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Exploring the effects of taurolidine on tumor weight and microvessel density in a murine model of osteosarcoma

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Oncol.g. Research 2024年第7期32卷 1163-1172页

作者： lISANNE K.A.NEIJENHUIS lEUTA l.NAUMANN SONIA A.M.FERKEl SAMUEl J.S.rubin STEPHAN ROgAllA Division of gastroenterol.g. and Hepatol.g. Department of MedicineSchool of MedicineStanford UniversityStanford94305USA Department of Surgery Leiden University Medical CenterLeiden2333 ZAThe Netherlands Centre for Human Drug Research Leiden2333 CLThe Netherlands Department of general VisceralVascular and Thoracic SurgeryCharite University Medicine BerlinBerlin10117Germany

Background:Osteosarcoma is the most common mal.g.ant primary bone *** prognosis for patients with disseminated disease remains very poor despite recent advancements in ***,current treatment regimens bear a signiﬁcant risk of serious side ***,there is an unmet clinical need for effective therapies with improved safety proﬁ*** is an antibacterial agent that has been shown to induce cell death in different types of cancer cell ***:In this study,we examined both the antineoplastic and antiangiogenic effects of taurolidine in animal models of osteosarcoma.K7M2 murine osteosarcoma cells were injected,both intramuscular and intraperitoneal,into 60 BAlB/c mice on day *** were then randomized to receive treatment with taurolidine 2%(800 mg/kg),taurolidine 1%(400 mg/kg),or NaCl 0.9%control for seven days by intravenous or intraperitoneal ***:After 35 days,mice were euthanized,and the tumors were harvested for *** mice were excluded from the analysis due to *** weight was signiﬁcantly lower in the 2%taurolidine intraperitoneal treatment group from day 9 to 21,consistent with elevated mortality in this *** tumor weight was signiﬁcantly lower in the 1%(p=0.003)and 2%(p=0.006)intraperitoneal taurolidine treatment groups compared to the *** antineoplastic effects were observed on intramuscular tumors or for intravenous administration of *** were no signiﬁcant differences in microvessel density or mitotic rate between treatment *** body weight and elevated mortality in the 2%taurolidine intraperitoneal.g.oup suggest that the lower 1%dose is ***:In conclusion,there is no evidence of antiangiogenic activity,and the antitumor effects of taurolidine on osteosarcoma observed in this study are ***,its toxic proﬁle grants further *** these observations,further research is necessary to

关键词： Osteosarcoma Taurolidine Cancer treatment Chemotherapy Murine models

Colorectal cancer and dysplasia in inflammatory bowel disease

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World Journal of gastroenterol.g. 2008年第17期14卷 2662-2669页

作者： Timothy l Zisman David T rubin Clinical Research Fellow in gastro-enterol.g. the University of Chicago Medical Center The University of Chicago Medical Center

Both ulcerative colitis and Crohn’s disease carry an increased risk of developing colorectal cancer. Established risk factors for cancer among patients with inflammatory bowel disease (IBD) include the younger age at diagnosis, greater extent and duration of disease, increased severity of inflammation, family history of colorectal cancer and coexisting primary sclerosing cholangitis. Recent evidence suggests that current medical therapies and surgical techniques for inflammatory bowel disease may be reducing the incidence of this complication. Nonetheless heightened vigilance and a careful, comprehensive approach to prevent or minimize the complications of invasive cancer are warranted in this unique cohort of patients. Current guidelines for the prevention and early detection of cancer in this high risk population are grounded in the concept of an inflammation-dysplasia- carcinoma sequence. A thorough understanding of the definition and natural history of dysplasia in IBD, as well as the challenges associated with detection and interpretation of dysplasia are fundamental to developing an effective strategy for surveillance and prevention, and understanding the limitations of the current approach to prevention. This article reviews the current consensus guidelines for screening and surveillance of cancer in IBD, as well as presenting the evidence and rationale for chemoprevention of cancer and a discussion of emerging technol.g.es for the detection of dysplasia.

