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Advancements in nutritional diagnosis and support strategies during the perioperative period for patients with liver cancer

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World Journal of Gastrointestinal Surgery 2024年第8期16卷 2409-2425页

作者： Xiao-Qin Li Yun Liang Chen-Feng Huang sui-Ning Li Lei Cheng Chuan You Yao-Xia Liu Tao Wang Department of Hepatobiliary Surgery The Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Paediatric Surgery The Affiliated Hospital of North Sichuan Medical CollegeNanchong 637000Sichuan ProvinceChina Department of Cardiovascular Surgery The First Affiliated HospitalJinan UniversityGuangzhou 510632Guangdong ProvinceChina Department of Geriatric Endocrinology Sichuan Provincial People's HospitalUniversity of Electronic Science and Technology of ChinaChengdu 610072Sichuan ProvinceChina Department of Pediatric Cardiology West China Second University HospitalSichuan UniversityChengdu 610041Sichuan ProvinceChina Department of Pediatrics Key Laboratory of Birth Defects and Related Diseases of Women and Children(Sichuan University)Ministry of EducationChengdu 610041Sichuan ProvinceChina

Liver cancer represents a grave hepatic condition and constitutes a significant global health *** resection remains the principal therapeutic modality for liver ***,perioperative malnutrition exerts a notable impact on patients with liver cancer,emerging as an independent risk factor for disease mortality and adverse ***,precise nutritional diagnosis and timely nutritional support hold the potential to enhance therapeutic efficacy and quality of life for liver cancer *** study represents a meticulous foray into the literature,extracting data from PubMed,Web of Science,and EMBASE databases,with a focus on the past 5 *** scrutinizes the impact of malnutrition on patients undergoing liver cancer surgery,the etiological underpinnings of malnutrition within this patient cohort,the critical assessment of perioperative nutritional status,and the strategic approaches to nutritional *** rigorous inclusion and exclusion criteria,the amassed scholarly works are meticulously synthesized,methodically organized,and categorically elaborated ***,the authors propose the incorporation of a multidisciplinary nutrition management team during the perioperative period,comprising nutritionists,pharmacists,physicians,nurses,psychologists,and rehabilitation therapists,among other specialized ***,they collaborate to devise and implement personalized nutritional support plans,monitor patients’nutritional status,and make necessary adjustments as *** comprehensive management and intervention,improvements in the nutritional status of liver cancer patients can be achieved,thereby enhancing surgical success rates and facilitating postoperative *** is believed that this manuscript will offer valuable insights to advance the nutritional management during the perioperative phase of liver cancer,aiding in ameliorating patients'nutritional status and treatment outcomes.

关键词： Liver cancer Nutritional diagnosis Nutritional support Perioperative period Genetic testing Immunonutrition Probiotics and gut microbiota

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盐酸多奈哌齐联合依达拉奉右莰醇治疗脑卒中后认知功能障碍的效果分析

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中国社区医师 2023年第32期39卷 34-36页

作者：王默野隋汝波张雯妍张磊刘洋孙菲阳锦州医科大学附属第一医院神经内科辽宁锦州121000 锦州医科大学护理学院辽宁锦州121001

目的:观察盐酸多奈哌齐联合依达拉奉右莰醇治疗脑卒中后认知功能障碍的效果。方法:选取2022年1月—2023年5月锦州医科大学附属第一医院收治的120例脑卒中后认知功能障碍患者作为研究对象,采用随机数字表法分为对照组与研究组,各60例。... 详细信息

目的:观察盐酸多奈哌齐联合依达拉奉右莰醇治疗脑卒中后认知功能障碍的效果。方法:选取2022年1月—2023年5月锦州医科大学附属第一医院收治的120例脑卒中后认知功能障碍患者作为研究对象,采用随机数字表法分为对照组与研究组,各60例。两组均行常规治疗,对照组在常规治疗基础上应用盐酸多奈哌齐治疗,研究组在对照组基础上应用依达拉奉右莰醇治疗。比较两组治疗效果。结果:治疗后,两组胼胝体侧束、下额枕束的各向异性分数与神经纤维束数量大于治疗前,且研究组大于对照组,差异有统计学意义(P<0.05);两组简易智能精神状态量表、蒙特利尔认知评估量表评分高于治疗前,且研究组高于对照组,差异有统计学意义(P<0.05)。研究组治疗总有效率高于对照组,差异有统计学意义(P=0.007)。治疗后,两组超氧化物歧化酶水平高于治疗前,且研究组高于对照组,丙二醛、超敏C反应蛋白、白细胞介素-6水平低于治疗前,且研究组低于对照组,差异有统计学意义(P<0.05)。结论:盐酸多奈哌齐联合依达拉奉右莰醇治疗脑卒中后认知功能障碍的效果显著,可改善患者病灶区域神经纤维束结构,促进神经功能恢复,缓解氧化应激与炎性反应。

