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Experimental study on Engineering Behavior of solidified soil for scour Repair and Protection

China Ocean Engineering 2024年第4期38卷 625-635页

作者： WU Xiao-ni Li ru-yu sHU Jian TANG Chao CHEN jin-jian WANG Hui-li JiANG Hai-li WANG Xiao state Key Laboratory of Ocean Engineering Department of Civil EngineeringShanghai Jiao Tong UniversityShanghai 200240China shanghai Road and Bridge Group Co. Ltd.Shanghai 200433China shanghai Engineering Research Center of Urban infrastructure Renewal Shanghai 200032China Jiangsu Kunze Technology Co. Ltd.Nanjing 210000China

A new scour countermeasure using solidified slurry for offshore foundation has been proposed *** solidified slurry is pumped to seabed area around foundation for scour protection or pumped into the developed scour holes for scour repair as the fluidized material solidifies *** the pumping operation and solidification,the engineering behaviors of solidified slurry require to be considered synthetically for the reliable application in scour repair and protection of ocean engineering such as the pumpability related flow value,flow diffusion behavior related rheological property,anti-scour performance related retention rate in solidification and bearing capacity related strength property after *** this study,a series of laboratory tests are conducted to investigate the effects of mix proportion(initial water content and binder content)on the flow value,rheological properties,density,retention rate of solidified slurry and unconfined compressive strength(UCs).The results reveal that the flow value increases with the water content and decreases with the binder *** the solidified slurry exhibits Bingham plastic behavior when the shear rate is larger than 5 s^(-1).The Bingham model has been employed to fit the rheology test results,and empirical formulas for obtaining the density,yield stress and viscosity are established,providing scientific support for the numerical assessment of flow and diffusion of solidified *** rate of solidified slurry decreases with the water flow velocity and flow value,which means the pumpability of solidified slurry is contrary to anti-scour *** unconfined compressive strength after solidification reduces as the water content increases and binder content decreases.A design and application procedure of solidified soil for scour repair and protection is also proposed for engineering reference.

关键词： scour repair and protection solidified soil pumpability strength flow properties anti-scour performance

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inhibiting MMP13 Attenuates Deep Vein Thrombosis in a Mouse Model by Reducing the Expression of Pdpn

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Current Medical science 2024年第2期44卷 369-379页

作者： Ji LUO jin ZHOU jing-zeng LUO Hai-long WANG Xue-ling ZHAO ru-dan ZHOU Department of intensive Care Unit The First People's Hospital of ZiyangZiyang 641300China Department of Orthopedics Kunming Medical University Second Affiliated HospitalKunming 650033China Department of Orthopedics Kunming Medical University First Affiliated HospitalKunming 650032China Department of Orthopedics The Third People's Hospital of Yunnan ProvinceKunming 650200China

Objective:Matrix metalloproteinase 13(MMP13)is an extracellular matrix protease that affects the progression of atherosclerotic plaques and arterial thrombi by degrading collagens,modifying protein structures and regulating inflammatory responses,but its role in deep vein thrombosis(DVT)has not been *** purpose of this study was to investigate the potential effects of MMP13 and MMP13-related genes on the formation of ***:We altered the expression level of MMP13 in vivo and conducted a transcriptome study to examine the expression and relationship between MMP13 and MMP13-related genes in a mouse model of *** screening genes possibly related to MMP13 in DVT mice,the expression levels of candidate genes in human umbilical vein endothelial cells(HUVECs)and the venous wall were *** effect of MMP13 on platelet aggregation in HUVECs was investigated in ***:Among the differentially expressed genes,interleukin 1 beta,podoplanin(Pdpn),and factor Viii von Willebrand factor(F8VWF)were selected for analysis in *** MMP13 was inhibited,the expression level of PDPN decreased significantly in *** HUVECs,overexpression of MMP13 led to an increase in the expression level of PDPN and induced platelet aggregation,while transfection of PDPN-siRNA weakened the ability of MMP13 to increase platelet ***:inhibiting the expression of MMP13 could reduce the burden of DVT in *** mechanism involves downregulating the expression of Pdpn through MMP13,which could provide a novel gene target for DVT diagnosis and treatment.

