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Chromatin-binding in vivo of the erythroid kruppel-like factor,EKLF,in the murine globin loci

Cell Research 2006年第4期16卷 347-355页

作者： Yu-Chiau Shyu Shau-Ching Wen Tung-Liang Lee Xin chen Chia-Tse Hsu Hsin chen ruei-lin chen Jau-Lang Hwang Che-Kun James Shen Institute of Molecular Biology Academia SinicaNankangTaipei 115 Institute of Life Sciences National Defense UniversityNei-huTaipei 114 Division of Biotechnology and Pharmaceutical Research National Health Research InstitutesZhunan TownMiaoli County 350 ~

EKLF is an erythroid-specific,zinc finger-containing transcription factor essential for the activation of the mamma-lian beta globin gene in erythroid cells of definitive *** have prepared a polyclonal anti-mouse EKLF antibodysuitable for Western blotting and immunoprecipitation(IP)qualities,and used it to define the expression patterns of theEKLF protein during mouse erythroid *** have also used this antibody for the chromatin-immunoprecipi-tation(ChIP)*** was found to bind in vivo at both the mouse beta-major-globin promoter and the HS2 site ofbeta-LCR in the mouse erythroleukemia cells(MEL)in a DMSO-inducible *** DMSO-induced bindings ofEKLF as well as three other proteins,namely,RNA polymerase Ⅱ,acetylated histone H3,and methylated histone H3,were not abolished but significantly lowered in CB3,a MEL-derived cell line with null-expression of p45/NF-E2,anerythroid-enriched factor needed for activation of the mammalian globin ***,binding of EKLF in vivowas also detected in the mouse alpha-like globin locus,at the adult alpha globin promoter and its far upstream regula-tory element alpha-MRE(HS26).This study provides direct evidence for EKLF-binding in vivo at the major regulatoryelements of the mouse beta-like globin gene clusters the data also have interesting implications with respect to the roleof EKLF-chromatin interaction in mammalian globin gene regulation.

关键词： EKLF mutine globin gene clusters chromatin-immunoprecipitation (CHIP) chromosome structure

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Path-Dependent Progressive Failure Analysis for 3D-Printed Continuous Carbon Fibre Reinforced Composites

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Chinese Journal of Mechanical Engineering 2024年第4期37卷 84-93页

作者： Yuan chen lin Ye School of System Design and Intelligent Manufacturing(SDIM) Southern University of Science and TechnologyShenzhen 518055China Shenzhen Key Laboratory of Intelligent Manufacturing for Continuous Carbon Fibre Reinforced Composites Southern University of Science and TechnologyShenzhen 518055China

In order to predict the damage behaviours of 3D-printed continuous carbon fibre(CCF)reinforced composites,when additional short carbon fibre(SCF)composite components are employed for continuous printing or special functionality,a novel path-dependent progressive failure(PDPF)numerical approach is ***,a progressive failure model using Hashin failure criteria with continuum damage mechanics to account for the damage initiation and evaluation of 3D-printed CCF reinforced polyamide(PA)composites is developed,based on actual fibre placement trajectories with physical measurements of 3D-printed CCF/PA ***,an elastic-plastic model is employed to predict the plastic damage behaviours of SCF/PA ***,the accuracy of the PDPF model was validated so as to study 3D-printed CCF/PA composites with either negative Poisson's ratio or high *** results demonstrate that the proposed PDPF model can achieve higher prediction accuracies in mechanical properties of these 3D-printed CCF/PA *** analyses show that the stress distribution is generally aggregated in the CCF areas along the fibre placement paths,and the shear damage and matrix tensile/compressive damage are the key damage *** study provides a new approach with valuable information for characterising complex 3D-printed continuous fibre-matrix composites with variable mechanical properties and multiple constituents.

