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Re-folded structure of syn-orogenic granitoids(Padrón dome, nW Iberia):Assessing rheological evolution of cooling continental crust in a collisional setting

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Geoscience Frontiers 2019年第2期10卷 651-669页

作者： rubén díez fernández Francisco J.rubio Pascual Luis Miguel Martín Parra departamento de Geodinámica Estratigrafía y PaleontologíaFacultad de Ciencias GeológicasUniversidad Complutense de Madrid Instituto Geológico y Minero de Espana

This contribution discusses about the rheological, kinematic and dynamic frameworks necessary to produce recumbent and upright folds from syn-orogenic granitic massifs that were formed during an early stage of magma genesis related to the onset of a migmatitic dome. Syn-kinematic granitoids occurring within the high-grade infrastructure of the Padron migmatitic dome(nW Iberia) are deformed into largescale recumbent folds(d_2) that are later affected by upright folds(d_3). Petrostructural analysis of a selected area of this dome reveals that after a period of crustal thickening(d_1), nnW-directed extensional flow gave way to recumbent folds and penetrative axial plane foliation(S_2). Superimposed subhorizontal compression resulted in upright folds(d_3). A closer view into the dynamics of the dome allows exploring the factors that may condition the nucleation of folds with contrasting geometries during progressive deformation of molten continental crust. The formation of folds affecting syn-kinematic granitoids suggests a cooling metamorphic path in migmatitic domes. Active and passive folding mechanisms require a crystallizing(cooling) magma to nucleate folds. A more competent metamorphic host inhibits fold nucleation from much less competent magmas. As it crystallizes, magma becomes more rigid(competent),and approaches viscosity values of its host. Passive folding is favored when no significant competence contrast exists between magma and host, so this folding mechanism is more likely shortly after magma genesis and emplacement. In such conditions, and under dominant subhorizontal flow accompanied by flattening(d_2),passive folding would produce isoclinal recumbent geometries. Further magma cooling introduces a shift into the rheological behavior of partially molten crust. Thereon, crystallizing magma bodies would represent significant competence contrasts relative to their host. At this point, buckling is a more likely folding mechanism, and more regular, buckle fo

关键词： Recumbent folds Migmatitic domes Partial melting Crustal-derived granitoids Orogenic collapse Variscan orogen

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Blockade of Rho-associated kinase prevents inhibition of axon regeneration of peripheral nerves induced by anti-ganglioside antibodies

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neural Regeneration Research 2024年第4期19卷 895-899页

作者： Andrés Berardo Cristian R.Bacaglio Bárbara B.Báez rubén Sambuelli Kazim A.Sheikh Pablo H.H.Lopez Laboratorio de neurobiología Instituto de Investigación Médica Mercedes y Martin Ferreyra(INIMEC)-Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET)Universidad Nacional de Córdoba departamento de Química Biológica-Centro de Investigaciones en Química Biológica de Córdoba(CIQUIBIC)-Consejo nacional de Investigaciones Cientificas y Técnicas(COnICET) Facultad de Cs.QuímicasUniversidad Nacional de Córdoba Servicio de Anatomía Patológica Clínica Universitaria Reina FabiolaUniversidad Católica de Córdoba department of neurology University of Texas Medical School at Houston

Anti-ganglioside antibodies are associated with delayed/poor clinical recovery in Guillain-Barrèsyndrome,mostly related to halted axon ***-linking of cell surface gangliosides by anti-ganglioside antibodies triggers inhibition of nerve repair in in vitro and in vivo paradigms of axon *** effects involve the activation of the small GTPase Rho A/ROCK signaling pathways,which negatively modulate growth cone cytoskeleton,similarly to well stablished inhibitors of axon regeneration described so *** aim of this work was to perform a proof of concept study to demonstrate the effectiveness of Y-27632,a selective pharmacological inhibitor of ROCK,in a mouse model of axon regeneration of peripheral nerves,where the passive immunization with a monoclonal antibody targeting gangliosides Gd1a and GT1b was previously reported to exert a potent inhibitory effect on regeneration of both myelinated and unmyelinated *** results demonstrate a differential sensitivity of myelinated and unmyelinated axons to the pro-regenerative effect of *** with a total dosage of 9 mg/kg of Y-27632 resulted in a complete prevention of anti-Gd1a/GT1b monoclonal antibody-mediated inhibition of axon regeneration of unmyelinated fibers to skin and the functional recovery of mechanical cutaneous *** contrast,the same dose showed toxic effects on the regeneration of myelinated ***,scale down of the dosage of Y-27632 to 5 mg/kg resulted in a significant although not complete recovery of regenerated myelinated axons exposed to anti-Gd1a/GT1b monoclonal antibody in the absence of toxicity in animals exposed to only ***,these findings confirm the in vivo participation of Rho A/ROCK signaling pathways in the molecular mechanisms associated with the inhibition of axon regeneration induced by anti-Gd1a/GT1b monoclonal *** findings open the possibility of therapeutic pharmacological intervention targeting Rho A/R

