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家族性高胆固醇血症大家系在两个世纪中的死亡率:家系死亡率研究

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英国医学杂志中文版 2002年第3期5卷 129-132页

作者： Eric j g Sijbrands rudi g j westendorp joep C Defesche Paul H E M deMeier Augustinus H M Smelt john j P Kastelein 马志毅 Department of Vascular Medicine and general Internal Medicine Clinical Epidemiology Leiden University MedicalCentre Department of general Internal University MedicalCentre

目的 :评估未经治疗的无冠状动脉疾病的家族性高胆固醇血症所有原因的死亡率。设计 :家系死亡率研究。背景 :荷兰的一个大家系 ,其宗亲源自 19世纪一对夫妇。先证者 :家族中所有超过 2 0岁且有 5 0 %可能性携带家族性高胆固醇血症突变... 详细信息

目的 :评估未经治疗的无冠状动脉疾病的家族性高胆固醇血症所有原因的死亡率。设计 :家系死亡率研究。背景 :荷兰的一个大家系 ,其宗亲源自 19世纪一对夫妇。先证者 :家族中所有超过 2 0岁且有 5 0 %可能性携带家族性高胆固醇血症突变基因者。主要结果测定指标 :各种原因的死亡率。结果 :分析自 6 95 0人年的 2 5 0人中共死亡的70人。突变基因携带者的死亡率在 19世纪和 2 0世纪早期并未升高 ,1915年后开始升高 ,1935～196 4年达到高峰 (标准化死亡率比 1 78,95 %可信区间 1 13～ 2 76 ,P =0 0 0 3) ,以后下降。家系的两大分支间死亡率有显著性差异 (相对危险性3 2 6 ,95 %可信区间 1 74～ 6 11;P =0 0 0 1)。结论 :家族性高胆固醇血症患者间的死亡危险性差异显著。这种时间上及家系的不同分支间的巨大差异表明环境因素与基因有强大的相互作用。有必要进一步研究以识别那些极高危并需早期和强力预防措施的家族性高胆固醇血症患者。

关键词：家族性高胆固醇血症死亡率家系死亡率研究

On the Influences of Urbanization on the Extreme Rainfall over Zhengzhou on 20 july 2021: A Convection-Permitting Ensemble Modeling Study

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Advances in Atmospheric Sciences 2023年第3期40卷 393-409页

作者： Yali LUO jiahua ZHANg Miao YU Xudong LIANg rudi XIA Yanyu gAO Xiaoyu gAO jinfang YIN State Key Laboratory of Severe Weather Chinese Academy of Meteorological SciencesBeijing 100081China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters Nanjing University of Information Science and TechnologyNanjing 210044China School of Atmospheric Sciences Chengdu University of Information TechnologyChengdu 610225China

This study investigates the influences of urban land cover on the extreme rainfall event over the Zhengzhou city in central China on 20 july 2021 using the Weather Research and Forecasting model at a convection-permitting scale[1-km resolution in the innermost domain(d3)].Two ensembles of simulation(CTRL,NURB),each consisting of 11 members with a multi-layer urban canopy model and various combinations of physics schemes,were conducted using different land cover scenarios:(i)the real urban land cover,(ii)all cities in d3 being replaced with natural land *** results suggest that CTRL reasonably reproduces the spatiotemporal evolution of rainstorms and the 24-h rainfall accumulation over the key region,although the maximum hourly rainfall is underestimated and displaced to the west or southwest by most *** ensemble mean 24-h rainfall accumulation over the key region of heavy rainfall is reduced by 13%,and the maximum hourly rainfall simulated by each member is reduced by 15–70 mm in CTRL relative to *** reduction in the simulated rainfall by urbanization is closely associated with numerous cities/towns to the south,southeast,and east of *** heating effects jointly lead to formation of anomalous upward motions in and above the planetary boundary layer(PBL),which exaggerates the PBL drying effect due to reduced evapotranspiration and also enhances the wind stilling effect due to increased surface friction in urban *** a result,the lateral inflows of moisture and high-θe(equivalent potential temperature)air from south and east to Zhengzhou are reduced.

