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Effects of different frequencies of repetitive transcranial magnetic stimulation on the recovery of upper limb motor dysfunction in patients with subacute cerebral infarction

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Neural Regeneration Research 2016年第10期11卷 1584-1590页

作者： Jiang li Xiang-min Meng ru-yi li ru Zhang Zheng Zhang yi-feng Du Shandong Provincial Hospital of Shandong University Jinan Shandong Province China Affiliated Hospital of Qingdao University Qingdao Shandong Province China

Studies have confirmed that low-frequency repetitive transcranial magnetic stimulation can decrease the activity of cortical neurons, and high-frequency repetitive transcranial magnetic stimulation can increase the excitability of cortical neurons. However, there are few studies concerning the use of different frequencies of repetitive transcranial magnetic stimulation on the recovery of upper-limb motor function after cerebral infarction. We hypothesized that different frequencies of repetitive transcranial magnetic stimulation in patients with cerebral infarction would produce different effects on the recovery of upper-limb motor function. This study enrolled 127 patients with upper-limb dysfunction during the subacute phase of cerebral infarction. These patients were randomly assigned to three groups. The low-frequency group comprised 42 patients who were treated with 1 Hz repetitive transcranial magnetic stimulation on the contralateral hemisphere primary motor cortex （M1）. The high-frequency group comprised 43 patients who were treated with 10 Hz repetitive transcranial magnetic stimulation on ipsilateral M1. Finally, the sham group comprised 42 patients who were treated with 10 Hz of false stimulation on ipsilateral M1. A total of 135 seconds of stimulation was applied in the sham group and high-frequency group. At 2 weeks after treatment, cortical latency of motor-evoked potentials and central motor conduction time were significantly lower compared with before treatment. Moreover, motor function scores were significantly improved. The above indices for the low- and high-frequency groups were significantly different compared with the sham group. However, there was no significant difference between the low- and high-frequency groups. The results show that low- and high-frequency repetitive transcranial magnetic stimulation can similarly improve upper-limb motor function in patients with cerebral infarction.

关键词： nerve regeneration brain injury repetitive transcranial magnetic stimulation cerebral infarction low-frequency stimulation high-frequency stimulation upper-limb motor function cerebral cortex stroke rehabilitation motor-evoked potential central motor conductiontime primary motor cortex neuroplasticity neural reorganization neural regeneration

内陆国家级新区发展政策建议——基于内陆与沿海新区的对比

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华东经济管理 2015年第6期29卷 61-65页

作者：茹伊丽李莉郭源园北京大学深圳研究生院广东深圳518055

文章依据内陆新区的优劣势,比对功能定位,研究认为其未来发展应在国家战略统领下,综合考虑地理位置、自然资源和生态环境以及社会经济条件上的具体特点,在注重环境保护、贯彻生态文明理念的同时,积极承接东部的产业转移,与沿海新区在对... 详细信息

文章依据内陆新区的优劣势,比对功能定位,研究认为其未来发展应在国家战略统领下,综合考虑地理位置、自然资源和生态环境以及社会经济条件上的具体特点,在注重环境保护、贯彻生态文明理念的同时,积极承接东部的产业转移,与沿海新区在对外开放和产业发展上形成差异化的竞争优势,并借助新区叠加优惠政策形成政策洼地,进一步完善基础设施和制度建设以促进生产要素和人才集聚,最终实现新区的增长极核心带动功能。

关键词：内陆新区沿海新区区位条件功能定位政策建议

Analysis of volatile oil in Rhizoma ligustici Chuanxiong-Radix Paeoniae rubra by gas chromatography-mass spectrometry and chemometric resolution

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Acta Pharmacologica Sinica 2006年第4期27卷 491-498页

作者： Xiao-ru li yi-zeng liANG~2 Fang-qiu GUO College of Chemistry and Chemical Engineering,Research Center of Modernization of Traditional Chinese Medicines,Central South University,Changsha 410083.China CollegeofChemistryandChemicalEngineering ResearchCenterofModernizationofTraditionalChineseMedicinesCentralSouthUniversityCha

