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母羊实验性流行性流产的胎盘病理学

畜牧与饲料科学 1977年第1期 86-95页

作者： M.N.Novilla rue jensen 梅文辉

30只妊娠母羊在怀孕的第90天,经由静脉接种了母羊流行性流产(EAE)的鹦鹉病—淋巴肉芽肿—砂眼(PLT)病原物。15只对照用妊娠母羊未接种。除流产者外,分别在接种后的第20天、30天和50天解剖;流产羊则立即扑杀解剖。自接种后的第1天下午起... 详细信息

30只妊娠母羊在怀孕的第90天,经由静脉接种了母羊流行性流产(EAE)的鹦鹉病—淋巴肉芽肿—砂眼(PLT)病原物。15只对照用妊娠母羊未接种。除流产者外,分别在接种后的第20天、30天和50天解剖;流产羊则立即扑杀解剖。自接种后的第1天下午起至第6天,30只中的20只动物直肠检温为40～41℃。接种后26天死亡的母羊有不发热的。30只中的11只母羊在接种后的第6天和第44天发生了流产。没有流产前驱症状。早期流产发现的胎盘(接种后第6～11天),以及含有死胎和软化胎儿的胎盘,已经自溶。接种后35～44天流产母羊的胎盘,具有典型的母羊流行性流产的病变,母羊的外生殖器及后肢见有黄褐色无臭粘性渗出物附着。未流产母羊胎盘的肉眼变化为:绒毛尿囊膜的早期水肿及红褐色渗出液在胎盘小体内和周围的潴积。显微镜下的早期变化为:中隔顶端的坏死及在胎盘门部见中隔细胞、绒毛膜细胞和血肿囊的感染。感染区有轻度炎症反应。当病机进展,则感染漫延至胎盘小体深部及胎盘小体间。结果造成内含本病病原物的粘性血样脓性渗出物的潴积。本病进行期的特徵是胎盘小体和绒毛膜的广泛性坏死。与此种变化有关的是显明的中性多形核白血球占优势的炎症反应。子宫见浆细胞浸润。子宫内膜细胞感染。母羊流行性流产又名羊病毒性流产(OVA)是一种PLT族微生物引起的传染病。病的特徵是没有明显临床症状的流产。病母羊产出未成熟的活的、死的、弱的或临床正常的羔羊。目前,对PLT感染的各方面已作了大量的研究。很多研究指出:PLT病原物是爱好在胎盘生长的。但迄今为止,很少见到致力于PLT病原物感染胎盘的病理变化的分析。本研究在于解决:用EAE病原物作实验性感染绵羊盘胎的肉眼及显微镜变化的形态形成(morphogenesis)。

关键词：胎盘形成早期流产胎盘绒毛膜胎儿母羊病原物病原体实验性

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疯草中毒(落科病)

畜牧兽医科技通讯 1978年第3期 44-46页

作者： rue jensen 王奉先张生民

疯草中毒是绵羊的一种慢性衰退性中毒病,病的特点是行为改变,感觉异常,肌肉共济失调,体重减轻,通常引起流产和胎儿畸形,病因是由于经常采食美国西北部常见的某种疯草而引起,因为此病分布广泛,引起母羊及羔羊大批死亡,造成经济的很大损失... 详细信息

疯草中毒是绵羊的一种慢性衰退性中毒病,病的特点是行为改变,感觉异常,肌肉共济失调,体重减轻,通常引起流产和胎儿畸形,病因是由于经常采食美国西北部常见的某种疯草而引起,因为此病分布广泛,引起母羊及羔羊大批死亡,造成经济的很大损失,对整个养羊业是一个严重的威胁,经济损失是由于母羊的衰弱和死亡,羔羊的流产、

关键词：疯草中毒绵羊冬季牧场胎儿美国上皮细胞曲细采食美利坚合众国北美洲动物行为羔羊空泡形成

Electroactivity of the magnetotactic bacteria Magnetospirillum magneticum AMB-1 and Magnetospirillum gryphiswaldense MSR-1

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Frontiers of Environmental Science & Engineering 2024年第4期18卷 103-110页

作者： Mathias Fessler Qingxian Su Marlene Mark jensen Yifeng Zhang Department of Environmental and Resource Engineering Technical University of DenmarkCopenhagenDK-2800Denmark

Magnetotactic bacteria reside in sediments and stratified water *** are named after their ability to synthesize internal magnetic particles that allow them to align and swim along the Earth’s magnetic field ***,we show that two magnetotactic species,Magnetospirillum magneticum strain AMB-1 and Magnetospirillum gryphiswaldense strain MSR-1,are *** *** and *** were able to generate current in microbial fuel cells with maximum power densities of 27 and 11μW/m^(2),*** the presence of the electron shuttle resazurin both species were able to reduce the crystalline iron oxide hematite(Fe_(2)O_(3)).In addition,*** could reduce poorly crystalline iron oxide(FeOOH).Our study adds *** and *** to the growing list of known electroactive bacteria,and implies that electroactivity might be common for bacteria within the Magnetospirillum genus.