关键词： deep vein thrombosis matrix metalloproteinase 13 podoplanin

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Predictive value of intracranial high-density areas in neurological function

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World Journal of Psychiatry 2024年第7期14卷 1080-1086页

作者： Zhi-Juan Lu jin-Xing Lai jing-ru Huang shu-Hua Xie Zhao-Hui Lai Department of Neurology Ganzhou People’s HospitalGanzhou 341000Jiangxi ProvinceChina

BACKGROUND intracranial high-density areas(HDAs)have attracted considerable attention for predicting clinical outcomes;however,whether HDAs predict worse neurological function and mental health remains controversial and unclear,which requires further *** this prospective study,96 patients with acute ischemic stroke(Ais)who accepted endovascular mechanical thrombectomy(EMT)were *** enrolled patients underwent cranial computed tomography(CT)examination within 24 hours after *** data in terms of National institutes of Health stroke scale(NiHss),the 3-month modified Rankin scale(mRs),self-rating depression scale(sDs),and self-rating anxiety scale(sAs)scores were collected and compared between patients with HDAs and non-HDAs and between patients with good and poor clinical *** to patients without HDAs,patients with HDAs presented severe neurological deficits(admission NiHss score:18±3 vs 19±4),were more likely to have post-stroke disabilities(mRss 62%),and suffered more severe depression(sDs score:58±16 vs 64±13)and anxiety disorder(sAs score:52±8 vs 59±10).Compared to patients with a good prognosis,patients with a poor prognosis presented severe neurological deficits(admission NiHss score:17±4 vs 20±3),were more likely to have HDAs on CT images(64%vs 33%),and suffered more severe depression(sDs score:55±19 vs 65±11)and anxiety(sAs score:50±8 vs 58±12).Multivariate analysis revealed that HDAs were independent nega-tive prognostic *** in conclusion,HDAs on CT images predicted poor prognosis and severe depressive and anxiety symptoms in patients with Ais who underwent EMT.

关键词： Acute ischemic stroke Endovascular mechanical thrombectomy High-density areas Depressive disorder Anxiety disorder

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Cretaceous crown male ant reveals the rise of modern lineages

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Zoological Research 2024年第5期45卷 983-989页

作者： Qiong Wu Alexander G.Radchenko Michael s.Engel Xiao-Qin Li Hong-ru Yang Xing-ru Li Chung-Kun shih Dong Ren Tai-Ping Gao College of Life sciences Capital Normal UniversityBeijing 100048China i.i.schmalhausen institute of Zoology NAS of UkraineKiev 01054Ukraine Division of invertebrate Zoology American Museum of Natural HistoryNew York 10024-5192USA Facultad de Ciencias Biológicas Universidad Nacional Mayor de San MarcosLima 11-0058Perú Departamento de Entomología Museo de Historia NaturalUniversidad Nacional Mayor de San MarcosLima 15072Perú Department of Chemistry Analytical and Testing CenterCapital Normal UniversityBeijing 100048China Department of Paleobiology National Museum of Natural HistorySmithsonian InstitutionWashington DC 20013-7012USA

Most described Mesozoic ants belong to stem groups that existed only during the Cretaceous ***,the earliest known crown ants were dated to the Turonian(Late Cretaceous,ca.94-90 million years ago(Ma))deposits found in the UsA,Kazakhstan,and ***,the recent discovery of an alate male ant in Kachin amber from the earliest Cenomanian(ca.99 Ma),representing a new genus and species,Antiquiformica alata,revises the narrative on ant *** can be distinctly differentiated from all known male stem ants by its geniculate antennae with elongated scape,extending far beyond the occipital margin of the head and half the length of the funiculus,as well as its partly reduced forewing ***,the combination of a one-segmented waist with a well-developed node,elongated scape extending beyond the occipital margin,and reduced forewing venation,particularly the completely reduced m-cu and rs-m crossveins and absence of rm and mcu closed cells,firmly places the fossil within the extant subfamily *** transform infrared spectroscopy(FTiR)confirmed that the amber containing Antiquiformica alata originated from the Kachin mines in *** discovery significantly revises our understanding of the early evolution of *** presence of Antiquiformica in Cenomanian amber indicates that the subfamily Formicinae emerged at least by the start of the Late Cretaceous,with crown ants likely originating earlier during the earliest Cretaceous or possibly the Late Jurassic,although paleontological evidence is lacking to support the latter hypothesis.

