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A novel bacteriohopanoid from Celtis australis ***

Chinese Chemical Letters 2011年第1期22卷 81-84页

作者： ruchi badoni Deepak Kumar Semwal Prabhakar P.badoni Sudhir Kumar Kothiyal Usha Rawat Department of Chemistry H.N.B.Garhwal UniversitySrinagar 246 174UttarakhandIndia Department of Chemistry Punjab UniversitySector 14Chandigarh 160 014PunjabIndia Department of Chemistry H.N.B.Garhwal University Campus Pauri(Garhwal)UttarakhandIndia

A novel bacteriohopanoid elucidated as 3fl-hydroxy-35-（cyclohexyl-5′-propan-7′-one）-33-ethyl-34-methyl-bactereohopane （1） has been isolated from the bark of Celtis australis （Ulmaceae） together with three known compounds apigenin, quercetin and its glucoside. The structure of 1 was characterized by means of chemical and spectral methods including advanced 2D NMR studies.

关键词： Celtis australis Ulmaceae Bacteriohopane

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Status of Indian medicinal plants in the International Union for Conservation of Nature and the future of Ayurvedic drugs: Shouldn’t think about Ayurvedic fundamentals?

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Journal of Integrative Medicine 2019年第4期17卷 238-243页

作者： Deepak Kumar Semwal Ashutosh Chauhan An kit Kumar Sonali Aswal ruchi badoni Semwal Abhimanyu Kumar Department of Phytochemistry Faculty of Biomedical Sciences Uttarakhand Ayurved University Harrawala Dehradun 248001 India Department of Biotechnology Faculty of Biomedical Sciences Uttarakhand Ayurved University Harrawala Dehradun 248001 India Research and Development Centre Faculty of Biomedical Sciences Uttarakhand Ayurved University Harrawala Dehradun 248001 India Department of Chemistry Pt. Lalit Mohan Sharma Government Postgraduate College Rishikesh Uttarakhand 249201 India Uttarakhand Ayurved University Harrawala Dehradun 248001 India

The present market for herbal drugs is estimated about ?40 billion, which is expected to increase by 16% in next 3-4 years. The current production of many Ayurvedic herbs is less than their market demand, which incentivizes adulteration in the Ayurvedic drug supply chain. The present work aims to highlight the most used Ayurvedic plants that have been listed in the International Union for Conservation of Nature's "red list" of endangered or vulnerable plants. The future of Ayurvedic medicines from these listed plants is uncertain, as the collection of herbs from their natural habitat is prohibited and their cultivation does not meet market demands. Many of these plants, such as Taxus baccata and T. wallichiana, are endangered and are only grown in their natural habitats;their cultivation in other areas is impractical. This is the present state, and will worsen as demand continues to grow, with increasing populations and increasing adoption of this system of medicine. It is possible that in coming years most of the Ayurvedic drugs will be adulterated, and will cause only side effects rather than the therapeutic effects. The Ayurvedic fundamentals are under-explored areas where the Ayurvedic practitioners and research scientists can work together. The scientific work on the basic principles will unravel many unknown or little-known facts of this ancient science. Hence, the present review emphasizes the conservation of Ayurvedic herbs, minimization of the use of medicinal plants and the promotion of the research based on Ayurvedic fundamentals.

关键词： Ayurvedic fundamentals Ayurvedic herbs Endangered plants Polyherbal formulations Prakriti

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Ethnomedicinal Investigation of Medicinal Plants of Chakrata Region(Uttarakhand)Used in the Traditional Medicine for Diabetes by Jaunsari Tribe

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Natural Products and Bioprospecting 2019年第3期9卷 175-200页

作者： Ankit Kumar Sonali Aswal Ashutosh Chauhan ruchi badoni Semwal Abhimanyu Kumar Deepak Kumar Semwal Research and Development Centre Faculty of Biomedical SciencesUttarakhand Ayurved UniversityHarrawalaDehradun 248001India Department of Biotechnology Faculty of Biomedical SciencesUttarakhand Ayurved UniversityHarrawalaDehradun 248001India Department of Chemistry Pt.Lalit Mohan Sharma Government Postgraduate CollegeRishikeshUttarakhand 249201India Uttarakhand Ayurved University HarrawalaDehradun 248001India Department of Phytochemistry Faculty of Biomedical SciencesUttarakhand Ayurved UniversityHarrawalaDehradun 248001India