Aim:To analyze the volatile chemical components of the herbal pair Rhizomaligustici Chuanxiong-Radix Paeoniae rubra(RLC-RPR)and compare them withthose of each of the herbs ***:Gas chromatography-mass spectrom-etry(GC-MS),a chemometric resolution technique using the heuristic evolvinglatent projections(HELP)method,and the overall volume integration methodwere ***:In total,52,38,and 61 volatile chemical components in RLC,RPR,and RLC-RPR essential oils were determined,respectively,accounting for95.14%,95.19%,and 89.68% of the total contents of essential oil of RLC,RPR,andRLC-RPR,*** main volatile chemical components werebutyldienephthalide(20.65%)and ligustilide(50.15%)for RLC;and n-hexadecanoicacid(20.18%),[Z,Z]9,12-octadecadienoic acid(30.11%),2-hydroxy-benzaldehyde(17.08%)for RPR,and butyldienephthalide(14.80%),and ligustilide(38.91%)*** main volatile chemical components of RLC-RPR were almost thesame as those of RLC,but the relative amounts were ***:Thenumber of volatile chemical components in RLC-RPR was almost equal to the sumof the number in the 2 constituent herbs,but the relative amounts were ***,an acid-base reaction takes place during the process of decoctingthe *** data gathered in this study may be helpful for understanding thesynergistic nature of this herb pair in traditional Chinese medicine.

关键词： herbal pair Rhizoma ligustici Chuanxiong-Radix Paeoniae rubra essential oil gas chromatography-mass spectrometry chemometric resolution method

The Effects of Warm and Tonify Kidney-Yang Herbs on the liver Mitochondria Proteome of the Kidney-Yang dificency in the Rats

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The Effects of Warm and Tonify Kidney-Yang Herbs on the Live...

Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

浙江省生物化学与分子生物学学术交流会

作者： WO Xing-De, LU De-Zhao, SHI Meng-ru, li yi, TANG li-Hua (Department of life Science, Zhejiang College of Traditional Chinese medicine, Hangzhou 310053, china)

Two-dimensional difference gel electrophoresis (2-D DIGE) was used to study the difference of liver mitochondria proteome between the normal rats, the kidney-yang deficiency rats and the kidney-yang d

关键词： Proteome. Shenyangxu. Wenbushenyang Mitochondria. Energy metabolism

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Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu Guan Mengting Qiu Na li Zhengxiang Zhou ru Ye liyan Zhong Yashuang Xu Junhui Ren yi liang Xiaomei Shao Jianqiao Fang Junfan Fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

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半刚性基层沥青路面的热传导试验特性

长安大学学报（自然科学版） 2016年第5期36卷 1-7页

作者：延西利艾涛游庆龙张祎茹王利娟长安大学公路学院陕西西安710064 长安大学材料科学与工程学院陕西西安710061

为了深化认识半刚性基层沥青路面的温度场及热力学特性,针对大体积堆积材料的结构组成特性,应用基于傅里叶（Fourier）热传导原理开发的“双试件平板式”热传导试验装置,结合实体工程的路面结构和温度场,制备了6种不同配比的水稳基层材... 详细信息

为了深化认识半刚性基层沥青路面的温度场及热力学特性,针对大体积堆积材料的结构组成特性,应用基于傅里叶（Fourier）热传导原理开发的“双试件平板式”热传导试验装置,结合实体工程的路面结构和温度场,制备了6种不同配比的水稳基层材料和4种不同类型的沥青面层材料,设定了不同的试验控制温度,测试了水稳混合料和沥青混合料的导热系数,分析了半刚性基层沥青路面的热传导性能。研究结果表明：沥青混合料和水泥稳定碎石混合料的导热系数是一个温变值,随温度的升高而呈线性增加态势;密级配沥青层的导热系数值为1.03-2.10 W/（m·K）,密实结构水稳层的导热系数值为1.03-1.60 W/（m·K）,前者略大于后者,说明沥青层总体上比水稳层具有更好的导热性能;相同温度条件下,密级配沥青混合料的导热系数值明显大于开级配类型,差别在0.33-1.84 W/（m·K）之间,说明空隙率的影响较大;相同级配类型时,粗粒式沥青混合料的导热系数值大于细粒式,表明石料的传热贡献较大;影响半刚性基层沥青路面导热系数的前提因素是材料种类,影响同类材料的关键因素,首先是空隙率,其次是粒径;沥青路面的热传导通常处于瞬态而非稳态。

关键词：道路工程半刚性基层沥青路面热传导导热系数试验特性

基因表达谱技术从消化道肿瘤基础研究到临床转化

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世界华人消化杂志 2018年第34期26卷 1966-1978页

作者：陆建波李汝懿昆明医科大学第一附属医院病理科云南省昆明市650032 昆明医科大学第二附属医院病理科云南省昆明市650032

基因表达谱技术是进行全基因组功能研究的一种新技术新方法,也是生命科学与信息科学相结合的一种综合性研究技术手段.基因表达谱在消化道肿瘤研究中,就针对其基因功能、发病机制、基因网络调控及生物学特性等方面进行了深入的基础性研究... 详细信息

