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Asian Journal of Urology 2019年第3期6卷 222-229页

作者： Sunny Goel Rahul J.Sinha Ved Bhaskar ruchir aeron Ashish Sharma Vishwajeet Singh Department of Urology King George Medical UniversityLucknowIndia

Objective:Neoadjuvant chemotherapy followed by radical cystectomy is considered the standard of care for patients with muscle invasive bladder *** the last decade,interest in neoadjuvant chemotherapy has slowly shifted from methotrexate,vinblastine,doxorubicin and cisplatin regime to gemcitabine and cisplatin *** are many publications on gemcitabine and cisplatin regime in literature which cover different aspects of *** review aims to summarise the findings published so far on gemcitabine and cisplatin regime and present it in a concise ***:A systematic literature review was conducted searching the PubMeddatabase in December 2016 using the medical subject heading(MeSH)with the terms gemcitabine,cisplatin,chemotherapy,muscle invasive bladder cancer,and *** relevant studies were included and results were ***:A total of 13 studies were included which published between 2007 and *** 13 studies comprised of 754 subjects suffering from muscle invasive bladder *** proportion of male patients ranged from 60%to 86.4%and the median age ranged from 54.2 to 77.3 years in various *** pathological response(pT0)was seen in 30.0%of patients and pathological downstaging(

关键词： Muscle invasive bladder cancer Gemcitabine Cisplatin Neoadjuvant chemotherapy Radical cystectomy

The thermal and storage stability of bovine haemoglobin by ultraviolet-visible and circular dichroism spectroscopies

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Journal of Pharmaceutical Analysis 2016年第4期6卷 242-248页

作者： ruchir Bhomia Vivek Trivedi Nichola J.Coleman John C.Mitchell School of Science University of GreenwichCentral Avenue

The effects of temperature,pH and long-term storage on the secondary structure and conformation changes of bovine haemoglobin（bHb） were studied using circular dichroism（CD） and ultraviolet-visible（UV-vis） *** network software was used to deconvolute the CD data to obtain the fractional content of the five secondary *** storage stability of bHb solutions in pH 6,7 and8 buffers was significantly higher at 4 ℃ than at 23 ℃ for the first 3 days.A complete denaturation of bHb was observed after 40 days irrespective of storage temperature or *** bHb solutions were also exposed to heating and cooling cycles between 25 and 65 ℃ and structural changes were followed by UVvis and CD *** experiments demonstrated that α-helix content of bHb decreased steadily with the increasing temperature above 35 ℃ at all pH *** loss in a-helicity and gain in random coil conformations was pH-dependent and the greatest under alkaline ***,there was minimal recovery of the secondary structure content upon cooling to 25 ℃.The use of bHb as a model drug is very common and this study elucidates the significance of storage and processing conditions on its stability.

关键词： Bovine haemoglobin Circular dichroism Thermal stability Storage stability Ultraviolet-visible spectroscopy

Anopheles gambiae strain(Ag55)cultured cells originated from Anopheles coluzzii and are phagocytic with hemocyte-like gene expression

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Insect Science 2022年第5期29卷 1346-1360页

作者： ruchir Mishra Gang Hua Ujwal R.Bagal Donald E.Champagne Michael J.Adang Department of Entomology College of Agricultural and Environmental SciencesUniversity of GeorgiaAthensGeorgiaUSA Department of Entomology and Nematology University of FloridaGainesvilleFloridaUSA Institute of Bioinformatics University of GeorgiaAthensGeorgiaUSA Department of Biochemistry and Molecular Biology University of GeorgiaAthensGeorgiaUSA

Anopheles gambiae and Anopheles coluzzii are closely related species that are predominant vectors of malaria in ***,*** form M was renamed *** and we now conclude on the basis of a diagnostic PCR-restriction fragment length polymorphism assay that Ag55 cells were derived from *** established an Ag55 cell transcriptome,and KEGG pathway analysis showed that Ag55 cells are enriched in phagosome pathway *** Ag55 transcriptome has an abundance of specific transcripts characteristic of mosquito *** *** bioparticle uptake experiments visualized by fluorescence microscopy and confocal microscopy and quantified by flow cytometry establish the phagocytic competence of Ag55 *** from this investigation of Ag55 cell properties will guide researchers in the use and engineering of the Ag55 cell line to better enable investigations of Plasmodium,other microbes,and insecticidal toxins.

