86%–95.72%,the Youden index was 0.316–0.754,the accuracy was 82.80%–88.30%,and the AUC was 0.771–*** AUC was largest when the cut-off value of the staining area was 12 mm^(2).Our results show that this software-based method is more accurate than the human eye in evaluating neutrophil *** on the sensitivity and specificity,neutrophils can be accurately identified during regeneration of contused skeletal *** TissueFAXS 200 digital pathological analysis system can also be used to optimize conditions for different cell types under various injury conditions to determine the optimal cut-off value of the staining area and provide optimal conditions for further ***,it will provide evidence for forensic pathology cases.

关键词： Forensic sciences forensic pathology immunohistochemistry TissueFAXS 200 digital pathological analysis system parameter optimization cut-off value of staining area neutrophil staining area

Use of Different Murder Weapons by a Single Murderer:Two Case Reports

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Journal of Forensic Science and Medicine 2016年第3期2卷 160-163页

作者： Eradil Orazhkan Tao Pu Longlong Wang Zhimin Wang Zhiwei Zhu rufeng bai Institute of Criminal Science and Technology of Public Security Bureau in Karamay City Xinjiang Uygur Autonomous RegionKaramay834000 The 2011 Collaborative Innovation Center of Judicial Civilization The Key Laboratory of Ministry of EducationChina University of Political Science and LawBeijing 100088P.R.China

Homicide is an extremely serious crime,and although the offender usually uses the same weapon to initially injure and complete the killing,there are *** report two cases in which a single murderer killed a victim using different weapons and summarize several situations in which a murderer might use different weapons to *** number of murders should be determined and estimated after a comprehensive complicated investigation of the scene,careful examination of the victim’s injuries,and evaluation of evidence reported by eyewitnesses.

关键词： Homicide injury‑causing weapon victim

Primary Screening for Proteins Differentially Expressed in the Myocardium of a Rat Model of Acute Methamphetamine Intoxication

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Journal of Forensic Science and Medicine 2016年第3期2卷 123-130页

作者： Guoqiang Qu Sizhe Huang Liang Liu Tianshui Yu rufeng bai Hongxia Liu Fangming Song Yongqi Wen Haidong Zhang Hubei Chongxin Forensic Identification Centre WuhanHubei 430000 Department of Forensic Medicine Tongji Medical College of Huazhong University of Science and TechnologyWuhanHubei 430030 Key Laboratory of Evidence Science China University of Political Science and LawMinistry of Education Collaborative Innovation Center of Judicial Civilization BeijingHaidian 100192China

The mechanism of myocardial injury induced by the cardiovascular toxicity of methamphetamine(MA)has been shown to depend onalterations in myocardial proteins caused by *** screening of the expression of myocardial proteins in a rat model of MA intoxicationwas achieved by combining two‑dimensional electrophoresis and mass spectrometry analyses,which revealed a total of 100 differentiallyexpressed *** these,13 displayed significantly altered ***,Western blotting and real‑time reverse transcriptionquantitative polymerase chain reaction analyses of several relative proteins demonstrated that acute MA intoxication lowers protein expressionand mRNA transcription of aldehyde dehydrogenase‑2 and NADH dehydrogenase(ubiquinone)1 alpha subcomplex subunit *** contrast,MA intoxication elevated the protein expression and mRNA transcription of heat shock protein family B(small)member *** combiningbehavioral assessments of experimental rat models with the histological and pathological changes evident in cardiomyocytes,a mechanismaccounting for MA myocardial toxicity was *** alters the regulation of gene transcription and the subsequent expression of certainproteins that participate in myocardial respiration and in responding to oxidative stress,resulting in myocardial dysfunction and structuralchanges that affect the functioning of the cardiovascular system.

