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Declining meta.olic sca.ing pa.a.lels a. ontogenetic cha.ge from elonga.e to deep-bodied sha.es in juvenile Brown trout

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Current Zoology 2023年第3期69卷 294-303页

作者： Jorge-ruben Sa.chez-gonzalez a.fredo G.Nicieza Depa.tment of Orga.isms a.dSystems Biology University of Oviedo33006O OviedoSpain Biodiversity Resea.ch Institute(IMIB) University of Oviedo-Principality of Asturias-CSIC33600 MieresSpain Depa.tment of a.ima. Science-Wildlife Section University of Lleida25006 LleidaSpain

Body sha.e a.d meta.olic ra.e ca. be importa.t determina.ts of a.ima. performa.ce,yet often their effects on influentia. tra.ts a.e eva.ua.ed in a.non-integra.ed *** crea.es a. importa.t ga. beca.se the integra.ion between sha.e a.d meta.olism ma. be crucia. to eva.ua.e meta.olic sca.ing ***,we mea.ured sta.da.d meta.olic ra.e in 1-a.d 2-yea.s old juvenile brown trout Sa.mo trutta.a.d used a.geometric morphometrics a.proa.h to extrica.e the effects of ontogeny a.d size on the link between sha.e a.d meta.olic *** evidenced nea.-isometric ontogenetic sca.ing of meta.olic ra.e with size,but a.so a.bipha.ic pa.tern driven by a.significa.t cha.ge in meta.olic sca.ing,from positive to nega.ive ***,the cha.ge in meta.olic a.lometry pa.a.lels a. ontogenetic cha.ge from elonga.e to deep-bodied *** is consistent with the dyna.ic energy budget(DEB)a.d surfa.e a.ea.Sa.theories,but not with the resource tra.sport network theory which predicts increa.ing a.lometric exponents for trends towa.ds more robust,three-dimensiona. *** a.dition,we found a.rela.ionship between body sha.e a.d size independent meta.olic ra.e,with a.positive correla.ion between robustness a.d meta.olic ra.e,which fits well within the view of Pa.e-of-Life Syndromes(POLS).Fina.ly,our results a.ign with previous studies tha. question the universa.ity of meta.olic sca.ing exponents a.d propose other mecha.istic models expla.ning the diversity of meta.olic sca.ing rela.ionships or empha.izing the potentia. contribution of ecologica. fa.tors.

关键词： bipha.ic a.lometric sca.ing meta.olic ra.e ontogenetic a.lometry sha.e surfa.e-a.ea trout

Histone dea.etyla.es,microRNa.a.d leptin crossta.k in pa.crea.ic ca.cer

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World Journa. of Clinica. Oncology 2017年第3期8卷 178-189页

作者： Cynthia.I Tchio Ma.tho a.ria.a.Ha.buza.iu ruben R gonzalez-Perez Depa.tment of Microbiology Biochemistry and ImmunologyMorehouse School of Medicine

Beca.se pa.crea.ic ca.cer(PC) historica.ly ha. ha. poor prognosis a.d five yea. surviva. ra.es,it ha. been intensely *** of PC incidence a.d biology ha. shown a.link between different risk fa.tors such a. smoking,a.coholism,a.d obesity a.d disea.e *** fa.tors a.fecting PC include the epigenomic cha.ges driven by DNa.methyla.ion a.d histone a.etyla.ion,a.d a.tions of microRNa.inducing oncogenic or tumor suppressor *** ha.e identified ma.kers whose dysregula.ion seem to pla. importa.t roles in PC *** ma.kers involve cla.sica. histone dea.etyla.es(HDa.),PC stem cell(PCSC),a.d *** this review,we discuss the role of severa. PC bioma.kers,a.d the potentia. crossta.k between HDa.,microRNa.a.d leptin in PC *** expression of these molecules ca. increa.e prolifera.ion,surviva.,PCSC,resista.ce to chemothera.y a.d tumor *** potentia. rela.ionships between these molecules a.e further a.a.yzed using da.a.from The Ca.cer Genome a.la. a.d crossta.k pa.hwa.s genera.ed by the Pa.hwa. Studio Pla.form(a.ia.ne Genomics,Inc.).Oncogenic miRNa.1 a.d tumor suppressor miRNa.00 ha.e been previously linked to leptin *** a.a.ysis of PC biopsies a.d signa.ing crossta.k suggests tha. the ma.n a.ipokine leptin could a.fect the expression of microRNa.a.d HDa. in *** a.a.ysis suggests tha. HDa.-microRNa.leptin signa.ing crossta.k ma. be a.new ta.get for PC thera.y.

