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Serum urate is associated with an increased risk of inflammatory bowel disease: A bidirectional Mendelian randomization study

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World Journal of Clinical Cases 2024年第5期12卷 891-902页

作者： Song Zhang Xue Fang Le Kang Xiang-Yu sui Miao Liu Yu-Jia Luo Shuo Fu Zhao-Shen Li Sheng-BingZhao Yu Bai Department of Gastroenterology Changhai HospitalShanghai 200433China Department of Gastroenterology Changhai HospitalSecond Military Medical University/Naval Medical UniversityShanghai 200433China Digestive Endoscopy Center Changhai HospitalNaval/Second Military Medical UniversityShanghai 200433China National Clinical Research Center for Digestive Diseases Shanghai 200433China

BACKGROUND Previous studies have indicated bidirectional associations between urate levels and inflammatory bowel disease(IBD),including ulcerative colitis(UC)and Crohn’s disease(CD).However,it remains unclear whether the observations are causal because of confounding *** To investigate the causal associations between urate levels and IBD using bidirec-tional Mendelian randomization(MR).METHODS Independent genetic variants for urate levels and IBD were selected as instru-mental variables from published genome-wide association studies(GWASs).Summary statistics for instrument-outcome associations were retrieved from three separate databases for IBD(the UK Biobank,the FinnGen database and a large GWAS meta-analysis)and one for urate levels(a large GWAS meta-analysis).MR analyses included the inverse-variance-weighted method,weighted-median estimator,MR-Egger and sensitivity analyses(MR-PRESSO).A meta-analysis was also conducted to merge the data from separate outcome databases using a fixed-effects *** Genetically higher serum urate levels were strongly associated with an increased risk of UC[odds ratio(OR):1.95,95%confidence interval(CI):1.86-2.05]after outlier correction,and the ORs(95%CIs)for IBD and CD were 0.94(95%CI:0.86-1.03)and 0.91(95%CI:0.80-1.04),*** studies have confirmed the positive association between urate levels and ***,genetically predicted IBD was inversely related to urate levels(OR:0.97,95%CI:0.94-0.99).However,no association was observed between genetically influenced UC or CD and urate *** Urate levels might be risk factors for UC,whereas genetically predicted IBD was inversely associated with urate *** findings provide essential new insight for treating and preventing IBD.

关键词： Inflammatory bowel disease Urate levels Antioxidant Mendelian randomization Single nucleotide polymorphism

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Analysis and prediction of disease burden of cirrhosis and other chronic liver diseases due to alcohol use in China from 1990 to 2030

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China Medical Abstracts(Internal Medicine) 2024年第2期41卷 109-110页

作者：朱穗 Sch Basic Med&Public Health Jinan UnivGuangzhou 510632

Objective Tocomprehensively understandthe disease burden of liver cirrhosis and other chronic liver diseases caused by alcohol use in China from 1990 to 2019,as well as to predict the trends in disease burden from 2020 to *** The analysis utilized data from the Global Burden of Disease study in 2019(GBD2019).Key indicators such as incidence rate,mortality rate,disability-adjusted life years(DALY),years of life lost due to premature mortality,and years lived with disability were selected to describe the disease burden of alcohol-related liver cirrhosis and other chronic liver diseases in China from 1990 to *** estimated annual percentage change(EAPC)was used to depict the temporal trends in disease ***,a Bayesian age-period-cohortt(BAPC)model was constructedd using R software to predict the agestandardized incidence rate(ASIR)and age-standardized mortality rate(ASMR)of alcohol-related liver cirrhosis and other chronic liver diseases in China from 2020 to *** From 1990 to 2019,the incidence of alcohol-related liver cirrhosis and other chronic liver diseases in China showed an upward trend,with an EAPC of 0.31%(95%Cl:0.10%-0.52%).However,the DALY declined,with an EAPC of-2.81%(95%CI:-2.92%-2.70%).