关键词：脑卒中认知功能障碍盐酸多奈哌齐依达拉奉右莰醇

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LA-ICP-MS zircon U-Pb dating of tuffites in the Sachakou Pb-Zn mining area, Karakorum, Xinjiang and its establishment of Early Triassic strata

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China Geology 2024年第1期7卷 150-152页

作者： Xiao-jian Zhao Nuo Li Kai Weng Ming Wang Qing-lin sui Deng-hui Chen Zhou-ping Guo Meng-qi Jin Xi’an Center China Geological SurveyMinistry of Natural ResourcesXi’an 710054China Xinjiang Research Center for Mineral Resources Xinjiang Institute of Ecology and GeographyChinese Academy of SciencesUrumqi 830011China College of Geography and Remote Sensing Sciences Xinjiang UniversityUrumqi 830046China University of Chinese Academy of Sciences Beijing 100029China No.8 Geological Party Xinjiang Bureau of Geology and Mineral Exploration and DevelopmentAksu 843000China School of Resource&Environment and Safety Engineering University of South ChinaHengyang 421001China

*** In the past decade,a group of medium to giant lead-zinc deposits,represented by Huoshaoyun,Sachakou,and Yuanbaoling,have been discovered in the Aksai Chin region of Karakoram,*** are all located in the Mesozoic carbonate and clastic rock *** Sachakou leadzinc mining area is adjacent to the northwest of the Huoshaoyun lead-zinc mining area and is in the same stratigraphic layer as *** many scholars have been arguing about the type and age of Huoshaoyun lead-zinc mineralization,few scholars have paid attention to the classification of the ore-bearing strata in the *** stratigraphy of the Lower Permian Shenxianwan Group to the Upper Cretaceous Tielongtan Group is exposed in the Sachakou area of Karakorum,Xinjiang,however,the Late Permian-Early Triassic stratigraphy is missing(Fig.1a).Due to the harsh natural conditions in the area and the low level of work,the stratigraphic delineation is not exhaustive,and the regional lithology is dominated by carbonates and clastic rocks,which makes it difficult to identify the age of the regional lithology and causes problems for the exploration and research of lead-zinc in the area.

关键词： strata Triassic Xinjiang

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建设精品《神经病学》教学团队

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辽宁医学院学报（社会科学版） 2011年第2期9卷 27-29页

作者：刘学文闵连秋方伯言隋汝波杨丽韩锟辽宁医学院第一临床学院辽宁锦州121001

神经病学教学团队建设是一项系统工程,要一贯坚持教学团队的建设理念和策略,以教学为主线,提供良好的教学实践平台,以实现培养人才的远大目标。我们为社会培养的,是将来要走向临床工作、救死扶伤、治病救人的医生,因此,加强神经病学教... 详细信息

神经病学教学团队建设是一项系统工程,要一贯坚持教学团队的建设理念和策略,以教学为主线,提供良好的教学实践平台,以实现培养人才的远大目标。我们为社会培养的,是将来要走向临床工作、救死扶伤、治病救人的医生,因此,加强神经病学教学团队的建设,势在必行。

关键词：团队精神神经病学教学团队建设理念建设策略

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卒中后认知障碍患者脑白质纤维束变化的临床观察

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锦州医科大学学报 2022年第2期43卷 80-84,88页

作者：董彬彬段晓迪隋汝波邓丽君祁杰张磊锦州医科大学附属第一医院神经内科锦州医科大学护理学院辽宁锦州121000

目的探讨卒中后认知障碍(post-stroke cognitive impairment,PSCI)患者上额枕束、下额枕束、扣带束的改变,并分析其与临床认知障碍严重程度的相关性。方法选取本院神经内科2020年1月至2021年1月首次左侧基底节区急性期缺血性卒中患者,利... 详细信息

目的探讨卒中后认知障碍(post-stroke cognitive impairment,PSCI)患者上额枕束、下额枕束、扣带束的改变,并分析其与临床认知障碍严重程度的相关性。方法选取本院神经内科2020年1月至2021年1月首次左侧基底节区急性期缺血性卒中患者,利用DTI技术(diffusion tensor imaging,DTI)联合DTT技术(diffusion tensor tracking,DTT)对脑白质纤维束的数量及各向异性分数(fractional anisotropy,FA)进行检测,并于6个月后对每一例研究对象进行简单精神状态检查表(MMSE)、蒙特利尔认知评估量表(MoCA)评定,根据测评结果将研究对象分为卒中后认知障碍组(PSCI组20例),无卒中后认知障碍组(N-PSCI组20例),并入组基础信息无统计学差异的20例健康志愿者作为正常对照组(NORM组20例)。最后对白质纤维束的数量及部分各向异性分数(FA值)与量表评分之间进行相关性分析。结果PSCI组患者病灶侧上额枕束、下额枕束、扣带束的FA值较N-PSCI组及NORM组均有显著降低(P<0.01),差异有统计学意义;且PSCI组患者病灶侧上额枕束、下额枕束、扣带束的FA值与MMSE、MoCA评分成正相关,以P<0.01为差异有统计学意义。Pearson相关性分析显示,PSCI组病灶侧上额枕束、下额枕束、扣带束FA值(r=0.560,P=0.010;r=0.736,P=0.000;r=0.829,P=0.000)及纤维束数量(r=0.856,P=0.000;r=0.586,P=0.007;r=0.663,P=0.001)与MMSE评分呈正相关,以及其FA值(r=0.568,P=0.009;r=0.823,P=0.000;r=0.969,P=0.000)及纤维束数量(r=0.817,P=0.000;r=0.600,P=0.005;r=0.794,P=0.000)与MoCA评分呈正相关。结论上额枕束、下额枕束、扣带束参与了卒中后认知障碍的发生。