关键词： Cancer Dysplasia Inflammatory Bowel Disease Ulcerative Colitis Crohn's Disease Chemoprevention

正极性人工触发闪电的向上负先驱脉冲放电过程研究

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大气科学 2024年第2期48卷 497-506页

作者：吕冠霖蒋如斌李宗祥袁善锋张鸿波李晓刘昆陈睿凌刘明远成都信息工程大学电子工程学院成都610225 中国科学院大气物理研究所中层大气和全球环境探测重点实验室北京100029 国民核生化灾害防护国家重点实验室北京102205 中国科学院大学北京100049 中国科学技术大学合肥230026

利用人工触发正极性闪电的综合同步探测资料,对引雷火箭上升过程中发生于金属导线顶端的向上负先驱脉冲放电过程进行了研究。除常规认识的峰值电流为十几到几十安培的先驱脉冲放电以外,高垂直分辨率电流探测系统记录到丰富的弱脉冲放电... 详细信息

利用人工触发正极性闪电的综合同步探测资料,对引雷火箭上升过程中发生于金属导线顶端的向上负先驱脉冲放电过程进行了研究。除常规认识的峰值电流为十几到几十安培的先驱脉冲放电以外,高垂直分辨率电流探测系统记录到丰富的弱脉冲放电过程。所有孤立发生的脉冲放电,均为弱脉冲,且在所有常规强度的先驱脉冲(簇)放电之前约20μs,均识别到这种弱脉冲。对测量到的弱脉冲、脉冲型脉冲和波纹型脉冲进行统计,得到了各自的峰值电流(3.6 A、32.2 A、11.1 A)、上升时间(0.39μs、0.9μs、3.2μs)、持续时间(2.8μs、5.1μs、12.7μs)和转移电荷量(4.7μC、50.8μC、83.2μC)。常规强度的先驱脉冲形成了可探测的发光通道,簇状先驱脉冲的放电通道具有与自持先导初始阶段相一致的梯级发展传输特征,二维平均速度在105 m s^(−1)量级。分析相邻先驱脉冲发光通道的时空关系,发现后一次先驱脉冲放电通道的起始高度一般位于前一次先驱脉冲放电通道的顶端,通道梯级延伸时电荷分布的调整降低了通道区域的电场强度。先驱脉冲放电是金属导线顶端形成了先导但又由于条件不足而熄灭的过程。

关键词：人工触发闪电负极性先驱脉冲击穿先导

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含交叉断层深埋隧洞围岩衬砌外水压力物理模型试验

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清华大学学报（自然科学版） 2024年第7期64卷 1179-1192页

作者：王如宾王新越张文全徐卫亚陆进彬向天兵河海大学岩土工程科学研究所南京210098 云南省滇中引水工程有限公司昆明650000 中国电建集团昆明勘测设计研究院有限公司昆明650051

为揭示复杂地质条件下富水区深埋隧洞围岩灌浆圈衬砌复合系统的外水压力作用规律,该文自行研制适用于深埋隧洞的大型高外水压力物理模型试验测试系统,选取滇中引水工程昆明段松林隧洞TSlT-005与TSlT-006(TSlT-005、TSlT-006为断层编号)... 详细信息