关键词： Anopheles coluzzii transcriptome Anopheles gambiae confocal microscopy flow-cytometry FPKM hemocyte-like phagocytosis

High throughput sequencing reveals Drosophila suzukiiresponses to insecticides

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Insect Science 2018年第6期25卷 928-945页

作者： ruchir Mishra Joanna C.Chiu Gang Hua Nilesh R.Tawari Michael J.Adang Ashfaq A.Sial Department of Entomology College of Agricultural and Environmental SciencesUniversity of GeorgiaAthensGeorgiaUSA. Department of Entomology and Nematology College of Agricultural and Environmental SciencesUniversity of CaliforniaDavisCall-fomiaUSA. Department of Biochemistry and Molecular Biology University of GeorgiaAthensGeorgiaUSA . Computational and Systems Biology Genome Institute of SingaporeSingapore.

Global climate change and acquired resistance to insecticides are threats to world food *** suzukii,a devastating invasive pest in many parts of the world,causes substantial economic losses to fruit production industries,forcing farmers to apply broad-spectrum insecticides frequently,This could lead to the development of insecticide *** determined the Lethal Concentration 50 (median lethal concen- tration,LC50)values of zeta-cypermethrin,spinosad,and malathion insecticides against *** colonies established from Clarke and Pierce county Georgia,United States. The LC50 values were 3 fold higher in the Pierce county population for all insecticide *** then used RNA sequencing to analyze the responses of Pierce and Clarke population flies surviving a LC50 treatment of the 3 *** identified a high num- ber of differentially expressed genes that are likely involved in detoxification and reduced cuticular penetration,especially in the Pierce population,with extensive overlap in differ- entially expressed genes between the 3 insecticide ***,we predicted fewer nonsynonymous single nucleotide variants having deleterious effects on protein function among detoxification,insecticide target,and cuticular protein encoding genes in Pierce *** a combination of increased gene expression and fewer deleterious single nu- cleotide variants highlights molecular mechanisms underlying the higher LC50 values for Pierce population flies.

关键词： differentially expressed genes Drosophila suzukii high throughput sequenc- ing insecticide response insertions and deletions single nucleotide variants

Management of pregnancy in Crigler Najjar syndrome type 2

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World Journal of Hepatology 2016年第11期8卷 530-532页

作者： Alisha Nitin Chaubal ruchir Patel Dhaval Choksi Kaivan Shah Meghraj Ingle Prabha Sawant Department of Gastroenterology LTMG Hospital

Crigler Najjar syndrome is associated with indirect hyperbilirubinemia due to a deficiency of enzyme Uridine Di Phospho Glucoronosyl Transferase(UDPGT).Presented here is a case of a female in the first trimester of pregnancy,who was diagnosed to have type 2 Crigler Najjar *** also discuss the management of this rare disease especially in *** bilirubin can cross the placental barrier causing neuro-logical damage in the *** was carefully monitored during pregnancy and treatment with pheno-barbitone in low doses was adjusted such that the serum bilirubin levels were below 10 mg/d *** Najjar syndrome being rare needs to be diagnosed early in pregnancy to avoid adverse fetal *** being an inducer of enzyme UDPGT is used as the first line of treatment and is not teratogenic in the low doses *** protocol followed was on the basis of previous reported cases and successful perinatal outcome was achieved.

关键词： Crigler Najjar type 2 Phenobarbitone Folic acid Pregnancy Kernicterus

The Therapeutic Role of Guided Mental Imagery in Treating Stress and Insomnia: A Neuropsychological Perspective

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Open Journal of Medical Psychology 2020年第1期9卷 21-39页

作者： Ravinder Jerath Connor Beveridge Michael Jensen ruchir Paladiya Charitable Medical Healthcare Foundation Augusta GA USA Department of Medical Illustration College of Allied Health Sciences Augusta University Augusta GA USA B. J. Medical College Ahmedabad India

Excessive distress and insomnia are much too common in the modern world and often lead to a myriad of detrimental effects including loss of cognitive ability and even physical ailments such as cancer. Current pharmaceutical treatments can be addictive, detrimental to health, and in the case of insomnia don’t produce naturalistic sleep. We present a viewpoint on a potential adjunctive treatment of distress and insomnia that harnesses specific mental imagery as a component of mind/body relaxation technique. Via our perspective on the modern nature of stress and insomnia, our theoretical perspective on how specific guided mental imagery can be used to treat these ailments, and our review on the current literature on treatment with mental imagery, we hope to stimulate further research into mental health treatment with mental imagery which has traditionally been neglected. This perspective on the pathology of insomnia and distress is founded in prevailing “dysevolution” and hyper-arousal theories. Hyper-arousal is characterized in part by a vicious cycle of chronic physiological and emotional stimulation/distress. We argue for spatially based mental imagery in the form of nighttime-sky imagery to attenuate such pathology by breaking one away from a vicious cycle of stimulation and distress and discuss neuropsychological bases for its potential treatment mechanisms which include the autonomic nervous system and a phenomenal foundation of conscious cognition.