关键词： Pa.crea.ic Ca.cer MicroRNA Histone dea.etyla.es Pa.crea.ic ca.cer stem cell ma.kers Leptin Obesity

Leptin signa.ing a.d ca.cer chemoresista.ce:Perspectives

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World Journa. of Clinica. Oncology 2017年第2期8卷 106-119页

作者： Pierre V Ca.dela.ia.a.tonio Ra.poldi a.ria.a.Ha.buza.iu ruben R gonzalez-Perez Depa.tment of Microbiology Bio-chemistry and ImmunologyMorehouse School of Medicine

Obesity is a.ma.or hea.th problem a.d currently is endemic a.ound the world. Obesity is a.risk fa.tor for severa. different types of ca.cer, significa.tly promoting ca.cer incidence, progression, poor prognosis a.d resista.ce to a.ti-ca.cer thera.ies. The study of this resista.ce is critica. a. development of chemoresista.ce is a.serious dra.ba.k for the successful a.d effective drug-ba.ed trea.ments of ca.cer. There is increa.ing evidence tha. a.gmented a.iposity ca. impa.t on chemothera.eutic trea.ment of ca.cer a.d the development of resista.ce to these trea.ments, pa.ticula.ly through one of its signa.ure media.ors, the a.ipokine leptin. Leptin is a.pro-infla.ma.ory, pro-a.giogenic a.d pro-tumorigenic a.ipokine tha. ha. been implica.ed in ma.y ca.cers promoting processes such a. a.giogenesis, meta.ta.is, tumorigenesis a.d surviva./resista.ce to a.optosis. Severa. possible mecha.isms tha. could potentia.ly be developed by ca.cer cells to elicit drug resista.ce ha.e been suggested in the litera.ure. Here, we summa.ize a.d discuss the current sta.e of the litera.ure on the role of obesity a.d leptin on chemoresista.ce, pa.ticula.ly a. it rela.es to brea.t a.d pa.crea.ic ca.cers. We focus on the role of leptin a.d its significa.ce in possibly driving these proposed chemoresista.ce mecha.isms, a.d exa.ine its effects on ca.cer cell surviva. signa.s a.d expa.sion of the ca.cer stem cell sub-popula.ions.

关键词： Obesity-rela.ed ca.cer Ca.cer stem cells Leptin Chemoresista.ce Brea.t ca.cer Pa.crea.ic ca.cer

Na.opa.ticle-linked a.ta.onist for leptin signa.ing inhibition in brea.t ca.cer

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World Journa. of Clinica. Oncology 2017年第1期8卷 54-66页

作者： Tia.Ha.mon a.ria.a.Ha.buza.iu Viola.La.ier Crysta. C Lipsey Wa.d Kirlin Lily Ya.g ruben R gonzalez-Perez Depa.tment of Microbiology Biochemistry and Immunology Morehouse School of Medicine Depa.tment of Pa.hology a.d La.ora.ory Medicine Emory University School of Medicine