关键词： Cardiotoxicity methamphetamine proteomics toxicology

Estimation of the Postmortem Interval by Measuring Blood Oxidation‑reduction Potential Values

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Journal of Forensic Science and Medicine 2016年第1期2卷 8-11页

作者： Zhuqing Jiang Meng You Xu Wang Di Lu Haidong Zhang Shengli Di Fengqin Zhang Zhaoming Guo Xiaofei E Lin Chang Jian Xiang rufeng bai Tiantong Yang Center of Cooperative Innovation for Judicial Civilization China University of Political Science and Law&Jilin University&Wuhan University China University of Political Science and Law Key Laboratory of Evidence ScienceMinistry of EducationBeijing 100040China

Accurate estimation of the postmortem interval(PMI)is an important task in forensic *** the last half-century,the use of postmortem biochemistry has become an important ancillary method in determining the time of *** present study was carried out to determine the correlation between blood oxidation-reduction potential(ORP)values and PMIs,and to develop a three-dimensional surface equation to estimate the PMI under various temperature conditions.A total of 48 rabbits were placed into six groups and sacrificed by air *** was obtained from the right ventricle of each rabbit,and specimens were stored at 10℃,15℃,20℃,25℃,30℃,and 35℃.At different PMIs(once every 4 h),the blood ORP values were measured using a PB-21 electrochemical *** analysis and curve fitting of the data yielded cubic polynomial regression equations and a surface equation at different ***:The results showed that there was a strong positive correlation between the blood ORP values at different temperatures and the *** study provides another example of using a three-dimensional surface equation as a tool to estimate the PMI at various temperature conditions.

关键词： Forensic science interpolation function oxidation‑reduction potential postmortem interval three‑dimensional surface equation

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企业知识产权情报安全的合规治理

情报杂志 2024年第5期43卷 176-183页

作者：百茹峰苏志远中国政法大学刑事司法学院北京100088

[研究目的]知识产权情报的安全与否关涉企业发展之根本。在合规治理视阈下,如何帮助企业防控知识产权情报风险是有待回答的重要问题。[研究方法]选取47个侵犯商业秘密犯罪案例,应用fsQCA、NCA方法探究高知识产权情报风险的影响因素和组... 详细信息

[研究目的]知识产权情报的安全与否关涉企业发展之根本。在合规治理视阈下,如何帮助企业防控知识产权情报风险是有待回答的重要问题。[研究方法]选取47个侵犯商业秘密犯罪案例,应用fsQCA、NCA方法探究高知识产权情报风险的影响因素和组态路径。[研究结论]在影响因素上,侵害行为是导致知识产权情报风险的必要条件;保护措施面对侵害行为呈现滞后性的应对态势;情报感知的缺失是知识产权情报安全的关键制约。在组态路径上,存在四个高知识产权情报风险组态,可进一步地归纳为内生—权力支配型、内生—人际主导型和外源—行为控制型。建议企业构建“一点两面,多元联动”的合规预警框架,保障知识产权情报安全。

关键词：知识产权知识产权情报情报安全情报风险商业秘密合规预警

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国家安全视阈下情报公私合作模式研究

情报杂志 2024年第6期43卷 66-72页

作者：百茹峰苏志远郝志恒中国政法大学刑事司法学院北京100088

[研究目的]在公共事业领域中,基于公共部门与私人部门参与的公私合作模式能够有效提升治理效能。在国家安全视阈下,情报工作存在公私合作的实践基础,对此开展理论研究具有重要意义。[研究方法]采用文本分析和比较研究相结合的方法,对国... 详细信息

[研究目的]在公共事业领域中,基于公共部门与私人部门参与的公私合作模式能够有效提升治理效能。在国家安全视阈下,情报工作存在公私合作的实践基础,对此开展理论研究具有重要意义。[研究方法]采用文本分析和比较研究相结合的方法,对国家安全中情报公私合作的理论阐释、文本结构、价值基础和实践保障展开探究。[研究结论]源于行政场域的公私合作模式,在国家安全情报工作中可以发挥重要作用。公私合作模式在《国家情报法》等法律中有结构性的文本体现。国家安全情报工作的公私合作模式具有人民性、系统性与能动性的价值基础。应当在国家安全的宏观框架内,完善公私合作的微观设计,协同构建法律体系,衔接贯通管理机制,管控执行程序风险。

