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The Plastid Envelope CHLOROPLAST MANGANESE TRANSPORTER1 Is Essential for Manganese Homeostasis in Arabidopsis

Molecular Plant 2018年第7期11卷 955-969页

作者： Marion Eisenhut Natalie Hoecker Sidsel Birkelund Schmidt rubek merina basgaran Samantha Flachbart Peter Jahns Tabea Eser Stefan Geimer Seren Husted Andreas P.M. Weber Dario Leister Anja Schneider Biochemie der Pflanzen Cluster of Excellence on Plant Science (CEPLAS) Heinrich-Heine-University Di3sseldorf 40225 Desseldorf Germany Molekularbiologie der Pflanzen (Botanik) Department Biologie I Ludwig-Maximilians-University Mernchen 82152 Martinsried Germany Department of Plant and Environmental Sciences and Copenhagen Plant Science Centre (CPSC) Faculty of Science University of Copenhagen 1871 Frederiksberg Denmark Zellbiologie/Elektronenmikroskopie NW I/B1 Universit&t Bayreuth 95447 Bayreuth Germany These authors contributed equally to this article.

The transition metal manganese （Mn） is indispensable for photoautotrophic growth since photosystem II （PSII） employs an inorganic Mn4CaOs cluster for water splitting. Here, we show that the Arabidopsis membrane protein CHLOROPLAST MANGANESE TRANSPORTER1 （CMT1） is involved in chloroplast Mn homeostasis. CMT1 is the closest homolog of the previously characterized thylakoid Mn transporter PHOTOSYNTHESIS-AFFECTED MUTANT71 （PAM71）. In contrast to PAM71, CMT1 resides at the chloro- plast envelope and is ubiquitously expressed. Nonetheless, like PAM71, the expression of CMT1 can also alleviate the Mn-sensitive phenotype of yeast mutant qomrl. The cmtl mutant is severely suppressed in growth, chloroplast ultrastructure, and PSII activity owing to a decrease in the amounts of pigments and thylakoid membrane proteins. The importance of CMT1 for chloroplast Mn homeostasis is demonstratedby the significant reduction in chloroplast Mn concentrations in cmtl-1, which exhibited reduced Mn binding in PSII complexes. Moreover, CMT1 expression is downregulated in Mn-surplus conditions. The pam71 cmtl-ldouble mutant resembles the cmtl-f single mutant rather than pare71 in most respects. Taken together, our results suggest that CMT1 mediates Mn2 uptake into the chloroplast stroma, and that CMT1 and PAM71 function sequentially in Mn delivery to PSII across the chloroplast envelope and the thylakoid membrane.

关键词： manganese transporter envelope chloroplast photosynthesis Arabidopsis

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Betalains protect various body organs through antioxidant and anti-inflammatory pathways

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Food Science and Human Wellness 2024年第3期13卷 1109-1117页

作者： Nilesh Prakash Nirmal Seema Medhe merina Dahal Pankaj Koirala Siriwan Nirmal Fahad Al-Asmari Baojun Xu Institute of Nutrition Mahidol UniversityNakhon Pathom 73170Thailand Department of Nutrition and Dietetics Central Campus of TechnologyTribhuvan UniversityKathmandu 46000Nepal Department of Adult Nursing Faculty of NursingBurapha UniversityChonburi 20131Thailand Department of Food Science and Nutrition College of Agriculture and Food SciencesKing Faisal UniversityAl-Ahsa 31982Saudi Arabia Food Science and Technology Program Department of Life SciencesBNU-HKBU United International CollegeZhuhai 519088China

Betalains are natural coloring pigments with betalamic acid as the core structure of all *** their coloring properties,betalains exhibit various biological activities,including antioxidant and anti-inflammatory properties,which are highly *** in-vivo studies reported that betalains protect various body organs,leading to health *** organs,including the heart,liver,kidney,lung,etc.,are important for a healthy ***,these organs can be affected or damaged by various stress factors,toxicants,and harmful *** studies have claimed that betalains could protect all vital organs of the body through antioxidant and anti-inflammatory *** review article described the in-vivo antioxidant and anti-inflammatory activities of betalains in various cell-line or animal models.A comprehensive discussion has been provided on the mechanism of action of betalains in protecting various body organs,including cardio-protective effect,hepato-protective ability,renal protection capacity,repro-protective ability,neuro-protective effect,lung protection,and gut protection ***,future research directions and conclusions have been outlined.