a.M To develop a.leptin peptide receptor a.ta.onist linked to na.opa.ticles a.d determine its effect on via.ility of brea.t ca.cer *** The leptin a.ta.onist, LPra., wa. coupled via.EDa. [1-Ethyl-3-(3-dimethyla.inopropyl)ca.bodiimide] to iron oxide na.opa.ticles(IONP-LPra.) to increa.e its ***-LPra. conjuga.ion wa. confirmed by Western blot a.d na.opa.ticle tra.king *** triple nega.ive brea.t ca.cer(TNBC) MDa.MB-231, HCC1806 a.d estrogen receptor positive(ER+) MCF-7 cells were a.a.yzed for the expression of the leptin receptor, *** effects of leptin a.d a.ta.onist on levels of leptin-induced STa.3 phosphoryla.ion a.d cyclin D1, cell cycle progression, cell prolifera.ion, a.d tumorsphere forma.ion in brea.t ca.cer cells were *** of the chemothera.eutics [cispla.in(Cis), cyclophospha.ide(CTX), doxorubicin(Dox) a.d pa.lita.el(PTX)] to effectively reduce cell via.ility were *** effects of combina.ion trea.ments of IONP-LPra. a.d chemothera.eutics on cell via.ility were *** Western blot a.a.ysis of coupling rea.tion products identified IONP-LPra. a. a.proxima.ely 100 ***2 significa.tly decrea.ed leptin-induced p STa.3 levels in HCC1806 cells a.d dra.tica.ly decrea.ed cyclin D1 levels in a.l cell ***-LPra. significa.tly reduced leptin-induced S pha.e progression a.d cell prolifera.ion in a.l brea.t ca.cer cell lines a.d the forma.ion of tumorspheres in MDa.MB-231 ***, IONP-LPra. showed a. a.ditive effect on the reduction of brea.t ca.cer cell surviva. with *** plus IONP-LPra. produced a.significa.t reduction in the surviva. of MDa.MB-231 a.d HCC1806 *** plus IONP-LPra. ca.sed a.significa.t decrea.e in the surviva. of MDa.MB-231 *** plus IONP-LPra. ca.sed a.ma.ked reduction in the surviva. of HCC1806 ***, PTX plus IONP-LPra. did not ha.e a.ma.or effect on the via.ility of the brea.t ca.cer cells when compa.ed to PTX *** Prese

关键词： Triple nega.ive brea.t ca.cer Obesity Leptin Leptin peptide receptor a.ta.onist 2 Iron oxide na.opa.ticles Chemothera.y a.juva.t

Microcellula. a.a.e Fibre-High Density Polyethylene Composites Produced by Injection Molding

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材料科学与工程（中英文a.） 2012年第11期2卷 677-692页

作者： Cedric Tissa.dier Roberto Ca.los Va.quez Fletes ruben gonzalez-Nunez Denis Rodrigue Depa.tement de Genie Chimique Universite Laval Quebec G1 V OA6 Canada Depa.ta.ento de Ingenierla.Quimica Universidad de Guadalajara Guadalajara 44430 Mexico

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来自苏联的爱 SU-122

模型世界 2019年第4期 32-41页

作者： ruben gonzalez

这台田宫(Ta.IYa.出品的SU-122年代已久,算是很有年头的老古董了。很多购入的玩家或许已将其忽视或遗忘,长期束之高阁。其实只需要一些胶条、网格、铜丝及Ma.quette的履带,再加上一点决心和耐心,这盒模型在一些基础技法的加持下完全可... 详细信息

这台田宫(Ta.IYa.出品的SU-122年代已久,算是很有年头的老古董了。很多购入的玩家或许已将其忽视或遗忘,长期束之高阁。其实只需要一些胶条、网格、铜丝及Ma.quette的履带,再加上一点决心和耐心,这盒模型在一些基础技法的加持下完全可以呈现出焕然一新的面貌。事实上,虽然如今充斥市面的诸多包含高科技含量的模型使玩家的制作更为简易,但这盒中古套件反而是一种良性的返璞归真。因此,在用传统技法将模型制作完毕以后,我们来看看如何运用多种技法将这台模型做出风尘仆仆的老旧外观。

关键词：油画颜料 SU-122 抛光效果金属网

Oncogenic role of leptin a.d Notch interleukin-1 leptin crossta.k outcome in ca.cer

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World Journa. of Methodology 2016年第1期6卷 43-55页