关键词： diseases cirrhosis mortality

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Selective core-shell doping enabling high performance 4.6 V-LiCoO_(2)

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Journal of Energy Chemistry 2024年第8期95卷 684-693,I0015页

作者： Yueming Xia Jianrui Feng Jinhui Li Yan Li Zhengfeng Zhang Xiaoqi Wang Jianli Shao Manling sui Pengfei Yan Beijing Key Laboratory of Microstructure and Property of Solids College of Materials Science&EngineeringBeijing University of TechnologyBeijing 100124China PetroChina Research Institute of Petroleum Exploration&Development Beijing 100083China State Key Laboratory of Explosion Science and Technology Beijing Institute of TechnologyBeijing 100081China

Constructing robust surface and bulk structure is the prerequisite for realizing high performance high voltage LiCoO_(2)(LCO).Herein,we manage to synthesize a surface Mg-doping and bulk Al-doping coreshell structured LCO,which demonstrates excellent cycling ***-cell shows 94.2%capacity retention after 100 cycles at 3.0-4.6 V(***/Li^(+))cycling,and no capacity decay after 300 cycles for fullcell test(3.0-4.55 V).Based on comprehensive microanalysis and theoretical calculations,the degradation mechanisms and doping effects are systematically *** the undoped LCO,high voltage cycling induces severe interfacial and bulk degradations,where cracks,stripe defects,fatigue H2 phase,and spinel phase are identified in grain *** the doped LCO,Mg-doped surface shell can suppress the interfacial degradations,which not only stabilizes the surface structure by forming a thin rock-salt layer but also significantly improves the electronic conductivity,thus enabling superior rate *** Al-doping can suppress the lattice"breathing"effect and the detrimental H3 to H1-3 phase transition,which minimizes the internal strain and defects growth,maintaining the layered structure after prolonged *** theoretical calculations,this work deepens our understanding of the doping effects of Mg and Al,which is valuable in guiding the future material design of high voltage LCO.

关键词： Lithium-ion battery Doping effect Failure mechanism High-voltage LiCoO_(2) Electron microscopy

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Emission and capture characteristics of deep hole trap in n-GaN by optical deep level transient spectroscopy

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Journal of Semiconductors 2024年第3期45卷 58-63页

作者： Jin sui Jiaxiang Chen Haolan Qu Yu Zhang Xing Lu Xinbo Zou School of Information Science and Technology ShanghaiTech UniversityShanghai 201210China Shanghai Institute of Microsystem and Information Technology Chinese Academy of SciencesShanghai 200050China School of Microelectronics University of Chinese Academy of SciencesBeijing 100049China School of Electronics and Information Technology Sun Yat-sen UniversityGuangzhou 510275China

Emission and capture characteristics of a deep hole trap(H1)in n-GaN Schottky barrier diodes(SBDs)have been investigated by optical deep level transient spectroscopy(ODLTS).Activation energy(Eemi)and capture cross-section(σ_(p))of H1 are determined to be 0.75 eV and 4.67×10^(−15)cm^(2),*** of apparent trap concentration in space charge region is ***-enhanced emission process is revealed by decrease of emission time ***-boosted trap emission kinetics are analyzed by the Poole−Frenkel emission(PFE)*** addition,H1 shows point defect capture properties and temperature-enhanced capture *** both hole capture and emission processes into account during laser beam incidence,H1 features a trap concentration of 2.67×10^(15)cm^(−3).The method and obtained results may facilitate understanding of minority carrier trap properties in wide bandgap semiconductor material and can be applied for device reliability assessment.

关键词： GaN deep level transient spectroscopy minority carrier trap time constant trap concentration

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Intelligent Vehicle Auxiliary Handling System Based on the Internet of Things Technology

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Journal of Electronic Research and Application 2024年第3期8卷 198-206页

作者： Chenxiao Wu Jue Wang Han sui Jingru Li Zihang Wang School of Civil Engineering and Transportation Northeast Forestry UniversityHarbin 150040China Aulin College Northeast Forestry UniversityHarbin 150040China College of Computer and Control Engineering Northeast Forestry UniversityHarbin 150040China

This paper proposes an intelligent vehicle auxiliary handling system based on Internet of Things(IoT)technology,featuring an innovative holding mechanism design that adjusts to the length and width of various *** system combines precise positioning using satellite tracking technology,intelligent recognition via OpenCV,and the interconnectivity of *** intelligent vehicle auxiliary handling system can independently identify vehicle positions and plan optimal handling paths,eliminating the traditional reliance on manual *** offers efficient and accurate handling,setting a new trend in the handling ***,the system integrates seamlessly with parking lot management systems,providing real-time updates on vehicle locations and *** allows managers to monitor the parking lot operations clearly and *** intelligent coordination greatly enhances overall work efficiency and streamlines parking ***,the innovative design of the intelligent vehicle auxiliary handling system represents a significant breakthrough in both function and performance,gaining user favor with its smooth *** ahead,continued technological advancements and the expansion of application fields will bring even more vitality and intelligence to societal development.

