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Comparison between two autorefractor performances in large scale vision screening in Chinese school age children

International Journal of Ophthalmology(English edition) 2020年第10期13卷 1660-1666页

作者： Di Wang Nan Jin ru-Xia Pei Li-Qiong Zhao Bei Du Gui-Hua Liu Xi-lian Wang rui-Hua Wei Xiao-Rong Li Tianjin International Joint Research and Development Centre of Ophthalmology and Vision Science Eye Institute and School of OptometryTianjin Medical University Eye HospitalTianjin 300384China Tianjin Beichen District Hospital of Traditional Chinese Medicine Tianjin 300400China

AIM:To evaluate the effectiveness of Grand Seiko Ref/Keratometer WAM-5500 compared to Topcon KR800 autorefractor in detecting refractive error in large scale vision screening for Chinese school age children with the WHO ***:A total of 886 participants were enrolled with mean age of 9.49±1.88 y from Tianjin,*** equivalent(SE)was obtained from un-cycloplegic autorefraction and cycloplegic *** KR 800(Topcon)and Grand Seiko WAM-5500(WAM)autorefractors were ***-Altman Plot and regression were generated to compare their *** overall effectiveness of detecting early stage refractive error was analyzed with receiver operating characteristic(ROC)***:The mean SE was-0.98±1.81 diopter(D)and the prevalence of myopia was 48.9%defined by WHO criteria according to the result of cycloplegic *** mean SE of un-cycloplegic autorefraction with Topcon and WAM were-1.21±1.65 and-1.20±1.68 D *** was a strong linear agreement between result obtained from WAM and cycloplegic autorefraction with an R2 of ***-Altman plot indicated a moderate agreement of cylinder values between the two *** sensitivity and specificity for detecting hyperopia were 90.52%and 83.51%;for detecting myopia were 95.60%and 90.24%;for detecting astigmatism were 79.40%and 90.21%;for detecting high myopia were 98.16%and 98.91%***:These findings suggest that both Grand Seiko and Topcon autorefractor can be used in large-scale vision screening for detecting refractive error in Chinese *** Seiko gives relatively better performance in detecting myopia,hyperopia,and high myopia for school age children.

关键词： myopia vision screening autorefraction spherical equivalent Grand Seiko WAM-5500

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Association of GTF2IRD1–GTF2I polymorphisms with neuromyelitis optica spectrum disorders in Han Chinese patients

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Neural Regeneration Research 2019年第2期14卷 346-353页

作者： Jing-Lu Xie Ju Liu Zhi-Yun lian Hong-Xi Chen Zi-Yan Shi Qin Zhang Hui-ru Feng Qin Du Xiao-Hui Miao Hong-Yu Zhou Department of Neurology West China Hospital Sichuan University

Variants at the GTF2I repeat domain containing 1(GTF2IRD1)–GTF2I locus are associated with primary Sj?gren's syndrome, systemic lupus erythematosus, and rheumatoid arthritis. Numerous studies have indicated that this susceptibility locus is shared by multiple autoimmune diseases. However, until now there were no studies of the correlation between GTF2IRD1–GTF2I polymorphisms and neuromyelitis optica spectrum disorders(NMOSD). This case control study assessed this association by recruiting 305 participants with neuromyelitis optica spectrum disorders and 487 healthy controls at the Department of Neurology, from September 2014 to April 2017. Peripheral blood was collected, DNA extracteds and the genetic association between GTF2IRD1–GTF2I polymorphisms and neuromyelitis optica spectrum disorders in the Chinese Han population was analyzed by genotyping. We found that the T allele of rs117026326 was associated with an increased risk of neuromyelitis optica spectrum disorders(odds ratio(OR) = 1.364, 95% confidence interval(CI) 1.019–1.828; P = 0.037). This association persisted after stratification analysis for aquaporin-4 immunoglobulin G antibodies(AQP4-IgG) positivity(OR = 1.397, 95% CI 1.021–1.912; P = 0.036) and stratification according to coexisting autoimmune diseases(OR = 1.446, 95% CI 1.072–1.952; P = 0.015). Furthermore, the CC genotype of rs73366469 was frequent in AQP4-IgG-seropositive patients(OR = 3.15, 95% CI 1.183–8.393, P = 0.022). In conclusion, the T allele of rs117026326 was associated with susceptibility to neuromyelitis optica spectrum disorders, and the CC genotype of rs73366469 conferred susceptibility to AQP4-IgG-seropositivity in Han Chinese patients. The protocol was approved by the Ethics Committee of West China Hospital of Sichuan University, China(approval number: 2016-31) on March 2, 2016.