关键词： Magnetotactic bacteria Magnetospirillum magneticum Magnetospirillum gryphiswaldense Extracellular electron transfer Microbial fuel cells

The effects of cool materials,façade orientation,and morphological parameters on energy consumption at the residential neighborhood scale

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Building Simulation 2024年第4期17卷 525-542页

作者： Fusuo Xu Dongdong Tian Zhi Gao Jianshun jensen Zhang Department of Mechanical and Aerospace Engineering Syracuse UniversitySyracuseNY13210USA School of Architecture and Urban Planning Nanjing University22 Hankou RoadNanjingJiangsu Province210093China

Building surface cool materials are novel materials that can reduce urban heat island intensity and decrease building energy *** study investigated the impact of radiative properties of materials,façade orientation,and morphological parameters on energy consumption in six typical residential neighborhoods in Nanjing,*** neighborhood energy consumption of 16 application schemes considering the façade orientation factor is compared to determine the best energy-saving *** and annual energy-saving rates,savings in electricity costs,and the price ceiling for materials per unit area are *** results show that for low-rise buildings,using cool materials only on the roof can reduce the annual energy consumption by 1%.When cool or super cool materials are also used on the building façade,the annual energy saving rate can be up to 3.4%and 4.3%,*** cool materials on the south façade of buildings is not recommended due to significant heat loss in *** savings in electricity costs and the price ceiling for materials per unit area,the price of cool and super cool materials should be less than 3.0 and 3.7 RMB/m2,respectively,assuming a lifespan of eight years in Nanjing.

关键词： cool materials building energy saving neighborhood morphology façade orientation

Neurological consequences of human calmodulin mutations

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Neural Regeneration Research 2024年第5期19卷 943-944页

作者： Helene H.jensen Anders Olsen Medical Biotechnology Department of Chemistry and BiosciencesAalborg UniversityAalborgDenmark

When calcium ions enter the cytosol,it is a stimulatory signal for cellular *** calcium sensor calmodulin picks up the change in calcium concentration and relays this information to its more than 300 downstream interaction *** this way,calmodulin affects cellular processes such as fertilization,muscle contraction,neuronal firing,and *** is,calmodulin is involved in(nearly)everything!The significance of calmodulin is emphasized by the fact that we all carry three different genes(CALM1,2,3)on different chromosomes that encode the exact same calmodulin protein,and these are all expressed in all cell ***,throughout vertebrate evolution,the protein sequence has remained completely unchanged.

关键词： consequences unchanged calmodulin

Robust Reactive Power Scheduling of Distribution Networks Based on Modified Bootstrap Technique

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 154-166页

作者： Wenlong Liao Shouxiang Wang Birgitte Bak-jensen Jayakrishnan Radhakrishna Pillai Zhe Yang the AAU Energy Aalborg UniversityAalborg 9220Denmark the Key Laboratory of Smart Grid Ministry of EducationSchool of Electrical and Information EngineeringTianjin UniversityTianjin 300072China

The uncertainties of the power load,wind power,and photovoltaic power lead to errors between point prediction values and real values,which challenges the safe operation of distribution *** this paper,a robust reactive power scheduling(RRPS)model based on a modified bootstrap technique is proposed to consider the uncertainties of power loads and renewable energy ***,a deterministic reactive power scheduling(DRPS)model and an RRPS model are ***,a modified bootstrap technique is proposed to estimate prediction errors of power loads and renewable energy sources without artificially assuming the probability density function of prediction *** represent all possible scenarios,point prediction values and prediction errors are combined to construct two worst-case scenarios in the RRPS ***,the RRPS model is solved to find a scheduling scheme,which ensures the security of distribution networks for all possible scenarios in *** results show that the worst-case scenarios constructed by the modified bootstrap technique outperform popular ***,the RRPS model based on the modified bootstrap technique balances economics and security well.