为揭示复杂地质条件下富水区深埋隧洞围岩灌浆圈衬砌复合系统的外水压力作用规律,该文自行研制适用于深埋隧洞的大型高外水压力物理模型试验测试系统,选取滇中引水工程昆明段松林隧洞TSlT-005与TSlT-006(TSlT-005、TSlT-006为断层编号)交叉断层典型洞段为研究对象,开展含交叉断层深埋隧洞衬砌外水压力物理模型试验,揭示不同隧洞埋深、不同地下水位及不同排水条件下,衬砌的外水压力变化规律,并给出各工况下的外水压力折减系数建议取值范围。结果表明:隧洞埋深和地下水位对衬砌结构的外水压力影响明显,随着隧洞埋深的增大,受高地应力影响,围岩与灌浆圈自身的孔隙度与渗透性下降,对地下水渗流势能起到较好的削弱作用,导致衬砌的外水压力整体呈降低趋势;随着地下水位升高,衬砌全环的外水压力呈增大趋势,且由于岩体中细颗粒会被高水压冲散,因此形成较为连通发育的渗流通道,渗压增速也会随地下水位的升高而增大;设置衬砌排水孔可有效降低隧洞拱肩及其以上部位的外水压力,当隧洞围岩存在交叉断层分布时,断层带影响的衬砌部位外水压力降低效果受到一定削弱,且对衬砌的外水压力分布影响较为明显,在高地下水位工况下,需重点关注“断层带”对围岩衬砌结构整体的影响范围;当衬砌结构不排水时,600 m埋深的外水压力折减系数约为200 m埋深的92%,设置排水孔后,600 m埋深的外水压力折减系数约为200 m埋深的85%;当隧洞围岩存在交叉断层时,在不排水情况下,衬砌最不利点的外水压力折减系数建议取值0.95以上,在排水条件下,衬砌处的外水压力折减系数建议放宽至0.82;最后,利用有限元数值模拟方法对衬砌的外水压力物理模型试验结果进行验证,在衬砌不排水工况下,误差约为9.3%,在衬砌排水工况下,误差约为7.8%,表明高外水压力作用物理模型装置和试验结果基本上合理可行。该研究为富水区深埋隧洞工程的设计施工及运行安全提供科学参考。

关键词：滇中引水隧洞物理模型试验高外水压力断层破碎带

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Eosinophil associated genes in the inflammatory bowel disease 4 region:Correlation to inflammatory bowel disease revealed

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World Journal of gastroenterol.g. 2012年第44期18卷 6409-6419页

作者： Kristin Blom Jenny rubin Jonas Halfvarson leif Trkvist Anders Rnnblom Per Sangfelt Mikael lrdal Ulla-Britt Jnsson Urban Sjqvist lena Douhan Hkansson Per Venge Marie Carlson Department of Medical Sciences Clinical ChemistryUppsala University HospitalSE-75185 UppsalaSweden Division of gastroenterol.g. Department of Intestinal Medicinerebro University HospitalSE-70185 rebroSweden School of Health and Medical Sciences rebro UniversitySE-70185 rebroSweden IBD Clinical research group Karolinska University HospitalSE-17177 StockholmSweden Department for Clinical Science Intervention and TechnologyKarolinska University HospitalSE-17177 StockholmSweden Department of Medical Sciences Gastroenterology Research GroupUppsala UniversitySE-75185 UppsalaSweden Department of Medicine Karolinska InstitutetSE-17177 StockholmSweden

AIM： To study the association between inflammatory bowel disease （IBD） and genetic variations in eosinophil protein X （EPX） and eosinophil cationic protein （ECP）. METHODS： DNA was extracted from ethylene diamine tetraacetic acid blood of 587 patients with Crohn＇s disease （CD）, 592 with ulcerative colitis （UC） and 300 healthy subjects. The EPX405 （g 〉 C, rs2013109）, ECP434 （g 〉 C, rs2073342） and ECP562 （g 〉 C, rs2233860） gene polymorphisms were analysed, by the 5＇-nuclease allelic discrimination assay. For de- termination of intracellular content of EPX and ECP in granulocytes, 39 blood samples was collected and extracted with a buffer containing cetyltrimethylam- monium bromide. The intracellular content of EPX was analysed using an enzyme-linked immunosorbent as- say. The intracellular content of ECP was analysed with the UniCAP system as described by the manufacturer. Statistical tests for calculations of results were χ2 test, Fisher＇s exact test, ANOVA, Student-Newman-Keuls test, and Kaplan-Meier survival curve with l.g.rank test for trend, the probability values of P 〈 0.05 were considered statistically ***： The genotype frequency for males with UC and with an age of disease onset of ≥ 45 years （n = 57） was for ECP434 and ECP562, gg = 37%, gC = 60%, CC = 4% and gg = 51%, gC = 49%, CC = 0% respectively. This was significantly different from the healthy subject＇s genotype frequencies of ECP434 （gg = 57%, gC = 38%, CC = 5%; P = 0.010） and ECP562 （gg = 68%, gC = 29%,CC = 3%; P = 0.009）. The genotype frequencies for females, with an age of dis- ease onset of ≥ 45 years with CD （n = 62）, was for the ECP434 and ECP562 genotypes gg = 37%, gC =52%, CC = 11% and gg = 48%, gC = 47% and CC = 5% respectively. This was also statistically different from healthy controls for both ECP434 （P = 0.010） and ECP562 （P = 0.013）. The intracellular protein concen- tration of EPX and ECP was calculated in μg/10^6 eosi- nophils and then correlated to the EPX 405 genotypes