作者： Crysta. C Lipsey a.ria.a.Ha.buza.iu Da.ielle Da.ey-Brown ruben R gonzalez-Perez Depa.tment of Microbiology Biochemistry and ImmunologyGraduate Education in Bio-medical SciencesMorehouse School of Medicine

Obesity is a.globa. pa.demic cha.a.terized by high levels of body fa.(a.iposity) a.d derived-cytokines(i.e., leptin). Resea.ch shows tha. a.iposity a.d leptin provide insight on the link between obesity a.d ca.cer progression. Leptin's ma.n function is to regula.e energy ba.a.ce. However, obese individua.s routinely develop leptin resista.ce, which is the consequence of the brea.down in the signa.ing mecha.ism controlling sa.iety resulting in the a.cumula.ion of leptin. Therefore, leptin levels a.e often chronica.ly eleva.ed in huma. obesity. Eleva.ed leptin levels a.e rela.ed to higher incidence, increa.ed progression a.d poor prognosis of severa. huma. ca.cers. In a.dition to a.ipose tissue, ca.cer cells ca. a.so secrete leptin a.d overexpress leptin receptors. Leptin is known to a.t a. a.mitogen, infla.ma.ory a.d pro-a.giogenic fa.tor tha. induces ca.cer cell prolifera.ion a.d tumor a.giogenesis. Moreover, leptin signa.ing induces ca.cer stem cells, which a.e involved in ca.cer recurrence a.d drug resista.ce. a.novel a.d complex signa.ing crossta.k between leptin, Notch a.d interleukin-1(IL-1) [Notch, IL-1 a.d leptin crossta.k outcome(NILCO)] seems to be a. importa.t driver of leptin-induced oncogenic a.tions. Leptin a.d NILCO signa.ing media.e the a.tiva.ion of ca.cer stem cells tha. ca. a.fect drug resista.ce. Thus, leptin a.d NILCO signa.ing a.e key links between obesity a.d ca.cer progression. This review presents upda.ed da.a.suggesting tha. a.iposity a.fects ca.cer incidence, progression, a.d response to trea.ment. Here we show da.a.supporting the oncogenic role of leptin in brea.t, endometria., a.d pa.crea.ic ca.cers.

关键词： Obesity Leptin Brea.t ca.cer Endometria. ca.cer Pa.crea.ic ca.cer Notch interleukin-1 a.d leptin crossta.k outcome

Sexua. Reversa. with 17α-Methyltestosterone in Oreochromis sp.:Compa.ison between Recircula.ion a.ua.ulture System(Ra.)a.d Biofloc Technology(BFT)

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Journa. of a.ricultura. Science a.d Technology(a. 2019年第2期9卷 131-139页

作者： Ca.los a.turo Da.id-Rua.es Elia.a.Ma.cela.Beta.cur-gonzalez ruben Da.io Va.buena.Villa.ea. a.ima. Science Progra. Corporación Universitaria LasallistaCaldas 0554Colombia Depa.tment of Exa.t a.d Na.ura. Sciences Universidad Surcolombiana4100Colombia

Precocity in tila.ia.implies the use of severa. methods of obta.ning monosex seed;the most common tends to use ma.culinizing hormone 17α-methyltestosterone(17αMT),with va.ia.le *** the objective of this study wa. to compa.e the efficiency of the sexua. reversion process using 17αMT,in a.recircula.ion system a.d in *** a.tota.ly ra.domized design,three ta.ks for recircula.ion(T-Ra.)a.d three ta.ks for biofloc(T-BIO)with a.ca.a.ity of 200 L effective volume were ta.en a.d filled with 1,056 la.va. of Oreochromis sp.,without reversing a.d with a. initia. weight of 0.02 g a.d a. initia. tota. length of 1.4 *** study wa. ca.ried out during 65 d,the fish were fed(10%bioma.s,a.justed every 15 d)by a.commercia. diet a. 45%of crude protein tha. included 17αMT(60 mg/kg).Wa.er qua.ity,microbiology,zootechnica. a.d gona.a. a.a.ysis were *** the wa.er qua.ity results showed tha. just dissolved oxygen(DO),tempera.ure(T-°C)a.d a.ka.inity did not show significa.t ***,in the productive pa.a.eters there were significa.t differences in the fina. length,the ga.n in length a.d in K which were better in *** microbiologica. ones did not present significa.t differences between the ***,the percenta.e of reversion wa. significa.tly better in ***,this study suggests tha. settlea.le solids concentra.ions a.ove 35 cm decrea.e the efficiency of the sexua. reversion for this species.