关键词： Betalains Antioxidant Anti-inflammatory Bioactivities Ogans-protection

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Perioperative cardiac risks in myasthenia gravis

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World Journal of Clinical Cases 2024年第13期12卷 2147-2150页

作者： Deb Sanjay Nag Abhishek Chatterjee Pratap Rudra Mahanty merina Sam Murari Kumar Bharadwaj Department of Anaesthesiology Tata Main HospitalJamshedpur 831001India Department of Anaesthesiology Manipal Tata Medical CollegeJamshedpur 831017India

Myasthenia gravis(MG)is an autoimmune disorder that affects the neuromuscular *** primary pathology in MG involves the presence of autoantibodies to acetylcholine receptors(AChRs),which results in qualitative and quantitative reductions in the availability of functional *** muscles are also affected,resulting in various perioperative cardiac *** antibodies are commonly reported in MG cases with cardiac *** the presence of thymoma,the prevalence of cardiac manifestations in patients with MG increases to approximately 10%-15%.Cardiac involvement in MG may range from asymptomatic electrocardiogram changes to ventricular tachycardia,myocarditis,conduction disorders,heart failure,and sudden *** incidence of atrial fibrillation,ventricular and supraventricular extra systoles,and prolonged QTc have also been reported in patients with *** should consider the evaluation of autonomic dysfunction and risk of cardiovascular disease in patients with MG.

关键词： Myasthenia Gravis Perioperative period Receptors Cholinergic Anesthesia

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Pitfalls in internal jugular vein cannulation

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World Journal of Clinical Cases 2024年第10期12卷 1714-1717页

作者： Deb Sanjay Nag Amlan Swain Seelora Sahu Bhanu Pratap Swain merina Sam Department of Anaesthesiology Tata Main HospitalJamshedpur 831001JharkhandIndia

Central venous catheter insertion in the internal jugular vein(IJV)is frequently performed in acute care settings,facilitated by its easy availability and increased use of ultrasound in healthcare *** the increased safety profile and insertion convenience,it has ***,we aim to inform readers about the existing literature on the plethora of complications with potentially disastrous consequences for patients undergoing IJV cannulation.

关键词： Catheterization Central venous Complications Thoracic duct Arteriovenous fistula Vocal cord paralysis Pneumothorax Cardiac tamponade

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软组织移植术后腭部供区并发症的发生 ——系统性评价

软组织移植术后腭部供区并发症的发生 ...

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作者： merina Shakya 重庆医科大学

学位级别：硕士

引言:在临床中,牙龈退缩和膜龈异常是最常遇到的问题。数年来,人们对牙龈退缩和膜龈异常的治疗采取了各种不同的治疗方式,其中游离软组织移植术被广泛应用。众所周知,腭部具有与角化龈相似的组织结构,最适合进行游离软组织移植术（口腔... 详细信息

引言:在临床中,牙龈退缩和膜龈异常是最常遇到的问题。数年来,人们对牙龈退缩和膜龈异常的治疗采取了各种不同的治疗方式,其中游离软组织移植术被广泛应用。众所周知,腭部具有与角化龈相似的组织结构,最适合进行游离软组织移植术（口腔内自体移植）。游离软组织移植术最常用的两种术式是游离龈移植术和结缔组织移植术。尽管游离软组织移植术已经被证明在治疗膜龈异常和牙龈退缩问题方面有益,但自体移植会造成第二个创口,局部并发症的发生和术后不适的可能性增加,这会导致患者可接受程度较低。因此,本研究的目的是通过系统地评价已发表的文献,探究有或无辅助手段的情况下最有效的移植获取技术,以最大限度减少腭部供区术后并发症的发生。材料和方法:在PubMed,Cochrane图书馆和Embase数据库使用相关关键词进行仅限英语的全面检索,检索时限为2000年1月至2020年12月。纳入的研究为随机对照试验,比较在有或无辅助手段的情况下不同类型的移植获取技术,辅助材料如透明质酸,富血小板纤维蛋白,血小板浓缩液,药用植物提取物,止血胶原蛋白,氰基丙烯酸酯和低水平激光治疗。研究仅限人体试验,随访时间至少一周。通过Cochrane协作工具对选定的文献进行质量评估,以评估偏差的风险。结果:共找到来自PubMed的1428篇文献,Cochrane图书馆的27篇文献和Embase数据库的23篇文献。此外,通过筛选所选文献的目录,发现数据库中缺少3篇文献。使用endnote x7.***.1.0软件删除了重复和不相关的文献,并对38篇文献进行了全文审查。最终纳入24篇文献。研究发现,结缔组织移植术更为保守,可显著降低术后并发症的发生。此外,各种辅助材料与游离龈移植术一起使用可显著降低术后一周并发症的发生。然而,在获取移植物后用低水平激光治疗进行光生物调节,没有明显降低供区部位的术后并发症发生。结论:供区创面覆盖2mm以上的软组织或辅助材料可显著降低术后一周并发症的发生。