关键词： 3D printing Continuous carbon fibre Modelling Energy absorption Negative Poisson's ratio

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Enhancing Safety in Autonomous Vehicle Navigation:An Optimized Path Planning Approach Leveraging Model Predictive Control

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Computers, Materials & Continua 2024年第9期80卷 3555-3572页

作者： Shih-lin lin Bo-chen lin Graduate Institute of Vehicle Engineering National Changhua University of EducationChanghua50007TaiwanChina

This paper explores the application of Model Predictive Control(MPC)to enhance safety and efficiency in autonomous vehicle(AV)navigation through optimized path *** evolution of AV technology has progressed rapidly,moving from basic driver-assistance systems(Level 1)to fully autonomous capabilities(Level 5).Central to this advancement are two key functionalities:Lane-Change Maneuvers(LCM)and Adaptive Cruise Control(ACC).In this study,a detailed simulation environment is created to replicate the road network between Nantun andWuri on National Freeway No.1 in *** MPC controller is deployed to optimize vehicle trajectories,ensuring safe and efficient *** onboard sensors,including vehicle cameras and millimeterwave radar,are used to detect and respond to dynamic changes in the surrounding environment,enabling real-time decision-making for LCM and *** simulation resultshighlight the superiority of the MPC-based approach in maintaining safe distances,executing controlled lane changes,and optimizing fuel ***,the MPC controller effectively manages collision avoidance,reduces travel time,and contributes to smoother traffic flow compared to traditional path planning *** findings underscore the potential of MPC to enhance the reliability and safety of autonomous driving in complex traffic *** research will focus on validating these results through real-world testing,addressing computational challenges for real-time implementation,and exploring the adaptability of MPC under various environmental *** study provides a significant step towards achieving safer and more efficient autonomous vehicle navigation,paving the way for broader adoption of MPC in AV systems.

关键词： Autonomous driving model predictive control(MPC) lane change maneuver(LCM) adaptive cruise control(ACC)

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Cellular angiofibroma arising from the rectocutaneous fistula in an adult: A case report

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World Journal of Clinical Cases 2024年第10期12卷 1778-1784页

作者： Hao-En chen Yu-Yang Lu ruei-Yu Su Hong-Hau Wang Chao-Yang chen Je-Ming Hu Jung-cheng Kang Kuan-Hsun lin Ta-Wei Pu Department of Surgery Taichung Armed Forces General HospitalTaichung 411Taiwan Department of Surgery Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Department of Pediatrics Tri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Department of Pathology Tri-Service General HospitalNational Defense Medical CenterTaipei 105Taiwan Department of Pathology and Laboratory Medicine Taoyuan Armed Forces General HospitalTaoyuan 32551Taiwan Department of Radiology Tri-Service General Hospital Songshan BranchNational Defense Medical CenterTaipei 105Taiwan Division of Colon and Rectal Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of Colon and Rectal Surgery Department of SurgeryTaiwan Adventist HospitalTaipei 105Taiwan Division of Thoracic Surgery Department of SurgeryTri-Service General HospitalNational Defense Medical CenterTaipei 114Taiwan Division of Colon and Rectal Surgery Department of SurgeryTri-Service General Hospital Songshan BranchNational Defense Medical CenterTaipei 105Taiwan

BACKGROUND Rectocutaneous fistulae are *** infection originates within the anal glands and subsequently extends into adjacent regions,ultimately resulting in fistula *** angiofibroma(CAF),also known as an angiomy ofibroblastoma-like tumor,is a rare benign soft tissue neoplasm predominantly observed in the scrotum,perineum,and inguinal area in males and in the vulva in *** describe the first documented case CAF that developed within a rectocutaneous fistula and manifested as a perineal *** SUMMARY In the outpatient setting,a 52-year-old male patient presented with a 2-year history of a growing perineal mass,accompanied by throbbing pain and minor scrotal *** examination revealed a soft,well-defined,non-tender mass at the left buttock that extended towards the perineum,without a visible *** initial assessment identified a soft tissue tumor,and the laboratory data were within normal *** and pelvic computed tomography(CT)revealed swelling of the abscess cavity that was linked to a rectal cutaneous fistula,with a track-like lesion measuring 6 cm×0.7 cm in the left perineal region and attached to the left *** examination found no significant inner orifices.A left medial gluteal incision revealed a thick-walled mass,which was excised along with the extending tract,and curettage was *** examination confirmed CAF *** patient achieved total resolution during follow-up assessments and did not require additional *** CT imaging supports perineal lesion diagnosis and *** angiofibromas,even with a cutaneous fistula,can be excised transperineally.