关键词： Mental Imagery Guided Imagery Insomnia Chronic Stress Hyperarousal Vicious Cycle

Predictors of visual outcome in traumatic cataract

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World Journal of Ophthalmology 2014年第4期4卷 152-159页

作者： Mehul Shah Shreya Shah Lalchand Gupta Amisha Jain ruchir Mehta Drashti Netralaya Dahod 389151 GujaratIndia

Traumatic cataract resulting from open- or closed-globe ocular trauma is one of the most common causes of blindness. Visual outcome is unpredictable because this is not determined solely by the lens. There is a lack of a standard classification, investigations, and treatment guidelines related to the outcome, with considerable debate regarding predictive models. We review the predictors of visual outcome following surgical treatment of traumatic cataracts, which may act as a guide to clinicians.

关键词： Traumatic cataract Visual outcome Birmingham Eye Trauma Terminology System Ocular trauma score Morphology of traumatic cataract Open globe injuries Classification of ocular trauma controversy Pediatric ocular trauma

Sensory Consciousness is Experienced through Amplification of Sensory Stimuli via Lateral Inhibition

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World Journal of Neuroscience 2017年第3期7卷 244-256页

作者： Ravinder Jerath Shannon M. Cearley ruchir Paladiya Vernon A. Barnes Augusta Women’s Center Augusta GA USA Georgia Prevention Institute Augusta University Augusta GA USA

At present, researchers are unclear about which activity within the brain is responsible for the emergence of consciousness—the subconscious or unconscious. Current literature suggests that consciousness is isolated in the brain;however, we suggest consciousness emerges from both—subconscious and unconscious activity, in addition to sensory consciousness. This article contends that sensory consciousness arises from neurophysiological brain activity, intrapersonal space, sensory information, and parallel processing of the external and internal environment through vision, olfaction, the integumentary system, gustation, and audition. Traditionally, lateral inhibition is defined as the ability for an excited neuron to laterally inhibit its neighbors, and is an integral part of neurophysiology in all senses. In this article, we are connecting the science behind the well-established physiological observations of gamma wave activity in the interneurons of peripheral receptors with what is currently unknown regarding the functional significance of seemingly unrelated gamma activity in the cortico-thalamic gamma oscillations. We suggest that this allows for instantaneous integration of the brain with sensory receptors. This article uses existing literature on lateral inhibition to investigate its role in sensory organs and various areas of the body. We explain how sensory consciousness is only one component of unified consciousness. We propose that lateral inhibition also plays a vital role in consciousness theory, and understanding this can help illustrate the dynamic interactions between the central and peripheral nervous systems within the body.

关键词： Sensory Consciousness Lateral Inhibition Sensory Perception Sensory Stimuli Amplification 3D Default Space Unified Consciousness

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远非一台发动机

科技英语学习 2007年第7期 35-38,34页

作者： ruchir Sharma 刘伟

Right Ventricular Failure Following Acute Type A Aortic Dissection: An Alternative Strategy

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World Journal of Cardiovascular Surgery 2019年第3期9卷 35-39页

作者： ruchir P. Mashar Rashmi P. Birla Paul D. Waterworth General Surgery Hereford County Hospital Hereford UK Cardiothoracic Surgery Liverpool Heart and Chest Hospital Liverpool UK Cardiac Surgery Wythenshawe Hospital Manchester UK

Coronary malperfusion is a complication of aortic dissection, and can lead to ventricular failure. We report 2 cases of right ventricular (RV) failure, following aortic dissection, successfully bridged to recovery using right ventricular assist devices (RVADs). The first was a 54 year-old man, who had difficulty weaning from bypass due to a stunned RV following aortic root replacement. The second was a 34 year-old woman, who after replacement of the ascending aorta, suffered episodes of ventricular fibrillation (VF), and RV failure. Both had an RVAD implanted, allowing eventual recovery. We recommend more widespread use of VADs in such cases.

关键词： Right Ventricular Failure Assist Devices Acute Type A Aortic Dissection