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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu Xiao-li li Xiao-Ting Sun li-Ting Wang Xia Wu ling-Jie Zhu Xiao-Jia Yang Qian-ru.He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constru.ted a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

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Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu Guan Mengting Qiu Na li Zhengxiang Zhou ru.Ye liyan Zhong Yashuang Xu Junhui Ren Yi liang Xiaomei Shao Jianqiao Fang Junfan Fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and dru. development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

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新质生产力的运行机理、生成逻辑与模式建构——基于生产力与生产关系辩证统一的视角

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新疆师范大学学报（哲学社会科学版） 2025年第1期46卷 89-97页

作者：李勇坚张海汝中国社会科学院财经战略研究院北京100005 浙江财经大学浙江杭州310018 江苏省社会科学院经济研究所江苏南京210004

新质生产力是创新发挥主导作用,摆脱传统经济增长方式、生产力发展路径,具有高科技、高效能、高质量特征,符合新发展理念的先进生产力质态。纵观三次科技革命变革生产力的历程,新质生产力的产生和发展是生产力与生产关系相互作用的结果... 详细信息

新质生产力是创新发挥主导作用,摆脱传统经济增长方式、生产力发展路径,具有高科技、高效能、高质量特征,符合新发展理念的先进生产力质态。纵观三次科技革命变革生产力的历程,新质生产力的产生和发展是生产力与生产关系相互作用的结果,具有生产力与生产关系的双重内涵和发展要求。新质生产力以新型劳动者、新型劳动资料、新型劳动对象及其组合模式和新型生产关系为架构要素与发展基础,其生成逻辑与运行机理是由技术革命性突破引发,在催生新型生产力要素、新型要素组合模式的基础上促使与新质生产力相适应的新型生产关系变革形成,新型生产关系的反作用促进新质生产力进一步生成的过程。发展新质生产力要以实施创新驱动战略、加快产业深度转型、构建要素生态系统和全面深化改革为基本模式和关键路径。亟须加快实现高水平科技自立自强,加快技术革命性创新;促进产业深度转型,构建现代化产业体系;促进生产要素创新配置,构建新质生产要素系统;全面深化改革,加快建立健全与新质生产力相适应的新型生产关系,促进新质生产力加快形成发展。

关键词：新质生产力新型生产关系技术革命性突破全面深化改革

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Analysis on MAV/UAV cooperative combat based on complex network

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Defence Technology（防务技术） 2020年第1期16卷 150-157页

作者： Jie-ru.Fan Dong-guang li ru.peng li Yue Wang Beijing Institute of Technology BeijingChina Beijing Electro-mechanical Engineering Institute BeijingChina Beijing Institute of Electronic System Engineering BeijingChina

A formation model of manned/unmanned aerial vehicle(MAV/UAV) collaborative combat can qualitatively and quantitatively analyze the synergistic ***,there is currently no effective and appropriate model constru.tion method or theory,and research in the field of collaborative capability evaluation is basically *** to the actual conditions of cooperative operations,a new MAV/UAV collaborative combat network model constru.tion method based on a complex network is *** analyzing the characteristic parameters of the abstract network,the index system and complex network are ***,a method for evaluating the synergistic effect of the cooperative combat network is *** method provides assistance for the verification and evaluation of MAV/UAV collaborative combat.

关键词： Complex network Stochastic network MAV/UAV collaborative combat Evaluation

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Probing granular inhomogeneity of a particle-emitting source by imaging two-pion Bose–Einstein correlations

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Nuclear Science and Techniques 2021年第2期32卷 81-89页

作者： li-Ya li Peng ru.Ying Hu School of Mathematics and Economics Hubei University of EducationWuhan 430205HubeiChina Guangdong Provincial Key Laboratory of Nuclear Science Institute of Quantum MatterSouth China Normal UniversityGuangzhou 510006China

