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Civil Ambassador Enriches Peru-China Relations

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China news Release 2024年第2期 54-57页

作者： rubén Tang the Pontificia Catholic University of Peruand Asian Academic Institutions

Peru and China are both ancient countries with rich histories and *** immigration to Peru is the most significant in Latin *** first Chinese immigrants arrived in Peru in 1849 to seek a new future in these distant *** initially worked in the fields and later established successful businesses,making important contributions to the country's development across various sectors.

关键词： initially Latin Per

Blockade of Rho-associated kinase prevents inhibition of axon regeneration of peripheral nerves induced by anti-ganglioside antibodies

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neural Regeneration Research 2024年第4期19卷 895-899页

作者： Andrés Berardo Cristian R.Bacaglio Bárbara B.Báez rubén Sambuelli Kazim A.Sheikh Pablo H.H.Lopez Laboratorio de neurobiología Instituto de Investigación Médica Mercedes y Martin Ferreyra(INIMEC)-Consejo Nacional de Investigaciones Cientificas y Técnicas(CONICET)Universidad Nacional de Córdoba Departamento de Química Biológica-Centro de Investigaciones en Química Biológica de Córdoba(CIQUIBIC)-Consejo nacional de Investigaciones Cientificas y Técnicas(COnICET) Facultad de Cs.QuímicasUniversidad Nacional de Córdoba Servicio de Anatomía Patológica Clínica Universitaria Reina FabiolaUniversidad Católica de Córdoba Department of neurology University of Texas Medical School at Houston

Anti-ganglioside antibodies are associated with delayed/poor clinical recovery in Guillain-Barrèsyndrome,mostly related to halted axon ***-linking of cell surface gangliosides by anti-ganglioside antibodies triggers inhibition of nerve repair in in vitro and in vivo paradigms of axon *** effects involve the activation of the small GTPase Rho A/ROCK signaling pathways,which negatively modulate growth cone cytoskeleton,similarly to well stablished inhibitors of axon regeneration described so *** aim of this work was to perform a proof of concept study to demonstrate the effectiveness of Y-27632,a selective pharmacological inhibitor of ROCK,in a mouse model of axon regeneration of peripheral nerves,where the passive immunization with a monoclonal antibody targeting gangliosides GD1a and GT1b was previously reported to exert a potent inhibitory effect on regeneration of both myelinated and unmyelinated *** results demonstrate a differential sensitivity of myelinated and unmyelinated axons to the pro-regenerative effect of *** with a total dosage of 9 mg/kg of Y-27632 resulted in a complete prevention of anti-GD1a/GT1b monoclonal antibody-mediated inhibition of axon regeneration of unmyelinated fibers to skin and the functional recovery of mechanical cutaneous *** contrast,the same dose showed toxic effects on the regeneration of myelinated ***,scale down of the dosage of Y-27632 to 5 mg/kg resulted in a significant although not complete recovery of regenerated myelinated axons exposed to anti-GD1a/GT1b monoclonal antibody in the absence of toxicity in animals exposed to only ***,these findings confirm the in vivo participation of Rho A/ROCK signaling pathways in the molecular mechanisms associated with the inhibition of axon regeneration induced by anti-GD1a/GT1b monoclonal *** findings open the possibility of therapeutic pharmacological intervention targeting Rho A/R

关键词： anti-ganglioside antibodies anti-glycan antibodies axon regeneration ganglioside Guillain-Barrésyndrome nerve repair ROCK Y-27632

High-repetition-rate source of nanosecond duration kA-current pulses driven by relativistic laser pulses

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High Power Laser Science and Engineering 2024年第3期12卷 106-115页

作者： Michael Ehret Jakub Cikhardt Philip Wykeham Bradford Iuliana-Mariana Vladisavlevici Tomas Burian Diego de Luis Jose Luis Henares rubén Hernández Martín Jon Imanol Apiñaniz Roberto Lera JoséAntonio Pérez-Hernández João Jorge Santos Giancarlo Gatti Centro de Láseres Pulsados(CLPU) VillamayorSpain Czech Technical University in Prague Faculty of Electrical EngineeringPragueCzech Republic Univ.Bordeaux-CnRS-CEA Centre Lasers Intenses et Applications(CELIA)UMR 5107TalenceFrance Department of Radiation and Chemical Physics FZU-Institute of Physics of the Czech Academy of SciencesPragueCzech Republic

We report the first high-repetition-rate generation and simultaneous characterization of nanosecond-scale return currents of kA-magnitude issued by the polarization of a target irradiated with a PW-class high-repetition-rate titanium:sapphire laser system at relativistic *** present experimental results obtained with the VEGA-3 laser at intensities from5×10^(18)to 1.3×10^(20)W cm^(-2).A non-invasive inductive return-current monitor is adopted to measure the derivative of return currents of the order of kA ns-1and analysis methodology is developed to derive return *** compare the current for copper,aluminium and Kapton targets at different laser *** data show the stable production of current peaks and clear prospects for the tailoring of the pulse shape,which is promising for future applications in highenergy-density science,for example,electromagnetic interference stress tests,high-voltage pulse response measurements and charged particle beam *** compare the target discharge of the order of hundreds of nC with theoretical predictions and a good agreement is found.