关键词： Formicidae Formicinae Morphology Taxonomy Antiquiformica alata Paleontology Kachin amber

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Kinetics of and solvent effects on photodegradation of hexachlorobenzene(HCB)and endosulfan(endosulfan i and endosulfan ii)in solution

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Emerging Contaminants 2024年第3期10卷 400-408页

作者： Ye Wu Yan Lv Jun jin Yuhao Fan ru Li Junsong Bao Junjie Jiang Jiali Han Ying Wang College of Life and Environmental sciences Minzu University of ChinaBeijing100081China Engineering Research Center of Food Environment and Public Health Beijing100081China state Key Laboratory of Water Environment simulation School of EnvironmentBeijing Normal UniversityBeijing100875China

Organochlorine pesticides are chlorinated hydrocarbon *** production and use of organochlorine pesticides have been restricted around the world because they are persistent and toxic and able to undergo long-range transport and *** is necessary to develop efficient techniques for eliminating organochlorine pesticides from environmental media,and we also need to better understand how these techniques *** how organochlorine herbicides behave in various environmental settings is very *** looked on the photodegradation of endosulfan(endosulfan i and ii)and hexachlorobenzene(HCB),two common organochlorine *** were conducted with pesticides at different concentrations,dissolved in various organic solvents,and exposed to light at different *** Functional Theory(DFT)was employed to study solvent *** kinetics followed first-order *** pesticides dissolved in various organic solvents showed a decrease in their degradation rates in the following order:toluene>acetone>*** was discovered that there was a good chance the Cl atoms on the benzene ring in HCB would be eliminated through nucleophilic *** was discovered that endosulfan breaks preferentially at the s=O double *** findings will aid in the development of strategies for successfully eliminating organochlorine pesticides from environmental media by aiding in the prediction and assessment of the photochemical behaviors of the pesticides under various environmental circumstances.

关键词： Organochlorine pesticides Degradation characteristics Density functional calculation solvent effect

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One-step controlled electrodeposition nickel sulfides heterointerfaces favoring the desorption of hydroxyl groups for efficient hydrogen generation

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Rare Metals 2024年第9期43卷 4377-4386页

作者： ru-Chun Li Xin-Yue Zhang Ze-Yue Qu Feng-Yi Liu Quan-Qing Xu Zhao-Xia Hu jing-Wei Li Mohamed-Nawfal Ghazzal jin-Li Yu Faculty of Chemistry and Chemical Engineering Yunnan Normal UniversityKunming 650500China Foshan Gaoke Hechuang Technology Co. Ltd.Foshan 528200China school of Chemistry and Chemical Engineering Guangzhou UniversityGuangzhou 510006China Universite´Paris-saclay UMR 8000 CNRSInstitut de Chimie PhysiqueOrsay 91405France Department of Chemistry City University of Hong KongHong Kong 999077China

The heterointerface engineering involving different components or phases represents a desirable strategy for enhancing the sluggish kinetics of hydrogen evolution reaction(HER).However,constructing desired heterointerfaces and elucidating the reaction mechanisms on the interface remains a considerable *** this work,we propose a straightforward electrochemical synthesis strategy to prepare the nickel sulfide-based heterointerfaces for *** mechanism of electrochemical synthesis is revealed,wherein metal-thiourea species can be formed at the cathode potential and subsequently oxidized to nickel sulfides at the anode *** this mechanism,a range of nickel sulfides,including Nis,Ni_(3)s_(2)/Nis,Ni/Ni_(3)s_(2)and Ni_(3)s_(2),have been successfully synthesized by tuning the potential range of cyclic *** these,the obtained Ni_(3)s_(2)/Nis@CC(CC:carbon cloth)exhibits the smallest overpotential of84 mV at 10 mA·cm^(-2)and high *** calculations further reveal that the combination of Nis and Ni_(3)s_(2)induces electron redistribution at the interface,and thus the Volmer process is effectively promoted with faster water dissociation and OH desorption ***,the simplicity method coupled with a clear synthesis mechanism and outstanding HER performance highlights its promising potential for practical applications.

