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neoadjuvant Therapy for Locally Advanced Renal Cell Carcinoma with Sorafenib in a Reference Center in Mexico

Surgical Science 2011年第6期2卷 356-359页

作者： Axel Costilla-Montero Benjamín Guadarrama-Benítez Marco A. Aragón-Castro Omar Morales-Ordaz Rubén Gutiérrez-Rosales Claudia Carrillo-Ponce Marcela Janka-Zires Luis Gabriel Vázquez-Lavista Departament of Urology Centro Médico ISSEMYM Toluca Toluca México

Background: neo - adjuvant therapy is usually indicated in locally advanced tumors, the aim is to decrease the tumoral burden and enhance overall survival. Renal cell carcinoma is a chemo and radio resistant neoplasm and this type of approach is not as effective as in other solid tumors. On the other hand immunotherapy is indicated in metastatic disease, demonstrating a better overall survival. Sorafenib is an antiangiogenic drug approved for locally advanced or metastatic RCC. We postulated that it can be used in a neoadjuvant way to decrease the vascularization of selected tumors. Report of the case: 57 years old male referred to our service with a right renal mass and metastatic disease to lumbar spine and suprarenal gland. He was treated with three months of sorafenib previous to the surgery. Results: The patient went into surgery three months after initiating the antiangiogenic drug, during the surgery we found less neo-formance vessels;the dissection was subjectively easier, due to peri-renal edema. The pathologic analysis of the specimen was renal cell carcinoma. Interestingly, 40% of central ischemic (coagulative) necrosis was found. Conclusion: There are no neoadjuvant drugs accepted for the treatment of renal cell carcinoma;using an antiagiogenic drug to decrease the vascular burden characteristic of this type of tumors could be a viable option in selected cases. We used a lower dose of the drug with an acceptable safety profile.

关键词： Renal Cell Carcinoma Antiagiogenic Drugs neoadyvant Therapy Sorafenib

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Effect of Kombucha and Its non-Polar Components on Morphological Aspects of the Pancreas of Diabetic Rats with Streptozotocin

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Open Journal of Veterinary Medicine 2022年第12期12卷 201-217页

作者： Guillermo nolasco-Rodríguez rubén González-Valadez Lucia García-Delgado Esther Albarrán-Rodríguez José Ricardo Cuellar-Pérez Jacinto Bañuelos-Pineda Manuel rosales-Cortés University Center Biological and Agricultural Sciences University of Guadalajara Zapopan México Department of Veterinary Medicine University Center of Biological and Agricultural Sciences University of Guadalajara Zapopan México

Objective: to evaluate the protective effect of kombucha and its components not polar, in pancreas of diabetic rats treated with streptozotocin. Material and methods: ninety-six male Wistar rats of 120 to 170 g of PC were used;four groups of 24 animals were formed: control (GC), control treatment (GCTx), kombucha treatment (GTxK) and treatment with non-polar components of kombucha (GTxCnP). Diabetes was induced in the last three groups with an intraperitoneal injection of streptozotocin at a dose of 65 mg/kg BW. At the same time, treatment was started in the different groups;GC and GCTx groups were administered, orally, 1 ml of sterile saline solution;to the GTxK group 324 mg/kg of kombucha;and to GTxCnP 0.006 mg/kg of the non-polar components. For the histopathological study, pancreas samples were obtained on days 1, 7, 14 and 21 and fixed in formalin. They were processed with the histological technique, 5-micron-thick sections were made and stained with the hematoxylin-eosin technique. Finally, the number of islets of Langerhans per field observed with the 10x objective was quantified. The results were subjected to a one-way analysis of variance and Tukey’s test (p Results: Significant changes in the number of islets were observed in histological sections of the pancreas. The groups treated with streptozotocin showed a significant decrease in the number of islets 7 days after starting treatment;Likewise, their number was lower in the GCTx group compared to the GTxK and GTxCnP groups (p ≤ 0.05). At 14 and 21 days, the lowest number of islets was maintained, although only in the GCTx and GTxK groups (p ≤ 0.05). Streptozotocin is a drug that can be used in rats to induce an experimental model of diabetes with an effect that can last up to 21 days. Conclusions: This fermented beverage and its non-polar components can be a complementary treatment alternative for diabetes mellitus, since it prevents further damage to the β cells of the pancreas and the Islets of Langerhans. Specific additional studies on the main, no

关键词： Diabetes Kombucha Rats Streptozotocin non-Polar Components of Kombucha

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Healing Effect of the Extract of Kombucha in Male Wistar Rats

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Open Journal of Veterinary Medicine 2015年第4期5卷 80-88页

作者： Manuel rosales-Cortés Esther Albarrán-Rodríguez Guillermo nolasco-Rodríguez David Avíla-Figueroa Raúl Leonel De Cervantes-Mireles rubén rosales-Ramírez Dora Manuela García-Carrasco División de Ciencias Veterinarias Centro Universitario de Ciencias Biológicas Agropecuarias Universidad de Guadalajara Guadalajara Mexico

In order to assess the impact of the early and late tissue repair of Kombucha extract on incised wounds in animal models, 24 Wistar male rats were used and divided into three groups: one of the groups received a topical cure on the wound with Brosin, and the other received the Kombucha extract. The third group did not receive any treatment, working as a control group. The objective was to evaluate and compare the Kombucha extract with a commercial healing product. Each one of the animals took a 1 cm wound in depth and length at a femur level on a side of the left thigh. The healing process was evaluated on an early and late phase by performing a morphometric and morphological analysis under the assumption of a faster recovery with the use of Kombucha. The results showed that there was a poor recovery in the control group. On the other hand, the other two groups, Brosin and Kombucha, were similar, with little inflammation and a high cell proliferation and migration along with basal array pulls of elastin and collagen which served for angiogenesis, repair and renovation of the new tissue.

关键词： Healing Kombucha Repair and Tissue Regeneration

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