关键词： current pulses electromagnetic pulse application high-power laser relativistic laser plasma

Effects of high glucose and severe hypoxia on the biological behavior of mesenchymal stem cells at various passages

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World Journal of Stem Cells 2024年第4期16卷 434-443页

作者： Fatimah Almahasneh Ejlal Abu-El-rub Ramada R Khasawneh Rawan Almazari Department of Basic Medical Sciences Faculty of MedicineYarmouk UniversityIrbid 21163Jordan

BACKGROUnD Mesenchymal stem cells(MSCs)have been extensively studied for therapeutic potential,due to their regenerative and immunomodulatory *** passage and stress factors may affect the biological characteristics of MSCs,but the details of these effects have not been recognized *** To investigate the effects of stress factors(high glucose and severe hypoxia)on the biological characteristics of MSCs at different passages,in order to optimize the therapeutic applications of *** In this study,we investigated the impact of two stress conditions;severe hypoxia and high glucose on human adipose-tissue derived MSCs(hAD-MSCs)at passages 6(P6),P8,and ***,senescence and apoptosis were evaluated measuring WST-1,senescence-associated beta-galactosidase,and annexin V,*** Cells at P6 showed decreased proliferation and increased apoptosis under conditions of high glucose and hypoxia compared to control,while the extent of senescence did not change significantly under stress *** P8 hAD-MSCs cultured in stress conditions had a significant decrease in proliferation and apoptosis and a significant increase in senescence compared to counterpart cells at *** cultured in high glucose at P10 had lower proliferation and higher senescence than their counterparts in the previous passage,while no change in apoptosis was *** the other hand,MSCs cultured under hypoxia showed decreased senescence,increased apoptosis and no significant change in proliferation when compared to the same conditions at *** These results indicate that stress factors had distinct effects on the biological processes of MSCs at different passages,and suggest that senescence may be a protective mechanism for MSCs to survive under stress conditions at higher passage numbers.

关键词： Mesenchymal stem cells High glucose Hypoxia Stressful microenvironment Serial passage Senescence Apoptosis

Microsurgical management of radicular cyst using guided tissue regeneration technique:A case report

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World Journal of Clinical Cases 2024年第7期12卷 1346-1355页

作者： Juan Carlos Gómez Mireles Eugenia Karina Martínez Carrillo Katia Alcalá Barbosa Evangelina Gutiérrez Cortés Javier González Ramos Luis Antonio González Gómez rubén Alberto Bayardo González Sarah Monserrat Lomelí Martínez Periodontics Specialty Department of Integral Dentistry ClinicsCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico Endodontics Specialty Department of Integral Dentistry ClinicsCentro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico Endodontics Specialty Department of ClinicsCentro Universitario de Los AltosUniversidad de GuadalajaraTepatitlán de Morelos 47620Mexico Specialty in Oral Pathology Surgical-Stomatological DepartmentAutonomous University of GuadalajaraZapopan 45129Mexico Independent Researcher Guadalajara 44340Mexico Department of Integral Dentistry Clinics Centro Universitario de Ciencias de la SaludUniversidad de GuadalajaraGuadalajara 44340Mexico Department of Medical and Life Sciences Centro Universitario de la CiénegaUniversidad de GuadalajaraOcotlán 47810Mexico Master of Public Health Department of Well-being and Sustainable DevelopmentCentro Universitario del NorteUniversidad de GuadalajaraColotlán 46200Mexico

BACKGROUnD Radicular cyst is a lesion of odontogenic origin that arises from epithelial remains due to periapical periodontitis caused by inflammatory reactions generated at the apex of affected teeth with infected or necrotic *** therapeutic mana gement of radicular cysts is *** is only one case report of enucleation of a radicular cyst managed with microsurgery and apicoectomy,but without the use of the guided tissue regeneration(GTR)technique in the same surgical *** present clinical case describes the management of a radicular cyst with microsurgical approach,performance of an apicoectomy of the tooth associated with the entity,application of GTR technique,use of a resorbable membrane of type I bovine collagen,and bovine *** SUMMARY A 68-year-old patient presented with a radicular cyst from an upper lateral *** microsurgical management used was aimed at enucleating the chemical membrane,performing apicoectomy of the tooth along with careful and precise retrograde filling,and implementing GTR technique using a resorbable collagen membrane and bovine *** diagnosis of radicular cyst was confirmed using histopathological *** patient underwent follow-up evaluations at 10 and 30 d *** 4 months postoperative evaluation,she remained asymptomatic,and radiographs showed significant periapical healing with adequate bone *** These results suggest that microsurgical management using the GTR technique with collagen membrane and xenograft,contributes to bone regeneration.