关键词：卒中后认知障碍上额枕束下额枕束扣带束

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以稻壳热解炭制备镧负载多孔炭复合电极材料

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高等学校化学学报 2024年第4期45卷 1-9页

作者：隋光辉程岩岩南昌师范学院化学与食品科学学院南昌330032

利用稻壳热解炭为原料制备镧负载多孔炭复合电极材料(La/PCs),先将稻壳热解炭分离出炭前驱体,再采用原位活化/负载的方法制备一系列镧负载多孔炭复合电极材料,分别考察了煅烧温度和浸渍比对其吸附性能和电化学性能的影响.采用X射线衍射(... 详细信息

利用稻壳热解炭为原料制备镧负载多孔炭复合电极材料(La/PCs),先将稻壳热解炭分离出炭前驱体,再采用原位活化/负载的方法制备一系列镧负载多孔炭复合电极材料,分别考察了煅烧温度和浸渍比对其吸附性能和电化学性能的影响.采用X射线衍射(XRD)、X射线光电子能谱(XPS)、扫描电子显微镜/X射线能谱仪(SEM-EDS)和Brunauer-Emmett-Teller比表面积(BET)法研究了该系列镧负载多孔炭复合电极材料的金属结构与价态、元素组成及表面形貌,并分析了孔结构与电容值之间可能存在的关系.结果表明,在6 mol/L KOH电解液中,La/PC_900/10材料的电容值为269.45 F/g.在电流密度为0.5 A/g时,由其组装的对称超级电容器具有23.45 W·h/kg的能量密度,此时的功率密度为0.70 kW/kg,并且循环5000次后的电容保持率为86.41%.La/PC_900/10良好的电容性能显示了其作为碳基电极应用于高性能超级电容器的潜力.研究结果为稻壳热解炭的利用和镧在新能源材料领域的应用提供了一条可行路径.

关键词：稻壳热解炭镧负载多孔炭复合电极

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Prediction of specific spoilage organisms in smoked chicken legs with modified atmosphere packaging at 4 ℃ using multivariate statistical analysis

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Food Science and Human Wellness 2024年

作者： Qiang Wang Yubo Zhao Yumeng sui Qian Chen Zhiming Dong Qian Liu Baohua Kong Ligang Qin College of Animal Science and Technology， Northeast Agricultural University College of Food Science， Northeast Agricultural University

The present study monitored bacterial succession， physicochemical properties， and volatile organic compounds (VOCs) changes in smoked chicken legs with modified atmosphere packaging (MAP， 60% CO2and 40% N2) during a 25-day storage period at 4 ℃. After 15 days of storage， Serratia proteamaculans and Pseudomonas fragi became the predominant bacteria. Furthermore， physicochemical properties changed significantly， as evidenced by an increase in thiobarbituric acid reactive substances and b* (yellowness) value， and a decrease in hardness. A total of 65 VOCs were identified during storage. Correlation between bacterial succession and quality indicators (including VOCs and physicochemical properties) allowed the identification of 26 core dominant bacteria， including S. proteamaculans， Psychrobacter alimentarius， Pseudomonas putide， and Pseudomonas poae， which were positively related to spoilage VOCs (e.g.， 1-octen-3-ol， 1-pentanol， and 3-methyl-1-butanol) and could be defined as specific spoilage organisms (SSOs). The results of this study provide a systematic approach to predict SSOs in smoked chicken legs during storage， which can also provide a basis for product safety.