关键词： Oreochromis sp. biofloc recircula.ion a.ua.ulture system 17α-methyltestosterone

Leptin-induced Notch a.d IL-1 signa.ing crossta.k in endometria. a.enoca.cinoma.is a.socia.ed with inva.iveness a.d chemoresista.ce

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World Journa. of Clinica. Oncology 2019年第6期10卷 222-233页

作者： Da.ielle Da.ey-Brown a.ria.a.Ha.buza.iu a.n a.u Kuria. Ga.riela.Oprea.Ilies ruben Rene gonzalez-Perez Depa.tment of Microbiology Biochemistry and Immunology Morehouse School of Medicine Atlanta GA 30310 United States Depa.tment of Pa.hology a.d La.ora.ory Medicine Emory University Atlanta GA 30322 United States

Ba.KGROUND Obesity is a.recognized risk fa.tor for endometria. ca.cer (EmCa. a.d other ca.cer types. Leptin levels a.e significa.tly increa.ed in obese individua.s. Leptin-induced signa.ing crossta.k [Notch, Interleukin-1 (IL-1) a.d leptin outcome, NILCO] ha. been a.socia.ed with brea.t ca.cer progression. This complex signa.ing crossta.k a.fects ca.cer cell prolifera.ion, migra.ion, inva.ion, a.giogenesis, a.optosis a.d chemoresista.ce. NILCO expression wa. previously detected in huma. EmCa. However, it is unknown whether leptin regula.es NILCO a.d a.ters EmCa.s response to chemothera.eutics. It is hypothesized tha. leptin induces NILCO a.d increa.es a.gressiveness a.d chemoresista.ce in EmCa.cells. a.M To determine whether leptin induces NILCO molecules in EmCa.a.fecting cell prolifera.ion, a.gressiveness a.d chemoresista.ce. METHODS Leptin’s effects on the expression of NILCO molecules [mRNa. a.d proteins for Notch receptors (Notch1-4), liga.ds (Ja.1 a.d DLL4) a.d downstrea. effectors (survivin, Hey2), a.d leptin (OB-R) a.d IL-1 (IL-1R tI) receptors] wa. exa.ined in EmCa.cells (type I: Ishika.a. a.d HEC-1a. a.d type II: a.3Ca.a.d KLE) using Rea.-time PCR a.d Western blot a.a.ysis, respectively. In a.dition, the effects of leptin on cell cycle, prolifera.ion a.d cell inva.ion were determined using cytometric a.a.ysis (Cellometer Vision CBa.system), MTT cell prolifera.ion a.d Ma.rigel-ba.ed inva.ion a.sa.s, respectively. Inhibitors of leptin (na.opa.ticlebound leptin peptide receptor a.ta.onist-2, IONP-LPra.), IL-1 (a.ti-IL-1R tI a.tibody) a.d Notch (siRNa.interference RNa. were used to investiga.e NILCO’s effects on cell prolifera.ion a.d inva.ion. Leptin’s effects on Pa.lita.el cytotoxicity in EmCa.cells wa. determined by the CCK8 a.d Cellometer-ba.ed a.nexin V a.sa.s. RESULTS For the first time it wa. shown tha. leptin is a. inducer of Notch in EmCa. Experimenta. da.a.suggest tha. leptin induced the expression of NILCO molecules, promoted prolifera.ion a.d S- ph

关键词： Endometria. ca.cer Leptin Notch Interleukin-1 Notch, IL-1 a.d Leptin crossta.k outcome Chemoresista.ce