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Effects of Siwei Yuganzi decoction on LXRα and CYP7A1 in hyperlipidemic rats

Traditional Medicine Research 2019年第6期4卷 305-313页

作者： ru-yi yang Hong-Bin Wang Pan-Pan Zhou Department of Integrative Medicine Affiliated Hospital of Qinghai UniversityXining 810000China Medical College of Qinghai University Xining 810000China.

Background:Hyperlipidemia(HLP)is a disorder in which lipids in the blood are disturbed due to abnormal lipid *** and fibrates lipid-regulating drugs prevent the generation of lipids and improves HLP,thereby reducing the likelihood of developing cardiovascular and cerebrovascular ***,their adverse reactions and side effects limit a wide range of clinical *** medicine compound preparation Siwei Yuganzi decoction(SYD)is an adaptation of a classical prescription of the Tibetan medicine Sanguo decoction,that has been proved to have the effect of improving lipid metabolism;however,its possible mechanism remains ***:Sixty specific-pathogen free grade Sprague Dawley rats were randomly divided into the blank control group,the HLP group,the Chinese patent medicine Xuezhikang positive control group,and the treatment groups with Tibetan SYD high-,middle-,and low-dosages *** rats were assigned to each *** rat in these groups was fed with a high-fat emulsion to establish the hyperlipidemic animal model,except for those in the blank control *** the rats in the blank control and HLP groups were fed with 0.9%normal saline,those in Xuezhikang group were fed with Xuezhikang suspension at the dose of 0.11 g/kg/d,and those in SYD groups were fed with the SYD suspension at the dosage of 16.2 g/kg/d(high dosage),10.8 g/kg/d(middle dosage),and 5.4 g/kg/d(low dosage),*** 8 weeks,the levels of serum total cholesterol(TC),triglyceride(TG),low-density lipoprotein cholesterol(LDL-C),and high-density lipoprotein cholesterol(HDL-C)were detected by the *** mRNA and protein expression levels of liver X receptorα(LXRα)and cholesterol 7α-hydroxylase 1(CYP7A1)were detected using RT-PCR,western blotting,and ***:The serum levels of TC,TG,and LDL-C in the HLP group were higher than those in the blank control group(Prum levels of HDL-C and the expression l

关键词： Hyperlipidemia Experimental study Tibetan medicine Siwei Yuganzi decoction LXRα CYP7A1

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Effect of Tongmai Huoxue decoction combined with warm needling on hemorheology and antioxidant capacity in patients with high altitude polycythemia

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Journal of Hainan Medical University 2017年第15期23卷 15-18页

作者： Wen-Ling Zhao ru-yi yang Chang-Xia Cao Zhan-Fang Guo Department of Integrated Traditional Chinese and Western Medicine Affiliated Hospital of Qinghai UniversityXining 810000China

Objective: To investigate the curative effect of Tongmai Huoxue Decoction combined with warm needling on the treatment of High altitude polycythemia (HAPC), and to analyze the changes of hemorheology and antioxidant ability before and after treatment. Methods: A total of 90 HAPC patients were randomly divided into control group and observation group. The control group was treated with low molecular weight dextran and captopril. On the basis of this, the observation group was supplemented with Tongmai Huoxue Decoction combined with warm needling. Hemorheology and antioxidant markers were measured before and after treatment in all subjects. Results: Before treatment, there were no significant differences in the hemorheology indexes between the control group and the observation group. After treatment, the two groups of hemorheology related indicators were significantly lower than those before treatment, including whole blood low shear reduction viscosity, whole blood high shear reduction viscosity, plasma viscosity, Hb, Hct and RBC. The levels of the observation group were significantly lower than that of the control group. Before treatment, there was no significant difference in antioxidant indexes between the control group and the observation group. After treatment, the levels of serum superoxide dismutase (SOD) and glutathione (GSH) in the two groups were higher than those in the pre-treatment, while the content of malondialdehyde (MDA) was lower than that before treatment. The levels of serum SOD and GSH in the observation group were higher than those in the control group, and the MDA content was lower than that in the control group. Conclusion: Routine treatment of Western medicine combined with Tongmai Huoxue Decoction joint warm needling method may reduce hemoglobin, improve hemorheology and improve antioxidant ability in HAPC patients, and it may be one of the potential effective drugs for adjuvant therapy of HAPC.