关键词： Vehicle handling Intelligent network OpenCV Image recognition

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Nomogram to predict severe retinopathy of prematurity in Southeast China

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International Journal of Ophthalmology(English edition) 2024年第2期17卷 282-288页

作者： Dan Liu Xing-Yong Li Hong-Wu He Ka-Lu Jin Ling-Xia Zhang Yang Zhou Zhi-Min Zhu Chen-Chen Jiang Hai-Jian Wu sui-Lian Zheng Department of Ophthalmology the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Eye Hospital and School of Ophthalmology and Optometry Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Taizhou Optometry Hospital Taizhou 318001Zhejiang ProvinceChina Department of Ophthalmology Jiaxing Maternity and Child Health Care HospitalJiaxing 314009Zhejiang ProvinceChina Department of Ophthalmology Taizhou Women and Children’s Hospital of Wenzhou Medical UniversityTaizhou 318001Zhejiang ProvinceChina Clinical Medical Research Center the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical UniversityWenzhou 325027Zhejiang ProvinceChina Department of Ophthalmology Taizhou Municipal HospitalTaizhou 318099Zhejiang ProvinceChina

AIM:To define the predictive factors of severe retinopathy of prematurity(ROP)and develop a nomogram for predicting severe ROP in southeast ***:Totally 554 infants diagnosed with ROP hospitalized in the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University and hospitalized in Taizhou Women and Children’s Hospital were *** data and 43 candidate predictive factors of ROP infants were collected *** regression model was used to identify predictive factors of severe ROP and to propose a nomogram for individual risk prediction,which was compared with WINROP model and Digirop-Birth ***:Infants from the Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University(n=478)were randomly allocated into training(n=402)and internal validation group(n=76).Infants from Taizhou Women and Children’s Hospital were set as external validation group(n=76).Severe ROP were found in 52 of 402 infants,12 of 76 infants,and 7 of 76 infants in training group,internal validation group,and external validation group,*** weight[odds ratio(OR),0.997;95%confidence interval(CI),0.996-0.999;P<0.001],multiple births(OR,1.885;95%CI,1.013-3.506;P=0.045),and non-invasive ventilation(OR,0.288;95%CI,0.146-0.570;P<0.001)were identified as predictive factors for the prediction of severe ROP,by univariate analysis and multivariate *** predicting severe ROP based on the internal validation group,the areas under receiver operating characteristic curve(AUC)was 78.1(95%CI,64.2-92.0)for the nomogram,32.9(95%CI,15.3-50.5)for WINROP model,70.2(95%CI,55.8-84.6)for Digirop-Birth *** external validation group,AUC of the nomogram was also higher than that of WINROP model and Digirop-Birth model(80.2 versus 51.1 and 63.4).The decision curve analysis of the nomogram demonstrated better clinical efficacy than that of WINROP model and Digirop-Birth *** calibration curves demonst

关键词： retinopathy of prematurity nomogram predictive factor birth weight multiple births non-invasive ventilation

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Influence of sex on outcomes of liver transplantation for hepatocellular carcinoma:a multicenter cohort study in China

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Cancer Biology & Medicine 2024年第4期21卷 347-362页