关键词：国家安全国家安全情报情报工作公私合作公共部门私人部门

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光纤通信的发展应用研究

科学之友 2012年第6期 154-154页

作者：白如峰史健芳太原理工大学

光纤通信因其自身所具有的优点,被市场广泛接受,发展非常迅速。现在它作为通信发展承载技术的主流,已进入到了和通信相关的各个领域,因此,对这一技术的认识和了解将会关系到很多专业的以及生活的内容。文章从概述、发展、应用3方面对这... 详细信息

光纤通信因其自身所具有的优点,被市场广泛接受,发展非常迅速。现在它作为通信发展承载技术的主流,已进入到了和通信相关的各个领域,因此,对这一技术的认识和了解将会关系到很多专业的以及生活的内容。文章从概述、发展、应用3方面对这一技术进行了论述。

关键词：光纤通信技术网络信息电子技术

转化生长因子β1的研究进展及其法医学应用价值

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中国法医学杂志 2014年第4期29卷 333-336页

作者：张艳于天水刘良张海东百茹峰张振华司法文明协同创新中心北京100088 中国政法大学证据科学教育部重点实验室北京100088 北市密云县检察院公诉一处北京101500 华中科技大学同济医学院法医学系湖北武汉430030

转化生长因子β1(transforming growth factor-β1,TGF-β1)是一种具有多种生物学活性的细胞因子,存在于多种生物的不同组织中,广泛参与调节细胞增殖和分化等过程。本文综述TGF-β1的生物学特性及其在法医学中的应用价值,以期为损伤时... 详细信息

转化生长因子β1(transforming growth factor-β1,TGF-β1)是一种具有多种生物学活性的细胞因子,存在于多种生物的不同组织中,广泛参与调节细胞增殖和分化等过程。本文综述TGF-β1的生物学特性及其在法医学中的应用价值,以期为损伤时间推断的基础研究和实际检案工作提供参考资料。

关键词：法医病理学损伤时间推断转化生长因子β1

功能MRI观察左旋甲状腺素对亚临床甲状腺功能减退空间工作记忆损伤的影响

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中国医学影像学杂志 2014年第9期22卷 664-669页

作者：黄冉冉马树华百茹峰尹晶晶谢磊孙宗博汕头大学医学院第一附属医院放射科广东汕头515041 广东省医学分子影像重点实验室广东汕头515041 证据科学教育部重点实验室(中国政法大学) 北京100040

目的采用血氧依赖水平功能磁共振成像(BOLD-fMRI)探讨左旋甲状腺素(LT4)替代治疗对亚临床甲状腺功能减退(SCH)患者空间工作记忆的影响。资料与方法 16例SCH患者进行LT4治疗6个月前后与对照组16例甲状腺功能正常志愿者分别进行n-back任... 详细信息

目的采用血氧依赖水平功能磁共振成像(BOLD-fMRI)探讨左旋甲状腺素(LT4)替代治疗对亚临床甲状腺功能减退(SCH)患者空间工作记忆的影响。资料与方法 16例SCH患者进行LT4治疗6个月前后与对照组16例甲状腺功能正常志愿者分别进行n-back任务负载下fMRI扫描,以AFNI软件对fMRI数据进行定位定量分析。结果在n-back任务负载下,所有受试者共同激活的脑区包括双侧背外侧前额叶(DLPFC)、双侧前运动区(PreMA)、双侧顶叶(PA)、前扣带皮层/辅助运动区及右侧尾状核/丘脑,且表现为右侧大脑半球优势。定量分析发现,对照组以上脑区均表现出与记忆负载相关的负载效应(P<0.001),而SCH组治疗前仅在左侧DLPFC、左侧PA、双侧PreMA及右侧尾状核/丘脑发现了这种负载效应。经LT4替代治疗6个月后,包括右侧DLPFC、右侧PA及前扣带回/辅助运动区在内的脑感兴趣区均出现与记忆负载相关的BOLD信号变化(P<0.001)。在n-back任务负载下,SCH组大部分工作记忆相关脑区的激活强度均比对照组小。结论 SCH患者存在空间工作记忆损伤,可能与右侧背外侧前额-右顶叶后部网络功能减退有关;LT4替代治疗对SCH患者记忆功能的恢复尤为重要。

关键词：甲状腺功能减退症甲状腺素磁共振成像记忆障碍