关键词： anti-ganglioside antibodies anti-glycan antibodies axon regeneration ganglioside Guillain-Barrésyndrome nerve repair ROCK Y-27632

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Civil Ambassador Enriches Peru-China Relations

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China news Release 2024年第2期 54-57页

作者： rubén Tang the Pontificia Catholic University of Peruand Asian Academic Institutions

Peru and China are both ancient countries with rich histories and *** immigration to Peru is the most significant in Latin *** first Chinese immigrants arrived in Peru in 1849 to seek a new future in these distant *** initially worked in the fields and later established successful businesses,making important contributions to the country's development across various sectors.

关键词： initially Latin Per

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Effects of high glucose and severe hypoxia on the biological behavior of mesenchymal stem cells at various passages

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World Journal of Stem Cells 2024年第4期16卷 434-443页

作者： Fatimah Almahasneh Ejlal Abu-El-rub Ramada R Khasawneh Rawan Almazari department of Basic Medical Sciences Faculty of MedicineYarmouk UniversityIrbid 21163Jordan

BACKGROUnd Mesenchymal stem cells(MSCs)have been extensively studied for therapeutic potential,due to their regenerative and immunomodulatory *** passage and stress factors may affect the biological characteristics of MSCs,but the details of these effects have not been recognized *** To investigate the effects of stress factors(high glucose and severe hypoxia)on the biological characteristics of MSCs at different passages,in order to optimize the therapeutic applications of *** In this study,we investigated the impact of two stress conditions;severe hypoxia and high glucose on human adipose-tissue derived MSCs(hAd-MSCs)at passages 6(P6),P8,and ***,senescence and apoptosis were evaluated measuring WST-1,senescence-associated beta-galactosidase,and annexin V,*** Cells at P6 showed decreased proliferation and increased apoptosis under conditions of high glucose and hypoxia compared to control,while the extent of senescence did not change significantly under stress *** P8 hAd-MSCs cultured in stress conditions had a significant decrease in proliferation and apoptosis and a significant increase in senescence compared to counterpart cells at *** cultured in high glucose at P10 had lower proliferation and higher senescence than their counterparts in the previous passage,while no change in apoptosis was *** the other hand,MSCs cultured under hypoxia showed decreased senescence,increased apoptosis and no significant change in proliferation when compared to the same conditions at *** These results indicate that stress factors had distinct effects on the biological processes of MSCs at different passages,and suggest that senescence may be a protective mechanism for MSCs to survive under stress conditions at higher passage numbers.

关键词： Mesenchymal stem cells High glucose Hypoxia Stressful microenvironment Serial passage Senescence Apoptosis

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Microsurgical management of radicular cyst using guided tissue regeneration technique:A case report

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World Journal of Clinical Cases 2024年第7期12卷 1346-1355页

作者： Juan Carlos Gómez Mireles Eugenia Karina Martínez Carrillo Katia Alcalá Barbosa Evangelina Gutiérrez Cortés Javier González Ramos Luis Antonio González Gómez rubén Alberto Bayardo González Sarah Monserrat Lomelí Martínez Periodontics Specialty Department of Integral Dentistry ClinicsCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico Endodontics Specialty Department of Integral Dentistry ClinicsCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico Endodontics Specialty Department of ClinicsCentro Universitario de Los AltosUniversidad de GuadalajaraTepatitlán de Morelos 47620Mexico Specialty in Oral Pathology Surgical-Stomatological DepartmentAutonomous University of GuadalajaraZapopan 45129Mexico Independent Researcher Guadalajara 44340Mexico department of Integral dentistry Clinics Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico department of Medical and Life Sciences Centro Universitario de la CiénegaUniversidad de GuadalajaraOcotlán 47810Mexico Master of Public Health Department of Well-being and Sustainable DevelopmentCentro Universitario del NorteUniversidad de GuadalajaraColotlán 46200Mexico

