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A systematic review of pharmacological activities, toxicological mechanisms and pharmacokinetic studies on Aconitum alkaloids

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Chinese Journal of Natural Medicines 2021年第7期19卷 505-520页

作者： MI li li Yu-Chen SUN Meng-ru ZHANG Pei-lin li yi YANG Hua State Key Laboratory of Natural Medicines School of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 210009China

The tubers and roots of Aconitum(Ranunculaceae)are widely used as heart medicine or analgesic agents for the treatment of coronary heart disease,chronic heart failure,rheumatoid arthritis and neuropathic pain since ancient *** a type of natural products mainly extracted from Aconitum plants,Aconitum alkaloids have complex chemical structures and exert remarkable biological activity,which are mainly responsible for significant effects of Aconitum *** present review is to summarize the progress of the pharmacological,toxicological,and pharmacokinetic studies of Aconitum alkaloids,so as to provide evidence for better clinical *** data concerning pharmacological,toxicological and pharmacokinetic studies of Aconitum alkaloids were collected from different scientific databases(PubMed,CNKI,Google Scholar,Baidu Scholar,and Web of Science)using the phrase Aconitum alkaloids,as well as generic *** alkaloids are both bioactive compounds and toxic ingredients in Aconitum *** produce a wide range of pharmacological activities,including protecting the cardiovascular system,nervous system,and immune system and anti-cancer ***,Aconitum alkaloids also exert strong cardiac toxicity,neurotoxicity and liver toxicity,which are supported by clinical ***,pharmacokinetic studies indicated that cytochrome P450 proteins(CYPs)and efflux transporters(ETs)are closely related to the low bioavailability of Aconitum alkaloids and play an important role in their metabolism and detoxification in vivo.

关键词： Aconitum alkaloids Pharmacological activities Toxicity Pharmacokinetics

Circumventing brittleness of 3D-printed Al_(2)O_(3)cellular ceramic structures via compositing with polyurea

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Rare Metals 2024年第11期43卷 5994-6005页

作者： Xue-Qin Zhang ru-Yue Su Xiong Gao Jing-yi Chen Guo liu ru-Jie He ying li Institute of Advanced Structure Technology Beijing Institute of TechnologyBeijing 100081China Department of Mechanical Engineering City University of Hong KongHongKong999077China

Benefiting from excellent mechanical properties and low density,cellular ceramic structures(CCSs)are competitive candidates as structural ***,inherent brittleness from strong chemical bonds among atoms extremely impeded CCSs'*** materials occupied outstanding strength and toughness simultaneously due to the dual-phase interpenetrated *** by natural materials,it was proposed to fabricate coating covered and fulfilled polyurea/CCS interpenetrated composites(C/CCSs and B/CCSs)to circumvent the brittleness of 3D-printed Al_(2)O_(3)*** was demonstrated that polyurea coating had less effect on the compressive strength of C/CCSs but tremendously improved their energy-absorbing *** energy-absorbing ability of C/CCSs was improved from26.48-52.57 kJ·m^(-3)of CCSs to 1.04-1.89 MJ·m^(-3)because of the extended plateau ***,compressive strength and energy-absorbing ability of B/CCSs were strengthened to 1.33-1.36 and 2.84-4.61 times of C/CCSs,***,failure mode of C/CCSs changed from localized deformation to fracturing entirely with the increase in relative density of CCSs inside,which was the same as that of ***,with the help of polyurea coating,C/CCSs were still intact at strains up to60%,which would neve r fail catastrophically as CCSs at low strains.B/CCSs tended to fracture as a whole,which was not influenced by relative density of pristine *** was believed that this work provided a creative way to circumvent the brittleness of CCSs and improve their mechanical performances.