关键词：结缔组织移植术游离龈移植术腭部供区腭部移植腭部愈合

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The Economic Burden of Head and Neck Cancers in Denmark

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International Journal of Otolaryngology and Head & Neck Surgery 2013年第3期2卷 103-109页

作者： Jens Olsen Tine Rikke Jorgensen Niclas rubek University of Southern Denmark Odense CDenmark Incentive HolteDenmark Sanofi Pasteur MSD ApS Kongens LyngbyDenmark Rigshospitalet CopenhagenDenmark

Introduction: The incidence of head and neck cancers has increased markedly over the last decade. A Danish study of the costs of head and neck cancers has not been undertaken. Such studies have again become relevant due to the development of the HPV vaccines, as some cases are attributable to high-risk HPV 16 or 18. The objective of study was to estimate the incidence of head and neck cancers and their health care costs. Methods: Data on incidence and health care use related to head and neck cancer were obtained from Danish health care registers. New cancer patients were identified in the Danish National Cancer Register. Resource use per year in the hospital sector was estimated using data from the National Patient Register applying charges as cost estimates. Health care consumption by cancer patients was compared with that by an age- and sex-matched cohort without cancer. Results: We found that nearly 1000 new cases of oral cavity, oropharyngeal, hypopharyngeal and laryngeal cancer are diagnosed annually. In total the cost of these cancers to the Danish hospital sector constituted 31.6 million Euros per year, with the majority of costs (74%) occurring in men. The total costs associated with HPV16/18-related head and neck cancers were estimated to be 6.1 million Euros per year. Conclusion: This study provides the first Danish estimates of the costs associated with non-cervical and non-genital HPV-related cancers based on very reliable, individual-based data. It is expected that the current HPV vaccination programme will reduce this burden.

关键词： Head and Neck Cancer Cost-of-Illness Human Papilloma Virus(HPV)Infections

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Update on the aetiopathogenesis of obstructive sleep apnea:Role of inflammatory and immune mediated mechanisms

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World Journal of Clinical Cases 2024年第35期12卷 6754-6759页

作者： Deb Sanjay Nag Koshy Varghese Amlan Swain Roushan Patel Seelora Sahu merina Sam Department of Anaesthesiology Tata Main HospitalJamshedpur 831001JharkhandIndia Department of Anaesthesiology Manipal Tata Medical CollegeJamshedpur 831017India

Obstructive sleep apnea(OSA)is often a lifestyle disease associated with obesity,which is rapidly evolving as a major health concern with diverse multisystemic *** prevent and mitigate its adverse effects and reduce its burden on society,its aetiopathogeneses must be precisely *** studies focusing on the range of diverse anatomic,functional,and lifestyle factors have already been carried out to determine the possible contributory roles of these factors in ***,evidence to validate the role of inflammatory pathways and immune mechanisms in the aetiopathogeneses of OSA is being *** allows for further research and translation of such knowledge for targeted therapeutic and preventive interventions in patients with or who are at risk of developing OSA.

关键词： Sleep apnea Obstructive Polysomnography Mendelian randomization analysis Cytokines C-reactive protein

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