关键词： nerve regeneration neuromyelitis optica spectrum disorders GTF2I GTF2IRD1 single-nucleotide polymorphism autoimmune diseases aquaporin-4 linkage disequilibrium haplotype neural regeneration

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中国旅游效率与乡村振兴耦合协调测度及时空演化

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地理与地理信息科学 2023年第1期39卷 111-119页

作者：吴儒练台州学院商学院浙江台州318000

旅游业与乡村振兴协调发展是当前旅游管理学和乡村地理学研究的重要课题。该文运用Super-SBM模型、熵值法、耦合协调度模型及探索性空间数据分析法对2010-2019年中国31个省域旅游效率与乡村振兴水平耦合协调度及其时空演变特征进行研究... 详细信息

旅游业与乡村振兴协调发展是当前旅游管理学和乡村地理学研究的重要课题。该文运用Super-SBM模型、熵值法、耦合协调度模型及探索性空间数据分析法对2010-2019年中国31个省域旅游效率与乡村振兴水平耦合协调度及其时空演变特征进行研究,结果表明:1)旅游效率与乡村振兴空间特征较相似,表现为整体发展水平较低且均呈现“东部>中部>西部”的阶梯状特征;2)研究期内,旅游效率与乡村振兴系统耦合协调等级以基本协调和中度协调为主,耦合协调度呈现“东高西低、中部均衡”的空间格局;3)旅游效率与乡村振兴耦合协调度具有显著的空间正相关性和集聚效应,高值集聚区主要位于京津冀、长三角等沿海地区,低值集聚区主要分布于西藏和西北地区,耦合协调度冷热点分布形成以长三角为核心的“中心—外围”空间结构特征,据此提出了促进旅游效率与乡村振兴良性协调发展的政策建议。

关键词：旅游效率乡村振兴耦合协调时空演化

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Geological characteristics and ‘‘sweet area'' evaluation for tight oil

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Petroleum Science 2015年第4期12卷 606-617页

作者： Cai-Neng Zou Zhi Yang lian-Hua Hou ru-Kai Zhu Jing-Wei Cui Song-Tao Wu Sen-Hu Lin Qiu-Lin Guo She-Jiao Wang Deng-Hua Li Petro China Research Institute of Petroleum Exploration and Development

Tight oil has become the focus in exploration and development of unconventional oil in the world, especially in North America and China. In North America, there has been intensive exploration for tight oil in marine. In China, commercial exploration for tight oil in conti- nental sediments is now steadily underway. With the dis- covery of China＇s first tight oil field--Xin＇anbian Oilfield in the Ordos Basin, tight oil has been integrated officially into the category for reserves evaluation. Geologically, tight oil is characterized by distribution in depressions and slopes of basins, extensive, mature, and high-quality source rocks, large-scale reservoir space with micro- and nanopore throat systems, source rocks and reservoirs in close contact and with continuous distribution, and local ＂sweet area.＂ The evaluation of the distribution of tight oil ＂sweet area＂ should focus on relationships between ＂six features.＂ These are source properties, lithology, physical properties, brittleness, hydrocarbon potential, and stress anisotropy. In North America, tight oil prospects are distributed in lamellar shale or marl, where natural fractures are fre- quently present, with TOC 〉 4 %, porosity 〉 7 %, brittle mineral content 〉 50 %, oil saturation of 50 %-80 %, API 〉 35~, and pressure coefficient 〉 1.30. In China, tight oil prospects are distributed in lamellar shale, tight sand- stone, or tight carbonate rocks, with TOC 〉 2 %, poros- ity 〉 8 %, brittle mineral content 〉 40 %, oil saturation of 60 %-90 %, low crude oil viscosity, or high formation pressure. Continental tight oil is pervasive in China and its preliminary estimated technically recoverable resources are about （20-25） × lO8^ t.