关键词： Cellular ceramic structures Dual-phase interpenetrated composites Energy-absorbing ability Compressive strength 3D printing

Atomic-scale structural evolution of electrode materials in li-ion batteries:a review

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Rare Metals 2020年第3期39卷 205-217页

作者： yi-ru Ji Su-Ting Weng Xin-Yan li Qing-Hua Zhang lin Gu Beijing National Laboratory for Condensed Matter Physics Institute of PhysicsChinese Academy of SciencesBeijing100190China School of Physical Sciences University of Chinese Academy of SciencesBeijing100049China Songshan Lake Materials Laboratory Dongguan523808China

Owing to the high spatial resolution at the atomic scale,the transmission electron microscopy(TEM)or scanning transmission electron microscopy is demonstrated as a promising characterization method to unveil the charge storage mechanism of electrode materials in li-ion *** structural evolution of electrode materials during charge/discharge process can be directly observed by using *** detailed analysis establishes a relationship between the structure of electrode material and battery ***,we present a brief review of the atomic-scale characterization in li-ion batteries,including li(de)insertion mechanism(both cations and anions charge-compensation mechanism),migration of transition metal ions,and surface phase *** indepth microscopic analysis reveals the detailed structural characteristics,which influence the properties of liBs,establish the structure-function relationship,and facilitate the development of li-ion batteries.

关键词： li(de)insertion mechanism Migration of transition metal ions Surface structural evolution

Dissecting the cell microenvironment of ovarian endometrioma through single-cell RNA sequencing

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Science China life Sciences 2025年第1期 116-129页

作者： Jiangpeng Wu Siyu Xia Wenting Ye Yan Sun Jing Cai Fubing Yu Haiping Wen Xiuwei yi Taikang li Mingwei Chen Jiayun Chen Ge Song Chuanbin Yang Yali Song Jigang Wang Department of Reproductive Medicine Dongguan Maternal and Child Health Care Hospital Department of Urology and Shenzhen Clinical Research Centre for GeriatricsShenzhen People's HospitalSouthern University of Science and Technology State Key Laboratory for Quality Ensurance and Sustainable Use of Dao-di Herbs Artemisinin Research Centerand Institute of Chinese Materia MedicaChina Academy of Chinese Medical Sciences Reproductive Medicine Center Foshan Women and Children Hospital State Key Laboratory of Antiviral Drugs School of PharmacyHenan University

Ovarian endometrioma（OE）, also known as “chocolate cysts,” is a cystic mass that develops in the ovaries due to endometriosis and is a common gynecological condition characterized by the growth of endometrial tissue outside the uterus, leading to symptoms such as dysmenorrhea, pelvic pain, and infertility. However, the precise molecular and cellular mechanisms driving this pathophysiology remain largely unknown, posing challenges for diagnosis and treatment. Here, we employed integrated single-cell transcriptomic profiling of over 52,000 individual cells from endometrial tissues of OE patients and healthy donors and identified twelve major cell populations. We identified notable alterations in cell type-specific proportions and molecular signatures associated with OE. Notably, the activation of IGFBP5+macrophages with pro-inflammatory properties, NK cell exhaustion, and aberrant proliferation of IQCG+and KLF2+epithelium are key features and may be the potential mechanisms underlying the pathogenesis of OE. Collectively, our data contribute to a better understanding of OE at the single cell level and may pave the way for the development of novel therapeutic strategies.

关键词： ovary high-throughput sequencing transcriptomics gene expression analysis ligand-receptor analysis

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3D nitrogen and boron dual-doped carbon quantum dots/reduced graphene oxide aerogel for advanced aqueous and flexible quasi-solid-state zinc-ion hybrid capacitors

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Rare Metals 2023年第7期42卷 2307-2323页

作者： Jun-Jun Yao Chang liu Jing-ying li Zhong-liang Hu ru-yi Zhou Chen-Chen Guo Xin-ru liu Fei-Fan Yang yi-Rong Zhu Hunan Key Laboratory of Green Metallurgy and New Energy Materials College of Materials and Advanced ManufacturingHunan University of TechnologyZhuzhou412007China School of Chemistry and Chemical Engineering Hunan Institute of EngineeringXiangtan411104China National&Local Joint Engineering Research Center for Advanced Packaging Material and Technology Hunan University of TechnologyZhuzhou412007China