Using the source imaging technique in two-pion interferometry,we study the image of the hydrodynamic particle-emitting source with the HIJING initial conditions for relativistic heavy-ion collisions on an event-by-event *** is shown that the initial-state fluctuations may give rise to bumpy stru.tures of the medium during hydrodynamical evolution,which affects the two-pion emission space and leads to a visible two-tiered shape in the source function imaged using the two-pion Bose–Einstein *** two-tiered shape can be understood within a similar but more analytic granular source model and is found to be closely related to the introduced quantity n,which characterizes the granular inhomogeneity of the *** fitting the imaged source function with a granular source parametrization,we extract the granular inhomogeneity of the hydrodynamic source,which is found to be sensitive to both the Gaussian smearing width of the HIJING initial condition and the centrality of the collisions.

关键词： Heavy-ion collision Bose-Einstein correlations Imaging technique

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Long-read sequencing reveals novel genetic polymorphisms in the major histocompatibility complex region and their impacts on the Han Chinese population

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Science China life Sciences 2025年

作者： Cong Zhou Tingting Gong Shuhang li li Jin Shaohua Fan State Key Laboratory of Genetic Engineering Lab for Evolutionary Synthesis School of Life Sciences Human Phenome Institute Fudan University Research Unit of Dissecting the Population Genetics and Developing New Technologies for Treatment and Prevention of Skin Phenotypes and Dermatological Diseases (2019ru.58) Chinese Academy of Medical Sciences

Human leukocyte antigen(HLA) genes in the major histocompatibility complex(MHC) region are cru.ial for immunity and are associated with numerous diseases and phenotypes. The MHC region's complexity and high genetic diversity make it challenging to analyze using short-read sequencing(SRS) technology. We sequence the MHC region of 100 Han Chinese individuals using both long-read sequencing(LRS) and SRS platforms at approximately 30X coverage to study genetic alterations and their potential functional impacts. LRS provides significantly greater coverage of the MHC region and eight classical HLA genes, particularly at the HLA-DRB1 locus, compared with SRS. We detect 78,249 single nucleotide polymorphisms(SNPs) using LRS, with 26.0% undetectable by SRS. Based on SNP and inferred HLA allele types, we constru.t an LRS-based MHC reference panel for the Han Chinese, containing approximately 2.6 times more genetic variants than the SRS-based Han-MHC reference panel. A phenome-wide association study assessing 26,024 phenotypes across 15 categories identifies significant associations for 7,879 independent variants(including 809 LRS-specific SNPs) with 409 phenotypes in nine categories. This analysis reveals 24 unreported HLA allele associations in the bioelectric and cellular categories. The conditional analysis identifies 530independent signals across the 409 phenotypes, including 28 previously unreported signals of eight classical HLA genes associated with 33phenotypes. Of the top-associated SNPs, 191 are detected by LRS only. Fine-mapping identifies 126 independent candidate causal SNPs for three immune-related cellular phenotypes, with 17 detected exclusively by LRS. Our study reveals previously unreported variants and their functional impacts in the MHC region, enhancing our understanding of genetic diversity and its potential biological implications in the Han Chinese population.

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高光谱预处理方法与多模型在分类判别中的对比研究

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光谱学与光谱分析 2025年第1期45卷 125-132页

作者：居雷于洁吴炎淼李丽卢天丁亚萍束茹欣上海烟草集团有限责任公司技术中心上海200082 上海大学化学系上海200444 上海数之微信息科技有限公司上海200444

高光谱技术能够快速、无损地获取丰富的信息,在植物研究和监测中已成为一种广泛应用的工具。茄科植物作为一种重要的经济农作物,与高光谱技术结合进行研究具有巨大的应用潜力。本研究采用高光谱技术对茄科植物的初烤后不同部位叶片进行... 详细信息

