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Vascular Calcification： Current Genetics Underlying This Complex Phenomenon

Chinese Medical Journal 2017年第9期130卷 1113-1121页

作者： Nonanzit Perez-Hernandez Gad Aptilon-Duque ruben blachman-braun Gilberto Vargas-Alarcon Adrian Asael Rodriguez-Cortes Shely Azrad-Daniez Rosalinda Posadas-Sanchez Jose Manuel Rodriguez-Perez Department of Molecular Biology National Institute of Cardiology "lgnacio Chavez" Mexico Mexico City 14080 Mexico 2Department of Endocrinology National Institute of Cardiology "Ignacio Chavez" Mexico Mexico City 14080 Mexico

Objective： Vascular calcification is the consequence of the complex interaction between genetic, environmental, and vascular factors, which ultimately lead to the deposition of calcium in the tunica intima （atherosclerotic calcification） or tunica media （M6nckenberg＇s sclerosis）. Vascular calcification is also closely related to other pathologies, such as diabetes mellitus, dyslipidemia, and chronic kidney disease. It has been concluded that the degree of vascular calcification may vary from person to person, even if the associated pathologies and environmental factors are the same. Therefore, this suggests an important genetic contribution to the development of vascular calcification. This review aimed to find the most recent evidence about vascular calcification pathophysiology regarding the genetic aspects and molecular pathways. Data Sources： We conducted an exhaustive search in Scopus, EBSCO, and PubMed with the keywords ＂genetics and vascular calcification＂, ＂molecular pathways, genetic and vascular calcification＂ and included the main articles from January 1995 up to August 2016. We focused on the most recent evidence about vascular calcification pathophysiology regarding the genetic aspects and molecular pathways. Study Selection： The most valuable published original and review articles related to our objective were selected. Results： Vascular calcification is a multifactorial disease; thus, its pathophysiology cannot be explained by a single specific factor, rather than by the result of the association of several genetic variants, molecular pathway interactions, and environmental factors that promote its development. Conclusion： Although several molecular aspects of this mechanism have been elucidated, there is still a need for a better understanding of the factors that predispose to this disease.

关键词： Atherosclerosis Cardiovascular Risk Genetics Polymorphisms Vascular Calcification

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Intravascular Foreign Bodies： A Single-Institution Experience and Description of a Novel Modified Percutaneous Retrieval Technique

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Chinese Medical Journal 2018年第4期131卷 484-485页

作者： Mario Enrique Baltazares-Lipp Benito Sarabia-Ortega Juan Ignacio Soto-Gonzalez Carlos Manuel Aboitiz-Rivera Hector A Carmona-Ruiz ruben blachman-braun Department of Hemodynamics and Echocardiography National Institute of Respiratory Diseases "Ismael Cosio Villegas" 14080 Mexico City Mexico Centro de Investigacion en Ciencias de la Salud F-acultad de Ciencias de la Saludl Universidad Anahuac Mexico Campus Norte Estado de Mexico 52786 Mexico

To the Editor： Catheters are frequently used as diagnostic and therapeutic devices that are frequently placed in critically ill patients. In addition, with the advantage of radiologic technology, the number of minimally invasive endovascular procedures has increased, and consequently the reports of intravascular foreign bodies （IFBs） and the numerous described IFBs retrieval technique.

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SCFD1 in amyotrophic lateral sclerosis:reconciling a genetic association with in vivo functional analysis

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Neural Regeneration Research 2024年第6期19卷 1201-1202页

作者： ruben J.Cauchi Centre for Molecular Medicine and Biobanking Biomedical Sciences BuildingDepartment of Physiology and BiochemistryFaculty of Medicine and SurgeryUniversity of MaltaMsidaMalta

Amyotrophic lateral sclerosis(ALS)is a neurodegenerative disease characterized by progressive loss of upper and lower motor neurons,resulting in muscle weakness and spasticity,eventually leading to death due to respiratory *** by our group of a casecontrol cohort from an isolated island population have found that genetics plays a significant role in disease etiology(Farrugia Wismayer et al.,2023).

关键词： sclerosis respiratory

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How can proton pump inhibitors damage central and peripheral nervous systems?

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Neural Regeneration Research 2020年第11期15卷 2041-2042页

作者： Tigran Makunts ruben Abagyan Skaggs School of Pharmacy and Pharmaceutical Sciences University of CaliforniaSan DiegoLa JollaCAUSA

Proton-pump inhibitors(PPIs)are first line therapy for most gastroesophageal acid-related *** include reflux disorders,Helicobacter pylori infections,Zollinger-Ellison syndrome,and gastroesophageal *** clinical practice,PPIs have largely replaced histamine-2 receptor antagonists(H2RAs)due to their superior efficacy and are currently widely prescribed and sold worldwide.(Kantor et al.,2015).Since the PPIs are,in addition,freely available without prescription in the United States,there has been a growing concern over proton-pump inhibitor prolonged use and serious side effects such as Alzheimer’s disease(AD)type dementia.A few large scale studies have shown an increased risk of the AD type and non-AD type dementia with PPI use,while others have questioned this association(Novotny et al.,2018;Khan et al.,2020).