作者： Jian Chen Zhe Yang Fengqiang Gao Zhisheng Zhou Junli Chen Di Lu Kai Wang Meihua sui Zhengxin Wang Wenzhi Guo Guoyue Lyu Haizhi Qi Jinzhen Cai Jiayin Yang Shusen Zheng Xiao Xu Zhejiang University School of Medicine Hangzhou 310030China Institute of Organ Transplantation Zhejiang UniversityHangzhou 310030China Department of Hepatobiliary and Pancreatic Surgery Shulan Hospital of HangzhouHangzhou 310006China National Center for Healthcare Quality Management in Liver Transplant Hangzhou 310003China Department of General Surgery Huashan HospitalFudan UniversityShanghai 200040China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052China Department of Hepatobiliary and Pancreatic Surgery The First Hospital of Jilin UniversityChangchun 130021China Department of Liver Transplantation Second Xiangya HospitalCentral South UniversityChangsha 410008China Department of Organ Transplantation Center The Affiliated Hospital of Qingdao UniversityQingdao 266003China Department of Liver Surgery and Liver Transplantation Center West China HospitalSichuan UniversityChengdu 610044China NHC Key Laboratory of Combined Multi-organ Transplantation Hangzhou 310003China Department of Hepatobiliary and Pancreatic Surgery The First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China

Objective:Sex-specific differences are observed in various liver diseases,but the influence of sex on the outcomes of hepatocellular carcinoma(HCC)after liver transplantation(LT)remains to be *** study is the first Chinese nationwide investigation of the role of sex in post-LT outcomes in patients with ***:Data for recipients with HCC registered in the China Liver Transplant Registry between January 2015 and December 2020 were *** associations between donor,recipient,or donor-recipient transplant patterns by sex and the post-LT outcomes were studied with propensity score matching(PSM).The survival associated with different sex-based donor-recipient transplant patterns was further ***:Among 3,769 patients enrolled in this study,the 1-,3-,and 5-year overall survival(OS)rates of patients with HCC after LT were 96.1%,86.4%,and 78.5%,respectively,in female recipients,and 95.8%,79.0%,and 70.7%,respectively,in male recipients after PSM(P=0.009).However,the OS was comparable between recipients with female donors and male *** analysis indicated that male recipient sex was a risk factor for post-LT survival(HR=1.381,P=0.046).Among the donor-recipient transplant patterns,the male-male donor-recipient transplant pattern was associated with the poorest post-LT survival(P<0.05).Conclusions:Our findings highlighted that the post-LT outcomes of female recipients were significantly superior to those of male recipients,and the male-male donor-recipient transplant pattern was associated with the poorest post-LT *** from male donors may provide the most benefit to female *** results indicate that sex should be considered as a critical factor in organ allocation.

关键词： Sex liver transplantation hepatocellular carcinoma outcome recipient donor

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Diversity and connectedness of brine shrimp viruses in global hypersaline ecosystems

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Science China(Life Sciences) 2024年第1期67卷 188-203页

作者： Xuan Dong Cixiu Li Yiting Wang Tao Hu Fan Zhang Fanzeng Meng Meirong Gao Xuekai Han Guohao Wang Jiahao Qin Hans Nauwynck Edward CHolmes Patrick Sorgeloos Liying sui Jie Huang Weifeng Shi State Key Laboratory of Mariculture Biobreeding and Sustainable Goods Yellow Sea Fisheries Research InstituteChinese Academy of Fishery SciencesLaboratory for Marine Fisheries Science and Food Production ProcessesLaoshan LaboratoryKey Laboratory of Maricultural Organism Disease ControlMinistry of Agriculture and Rural AffairsQingdao Key Laboratory of Mariculture Epidemiology and BiosecurityQingdao 266071China Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan 250021China Key Laboratory of Emerging Infectious Diseases in Universities of Shandong Shandong First Medical University&Shandong Academy of Medical SciencesTaian 271000China Dalian Ocean University Dalian 116023China Asian Regional Artemia Reference Center Tianjin University of Science&TechnologyTianjin 300457China Ghent University Ghent 9000Belgium Sydney Institute for Infectious Diseases School of Medical SciencesThe University of SydneySydney 2006Australia Network of Aquaculture Centres in Asia-Pacific Bangkok 10900Thailand School of Public Health Shandong First Medical University&Shandong Academy of Medical SciencesJinan 250117China