The Himalayan region is the treasure house of natural wealth,particularly of medicinal and aromatic *** plants are used by the Indian traditional healers for the past many centuries to treat various ailments such as skin disorders,asthma,diabetes,snake bite,fever,pain,eye diseases,diarrhoea,indigestion,jaundice,burn,wound,liver disorder,CNS disorders and urinary tract *** indigenous traditional knowledge of medicinal plants and therapies of various local communities has been lost due to changes in traditional culture and the introduction of modern ***,it is essential to explore the traditional knowledge of the indigenous medicinal plants mainly in such areas where there is a severe threat to natural vegetation owing to human *** present study aimed to explore the medicinal plants of Chakrata region(Jaunsar-Bawar Hills),Uttarakhand,India used in the folk medicine for the management of diabetes by Jaunsari *** a comprehensive feld survey,the information about the medicinal plants have been mainly collected from the traditional healers and other elderly people belong to the tribal *** the information about the medicinal plants of the study area was documented in a feld *** tools have been used to collect the samples for identifcation purpose and the authentication of the plants was done with the help of *** literature on these plants was also searched from online(PubMed and Scopus)as well as from some textbooks and Ayurvedic classical *** present survey-based work described a total of 54 plants belonging to 47 genera and 30 families used in the traditional medicine for the management of diabetes in Chakrata *** information gathered from the local community revealed that the plants are efective in diabetes and one can use most of them without consulting a practitioner or traditional *** literature revealed that most of the surveyed plants are already used in the pr

关键词： Ayurveda Diabetes Herbal formulations Traditional healers Folk medicine

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Ayurvedic concept of Shatkriyakala:a traditional knowledge of cancer pathogenesis and therapy

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Journal of Integrative Medicine 2017年第2期15卷 88-94页

作者： Ashutosh Chauhan Deepak Kumar Semwal Satyendra Prasad Mishra ruchi badoni Semwal Department of Biotechnology Faculty of Biomedical Sciences Uttarakhand Ayurved University Harrawala Dehradun 248001 India Department of Phytochemistry Faculty of Biomedical Sciences Uttarakhand Ayurved University Harrawala Dehradun 248001 India Uttarakhand Ayurved University Harrawala Dehradun 248001 India Department of Pharmaceutical Sciences Tshwane University of Technology Pretoria 0001 South Africa

The term Kriyakala refers to the recognition of the stage of a disease＇s progress, which helps to determine appropriate measure to correct the imbalance in Doshas （biological factors）. It is a compound expression, comprised of Kriya and Kala, where Kriya means the choice to treatment （medicine, food and daily-routine） used to improve the disturbance in Doshas, and Kala refers to the stage of progress of a disease. Sushruta, an ancient Indian surgeon, has described the concept of Kriyakala in Vamaprashnadhyaya, an ancient Vedic Sanskrit text, which seeks to explain the incidence of Vamas in terms of Doshic disturbances. Vama, in modern parlance, may be described as an inflammatory process that may lead ulceration and chronic inflammation, promoting all stages of carcinogenesis. Abnormal interactions between Prakriti （genotype） and environmental factors vitiate the Doshas and impair immunity, which can lead to aberrant cell growth and cancer. Moreover, the interaction between vitiated Doshas and weak Dhatus （body tissues） manifests as cancers of a specific organ. Shatkriyakala （six stages of progress of a disease）, on the other hand, provides a framework to assess the cancer and its pathogenesis in different stages. According to Ayurvedic concepts, all cancer therapies treat the affected tissues indirectly by eliminating vitiated Doshas, rejuvenating Dhatus and restoring immunity in cancer patients. The present review describes the six stages of Shatkriyakala in detail, with an emphasis on research areas to validate the concept of Shatkriyakala. This traditional knowledge can be utilized with modern technologies to detect predisposition for cancer or diagnose cancer in its early stages.

关键词： medicine, Ayurvedic Shatkriyakala tumors, malignant

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