关键词： Distribution network worst-case scenario robust programming prediction error bootstrap technique

Mucopolysaccharidosis typeⅢB:a current review and exploration of the AAV therapy landscape

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Neural Regeneration Research 2024年第2期19卷 355-359页

作者： Courtney J.Rouse Victoria N.jensen Coy D.Heldermon Lacerta Therapeutics AlachuaFLUSA University of Florida College of Medicine GainesvilleFLUSA

Mucopolysaccharidoses typeⅢB is a rare genetic disorder caused by mutations in the gene that encodes for *** results in the aggregation of heparan sulfate polysaccharides within cell lysosomes that leads to progressive and severe debilitating neurological *** treatment options are expensive,limited,and presently there are no approved cures for mucopolysaccharidoses typeⅢ***-associated virus gene therapy has significantly advanced the field forward,allowing researchers to successfully design,enhance,and improve potential *** group recently published an effective treatment using a codon-optimized triple mutant adeno-associated virus 8 vector that restores N-acetyl-alpha-glucosaminidase levels,auditory function,and lifespan in the murine model for mucopolysaccharidoses typeⅢB to that seen in healthy ***,we review the current state of the field in relation to the capsid landscape,adeno-associated virus gene therapy and its successes and challenges in the clinic,and how novel adenoassociated virus capsid designs have evolved research in the mucopolysaccharidoses typeⅢB field.

关键词： adeno-associated virus central nervous system gene therapy heparan sulfate immune response mucopolysaccharidoses type IIIB N-acetyl-alpha-glucosaminidase newborn screening

Magnetic field regression using artificial neural networks for cold atom experiments

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Chinese Physics B 2024年第2期33卷 46-51页

作者：陈子霆黃建陶 Bojeong Seo 黄明琛 Mithilesh K.Parit 何逸飞甄浩廷 jensen Li Gyu-Boong Jo Department of Physics The Hong Kong University of Science and TechnologyKowloon 999077China

Accurately measuring magnetic fields is essential for magnetic-field sensitive experiments in areas like atomic,molecular,and optical physics,condensed matter experiments,and other ***,since many experiments are often conducted in an isolated environment that is inaccessible to experimentalists,it can be challenging to accurately determine the magnetic field at the target ***,we propose an efficient method for detecting magnetic fields with the assistance of an artificial neural network(NN).Instead of measuring the magnetic field directly at the desired location,we detect fields at several surrounding positions,and a trained NN can accurately predict the magnetic field at the target *** training,we achieve a below 0.3%relative prediction error of magnetic field magnitude at the center of the vacuum chamber,and successfully apply this method to our erbium quantum gas apparatus for accurate calibration of magnetic field and long-term monitoring of environmental stray magnetic *** demonstrated approach significantly simplifies the process of determining magnetic fields in isolated environments and can be applied to various research fields across a wide range of magnetic field magnitudes.

关键词： ultracold gases trapped gases measurement methods and instrumentation

Identific tion of quantitative trait loci and associated candidate genes for pregnancy success in Angus–Brahman crossbred heifers

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Journal of Animal Science and Biotechnology 2024年第1期15卷 162-170页

作者： Quinn A.Hoorn Gabriel A.Zayas Eduardo E.Rodriguez Laura M.jensen Raluca G.Mateescu Peter J.Hansen Department of Animal Sciences Donald Henry Barron Reproductive and Perinatal Biology Research Programand the Genetics InstituteUniversity of FloridaGainesvilleFLUSA School of Applied Systems Biology La Trobe UniversityBundooraVIC 3083Australia

Background In beef cattle, more than 50% of the energy input to produce a unit of beef is consumed by the female that produced the calf. Development of genomic tools to identify females with high genetic merit for reproductive function could increase the profitability and sustainability of beef *** Genome-wide association studies(GWAS) were performed using a single-step genomic best linear unbiased prediction approach on pregnancy outcome traits from a population of Angus–Brahman crossbred heifers. Furthermore, a validation GWAS was performed using data from another farm. Heifers were genotyped with the Bovine GGP F250 array that contains 221,077 SNPs. In the discovery population, heifers were bred in winter breeding seasons involving a single round of timed artificial insemination(AI) followed by natural mating for 3 months. Two phenotypes were analyzed: pregnancy outcome to first-service AI(PAI;n = 1,481) and pregnancy status at the end of the breeding season(PEBS;n = 1,725). The heritability was estimated as 0.149 and 0.122 for PAI and PEBS, respectively. In the PAI model, one quantitative trait locus(QTL), located between 52.3 and 52.5 Mb on BTA7, explained about 3% of the genetic variation, in a region containing a cluster of γ-protocadherin genes and SLC25A2. Other QTLs explaining between 0.5% and 1% of the genetic variation were found on BTA12 and 25. In the PEBS model, a large QTL on BTA7 was synonymous with the QTL for PAI, with minor QTLs located on BTA5, 9, 10, 11, 19, and 20. The validation population for pregnancy status at the end of the breeding season were Angus–Brahman crossbred heifers bred by natural mating. In concordance with the discovery population, the large QTL on BTA7 and QTLs on BTA10 and 12 were *** In summary, QTLs and candidate SNPs identified were associated with pregnancy outcomes in beef heifers, including a large QTL associated with a group of protocadherin genes. Confirmation of these associations

关键词： Beef cattle Fertility GWAS QTL