关键词： Angiofibroma Perineal mass Rectocutaneous fistula Anorectal fistula Anal fistula Case report

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NSNO:Neumann Series Neural Operator for Solving Helmholtz Equations in Inhomogeneous Medium

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Journal of Systems Science & Complexity 2024年第2期37卷 413-440页

作者： chen Fukai LIU Ziyang lin Guochang chen Junqing SHI Zuoqiang Department of Mathematical Sciences Tsinghua UniversityBeijing 100084China Yau Mathematical Sciences Center Tsinghua UniversityBeijing 100084China Yanqi Lake Beijing Institute of Mathematical Sciences and Applications Beijing 101408China

In this paper,the authors propose Neumann series neural operator(NSNO)to learn the solution operator of Helmholtz equation from inhomogeneity coefficients and source terms to *** equation is a crucial partial differential equation(PDE)with applications in various scientific and engineering ***,efficient solver of Helmholtz equation is still a big challenge especially in the case of high ***,deep learning has shown great potential in solving PDEs especially in learning solution *** by Neumann series in Helmholtz equation,the authors design a novel network architecture in which U-Net is embedded inside to capture the multiscale *** experiments show that the proposed NSNO significantly outperforms the state-of-the-art FNO with at least 60%lower relative L^(2)-error,especially in the large wavenumber case,and has 50%lower computational cost and less data ***,NSNO can be used as the surrogate model in inverse scattering *** tests show that NSNO is able to give comparable results with traditional finite difference forward solver while the computational cost is reduced tremendously.

关键词： Helmholtz equation inverse problem neumann series neural network solution operator

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Heat Transfer Characteristics of a Microchannel Heat Sink with Highly-Dense Micro-Jet Arrays

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Journal of Thermal Science 2024年第3期33卷 1148-1160页

作者： ZHANG Yu chen Xiaoyan MIAO lin chen Liang HOU Yu State Key Laboratory of Multiphase Flow in Power Engineering Xi’an Jiaotong UniversityXi’an710049China Beijing Aerospace Technology Institute Beijing100083China

This paper proposed a new structure of highly-dense micro-jet arrays for hybrid jet-impingement/microchannel heat sinks(~120 jet per cm^(2) with jet width of 0.35 mm).Parametric study is performed to investigate the influence of structure and flow parameters on the convective heat transfer of water jet cooling in confined *** simulation results show that the optimal jet width,jet spacing and impingement distance are around 0.2 mm,0.2 mm and 0.3 mm,respectively,which can achieve a low thermal resistance as well as a relatively low pressure *** analysis of the heat transfer pathways shows that the micro-fin jet structures can extend the impinging heat transfer area and conduct a considerable proportion of heat,which can reach up to 38.9%with the Reynolds number ranging from 797.1 to *** heat transfer characteristics in the heat sink will shift from impingement dominated heat transfer to the channel-convection dominated heat transfer as the jet impingement distance increases.A correlation is proposed to predict the average Nusselt number on the stagnation area for the heat sink with different structure parameters,and the deviations of predictions from the numerical results are less than 10%.

关键词： hybrid heat sink impingement microchannel thermal management high heat flux

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Quantifying quantum entanglement via machine learning models

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Communications in Theoretical Physics 2024年第7期76卷 52-56页

作者： Changchun Feng lin chen LMIB(Beihang University) Ministry of EducationBeijing 100191China School of Mathematical Sciences Beihang UniversityBeijing 100191China International Research Institute for Multidisciplinary Science Beihang UniversityBeijing 00191China

Quantifying entanglement measures for quantum states with unknown density matrices is a challenging *** learning offers a new perspective to address this *** training machine learning models using experimentally measurable data,we can predict the target entanglement *** this study,we compare various machine learning models and find that the linear regression and stack models perform better than *** investigate the model's impact on quantum states across different dimensions and find that higher-dimensional quantum states yield better ***,we investigate which measurable data has better predictive power for target entanglement *** correlation analysis and principal component analysis,we demonstrate that quantum moments exhibit a stronger correlation with coherent information among these data features.