关键词： urbanization extreme rainfall convection-permitting ensemble simulation land-atmosphere interaction boundary layer water vapor transport

Definition of colorectal anastomotic leakage: A consensus survey among Dutch and Chinese colorectal surgeons

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World journal of gastroenterology 2017年第33期23卷 6172-6180页

作者： Stefanus j van Rooijen Audrey CHM jongen Zhou-qiao Wu jia-fu ji gerrit D Slooter rudi MH Roumen Nicole D Bouvy Department of Surgery Máxima Medical Center NUTRIM School of Nutrition and Translational Research in Metabolism Department of Surgery Maastricht University Medical Center Key laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing) Ward I of Gastrointestinal Cancer CenterPeking University Cancer Hospital and Institute

AIM To determine the level of consensus on the definition of colorectal anastomotic leakage(CAL) among Dutch and Chinese colorectal *** Dutch and Chinese colorectal surgeons were asked to partake in an online questionnaire. Consensus in the online questionnaire was defined as > 80% agreement between respondents on various statements regarding a general definition of CAL,and regarding clinical and radiological diagnosis of the *** Fifty-nine Dutch and 202 Chinese dedicated colorectal surgeons participated in the online survey. Consensus was found on only one of the proposed elements of a general definition of CAL in both countries: ‘extravasation of contrast medium after rectal enema on a CT scan'. Another two were found relevant according to Dutch surgeons: ‘necrosis of the anastomosis found during reoperation',and ‘a radiological collection treated with percutaneous drainage'. No consensus was found for all other proposed elements that may be included in a general *** There is no universally accepted definition of CAL in the Netherlands and China. Diagnosis of CAL based on clinical manifestations remains a point of discussion in both countries. Dutch surgeons are more likely to report ‘subclinical' leaks as CAL,which partly explains the higher reported Dutch CAL rates.

关键词： Colorectal anastomotic leakage Colorectal surgery Definition Complication

骨组织对骨水泥造影剂硫酸钡生物反应的动物实验研究

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中华骨科杂志 1989年第6期9卷 435-437页

作者：柯勇 rudi.,j 上海医科大学中山医院

本文主要报道一组家兔的骨组织对骨水泥造影剂硫酸钡的生物反应。于不同时间对股骨标本做组织学和显微X线照像检查。结果表明，植入含有硫酸钡骨水泥的一侧股骨，其骨组织原发性损伤与弥散性坏死较另一侧无硫酸钡对照组严重。同时，新... 详细信息

本文主要报道一组家兔的骨组织对骨水泥造影剂硫酸钡的生物反应。于不同时间对股骨标本做组织学和显微X线照像检查。结果表明，植入含有硫酸钡骨水泥的一侧股骨，其骨组织原发性损伤与弥散性坏死较另一侧无硫酸钡对照组严重。同时，新生骨形成量较对照组少。推测硫酸钡可能是造成这种生物反应差别的主要原因。

关键词：骨组织硫酸钡生物反应动物实验

High-Dimensional Regression on Sparse grids Applied to Pricing Moving Window Asian Options

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Open journal of Statistics 2013年第6期3卷 427-440页

作者： Stefan Dirnstorfer Andreas j. grau rudi Zagst Technical University Munich Munich Germany Thetaris gmbH Munich Germany

The pricing of moving window Asian option with an early exercise feature is considered a challenging problem in option pricing. The computational challenge lies in the unknown optimal exercise strategy and in the high dimensionality required for approximating the early exercise boundary. We use sparse grid basis functions in the Least Squares Monte Carlo approach to solve this “curse of dimensionality” problem. The resulting algorithm provides a general and convergent method for pricing moving window Asian options. The sparse grid technique presented in this paper can be generalized to pricing other high-dimensional, early-exercisable derivatives.

关键词： Sparse grid Regression Least-Squares Monte Carlo Moving Window Asian Option

The Application for Measuring the Maturity Level of Information Technology governance on Indonesian government Agencies Using COBIT 4.1 Framework

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Intelligent Information Management 2014年第1期6卷 12-19页

作者： johan j. C. Tambotoh rudi Latuperissa Department of Information System Satya Wacana Christian University Salatiga Indonesia

Investment of information technology (IT) in the government sector in Indonesia continues to increase every year. However, this increase has not been followed by good governance due to the lack of attention to good IT management. Measurement of IT governance is therefore required as a basis for the continuous improvement of the IT services to government agencies. This study is aimed at producing an application to measure the maturity level of IT governance in government institutions, thus facilitating the process of improvement of IT services. The application developed is based on COBIT 4.1 framework and the design used is Unified Modeling Language. Through stages of information system development, this research results in an application for measuring the maturity level of IT governance that can be used by government agencies in assessing existing IT governance.