关键词： Odontogenic cysts Apical periodontal cyst Dental root end cyst Case report

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西班牙外换银行总部

世界建筑导报 2024年第3期39卷 78-81页

作者： rubén P.Bescós(摄) 不详

地理位置:西班牙外换银行(BBVA)新总部位于首都马德里的北部城郊,该地块面向高速公路,周边的新建办公室、商业建筑以及住宅将该地块包围。当银行收购该地块时,当中八座未完工的建筑占据了地块很大一部分面积,并且更多的现有建筑将被纳... 详细信息

地理位置:西班牙外换银行(BBVA)新总部位于首都马德里的北部城郊,该地块面向高速公路,周边的新建办公室、商业建筑以及住宅将该地块包围。当银行收购该地块时,当中八座未完工的建筑占据了地块很大一部分面积,并且更多的现有建筑将被纳入新的开发项目计划中。一块地毯:一座三层楼的线性建筑建在具有一定坡度的地块上,这座建筑包含庭院、通道以及灌溉花园,像阿拉伯花园文化中的一块地毯一样。设计师选择主观化整个综合体,围绕BBVA的需求设计其功能。

关键词：现有建筑住宅三层楼高速公路庭院地毯综合体银行总部

Therapeutic and regenerative potential of different sources of mesenchymal stem cells for cardiovascular diseases

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BIOCELL 2024年第4期48卷 559-569页

作者： YARA ALZGHOUL HALA J.BAnI ISSA AHMAD K.SAnAJLEH TAQWA ALABDUH FATIMAH RABABAH MAHA AL-SHDAIFAT EJLAL ABU-EL-rub FATIMAH ALMAHASnEH RAMADA R.KHASAWnEH AYMAn ALZU’BI HUTHAIFA MAGABLEH Department of Basic Medical Sciences Faculty of MedicineYarmouk UniversityIrbidJordan

Mesenchymalstemcells(MSCs)*** the internal cardiac microenvironment to facilitate their immunomodulatory and differentiation abilities,which are essential to restore heart *** can be easily isolated from different sources,including bone marrow,adipose tissues,umbilical cord,and dental *** from various sources differ in their regenerative and therapeutic abilities for cardiovascular *** this review,we will summarize the therapeutic potential of each MSC source for heart diseases and highlight the possible molecular mechanisms of each source to restore cardiac function.

关键词： Bone marrow mesenchymal stem cells Adipose tissue mesenchymal stem cells Dental pulp stem cells Umbilical cord mesenchymal stem cells Cardiomyocytes Regeneration Myocardial infarction Mesenchymal stem cells Differentiation Immunomodulation

The digital‘connected’earth:open technology for providing location-based services on degraded communication environments

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International Journal of Digital Earth 2018年第8期11卷 761-782页

作者： Ramón Piedrafita rubén Béjar rubén Blasco Alvaro Marco F.Javier Zarazaga-Soria Aragón Aragón Institute of Engineering Research Universidad de ZaragozaZaragozaSpain

n the current world,it is easy to listen that everybody and everything is *** this connected world,the concept of location-based services has grown in order to provide digital services in everyplace and at every ***,this is not 100%true because the connection is not guaranteed for many people and in many *** are the Degraded Communications Environments(DCE),environments where the availability of high-speed communications is not guaranteed in at least the 75%of the *** paper works over the experience of a previous work in developing light protocols that do not need broadband for *** work provides an extension of these protocols for the inclusion of mobile devices as elements of the communication process and a set of libraries to allow the development of applications in *** work done has involved the development of two frameworks:an Android framework that makes the incorporation of Android devices easier and a server-based framework that provides the server side for the development of the referred applications.A use case that uses these two frameworks has been ***,all technology developed is available throw a public Git repository.

关键词： Location-based services degraded communications environments open technology

Master of one trade:Arbutus unedo relies on plasticity to persist under habitats differing in water availability

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Journal of Plant Ecology 2017年第5期10卷 869-881页

作者： Xabier Santiso rubén Retuerto Área de Ecología Facultad de BiologíaCampus VidaUniversidade de Santiago de Compostela15782 Santiago de CompostelaSpain

Aims the limited water supply in the Mediterranean Basin will be exacerbated in the immediate future as result of severe drought ***,the study of the intraspecific variability in functional traits of plant species is important,because such variability modulates species’***,we aimed to analyse the variability in plasticity of physiological and structural traits of Arbutus unedo *** response to water availability and to determine whether the levels of phenotypic plasticity varied in plants of different *** We kept two sets of plants under contrasted water regimes(high water and low water)and calculated a phenotypic plasticity index to determine the plastic response to water *** compared the response among kind of traits and *** also per-formed analysis of variance to assess the trait and provenance *** Findings We found that biomass and key physiological traits decrease under drought conditions,while the water use efficiency *** differed between groups of traits,being higher in structural and gas exchange parameters,but the provenance did not account for signifi-cant variation in *** has evolved a‘good saver’strat-egy,involving decreasing growth and water use-when this resource is unavailable-together with the dissipation of excess of radiation that it cannot *** homogeneous response between provenances may be the result of a canalization *** strategy,based on a high degree of plasticity,is a probable determining factor in the success of the species over its wide range of environmental conditions and will be critical to withstand the ongoing environmental changes.

关键词： adaptation canalization contrasted provenances drought global change phenotypic plasticity