BACKGROUnd Radicular cyst is a lesion of odontogenic origin that arises from epithelial remains due to periapical periodontitis caused by inflammatory reactions generated at the apex of affected teeth with infected or necrotic *** therapeutic mana gement of radicular cysts is *** is only one case report of enucleation of a radicular cyst managed with microsurgery and apicoectomy,but without the use of the guided tissue regeneration(GTR)technique in the same surgical *** present clinical case describes the management of a radicular cyst with microsurgical approach,performance of an apicoectomy of the tooth associated with the entity,application of GTR technique,use of a resorbable membrane of type I bovine collagen,and bovine *** SUMMARY A 68-year-old patient presented with a radicular cyst from an upper lateral *** microsurgical management used was aimed at enucleating the chemical membrane,performing apicoectomy of the tooth along with careful and precise retrograde filling,and implementing GTR technique using a resorbable collagen membrane and bovine *** diagnosis of radicular cyst was confirmed using histopathological *** patient underwent follow-up evaluations at 10 and 30 d *** 4 months postoperative evaluation,she remained asymptomatic,and radiographs showed significant periapical healing with adequate bone *** These results suggest that microsurgical management using the GTR technique with collagen membrane and xenograft,contributes to bone regeneration.

关键词： Odontogenic cysts Apical periodontal cyst dental root end cyst Case report

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西班牙外换银行总部

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世界建筑导报 2024年第3期39卷 78-81页

作者： rubén P.Bescós(摄) 不详

地理位置:西班牙外换银行(BBVA)新总部位于首都马德里的北部城郊,该地块面向高速公路,周边的新建办公室、商业建筑以及住宅将该地块包围。当银行收购该地块时,当中八座未完工的建筑占据了地块很大一部分面积,并且更多的现有建筑将被纳... 详细信息

地理位置:西班牙外换银行(BBVA)新总部位于首都马德里的北部城郊,该地块面向高速公路,周边的新建办公室、商业建筑以及住宅将该地块包围。当银行收购该地块时,当中八座未完工的建筑占据了地块很大一部分面积,并且更多的现有建筑将被纳入新的开发项目计划中。一块地毯:一座三层楼的线性建筑建在具有一定坡度的地块上,这座建筑包含庭院、通道以及灌溉花园,像阿拉伯花园文化中的一块地毯一样。设计师选择主观化整个综合体,围绕BBVA的需求设计其功能。

关键词：现有建筑住宅三层楼高速公路庭院地毯综合体银行总部

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Therapeutic and regenerative potential of different sources of mesenchymal stem cells for cardiovascular diseases

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BIOCELL 2024年第4期48卷 559-569页

作者： YARA ALZGHOUL HALA J.BAnI ISSA AHMAd K.SAnAJLEH TAQWA ALABdUH FATIMAH RABABAH MAHA AL-SHdAIFAT EJLAL ABU-EL-rub FATIMAH ALMAHASnEH RAMAdA R.KHASAWnEH AYMAn ALZU’BI HUTHAIFA MAGABLEH department of Basic Medical Sciences Faculty of MedicineYarmouk UniversityIrbidJordan

Mesenchymalstemcells(MSCs)*** the internal cardiac microenvironment to facilitate their immunomodulatory and differentiation abilities,which are essential to restore heart *** can be easily isolated from different sources,including bone marrow,adipose tissues,umbilical cord,and dental *** from various sources differ in their regenerative and therapeutic abilities for cardiovascular *** this review,we will summarize the therapeutic potential of each MSC source for heart diseases and highlight the possible molecular mechanisms of each source to restore cardiac function.

关键词： Bone marrow mesenchymal stem cells Adipose tissue mesenchymal stem cells dental pulp stem cells Umbilical cord mesenchymal stem cells Cardiomyocytes Regeneration Myocardial infarction Mesenchymal stem cells differentiation Immunomodulation

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Immediate effect of high-intensity exercise on brain-derived neurotrophic factor in healthy young adults:A systematic review and meta-analysis

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Journal of Sport and Health Science 2022年第3期11卷 367-375页

作者： rubén fernández-Rodríguez CeliaÁlvarez-Bueno Isabel A.Martínez-Ortega Vicente Martínez-Vizcaíno Arthur Eumann Mesas Blanca notario-Pacheco Health and Social Research Center Universidad de Castilla-La ManchaCuenca 16071Spain Universidad Politécnica y Artística del Paraguay Asunción 2024Paraguay Faculty of Medicine Universidad Autónoma de ChileTalca 3460000Chile Postgraduate Program in Public Health Universidad Estadual de LondrinaLondrina 86051-990Brazil