关键词： Hydrogen evolution reaction Heterointerfaces OH desorption kinetics Electrochemical synthesis

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integral precession calibration method of PiGA on linear vibration table

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Chinese Journal of Aeronautics 2024年第3期37卷 219-236页

作者： Chuang sUN shun-qing REN Jun-wei CAO ru HUO Department of Automation Tsinghua UniversityBeijing 100084China school of Astronautics Harbin Institute of TechnologyHarbin 150001China Beijing National Research Center for information science and Technology Tsinghua UniversityBeijing 100084China Faculty of information technology Beijing University of TechnologyBeijing 100124China

Linear vibration table can provide harmonic accelerations to excite the nonlinear error terms of Pendulous integrating Gyro Accelerometer(PiGA).integral precession calibration method is proposed to calibrate PiGA on a linear vibration table in this *** on the precise expressions of PiGA’s inputs,the error calibration model of PiGA is *** angular velocity errors of PiGA are suppressed by integer periodic precession and the errors caused by non-integer periods vibrating are *** complete calibration process,including planning,preparation,PiGA testing,and coefficient identification,is designed to optimize the test operations and evaluate the calibration *** effect of the main errors on calibration uncertainty is analyzed and the relative sensitivity function is proposed to further optimize the test *** and simulation results verify that the proposed 10-position calibration method can improve calibration uncertainties after compensating for the related *** order of calibration uncertainties of the second-and third-order coefficients are decreased to 10^(-8)(rad.s^(-1))/g^(2)and 10^(-8)(rad.s^(-1))/g3,*** with the other two classical calibration methods,the calibration uncertainties of PiGA’s nonlinear error coefficients can be effectively reduced and the proportional residual errors are decreased less than 3×10-6(rad.s^(-1))/g by using the proposed calibration method.

关键词： PiGA Linear vibration table Vibration measurement Calibration Error analysis Uncertainty analysis

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Heavy neutral leptons in gauged U(1)Lμ-Lτ at muon collider

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Chinese Physics C 2024年第9期48卷 36-49页

作者： ru-Yi He Jia-Qi Huang jin-Yuan Xu Fa-Xin Yang Zhi-Long Han Feng-Lan shao school of Physics and Technology University of JinanJinan 250022China school of Physics and Physical Engineering Qufu Normal UniversityQufu 273165China

Heavy neutral leptons N are the most appealing candidates to generate tiny neutrino *** studied the signature of heavy neutral leptons in gauged U(1)Lμ-Lτ at a muon *** under the U(1)Lμ-Lτ symmetry,the heavy neutral leptons can be pair produced via the new gauge boson Z' at the muon collider as μ^(+)μ^(-)→Z′*→NN AND μ^(+)μ^(-)→Z′(*)γ→NNγ.We then performed a detailed analysis on the lepton number violation signature μ^(+)μ^(-)→NN→μ^(±)μ^(±)W■W■ and μ^(+)μ^(-)→NN→μ^(±)μ^(±)W■W■γ at the 3 TeV muon collider,where the hadronic decays of W boson are treated as fat-jets *** lepton number violation signatures have quite clean backgrounds at the muon *** simulation shows that a wide range of viable parameter space is within the reach of the 3 TeV muon *** instance,with new gauge coupling g'=0.6 and an integrated luminosity of 1000 fb^(-1),the μ^(±)μ^(±)JJ signal could probe m_(Z′)■13 ***,if the gauge boson mass satisfies 2m_(N)s,the μ^(±)μ^(±)JJγ signature would be more promising than the μ^(±)μ^(±)JJ signature.