关键词： Tongmai Huoxue Decoction Hemorheology Anti-oxidation Warm needling High altitude polycythemia

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Bioinformatics-based analysis of the relationship between core genes and immune infiltration and tumor metastasis in esophageal cancer

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Gastroenterology & Hepatology Research 2022年第1期4卷 32-45页

作者： Fa-zhang Chen Ye Li Xue-lian Zhang Xiao-lan Zhang ru-yi yang Affiliated Hospital of Qinghai University XiningQinghai.

We analysed four gene microarray datasets by GEO2R and obtained differential genes expressed in oesophageal *** further elaborate the functions of DGEs,this study performed gene ontology(GO)and Kyoto Encyclopedia of Genes and Genomes(KEGG)enrichment analysis of *** constructed protein interaction networks of DGEs through the String database and screened core *** used the GEPIA online database with the Kaplan-Meier plotter database to verify the expression of Hub genes in expressed normal versus tumour tissues and the effect of Hub genes on overall and disease-free survival in oesophageal *** further understand the relationship between Hub gene and tumour metastasis,we analysed the difference in Hub gene expression in patients without metastatic oesophageal cancer versus those with metastatic oesophageal cancer with the help of the HCMDB *** relationship between Hub genes and tumour immune infiltration was analysed by the TIMER *** obtained a total of 149 DEGs,of which 49 were up-regulated genes and 100 were down-regulated *** DGEs were importantly enriched in IL-17 signalling pathway,ECM-receptor interactions,p53 signalling pathway,estrogen signalling pathway,complement and coagulation cascade *** screened 10 Hub genes,MMP9,CXCL8,COL1A1,TIMP1,POSTN,MMP3,MMP1,COL3A1,SERPINE1,LUM,among 149 *** genes were all up-regulated in expression in esophageal cancer tissues,in addition,MMP9,T1MP1,CXCL8,POSTN and The expression of COL3A1,LUM,MMP1,MMP3,MMP9,POSTN,SERPINE1 and TIMP1 was positively correlated with the infiltration of immune cells in the tumor *** conclusion,our study identified 10 signature genes for oesophageal *** genes are associated with the development,metastasis,prognosis and immune infiltration of oesophageal cancer and may be markers of development,metastasis and prognosis as well as targets for immunotherapy.

关键词： bioinformatics esophageal cancer data mining GEO immune infiltration.

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Screening of prognostic genes associated with ferroptosis in esophageal adenocarcinoma and the establishment of its prognostic model

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Medical Data Mining 2022年第2期5卷 1-15页

作者： Fa-Zhang Chen Jun-Song Wu Ye Li Xue-Lian Zhang Xiao-Lan Zhang ru-yi yang Medical institute of Qinghai University Qinghai UniversityXining 810000China Affiliated Hospital of Qinghai University Xining 810000China

We analyzed three gene microarray datasets by GEO2R and obtained differential genes associated with ferroptosis in esophageal adenocarcinoma by obtaining the FerrDb database to obtain ferroptosis-related genes for the *** further elaborate on the functions of differentially expressed genes(DGEs),this study performed gene ontology and Kyoto Encyclopedia of Genes and Genomes enrichment analysis on *** used the Kaplan-Meier plotter database to verify the effect of DGEs genes on the overall survival of esophageal *** performed univariate/multifactorial COX regression analysis of DGEs genes associated with esophageal adenocarcinoma prognosis by R language to obtain ferroptosis-associated independent prognostic *** further understand the relationship between the upstream molecules of independent prognostic genes and ferroptosis,we obtained the upstream regulatory molecules miRNAs and LncRNAs of prognosis-related ferroptosis genes with the help of the miRWalk database,Oncomi database and StarBase *** obtained a total of 75 *** DGEs were mainly enriched in the cellular response to lipids,and negative regulation of *** DGEs were mainly enriched in the negative regulation of intracellular signaling,positive regulation of cell death,cellular autophagy,HIF-1 signaling pathway,microRNAs in cancer,and *** performed prognostic analysis and univariate/multifactorial COX regression analysis on 75 ferroptosis-related genes and established four independent genes for esophageal adenocarcinoma,ATF3,ATM,ATG5,and *** study also established hsa-miR-876-5p,hsa-miR-186-5p,hsa-miR-421,hsa-miR-505-3p,hsa-miR-503-5p,hsa-miR-299-3p and hsa-miR-191-5p,seven miRNAs with upstream regulation of *** miRNAs can be competitively bound by LncRNAs to prevent the inhibition of translation of target gene expression by *** conclusion,our study identified four esophageal adenocarcinoma independent prognostic ge