关键词： al. Ellison damage

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Individual and demographic responses of a marsh bird assemblage to habitat loss and subsequent restoration

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Avian Research 2020年第1期11卷 25-33页

作者： ruben Moreno-Opo Monticola Ornithological Group Faculty of BiologyUniversity Autonoma of MadridMadrid 28049Spain Deputy Directorate on Biodiversity Ministry for the Ecological TransitionMadrid 28071Spain

Background: The alteration and loss of habitats are two of the main threats that biodiversity conservation is cur?rently facing up to. The present study describes the effects of a perturbation and restoration in a reedbed habitat on a bird assemblage. We studied the bird community of a wetland of central Spain between 1995 and 2009, during which time an anthropic perturbation altered the original structure of the habitat;subsequently, as a result of restoration works, the habitat returned to its original ***: We evaluated the effects on six population and physical parameters of the birds at three different phases of their life cycles(breeding, wintering and post?breeding migration seasons) before, during and after the habitat alteration. GLM was used to analyze the influence of three independent variables(year, perturbation phase and temperature).Results: The relative abundance and the species richness values decreased when habitat was altered, but then recovered as a result of the regeneration works. This pattern was the clearest amongst specialist species. Breeding success also declined during the perturbation phase and then increased;likewise, the sex ratio changed given that the proportion of male birds increased when habitat was altered. These results are discussed in relation to changes on availability of resources in altered habitats, to the adaptive mechanisms in the exploitation of ecological requirements and to the selection of optimum and sub?optimum habitats by generalist and specialist ***: Ecosystem restoration can favour the recovery of population indexes of specialist passerines, although it depends on the efficiency of the type of restoration activity performed and on the complexity of the habitat.

关键词： Habitat loss Land-use planning Marsh Restoration Ringing station Reedbed

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Cohomology in 3D Magneto-Quasistatics Modeling

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Communications in Computational Physics 2013年第6期14卷 48-76页

作者： Pawel Dlotko ruben Specogna Institute of Computer Science Jagiellonian Universityul.St.Łojasiewicza 630-348 KrakowPoland Universita di Udine Dipartimento di Ingegneria ElettricaGestionale e MeccanicaVia delle Scienze 20833100 UdineItaly

Electromagnetic modeling provides an interesting context to present a link between physical phenomena and homology and cohomology *** the past twenty-five years,a considerable effort has been invested by the computational electromagnetics community to develop fast and general techniques for defining *** magneto-quasi-static discrete formulations based on magnetic scalar potential are employed in problems which involve conductive regions with holes,cuts are needed to make the boundary value problem well *** an intimate connection with homology theory has been quickly recognized,heuristic definitions of cuts are surprisingly still dominant in the *** aim of this paper is first to survey several definitions of cuts together with their ***,cuts are defined as generators of the first cohomology group over integers of a finite *** provably general definition has also the virtue of providing an automatic,general and efficient algorithm for the computation of *** counter-examples show that heuristic definitions of cuts should be *** use of cohomology theory is not an option but the invaluable tool expressly needed to solve this problem.

关键词： Algebraic topology (co)homology computational electromagnetics cuts

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Corrosion Behavior of Reactive Sputtered Al_2O_3 and ZrO_2 Thin Films on Mg Disk Immersed in Saline Solution

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Journal of Materials Science & Technology 2015年第9期31卷 873-880页

作者： ruben Kotoka Sergey Yarmolenko Devdas Pai Jag Sankar Engineering Research Center for Revolutionizing Metallic Biomaterials North Carolina A&T State University

Magnesium has attracted a lot of attention over the last few decades due to its light weight and potential use as biomaterial However, the poor corrosion resistance of magnesium restricts its practical use for ap- plication where exposure to aggressive aqueous media is unavoidable. This paper describes the growth, characterization and corrosion analyses of Al2O3 and ZrO2 thin film coatings aimed at slowing down the fast degradation of Mg in saline solution. In this study, different thicknesses of Al2O3 and ZrO2 were de- posited on pure magnesium （99.95%） disk using pulsed-DC reactive sputtering process. The microstructure and phase analyses were performed using scanning electron microscopy （SEM） and X-ray diffraction （XRD）, respectively. The corrosion protection behavior of the Al2O3 and ZrO2 coated magnesium samples im- mersed in 0,9 wt% NaCl solution were evaluated using electrochemical measurement techniques, such as open-circuit potential （OCP）, potentiodynamic polarization （PD） and electrochemical impedance spectros- copy （EIS）. The microstructural analyses showed that the Al2O3 thin film coatings have circular grains between 5 and 25 nm, while the ZrO2 coatings have bigger ellipsoidal grains. The results from the electrochemical corrosion analyses showed that the Al2O3 coated Mg disk had corrosion resistance of approximately 3 times that of ZrO2 coated Mg disk. It was also observed that increasing the thickness of the Al2O3 coating im- proved the corrosion resistance of the Mg disk. These results suggest that Al2O3 and ZrO2 coating can be used to effectively control the fast degradation of magnesium for medical implant applications.

