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The extract of Mucuna pruriens possesses histamine activity

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Asian Pacific Journal of Tropical Medicine 2010年第1期3卷 29-31页

作者： Reginald np Nwankwoala Georgewill OA Department of Pharmacology and Toxicology Faculty of Basic Medical SciencesUniversity of Port Harcourt

Objective:To investigate the activity of the active principle in the spines of the seed pods of Mucuna pruriens using contraction of guinea pig ileum as index of pharmacological activity. Methods:The active principle was extracted with 0.0015 M *** strips of guinea pig ileum were prepared and contractile responses were measured using a *** sets of experiment were conducted:（1）.The contraction of the ileum in presence of different concentrations of histamine,2-methylhistamine and the extract of Mucuna pruriens.（2）.The contractile response of the ileum in presence of different concentrations of the extract and antagonists including diphenhydramine,atropine and ***:（1） The extract of Mucuna pruriens hair, 2- methylhistamine and histamine produced dose dependent contraction of guinea pig ileum (Extract ED50 = 13.0μg/mL,2-methylhistamine ED50=8.5μg/mL and histamine ED50=10.0μg/ mL).（2） Diphenhydramine,an H,antagonist competitively blocked the contractile response of the Mucuna pruriens extract（3） Coadminstration of the Mucuna pruriens extract either with different doses of antimuscarinic agent atropine or 5-hydroxytryptamine blocking agent methysergide did not alter the extract induced contractile response of the guinea pig ***:These results demonstrate that the spines of Mucuna pruriens possess histamine activity which may contribute to its itching and painful irritation effects.

关键词： Mucuna pruriens Histamine activity Itching Irritation

Synthesis of silica-pillared layered lanthanum titanate with high thermal stability

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Chinese Journal of Chemistry 1996年第2期14卷 186-189页

作者： Wang, np Hou, WH Ma, J Yan, QJ NANJING UNIV INST COORDINAT CHEMDEPT CHEMNANJING 210093JIANGSUPEOPLES R CHINA

It is now well established that layered solids other than smectite clays may bepillared to form three-dimensional crosslinked materials, the porosity of which isultimately tunable by the nature of the host substrate a... 详细信息

关键词： pillaring aminopropyltriethoxysilane potassium lanthanum titanate

Inflammation and immunosuppression in severe acute pancreatitis

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World Journal of Gastroenterology 2010年第23期16卷 2867-2872页

作者： Marja-Leena Kylnp Heikki Repo Pauli Antero Puolakkainen Department of Surgery University of Helsinki Department of Bacteriology and Immunology Haartman InstituteUniversity of Helsinki

Acute pancreatitis(AP) is a common disease,which usually exists in its mild ***,in a fifth of cases,the disease is severe,with local pancreatic complications or systemic organ dysfunction or *** the development of organ failure is the major cause of death in AP,early identification of patients likely to develop organ failure is *** is initiated by intracellular activation of pancreatic proenzymes and autodigestion of the *** of the pancreatic parenchyma first induces an inflammatory reaction locally,but may lead to overwhelming systemic production of inflammatory mediators and early organ ***,anti-inflammatory cytokines and specific cytokine inhibitors are *** anti-inflammatory reaction may overcompensate and inhibit the immune response,rendering the host at risk of systemic *** present,there is no specific treatment for *** understanding of the pathogenesis of systemic inflammation and development of organ dysfunction may provide us with drugs to ameliorate physiological disturbances.

关键词： Acute pancreatitis Organ failure Inflammatory response Immunosuppression Coagulation

Calculation of latent and sensible heat fluxes during summer in ocean area around Antarctic

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Chinese Science Bulletin 1997年第7期42卷 570-573页

作者： Li, SM Zhou, MY Su, LR Lu, np National Research Center for Marine Environmental Forecasts Beijing China

THE transfer of latent and sensible heat fluxes over the ocean surface makes an important effect on the global climatic variation. The heat fluxes can be calculated directly by using the data of fluctuations of temper... 详细信息

关键词： Antarctic heat flux marine observation.