关键词： Esophageal adenocarcinoma bioinformatics ferroptosis non-coding RNA

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支持安全外包计算的无线体域网数据共享方案

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通信学报 2017年第4期38卷 64-75页

作者：张维纬张育钊黄焯张茹杨义先华侨大学工学院福建泉州362021 工业智能化技术与系统福建省高校工程研究中心福建泉州362021 北京邮电大学信息安全中心北京100876

如何有效保护无线体域网(WBAN)中数据共享时的数据安全是一个亟待解决的关键问题。传统的CP-ABE机制具有"一对多"的数据安全通信功能,适用于WBAN中的访问控制,但运算复杂度高且不支持属性撤销。充分考虑WBAN节点资源的有限性和用户属性... 详细信息

如何有效保护无线体域网(WBAN)中数据共享时的数据安全是一个亟待解决的关键问题。传统的CP-ABE机制具有"一对多"的数据安全通信功能,适用于WBAN中的访问控制,但运算复杂度高且不支持属性撤销。充分考虑WBAN节点资源的有限性和用户属性的动态性,提出一种在标准模型下CPA安全、支持属性撤销、加密和解密安全外包计算的CP-ABE方案。与已有的方案相比,提出的方案在保证安全性的同时,终端的运算负担大为减少,且可以实时、细粒度地撤销用户属性。

关键词：无线体域网安全共享外包计算属性基加密属性撤销

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Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

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Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu Guan Mengting Qiu Na Li Zhengxiang Zhou ru Ye Liyan Zhong Yashuang Xu Junhui Ren yi Liang Xiaomei Shao Jianqiao Fang Junfan Fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

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0010号台风“碧利斯”对厦门港湾表层海水中溶解无机砷含量的影响

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台湾海峡 2002年第4期21卷 404-410页

作者：李俊郑佩如杨逸萍胡明辉厦门大学海洋系福建厦门361005

本文研究了 0 0 1 0号台风“碧利斯”影响期间及其随后的恢复期中 ,厦门港湾中九龙江口和西港海域站表层海水总溶解砷 (TDIAs)、As3 + 含量和As3 + As5+ 值的变化特征 .结果表明 ,观测期间两站TDIAs和As5+ 含量均比非台风时期呈数倍增... 详细信息

本文研究了 0 0 1 0号台风“碧利斯”影响期间及其随后的恢复期中 ,厦门港湾中九龙江口和西港海域站表层海水总溶解砷 (TDIAs)、As3 + 含量和As3 + As5+ 值的变化特征 .结果表明 ,观测期间两站TDIAs和As5+ 含量均比非台风时期呈数倍增加 ,经1 0d后仍未恢复到非台风时的水平 .As3 + 含量也有较大幅度的增加 ,但波动较大 .文中还对观测期间影响溶解无机砷含量的因素进行了初步的探讨 .

关键词：溶解无机砷台风厦门港湾表层海水溶解度生物活性毒性

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益气复脉对中晚期肺癌患者免疫功能和生存质量的影响

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中国现代医学杂志 2017年第6期27卷 88-92页

作者：郭占芳张红武杨如意孙兆刘永萍青海大学附属医院中西医结合科青海西宁810000

目的探讨注射用益气复脉(冻干)对中、晚期肺癌患者免疫功能和生存质量的影响。方法选取2013年9月-2014年8月在该院经组织病理学或细胞学确诊为中、晚期肺癌并化疗的患者63例为对照组;选择2015年1月-2015年12月该院同类患者67例为观察组... 详细信息

目的探讨注射用益气复脉(冻干)对中、晚期肺癌患者免疫功能和生存质量的影响。方法选取2013年9月-2014年8月在该院经组织病理学或细胞学确诊为中、晚期肺癌并化疗的患者63例为对照组;选择2015年1月-2015年12月该院同类患者67例为观察组。两组患者给予相同的化疗方案,辅助健康指导、营养支持、心理及康复锻炼指导,并给予止痛、止呕等治疗。观察组在对照组的基础上加用注射用益气复脉。6个疗程后比较两组的免疫功能血液学指标、生存质量、卡氏评分、疗效及不良反应。结果观察组可降低C-反应蛋白和白细胞的数量,增加NKT细胞活性,增加T细胞亚群中CD3^+、CD4^+及CD4/CD8^+的比例,增强机体的免疫功能。治疗前两组患者的生存质量评分差异无统计学意义,治疗后两组患者的生存质量均提高。观察组患者在认知功能和经济困难方面与对照组患者改善程度一致,在其他维度方面优于对照组。治疗后观察组患者卡氏评分与对照组比较,差异有统计学意义(P<0.05)。观察组患者显效率为95.52%,对照组为60.32%,差异有统计学意义(P<0.05)。观察组白细胞计数下降、血小板计数下降、血红蛋白下降、肝功能异常、肾功能异常比例比较,差异有统计学意义(P<0.05)。结论注射用益气复脉不仅可提高机体的免疫功能,而且可减少不良反应的发生,提高患者生存质量。