关键词： Information Technology governance IT governance Maturity Level COBIT 4.1

Practical Non-Uniform Channelization for Multistandard Base Stations

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ZTE Communications 2011年第4期9卷 15-24页

作者： lvaro Palomo Navarro rudi Villing Ronan j. Farrell Callan Institute Electronic Engineering Department National University of Ireland Maynooth (NUIM) Ireland

A multistandard software-defined radio base station must perform non-uniform channelization of multiplexed frequency bands. Non-uniform channelization accounts for a significant portion of the digital signal processing workload in the base station receiver and can be difficult to realize in a physical implementation. In non-uniform channelization methods based on generalized DFT filter banks, large prototype filter orders are a significant issue for implementation. In this paper, a multistage filter design is applied to two different non-uniform generalized DFT-based channelizers in order to reduce their filter orders. To evaluate the approach, a TETRA and TEDS base station is used. Experimental results show that the new multistage design reduces both the number of coefficients and operations and leads to a more feasible design and practical physical implementation.

关键词： SDR non-uniform channelization base station TETRA

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肝脏遗传性缺陷的诊断和治疗

上海医学 1979年第4期 76-79页

作者： rudi Schmid 杨永彰刘厚钰美国旧金山加利福尼亚大学内科教授

肝脏遗传性的缺陷分三大类: 一、功能性肝脏缺陷,组织学正常:遗传性高血氨症,急性间歇性卟啉病,gilbert综合征。二、功能性肝脏缺陷,具特征性,非进行性的组织病理学改变:D-j综合征,醣原累积症。三、遗传性肝脏缺陷,有进行性慢性肝病（... 详细信息

肝脏遗传性的缺陷分三大类: 一、功能性肝脏缺陷,组织学正常:遗传性高血氨症,急性间歇性卟啉病,gilbert综合征。二、功能性肝脏缺陷,具特征性,非进行性的组织病理学改变:D-j综合征,醣原累积症。三、遗传性肝脏缺陷,有进行性慢性肝病（并可发展为肝硬化）:血色病,Wilson病,α1-抗胰蛋白酶缺乏,原卟啉病。遗传性高血氨症肝脏的功能和组织学正常,但血氨增高。正常人血氨不超过1微克/毫升、遗传性高氨血症可达2～

关键词：肝脏肝硬化遗传性杂合子

Decision support model for effects estimation and proportionality assessment for targeting in cyber operations

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Defence Technology（防务技术） 2021年第2期17卷 352-374页

作者： C.Maathuis W.Pieters j.van den Berg Delft University of Technology Jaffalaan 52628 BXDelftNetherlands TNO Military Operations Oude Waaldorperweg 632597 AKDen HaagNetherlands Netherlands Defense Academy De la Reyweg 1204818 BBBredaNetherlands Open University of the Netherlands Valkenburgerweg 1776419 ATHeerlenNetherlands

Cyber operations are relatively a new phenomenon of the last two *** that period,they have increased in number,complexity,and agility,while their design and development have been processes well kept under *** a consequence,limited data(sets)regarding these incidents are *** various academic and practitioner public communities addressed some of the key points and dilemmas that surround cyber operations(such as attack,target identification and selection,and collateral damage),still methodologies and models are needed in order to plan,execute,and assess them in a responsibly and legally compliant *** on these facts,it is the aim of this article to propose a model that i))estimates and classifies the effects of cyber operations,and ii)assesses proportionality in order to support targeting decisions in cyber *** order to do that,a multi-layered fuzzy model was designed and implemented by analysing real and virtual realistic cyber operations combined with interviews and focus groups with technical e military *** proposed model was evaluated on two cyber operations use cases in a focus group with four technical e military *** the design and the results of the evaluation are revealed in this article.

关键词： Cyber operations Cyber warfare Cyber weapons Artificial intelligence Fuzzy logic Targeting