As prospective energy storage devices,zinc-ion hybrid capacitors(ZHCs)still suffer from unsatisfactory cathode ***,the three dimensional(3D)N,B dual-doped carbon quantum dots/reduced graphene oxide(N,B-CQDs/rGO)composite aerogel is prepared via a onepot hydrothermal *** to the synergism of CQDs modification and N,B dual-doping,the resultant N,B-CQDs/rGO composite aerogel delivers superior electrochemical ***,the as-obtained N,B-CQDs/rGO composite aerogel is served as a cathode for aqueous and flexible quasi-solid-state ZHCs for the first ***,the aqueous N,B-CQDs/rGO//Zn ZHC manifests a large energy density of 96.2 Wh·kg^(-1)at80 W·kg^(-1)and still remains a high energy density of 54.7Wh·kg^(-1)at a superb power density of 80 kW·kg^(-1).Meanwhile,kinetic analyses are employed to elucidate the prominent power performance,and various ex situ tests are undertaken to explore the energy storage mechanism of aqueous *** notably,the flexible quasi-solid-state N,B-CQDs/rGO//Zn ZHC displays a desirable energy density(89.1μWh·cm^(-2)),a superior power density(96,000μW·cm^(-2))and exceptional flexible *** present study offers a valuable reference for designing and developing advanced cathode materials for aqueous and flexible quasi-solid-state ZHCs.

关键词： Carbon quantum dots(CQDs) Graphene aerogel Heteroatom dual-doping Energy storage mechanism Zinc-ion hybrid capacitors(ZHCs)

CT local reconstruction of solid rocket motor based on PI-POCS-TVM

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航空动力学报 2017年第2期32卷 470-476页

作者： LU Hong-yi CHEN Qing-gui ZHU Min li Peng ZHAO ru-yan WANG Bin Airborne Vehicle Engineering Department Naval Aeronautical and Astronautical University Yantai Shandong 264001 China Qingdao Branch Naval Aeronautical and Astronautical University Qingdao Shandong 266041 China No. 7 Department Naval Aeronautical and Astronautical University Yantai Shanctong 264001 China

In order to test the defects of solid rocket motor(SRM)accurately and efficiently,the computed tomography(CT)inspection scheme for SRM's defects was investigated and a CT local reconstruction algorithm called prior information-projection onto convex sets-total variation minimization(PI-POCS-TVM)was *** SRM was first inspected by industrial CT(ICT)to generate a low-resolution SRM image used as the prior information,then high-resolution local inspection was carried out for SRM's *** validate the effectiveness of the CT inspection scheme for SRM's defects,one SRM was inspected by a narrow fan beam ICT *** back projection(FBP)algorithm,POCS,POCS-TVM and PI-POCS-TVM algorithms were applied to reconstruct CT *** performance of these algorithms was also *** demonstrated the effectiveness of the CT inspection scheme for SRM's ***,the PI-POCS-TVM algorithm has better local reconstruction image quality than the other three algorithms,showing great significance for accurate measurement of SRM's defects.

关键词： interior tomography exterior tomography compressed sensing prior information projection onto convex sets-total variation minimization(POCS-TVM) solid rocket motor

Effect of thermal exposure on the stress-rupture life and microstructure of a low Re-containing single crystal alloy

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Progress in Natural Science:Materials International 2015年第1期25卷 84-89页

作者： Heng Zhang Yunfei liang yi ru Shusuo li Jian Zhou Shengkai Gong School of Material Science and Engineering Beijing University of Aeronautics and Astronautics

In this paper, the stress-rupture tests of a low Re-containing single crystal alloy IC21 before and after thermal exposure at 1100 ℃for various periods of time were conducted under the test condition of 1100 ℃/137 MPa, and the microstructure of the tested specimens was characterized by SEM and TEM. The experimental results showed that the stress rupture life of this alloy was over 150 h after the standard heat treatment of1320 ℃, 10 h/AC t 870, 32 h/AC, however the stress rupture life decreased with the increase of exposure time due to the microstructure degradation. The TEM analysis revealed that the interface mismatch dislocation networks were well established. It was observed that these mismatch networks could form at 1100 ℃ even after thermal exposure for 1 h without the external stress, which is quite different from that in the traditional single crystal superalloys.