关键词：注射用益气复脉肺癌免疫功能生存质量

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利用SSR标记解析京科968等系列玉米品种的杂优模式

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玉米科学 2017年第5期25卷 1-8页

作者：赵久然李春辉宋伟王元东邢锦丰张如养易红梅杨扬石子王继东北京市农林科学院玉米研究中心/玉米DNA指纹及分子育种北京市重点实验室北京100097

利用SSR标记从分子水平上对京科968、京科665、NK718和京农科728系列玉米品种的杂种优势模式进行分析。40对SSR引物在37份供试自交系中共检测出270个等位基因变异,平均每对引物检测出6.75个等位基因,平均多态性信息含量为0.66。UPGMA聚... 详细信息

利用SSR标记从分子水平上对京科968、京科665、NK718和京农科728系列玉米品种的杂种优势模式进行分析。40对SSR引物在37份供试自交系中共检测出270个等位基因变异,平均每对引物检测出6.75个等位基因,平均多态性信息含量为0.66。UPGMA聚类分析和群体结构分析结果一致,所测自交系被划分成8个杂种优势群,京科968母本京724等5个自交系单独成群,命名为X群;两个骨干父本自交系京92、京2416与自交系黄早四、昌7-2划为一群,同属黄改群(塘四平头群);其他6个群分别为旅大红骨群、瑞德群、P群、兰卡斯特群、改良瑞德群和Iodent群。京科968等系列品种的杂优模式为"X群×黄改群"。通过近年来育种实践和大面积生产证明,"X群×黄改群"已成为我国玉米生产上一种快速上升的主要杂优模式。

关键词：玉米京科968 SSR标记杂种优势模式 X群×黄改群

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Robust microwave absorption in silver-cobalt hollow microspheres with heterointerfaces and electric-magnetic synergism:Towards achieving lightweight and absorption-type microwave shielding composites

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Journal of Materials Science & Technology 2023年第7期138卷 245-255页

作者： Dian yang Jun-ru Tao yi yang Qian-Ming He Ming Wang Chongqing Key Laboratory of Soft-Matter Material Chemistry and Function Manufacturing School of Chemistry and Chemical EngineeringSouthwest UniversityChongqing 400715China

Lightweight and high-efficiency microwave shielding materials based on high absorption loss are the hotspot of current ***,the silver-cobalt bimetallic hollow microspheres(Ag-Co-HM)with low reflection loss and broadband absorption efficiency were fabricated and then used to construct bimetallic hollow structures in polydimethylsiloxane/carbon nanotube composites(PDMS/CNT)to obtain the lightweight and absorption-type microwave shielding *** microwave absorption of Ag-Co-HM and the microwave shielding effectiveness(SE T)of the PDMS/CNT/Ag-Co-HM composites was evaluated and *** Ag-Co-HM with a molar ratio(Co/Ag)of 2.07 exhibited a low reflection loss as-46.6 dB at a thickness of 2.6 mm,and an effective absorption bandwidth of 8.40 *** SE T of the PDMS/CNT composites was greatly enhanced by the incorporation of the ***,the absorption coefficient(A)was also improved by adding the Ag-Co-HM and was much higher than the reflection *** composites exhibited absorption-type microwave shielding *** example,the average microwave SE T of 59.4 dB and A value of 0.78 are achieved in the PDMS/CNT/Ag-Co-HM composites containing 5 wt%CNTs and 10 wt%Ag-Co-HMs,which are much higher than the cor-responding values of 33.7 dB and 0.63 in the PDMS/CNT composites with only 5 wt%*** addition,the hollow structure of Ag-Co-HM endows the PDMS/CNT/Ag-Co-HM composites to have a low density.

关键词： Microwave shielding Absorption loss Lightweight Polydimethylsiloxane Carbon nanotube

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