关键词： Eosinophil derived neurotoxin RNase 2 RNase 3 Single nucleotide polymorphism Inflamma-tion bowel disease Crohn's disease Ulcerative colitis

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糖尿病自我管理101 全面管理 1

2004年

作者：（美）RICHARD R.rubin gARY ARSHAM CATHERINE FESTE DAVID g.MARRERO STEFAN H.rubin 张萍译

本书提出了依靠“知识、技巧和支持”3因素来改变“糖尿病生活”。内容包括控制心理压力，增强信心；控制你的体重，吃得更健康；控制血糖水平等9章。

ISBN: (纸本)7810861042

关键词：糖尿病防治

来源：汇雅图书（南通市图书馆... 评论

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低温测量进展的评论

国外计量 1984年第3期 41-43页

作者： l.g.rubin 汪效俭

一、蒸气压测温和气体测温1.蒸气压测温蒸气压测温对于低温测量仍然是一种好方法。已用固态和液态氖、平衡氢和氧的沸点和凝固点间的新的蒸气压测量结果,定量地确定杂质对压力和温度间关系的影响。以氮从三相

关键词：测温法镍铬合金康铜传感器镍合金换能器电子技术定容气体温度计铂电阻温度计

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低温测温学近代发展评论(Ⅱ)

低温与特气 1984年第2期2卷 19-26页

作者： l.g.rubin 宋德华王荣荫不详光明所辽宁省计量测试技术研究所

1970年曾发表过一篇评论,涉及内容主要是六十年代的低温测温学的进展情况。本文的意图是想对过去的十年,具体地说,即从1969年至1981年的测温发展继续进行评论。本评论着重讨论1K 至约100K 范围内所完成的工作。各节的标题如下:温标;固... 详细信息

1970年曾发表过一篇评论,涉及内容主要是六十年代的低温测温学的进展情况。本文的意图是想对过去的十年,具体地说,即从1969年至1981年的测温发展继续进行评论。本评论着重讨论1K 至约100K 范围内所完成的工作。各节的标题如下:温标;固定点和蒸汽压测温;气体测温;电阻和二极管测温;热电偶、电容和噪声测温;其它测温方法;环境影响;仪器设备、使用方法和各种材料。参考文献多达400余篇。

关键词：测温学评论低温近代环境影响仪器设备使用方法参考文献二极管热电偶电容

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新兴结构材料—金属基复合材料的应用

材料工程 1980年第1期 35-41页

作者： l.rubin 于琨美国宇航公司材料科学实验室研究工程师

“金属基复合材料大有希望并已达到成熟的程度,它们的用途将不断扩大。然而要充分发挥其潜力,还应给予更大的关心和支持。”这段话是全国材料咨询委员会关于金属基复合材料的报告(1974年)中的第一个结论。自1974年以来,金属基复合材料... 详细信息

“金属基复合材料大有希望并已达到成熟的程度,它们的用途将不断扩大。然而要充分发挥其潜力,还应给予更大的关心和支持。”这段话是全国材料咨询委员会关于金属基复合材料的报告(1974年)中的第一个结论。自1974年以来,金属基复合材料的研制和应用引起了很大注意并给予支持,而此类复合材料当前的工艺技术水平再次有力地肯定了这一结论的正确

关键词：金属基复合材料增强体石墨纤维人造无机纤维纤维含量结构材料