关键词： heavy neutral leptons gauged U(1)_(Lμ-Lτ) muon collider lepton number violation

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Chalcone derivatives as novel,potent and selective inhibitors against human Notum:structure–activity relationships and biological evaluations

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Chinese Chemical Letters 2024年第3期35卷 321-325页

作者： jin-Hui shi Bei Zhao Li-Lin song Yu-Qing song Meng-ru sun Tian Tian Hong-Yu Chen Yun-Qing song Jian-Ming sun Guang-Bo Ge shanghai Frontiers science Center of TCM Chemical Biology institute of interdisciplinary integrative Medicine Research Shanghai University of Traditional Chinese MedicineShanghai 201203China Dalian Engineering Research Center for Carbohydrate Agricultural Preparations Liaoning Provincial Key Laboratory of CarbohydratesDalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023China seventh People's Hospital of shanghai University of Traditional Chinese Medicine Shanghai 200137China

Human Notum(hNotum)inhibitors could be used for treating Wnt signalling-associated diseases including colorectal ***,two series of chalcone derivatives were designed and synthesized aiming to find selective and potent hNotum ***–activity relationship(sAR)studies showed that 2-methoxyl and 5-bromine substitutions on A-ring significantly enhanced anti-hNotum effect,while 4’-ethoxyl and 3’-alkyl substitutions on B-ring were beneficial for hNotum *** all tested chalcones,B11 displayed the most potent anti-Notum effect(iC_(50)=3.6 nmol/L),good selectivity,excellent chemical stability and suitable metabolic *** investigations showed that B11 acted as a competitive inhibitor of hNotum,while this agent(5μmol/L)significantly weaken the migration abilities of colorectal cancer ***,this study deciphers the sARs of chalcones as hNotum inhibitors and reports a novel and potent hNotum inhibitor with the anti-migration effect on colorectal cancer cells,which offers a promising lead compound to develop novel anti-cancer agents.

关键词： Human notum(hNotum) Chalcone Computer-assisted drug discovery structure–activity relationship(sAR) Anti-colorectal cancer agent

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Hole mobility enhancement in monolayer Wse2 p-type transistors through molecular doping

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science China(information sciences) 2024年第6期67卷 207-213页

作者： shiyuan LiU Xiong XiONG Xin WANG Xinhang sHi ru HUANG Yanqing WU school of integrated Circuits and Beijing Advanced innovation Center for integrated Circuits Peking University Wuhan National High Magnetic Field Center and school of integrated Circuits Huazhong University of Science and Technology

Two-dimensional （2D） transition metal dichalcogenide （TMDC） semiconductor materials exhibit extraordinary electrical properties,holding promise for the realization of next-generation complementary metal-oxide-semiconductor （CMOs） devices at ultimate ***,constrained by effective device doping strategies,the hole mobility and device performance of tungsten diselenide （Wse2） p-type transistors,especially monolayer chemical vapor deposition （CVD）-grown Wse2,have not met *** this paper,an effective performance enhancement of monolayer Wse2p-type transistor was achieved through a molecular doping *** monolayer Wse2directly on siO2back-gated substrates and leveraging energy band alignment design,4-nitrobenzenediazonium tetrafluoroborate （4-NBD） molecular dopant with a concentration of 10 m M was utilized to modulate the Fermi level position of monolayer Wse2for hole *** devices demonstrated a more than 98%increase in hole mobility,reaching up to 97 cm2·V-1·s-1while maintaining the current on/off ratio of *** p-type Wse2transistors with 1μm channel length exhibit a high drive current surpassing 176μA·μm-1,exceeding previous CVD-Wse2devices with similar channel *** straightforward and effective approach to improving the electrical performance of Wse2transistors paves the way for advanced logic technologies based on transition metal dichalcogenide semiconductors.

关键词： CVD-grown Wse$_2$ molecular doping 4-NBD p-type transistors hole mobility

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