关键词： quantum information entanglement predict machine learning coherence

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High Order IMEX Stochastic Galerkin Schemes for linear Transport Equation with Random Inputs and Diffusive Scalings

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Communications on Applied Mathematics and Computation 2024年第1期6卷 325-339页

作者： Zheng chen lin Mu Department of Mathematics University of Massachusetts Dartmouth285 Old Westport RoadDartmouth02747MAUSA Department of Mathematics University of GeorgiaAthens30602GAUSA

In this paper,we consider the high order method for solving the linear transport equations under diffusive scaling and with random *** tackle the randomness in the problem,the stochastic Galerkin method of the generalized polynomial chaos approach has been ***,the high order implicit-explicit scheme under the micro-macro decomposition framework and the discontinuous Galerkin method have been *** provide several numerical experiments to validate the accuracy and the stochastic asymptotic-preserving property.

关键词： Stochastic Galerkin scheme linear transport equations generalized polynomial approach stochastic asymptotic-preserving property

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Vickrey-Clark-Groves-based Method for Eradicating Deceptive Behaviors in Demand Response Transactions

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Journal of Modern Power Systems and Clean Energy 2024年第4期12卷 1260-1271页

作者： Yingjun Wu chengjun Liu Zhiwei lin Zhaorui chen Runrun chen Yuyang chen College of Energy and Electrical Engineering Hohai UniversityNanjingChina

Demand response transactions between electric con-sumers,load aggregators,and the distribution network manag-er based on the"combination of price and incentive"are feasi-ble and ***,the incentive payment of demand re-sponse is quantified based on private information,which gives the electric consumers and load aggregators the possibility of defrauding illegitimate interests by declaring false *** paper proposes a method based on Vickrey-Clark-Groves(VCG)theory to prevent electric consumers and load aggrega-tors from taking illegitimate interests through deceptive behav-iors in the demand response ***,a demand re-sponse transaction framework with the price-and-incentive com-bined mode is established to illustrate the deceptive behaviors in the demand response ***,the idea for eradi-cating deceptive behaviors based on VCG theory is given,and a detailed VCG-based mathematical model is constructed follow-ing the demand response transaction ***,the proofs of incentive compatibility,individual rationality,cost minimization,and budget balance of the proposed VCG-based method are ***,a modified IEEE 33-node system and a modified IEEE 123-node system are used to illustrate and val-idate the proposed method.

关键词： Demand response transaction incentive mode cost-sharing false information deceptive behavior

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Risk-averse Robust Interval Economic Dispatch for Power Systems with Large-scale Wind Power Integration

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CSEE Journal of Power and Energy Systems 2024年第1期10卷 105-116页

作者： Zhenjia lin Haoyong chen Jinbin chen Jianping Huang Mengshi Li School of Electric Power Engineering South China University of TechnologyGuangzhou 510641China Department of Electrical Engineering Technical University of DenmarkDenmark

This paper presents a robust interval economic dispatch(RIED)model for power systems with large-scale wind power *** from existing interval optimization(IO)approaches that merely rely on the upper and lower boundaries of random variables,the distribution information retained in the historical data is introduced to the IO method in this *** on the available probability distribution function(PDF),wind power curtailment and load shedding are quantified as the operational risk and incorporated into the decision-making *** this model,we need not rely on the forecasted value of wind power,which is randomly fluctuating and quite ***,when the PDFs of wind power are taken into account,the resulting dispatch solution makes a good tradeoff between the generation cost and the operational ***,the RIED model yields an optimal dispatch solution for thermal units and the allowable intervals of wind power for the wind farms,which efficiently mitigates the uncertainty in wind power generation and provides more practical suggestions for system *** studies are conducted on a modified IEEE-118 bus system and the results verify the effectiveness of the proposed RIED model.

关键词： Economic dispatch interval optimization risk-averse wind power generation

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