Background Although brain-derived neurotrophic factor(BdnF)has been identified as a molecular biomarker of the neurophysiological effects induced by exercise,the acute effects of high-intensity exercise(HIE)on BdnF levels are *** study aims to estimate the immediate effects of HIE on BdnF levels in healthy young *** A systematic search was conducted in the MEdLInE,Scopus,Cochrane CEnTRAL,and SPORTdiscuss databases up to december *** controlled trials(RCTs)and non-RCTs reporting pre-post changes in serum or plasma BdnF after an acute intervention of HIE compared to a control condition were *** effect sizes(p-ESs)and 95%confidence intervals(95%CIs)were calculated for RCTs using a random effects model with Stata/SE(Version 15.0;StataCorp.,College Station,TX,USA).The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines were *** registration number:*** A total of 22 studies with 552 individuals(age range:20-31 years;59.1%male)were *** meta-analysis included 10 RCTs that reported valid outcome *** BdnF levels were observed when HIE interventions were compared with non-exercise(p-ES=0.55,95%CI:0.12-0.98;I^(2)=25.7%;n=4 studies)and light-intensity exercise(p-ES=0.78,95%CI:0.15-1.40;I^(2)=52.4%;n=3 studies)but not moderate-intensity exercise(p-ES=0.93,95%CI:-0.16 to 2.02;I^(2)=88.5%;n=4 studies)*** In comparison to non-exercise or light-intensity exercises,an immediate increase in BdnF levels may occur when young adults perform *** the benefits obtained maximizing circulating BdnF when performing HIE and its potential effects on brain health,our findings suggest that HIE could be recommended by clinicians as a useful exercise strategy to healthy adults.

关键词： Cognition Exercise neurogenesis neuroplasticity

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Scheduling multi-tenant cloud workflow tasks with resource reliability

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Science China(Information Sciences) 2022年第9期65卷 127-144页

作者： Xiaoping LI dongyuan PAn Yadi WAnG rubén RUIZ School of Computer Science and Engineering Southeast University Institute of data and Knowledge Engineering School of Computer and Information EngineeringHenan University Grupo de Sistemas de Optimización Aplicada Universitat Politècnica de València

Resource reliability is crucial in scheduling workflow instances for different tenants. Both cloud resource reliability and precedence constraints in workflows bring about great challenges for these kinds of scheduling problems. In this paper, we construct a hybrid resource reliability model which is adaptively evaluated in every time window. The objective is to optimize the QoS(quality of service) for tenants which is measured by the introduced AISE(all instance success entropy) index. A scheduling algorithmic framework is proposed for the studied workflows which consider cloud resource reliability. deadline and budget division(Bd) methods are presented to divide deadlines and budgets of instances into those of tasks. A tenant sequence method is developed to determine the order of tenants. A task allocation strategy is investigated to schedule tasks that are ready to appropriate available resources. Parameters and algorithm component candidates are statistically calibrated over a comprehensive set of random instances using the analysis of variance technique. The performance of the proposed algorithm is also evaluated in practical instances.

关键词： multi-tenancy resource reliability cloud computing scheduling

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Approach to Simplify the development of IoT Systems that Interconnect Embedded devices Using a Single Program

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Computers, Materials & Continua 2023年第11期77卷 2463-2480页

作者： Enol Matilla Blanco Jordán Pascual Espada rubén Gonzalez Crespo department of Computer Science University of OviedoOviedo33007Spain department of Computer Science and Technology Universidad Internacional de La RiojaLogroño26006Spain

Many Internet of Things(IoT)systems are based on the intercommunication among different devices and centralized ***,there are several commercial and research platforms available to simplify the creation of such IoT ***,developing these systems can often be a tedious *** address this challenge,a proposed solution involves the implementation of a unified program or script that encompasses the entire system,including IoT devices *** approach is based on an abstraction,integrating the control of the devices in a single program through a programmable ***,the proposal processes the unified script to generate the centralized system code and a controller for each *** adopting this approach,developers will be able to create IoT systems with significantly reduced implementation costs,surpassing current platforms by more than 10%.The results demonstrate that the single program approach can significantly accelerate the development of IoT systems relying on device communication.

关键词： IoT interconnected devices IoT platform programing devices devices coordination and communication

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