关于全球冷暖和亚、非夏季风区干湿变迁之联系的一个述评

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地理学报 1995年第5期50卷 471-479页

作者：严中伟 Maire,np 中国科学院大气物理研究所

基于近年来的多种资料分析结果，讨论了不同时间尺度上全球热状况之于中国东部和其它低纬亚非夏季风影响区干湿变迁的宏观控制作用。指出：在百年以上时间尺度上，全球暖而夏季风强从而导致有关区域多雨偏湿，全球冷则夏季风区域多偏干... 详细信息

基于近年来的多种资料分析结果，讨论了不同时间尺度上全球热状况之于中国东部和其它低纬亚非夏季风影响区干湿变迁的宏观控制作用。指出：在百年以上时间尺度上，全球暖而夏季风强从而导致有关区域多雨偏湿，全球冷则夏季风区域多偏干；但较短时间尺度上的全球性冷暖波动往往不足以使各地的夏季风系统和干湿状况产生一致响应。

关键词：全球变化区域干湿季风气候变化

Identification of the Metabolite of 7-(4-Chlorbenzyl)-7,8,13,13a-tetrahydroberberine chloride in Rat Bile by LC/MS and LC/NMR

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Chinese Chemical Letters 1997年第6期8卷 515-518页

作者： Feng, np Zhang, ZX An, DK Huang, WL Wang, GJ Han, XW Bao, XH CHINA PHARMACEUT UNIV NANJING 210009PEOPLES R CHINA CHINESE ACAD SCI DALIAN INST CHEM PHYSDALIAN 116023PEOPLES R CHINA

The metabolism of 7-(4-Chlorbenzyl)-7,8,13,13a-tetrahydroberberine chloride (CTHB), a potential anti-arrhythmia and anti-ischemia drug,was studied in rat bile. A metabolite and unchanged CTHB were found in the bile. C... 详细信息

关键词： MS LC tetrahydroberberine chloride in Rat Bile by LC/MS and LC/NMR Chlorbenzyl Identification of the Metabolite of 7

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重钙—尿素基np／npK复肥造粒新法

化肥工业译丛 1990年第2期 45-50页

作者： Misra,np 卢朝阳

Ileal loop interposition:an alternative biliary bypass technique

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Hepatobiliary & Pancreatic Diseases International 2010年第6期9卷 654-657页

作者： Felipe JF Coimbra Alessandro L Diniz Heber SC Ribeiro Wilson L Costa Jr. Eduardo np Lima AndréL Montagnini Abdominal Surgery Department Hospital do Cncer A.C.CamargoRua Professor Antnio Prudente 211LiberdadeSo PauloSP 01509-010Brazil Nuclear Medicine Imaging Department Hospital do Cncer A.C.CamargoRua Professor Antnio Prudente 211LiberdadeSo PauloSP 01509-010Brazil

BACKGROUND:Obstructive jaundice is a common condition in advanced digestive *** procedures can improve quality of life and allow patients to attempt a systemic *** anastomosis is still the procedure of choice for patients in many *** a surgical bypass is not possible,biliary drainage can be done by placing endoscopic or transparietal stents,which are less durable methods even when an expandable stent is employed. METHODS:A 47-year-old male with an excellent clinical status and a previous cholecystectomy and an exploratory laparotomy for advanced gastric cancer was referred with obstructive jaundice.A preoperative CT scan showed a dilated bile duct and a small mass at the distal hepatic *** other signs of metastasis were found.A surgical bilioenteric anastomosis was *** surgery,a distal choledochal obstruction and a mesenteric retraction by a lymph node mass prevented the jejunum to ascend for a bilioenteric anastomosis. Surgically,an alternative bilioenteric bypass was performed by means of an ileal loop interposition between the bile duct and the jejunum. RESULT:The recovery of the patient was uneventful and his bilirubin levels normalized after one *** patient was then referred for systemic chemotherapy. CONCLUSIONS:This alternative biliary bypass can be safely and easily performed,and may be a good alternative for patients already referred for surgery because of a better life expectancy and when the jejunum is not an alternative.

关键词： biliary bypass ileal loop interposition biliary cancer

EHR Technology： Improvement Review of a Small Rural Hospital

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Journal of Health Science 2016年第5期4卷 277-282页

作者： Nancy Norman-Marzella, RN, MSN, np, CNE Department of Nursing Lincoln University 1570 Baltimore Pike Lincoln Univeristy PA 19352 USA