关键词： Magnetron sputteringMagnesiumAluminum oxideZirconium oxidePorosity

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Shoot-level biomass allocation is affected by shoot type in Fagus sylvatica

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Journal of Plant Ecology 2012年第4期5卷 422-428页

作者： Benjamín Jarcuska ruben Milla Institute of Forest Ecology Slovak Academy of SciencesSturova 296053 ZvolenSlovakia Area de Biodiversidad y Conservacion Universidad Rey Juan Carlosc/Tulipan s/n.E-28933 Mostoles(Madrid)Spain

Aims The present study aims(i)to examine if recently reported interspecific shoot-level biomass allocational trade-offs,*** trade-offs between leaf mass(LM)and stem mass(SM)and between leaf size and leaf number,hold intraspecifically and(ii)to explore whether those scaling relationships are independent of shoot type(*** *** shoots).Methods In order to address our questions,we used Fagus sylvatica saplings growing under a broad light range that were sampled in theWestern Carpathians Mountains(Slovakia).Important Findings We found that:(i)intraspecific shoot-level biomass allocational trade-offs differ from those reported interspecifically and that(ii)long and short shoots differ in biomass allocation scaling *** relationships with slopes statistically smaller than 1.0 or higher than-1.0,were found between SM and LM and between mean leafing intensity and individual leaf mass,respectively,in long *** contrast,isometric scaling was found in short *** suggests that leaf mass in short shoots is unaffected by shoot stem mass,in contrast to long *** shoots also had a larger fraction of biomass allocated to *** shoots,as has been observed in other shoot dimorphic species,are specialized,with short shoots specializing in carbon gain and long shoots in space acquisition.A greater shift in LM than in SM among species during speciation shifting from allometric intraspecific relationships to an isometric interspecific scaling relationship between those traits could explain the discrepancies between the outputs of the present intraspecific study and others similar *** study draws attention to the importance of considering shoot types in future studies dealing with allocation rules in species with dimorphic shoots.

关键词： biomass allocation dimorphic shoots leaf size stem size scaling relationships

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Germ-free, carefree: injured skin uses IL-24 to kick-start repair independent of pathogen-recognition

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Signal Transduction and Targeted Therapy 2023年第11期8卷 5129-5131页

作者： ruben A.Ferrer Marta Torregrossa Sandra Franz Department of Dermatology Allergology and VenerologyUniversity LeipzigLeipzigGermany

Skin injury releases damage-associated molecular patterns(DAMPs)represented by tissue-components and intracellular contents as well as changes in the levels of certain molecules and metabolites that signal the“non-homeostatic”state of the *** addition,microorganisms entering a wound release molecules,which are sensed as“non-self”(pathogen-associated molecular patterns,PAMPs).Together,DAMPs and PAMPs initiate a complex and coordinated repair process aimed at restoring *** exciting work from Liu et *** of an additional novel mechanism by which a“non-homeostatic”state in murine cutaneous wounds elicits a response through IL-24 to mediate repair(Fig.1).

关键词： wound homeostasis release

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cell2mol:encoding chemistry to interpret crystallographic data

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npj Computational Materials 2022年第1期8卷 1787-1794页

作者： Sergi Vela ruben Laplaza Yuri Cho Clémence Corminboeuf Laboratory for Computational Molecular Design(LCMD) Institute of Chemical Sciences and Engineering(ISIC)École Polytechnique Fédérale de Lausanne(EPFL)CH-1015LausanneSwitzerland National Centre for Computational Design and Discovery of Novel Materials(NCCR MARVEL) Ecole Polytechnique Fédérale de Lausanne1015LausanneSwitzerland National Centre for Competence in Research“Sustainable chemical processes through catalysis(NCCR Catalysis)” École Polytechnique Fédérale de Lausanne1015LausanneSwitzerland

The creation and maintenance of crystallographic data repositories is one of the greatest data-related achievements in *** such as the Cambridge Structural Database host what is likely the most diverse collection of synthesizable *** properly mined,they could be the basis for the large-scale exploration of new regions of the chemical space using quantum chemistry(QC).Yet,it is currently challenging to retrieve all the necessary information for QC codes based exclusively on the available structural data,especially for transition metal *** overcome this limitation,we present cell2mol,a software that interprets crystallographic data and retrieves the connectivity and total charge of molecules,including the oxidation state(OS)of metal *** demonstrate that cell2mol outperforms other popular methods at assigning the metal OS,while offering a comprehensive interpretation of the unit *** code is made available,as well as reliable QC-ready databases totaling 31k transition metal complexes and 13k ligands that contain incomparable chemical diversity.

关键词： offering overcome properly

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