Brine shrimp(Artemia)has existed on Earth for 400 million years and has major ecological importance in hypersaline *** a crucial live food in aquaculture,brine shrimp cysts have become one of the most important aquatic products traded ***,our understanding of the biodiversity,prevalence and global connectedness of viruses in brine shrimp is still very limited.A total of 143 batches of brine shrimp(belonging to seven species)cysts were collected from six continents including 21 countries and more than 100 geographic locations worldwide during 1977–*** total,55 novel RNA viruses were identified,which could be assigned to 18 different viral families and related *** viruses were dsRNA viruses,16 were+ssRNA viruses,and 28 were−ssRNA *** analyses of the RNA-directed RNA polymerase(RdRp)showed that brine shrimp viruses were often grouped with viruses isolated from other invertebrates and ***,most brine shrimp viruses were related to those from different hosts that might feed on brine shrimp or share the same ecological niche.A notable case was the novel brine shrimp noda-like virus 3,which shared 79.25%(RdRp)and 63.88%(capsid proteins)amino acid identity with covert mortality nodavirus(CMNV)that may cause losses in *** addition,both virome composition and phylogenetic analyses revealed global connectedness in certain brine shrimp viruses,particularly among Asia and Northern *** highlights the incredible species diversity of viruses in these ancient species and provides essential data for the prevalence of RNA viruses in the global aquaculture *** broadly,these findings provide novel insights into the previously unrecognized RNA virosphere in hypersaline ecosystems worldwide and demonstrate that human activity might have driven the global connectedness of brine shrimp viruses.

关键词： brine shrimp Artemia virus diversity novel virus discovery global connectedness hypersaline ecosystem

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“常人的神谕”:ChatGPT类生成式人工智能与人类未来

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江汉论坛 2024年第7期 91-98页

作者：隋婷婷郭喨北京大学哲学系北京100871 浙江大学科技与法律研究中心浙江杭州310008

ChatGPT等生成式人工智能是一种能够理解人类语言和意图的“全领域超级智能”,重新定义了“智能的边界”。ChatGPT具有基于自然语言进行无监督训练的主导性技术特征,其优点在于广泛的自适应性,缺点在于对数据质量的高度依赖以及缺乏可... 详细信息

ChatGPT等生成式人工智能是一种能够理解人类语言和意图的“全领域超级智能”,重新定义了“智能的边界”。ChatGPT具有基于自然语言进行无监督训练的主导性技术特征,其优点在于广泛的自适应性,缺点在于对数据质量的高度依赖以及缺乏可解释性。这一特征既形塑了生成式人工智能擅长处理自然语言的优势,也使其无法被轻易地转化为传统的“专家系统”,同时还存在“生成式错误”与“生成式偏见”等问题。依赖不甚严谨的“常人知识”语料库,这是其“生成式错误”的来源;基于特定语料库生成的文本可能表现出特定文化的固有偏见,训练阶段要素错配可能导致关联偏见,这是其两类“生成式偏见”的来源。作为先进的“神谕智能”,ChatGPT天然地带有“无所不知”的隐喻,但“生成式错误”与“生成式偏见”的存在,以及内在拒绝“噪声”与“意外”以求与“人类均值”保持一致,又使ChatGPT显著地表现出“常人”状态,使其与人类的交互整体呈现为“常人的神谕”。是否宽容甚至主动拥抱“噪声”与“意外”,是人类与生成式智能系统的重要差异。将之视为人类的“外置大脑”与“延展认知”,是人类面对“常人的神谕”时的理性选择。

关键词： ChatGPT 生成式人工智能生成式错误生成式偏见

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How to manage the malposition of deep vein catheterization into the artery?

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Journal of Geriatric Cardiology 2024年第6期21卷 682-685页

作者： Jun-Na SUN Hai DONG Peng CHEN Zi-Qi LI Li-You sui Bin QI Quan-Min JING Department of Cardiovascular Diseases the First Affiliated Hospital of Henan University of Chinese MedicineZhengzhouChina Department of Cardiology General Hospital of Northern Theater CommandShenyangChina

Central venous catheterization establishes temporary,efficient,and rapid use of deep venous access in patients,which provides high flow rate fluid perfusion,enables measurement of central venous pressure,and acts as an important reference for clinical ***,various complications such as pneumothorax,hemothorax,hematoma,and puncture failure can easily occur during the puncture and catheterization process.

关键词： process enable catheter

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