基因表达谱技术是进行全基因组功能研究的一种新技术新方法,也是生命科学与信息科学相结合的一种综合性研究技术手段.基因表达谱在消化道肿瘤研究中,就针对其基因功能、发病机制、基因网络调控及生物学特性等方面进行了深入的基础性研究,同时也已转化应用于临床病理诊断、鉴别诊断、分子分型、靶向治疗等方面的探讨.但要对这一转化过程中不断产生的海量数据进行充分的挖掘与利用,对现有基因表达数据库进行有效的规范化建设与管理,应逐步实现数据共享,加强基因表达谱技术质量控制,才能使基因表达谱技术在未来的研究中得到健康、稳定和快速的发展.

关键词：消化道肿瘤基因表达谱基因芯片生物信息学转化医学

Magneto‑Dielectric Synergy and Multiscale Hierarchical Structure Design Enable Flexible Multipurpose Microwave Absorption and Infrared Stealth Compatibility

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Nano-Micro Letters 2025年第2期17卷 401-416页

作者： Chen li Leilei liang Baoshan Zhang yi Yang Guangbin Ji School of Electronic Science and Engineering Nanjing UniversityNanjing 210093People’s Republic of China College of Materials Science and Technology Nanjing University of Aeronautics and AstronauticsNanjing 210016People’s Republic of China

Developing advanced stealth devices to cope with radar-infrared(IR)fusion detection and diverse application scenarios is increasingly demanded,which faces significant challenges due to conflicting microwave and IR cloaking mechanisms and functional integration ***,we propose a multiscale hierarchical structure design,integrating wrinkled MXene IR shielding layer and flexible Fe_(3)O_(4)@C/PDMS microwave absorption *** top wrinkled MXene layer induces the intensive diffuse reflection effect,shielding IR radiation signals while allowing microwave to pass ***,the permeable microwaves are assimilated into the bottom Fe_(3)O_(4)@C/PDMS layer via strong magneto-electric *** theoretical and experimental optimization,the assembled stealth devices realize a near-perfect stealth capability in both X-band(8–12 GHz)and long-wave infrared(8–14μm)wavelength ***,it delivers a radar cross-section reduction of−20 dB m^(2),a large apparent temperature modulation range(ΔT=70℃),and a low average IR emissivity of ***,the optimal device demonstrates exceptional curved surface conformability,self-cleaning capability(contact angle≈129°),and abrasion resistance(recovery time≈5 s).This design strategy promotes the development of multispectral stealth technology and reinforces its applicability and durability in complex and hostile environments.

关键词： Microwave absorption Radar-infrared compatible stealth Wrinkled MXene Magneto-dielectric synergy Multifunction

Application of the improved dung beetle optimizer,muti-head attention and hybrid deep learning algorithms to groundwater depth prediction in the Ningxia area,China

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Atmospheric and Oceanic Science Letters 2025年第1期18卷 18-23页

作者： Jiarui Cai Bo Sun Huijun Wang yi Zheng Siyu Zhou Huixin li Yanyan Huang Peishu Zong Collaborative Innovation Center on forecast and Evaluation of Meteorological Disasters/Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment ChangeNanjing University of Information Science and TechnologyNanjingChina Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) ZhuhaiChina China Meteorological Administration Key Laboratory of Transportation MeteorologyNanjingChina Jiangsu Meteorological Observatory NanjingChina

Due to the lack of accurate data and complex parameterization,the prediction of groundwater depth is a chal-lenge for numerical *** learning can effectively solve this issue and has been proven useful in the prediction of groundwater depth in many *** this study,two new models are applied to the prediction of groundwater depth in the Ningxia area,*** two models combine the improved dung beetle optimizer(DBO)algorithm with two deep learning models:The Multi-head Attention-Convolution Neural Network-Long Short Term Memory networks(MH-CNN-LSTM)and the Multi-head Attention-Convolution Neural Network-Gated Recurrent Unit(MH-CNN-Gru).The models with DBO show better prediction performance,with larger R(correlation coefficient),RPD(residual prediction deviation),and lower RMSE(root-mean-square error).Com-pared with the models with the original DBO,the R and RPD of models with the improved DBO increase by over 1.5%,and the RMSE decreases by over 1.8%,indicating better prediction *** addition,compared with the multiple linear regression model,a traditional statistical model,deep learning models have better prediction performance.

关键词： Groundwater depth Multi-head attention Improved dung beetle optimizer CNN-LSTM CNN-Gru Ningxia