高光谱技术能够快速、无损地获取丰富的信息,在植物研究和监测中已成为一种广泛应用的工具。茄科植物作为一种重要的经济农作物,与高光谱技术结合进行研究具有巨大的应用潜力。本研究采用高光谱技术对茄科植物的初烤后不同部位叶片进行分类研究。采用Field Spec 3光谱辐射仪对293份不同部位的茄科植物粉末样本进行高光谱采样,采用S-G平滑以及一阶导数和二阶导数的方法对数据进行预处理,用于信息增强和去除噪声,并通过偏最小二乘法对数据进行降维,以减少冗余特征。基于降维数据,采样支持向量机、逻辑回归、K近邻、决策树、随机森林和梯度提升决策树这六种机器学习算法建立分类模型。结果显示,在分类任务中,经过一阶导数处理后,支持向量机模型最佳,在训练集和测试集上分别实现了100.0%和84.7%的准确率。经网格参数优化后确定最优参数为:最大深度不限制,最小样本分割数为4,估计器数量为200。参数优化后五折交叉验证准确率为88.1%,训练集准确率为100%,测试集准确率为86.4%。研究结果表明,预处理方法结合降维方法能够增强数据信息使得分类模型能够更好地捕捉茄科植物样本的特征。该研究对于快速、准确、无损地区分茄科植物的部位具有重要意义。

关键词：高光谱部位分类机器学习

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A binary study of color-magnitude diagrams of 12 globular clusters

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Research in Astronomy and Astrophysics 2010年第2期10卷 135-141页

作者： Zhong-Mu li Cai-Yan Mao ru.Heng li ru.Xi li Mao-Cai li College of Physics and Electronic Information Dali University Dali 671003 China National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China

Binary stars are common in star clusters and galaxies, but the detailed ef- fects of binary evolution are not taken into account in some color-magnitude diagram （CMD） studies. This paper studies the CMDs of twelve globular clusters via binary- star stellar populations. The observational CMDs of the star clusters are compared to those of binary-star populations, and then the stellar metallicities, ages, distances and reddenings of these star clusters are obtained. The paper also tests the different effects of binary and single stars on CMD studies. It is shown that binaries can better fit the observational CMDs of the sample globular clusters compared to single stars. This suggests that the effects of binary evolution should be considered when modeling the CMDs and stellar populations of star clusters and galaxies.

关键词： (Galaxy:) globular clusters: general -- galaxies: star clusters

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Reduction of Interference Oscillations in Observing Intersubband Transitions in AlSb/GaSb Superlattices by Fourier Transform Infrared Spectroscopy

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Chinese Physics Letters 1995年第11期12卷 685-688页

作者： ru.Guoping li Aizhen State Key Laboratory of Functional Materials for Informatics Shanghai Institute of MetallurgyAcademia SinicaShanghai 200050

Intersubband transitions from L_(1) to L_(2) subbands in AISb/GaSb superlattices in the 8-18μm wavelength range are observed by employing normal-and oblique-incident Fourier transform infrared(FTIR)spectroscopic *** AlSb rather than GaSb as the buffer layer,interference oscillations in normal-incident FTlR spectra are significantly reduced,which facilitates one to distinguish intersubband transition *** the oblique-incident mode where a 45°thallium hexahedron is used for internal reflection,interference oscillations are eliminated,making it possible to observe weak intersubband transitions that cannot be distinguished in normal-incident absorption spectra.

关键词： spectra. incident transitions

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Nonlinear Wavelet Methods for High-dimensional Backward Heat Equation

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Acta Mathematica Sinica,English Series 2013年第5期29卷 913-922页

作者： ru. li Jin ru.WANG Department of Applied Mathematics Beijing University of Technology

The backward heat equation is a typical ill-posed problem. In this paper, we shall apply a dual least squares method connecting Shannon wavelet to the following equation Motivated by Reginska＇s work, we shall give two nonlinear approximate methods to regularize the approximate solutions for high-dimensional backward heat equation, and prove that our methods are convergent.

关键词： Backward heat equation nonlinear wavelet method convergence

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