关键词： Single crystal alloy Low Re-containing Stress-rupture test Interface dislocation networks TEM

Maintaining moderate levels of hypochlorous acid promotes neural stem cell proliferation and differentiation in the recovery phase of stroke

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Neural Regeneration Research 2025年第3期20卷 845-857页

作者： lin-Yan Huang yi-De Zhang Jie Chen Hai-Di Fan Wan Wang Bin Wang Ju-Yun Ma Peng-Peng li Hai-Wei Pu Xin-yian Guo Jian-Gang Shen Su-Hua Qi School of Medical Technology Xuzhou Key Laboratory of Laboratory DiagnosticsXuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Pharmacy Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina Department of Laboratory Medicine Branch Hospital of Huai’an First People’s HospitalHuai’anJiangsu ProvinceChina Department of Laboratory Medicine the Affiliated Hospital of Xuzhou Medical UniversityXuzhouJiangsu ProvinceChina School of Chinese Medicine The University of Hong KongHong Kong Special Administrative RegionChina

It has been shown clinically that continuous removal of ischemia/reperfusion-induced reactive oxygen species is not conducive to the recovery of late ***,previous studies have shown that excessive increases in hypochlorous acid after stroke can cause severe damage to brain *** previous studies have found that a small amount of hypochlorous acid still exists in the later stage of stroke,but its specific role and mechanism are currently *** simulate stroke in vivo,a middle cerebral artery occlusion rat model was established,with an oxygen-glucose deprivation/reoxygenation model established in vitro to mimic *** found that in the early stage(within 24 hours)of ischemic stroke,neutrophils produced a large amount of hypochlorous acid,while in the recovery phase(10 days after stroke),microglia were activated and produced a small amount of hypochlorous ***,in acute stroke in rats,hypochlorous acid production was prevented using a hypochlorous acid scavenger,taurine,or myeloperoxidase inhibitor,4-aminobenzoic acid *** results showed that high levels of hypochlorous acid(200μM)induced neuronal apoptosis after oxygen/glucose deprivation/***,in the recovery phase of the middle cerebral artery occlusion model,a moderate level of hypochlorous acid promoted the proliferation and differentiation of neural stem cells into neurons and *** suggests that hypochlorous acid plays different roles at different phases of cerebral ischemia/reperfusion *** levels of hypochlorous acid(5 and 100μM)promoted nuclear translocation ofβ-*** transfection of single-site mutation plasmids,we found that hypochlorous acid induced chlorination of theβ-catenin tyrosine 30 residue,which promoted nuclear ***,our study indicates that maintaining low levels of hypochlorous acid plays a key role in the recovery of neurological function.

关键词： cell differentiation cerebral ischemia/reperfusion injury chlorination hypochlorous acid microglia neural stem cell neurogenesis nuclear translocation stroke β-catenin

Agricultural Ontology Based Feature Optimization for Agricultural Text Clustering

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Journal of Integrative Agriculture 2012年第5期11卷 752-759页

作者： SU Ya-ru WANG ru-jing CHEN Peng WEI Yuan-yuan li Chuan-xi HU yi-min Institute of Intelligent Machines Chinese Academy of Sciences Hefei 230031 P.R.China School of Information Science and Technology University of Science and Technology of China Hefei 230026 P.R.China

Feature optimization is important to agricultural text mining. Usually, the vector space model is used to represent text documents. However, this basic approach still suffers from two drawbacks： thecurse of dimension and the lack of semantic information. In this paper, a novel ontology-based feature optimization method for agricultural text was proposed. First, terms of vector space model were mapped into concepts of agricultural ontology, which concept frequency weights are computed statistically by term frequency weights; second, weights of concept similarity were assigned to the concept features according to the structure of the agricultural ontology. By combining feature frequency weights and feature similarity weights based on the agricultural ontology, the dimensionality of feature space can be reduced drastically. Moreover, the semantic information can be incorporated into this method. The results showed that this method yields a significant improvement on agricultural text clustering by the feature optimization.

关键词： agricultural ontology feature optimization agricultural text clustering