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Lactobacillus rhamnosus RL-H3-005 ameliorates allergic airway inflammation by modulating the gut microbiota in asthmatic mice

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Food Science and Human Wellness 2024年

作者： Shugang Li Mingxin Li Guopeng Li Huanhuan Liu Wenxiu Zhu Donglin sui Yixuan Li Xiaomeng Ren Collaborative Innovation Center of Seafood Deep Processing， National Engineering Research Center of Seafood， School of Food Science and Technology， Dalian Polytechnic University Dalian Jinshiwan Laboratory

The symptoms of allergic airway disease are impacted by the interplay of gut microbiota， which may be modulated by probiotics. This study aimed to investigate the potential anti-inflammatory effects of three lactic acid bacteria (LAB) on allergic asthma through modulation of the gut microbiota. Ovalbumin (OVA)-induced asthmatic mice were treated with three LAB strains， and their gut microbiota profiles were analyzed using 16S rRNA sequencing. Fecal microbiota transplantation (FMT) from mice fed with Lactobacillus rhamnosus RL-H3-005 was administered to OVA-induced asthmatic mice. The results demonstrated that RL-H3-005 effectively reduced inflammatory infiltrates in the lung and colon， as well as suppressed cytokine levels associated with allergic asthma compared to other strains. In addition， the supplementation of RL-H3-005 modulated the composition of gut microbiota in mice with allergic asthma. FMT results further supported the notion that modulating the gut microbiota with RL-H3-005 plays a crucial role in attenuating airway inflammatory symptoms in allergic asthma.

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Engineered AAV13 variants with enhanced transduction and confined spread

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Zoological Research 2024年第4期45卷 781-790页

作者： Neng-Song Luo Yu-Xiang Cai Zeng-Peng Han Xiao-Kai sui Wen-Jia Yuan Zi-Lian Zhang Hao-Dong Guo Jie Wang Kun-Zhang Lin Fu-Qiang Xu Wuhan National Laboratory for Optoelectronics Huazhong University of Science and TechnologyWuhanHubei 430074China Shenzhen Key Laboratory of Viral Vectors for Biomedicine Shenzhen-Hong Kong Institute of Brain ScienceShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China Key Laboratory of Magnetic Resonance in Biological Systems State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsNational Center for Magnetic Resonance in WuhanInnovation Academy for Precision Measurement Science and TechnologyChinese Academy of SciencesWuhanHubei 430071China Key Laboratory of Quality Control Technology for Virus-Based Therapeutics Guangdong Provincial Medical Products AdministrationNMPA Key Laboratory for Research and Evaluation of Viral Vector Technology in Cell and Gene Therapy Medicinal ProductsBrain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhenGuangdong 518055China University of Chinese Academy of Sciences Beijing 100049China Zhongnan Hospital Wuhan UniversityWuhanHubei 430072China Brain Case Biotechnology Co. Ltd.ShenzhenGuangdong 518107China College of Life Sciences Wuhan UniversityWuhanHubei 430072China Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of SciencesShanghai 200031China

Precise targeting of specific regions within the central nervous system(CNS)is crucial for both scientific research and gene therapy in the context of brain ***-associated virus 13(AAV13)is known for its restricted diffusion range within the CNS,making it an ideal choice for precise labeling and administration within small brain ***,AAV13 mediates relatively low expression of target ***,we introduced specifically engineered modifications to the AAV13 capsid protein to enhance its transduction *** first constructed AAV13-YF by mutating tyrosine to phenylalanine on the surface of the AAV13 *** then inserted the 7m8 peptide,known to enhance cell transduction,into positions 587/588 and 585/586 of the AAV13 capsid,resulting in two distinct variants named AAV13-587-7m8 and AAV13-585-7m8,*** found that AAV13-YF exhibited superior in vitro infectivity in HEK293T cells compared to AAV13,while AAV13-587-7m8 and AAV13-585-7m8 showed enhanced CNS infection capabilities in C57BL/6 mice,with AAV13-587-7m8 infection retaining a limited spread *** modified AAV13 variants hold promising potential for applications in gene therapy and neuroscience research.

关键词： Adeno-associated virus 13 AAV13-YF AAV13-587-7m8 AAV13-585-7m8 transduction efficiency

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我国台湾地区数位典藏产业化发展要素及其启示

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山西档案 2024年第6期 13-19页

作者：隋鑫福建师范大学社会历史学院福州350117

国家文化数字化战略为档案产业化发展提供了契机。通过对中国内地地区档案产业化发展历程的回溯,总结以往档案产业化发展的重点与困境,以我国台湾地区数位典藏产业发展为实验案例,分析其产业发展中的政策要素、规范要素、市场要素及技... 详细信息

国家文化数字化战略为档案产业化发展提供了契机。通过对中国内地地区档案产业化发展历程的回溯,总结以往档案产业化发展的重点与困境,以我国台湾地区数位典藏产业发展为实验案例,分析其产业发展中的政策要素、规范要素、市场要素及技术要素,为新时代档案产业化发展提供启示:借力政策,发挥基石作用;产业规范,推动产业运行;奠基市场,整合营销推广;技术支撑,搭建共享平台。

关键词：数位典藏档案产业化国家文化数字化战略档案开发利用

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