关键词： Tight oil Geological features "Sweet area"evaluation Tight reservoirs Unconventional oil and gas Shale oil

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三轴压缩煤岩三维裂隙CT图像重构及体分形维研究

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岩土力学 2015年第6期36卷 1633-1642页

作者：李果张茹徐晓炼张艳飞四川大学水力学与山区河流开发保护国家重点试验室四川成都610065 四川大学水利水电学院四川成都610065

通过对煤岩试件进行常规三轴力学试验,并对破坏后的煤岩试件进行CT扫描,之后将处理过的CT图片导入Mimics10.01进行三维重构,得到了煤岩试件内部裂隙空间的分布情况。另外,利用自编的Matlab程序对煤岩试件的体分形维进行了初步分析。结... 详细信息

通过对煤岩试件进行常规三轴力学试验,并对破坏后的煤岩试件进行CT扫描,之后将处理过的CT图片导入Mimics10.01进行三维重构,得到了煤岩试件内部裂隙空间的分布情况。另外,利用自编的Matlab程序对煤岩试件的体分形维进行了初步分析。结果表明:煤岩试件在三轴加载条件下主要发生压剪破坏;且围压不同,煤岩试件表现出了特定的力学规律;利用Mimics10.01重构得到的煤岩三维裂隙空间分布情况显示,随着围压的增大,煤岩试件剪切破坏面的连通率和体密度有增大的趋势;体分形维计算的结果显示,煤岩内部破坏越严重,体分形维值越小。

关键词：煤岩裂隙网络三维重构体分形维

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Tb^(3+)和Ce^(3+)在Sr_7Zr(PO_4)_6基质中能量传递及发光特性研究

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发光学报 2017年第4期38卷 450-456页

作者：曹铷田莲花延边大学理学院物理系吉林延吉133002

用高温固相法制备了Sr_7Zr(PO_4)_6∶Tb^(3+)、Sr_7Zr(PO_4)_6∶Ce^(3+)及Sr_7Zr(PO_4)_6∶Tb^(3+),Ce^(3+)一系列荧光粉,并通过X射线衍射仪及荧光光谱仪分析了其结构和发光性质。结果表明,Sr_7Zr(PO_4)_6∶Tb^(3+)呈现特征绿色发射,最强发射峰位于543 nm,属于Tb^(3+)的5D4→7F5跃迁,激发峰位于226 nm处,但激发带较窄。为拓宽其激发带的宽度,在Sr_7Zr(PO_4)_6∶Tb^(3+)中掺入了Ce^(3+),观察到掺入Ce^(3+)后激发带变宽,且在Ce^(3+)的激发波长处激发得到了Tb^(3+)的发射,表明存在Ce^(3+)到Tb^(3+)的能量传递。

关键词：磷酸盐固相法能量传递

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Synthesis of New Germanium Compounds Containing α-Amino AcidEster or α-Phosphonate Groups

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Chinese Chemical Letters 1997年第1期8卷 9-10页

作者： Zhong Biao ZHANG lian Sheng LI ru Yu CHEN Qing Min WANG Qiang ZENG(Institute of Elemento-Organic ChemistryState Key Laboratory of Elemento-Organic Chmisrty Nankai University, Tianjin 300071) Inst. of Elemento-Organic Chemistry State Key Lab. Elemento-Organ. Ctr. Nankai University Tianjin 300071 China

A series of new type of germasesquioxides. germatranes, and β-trichlorogermylpropionic acid derivatives containing a-tmino group or a-aminophosphonyl group were synthesized by a convenient condensation reaction of β-trichlorogermyl propionyl chloride with a-amino acid esters or a-phosphonates in the presense of organic base. The mectures of products were detethened by 1HNMR 31PNMR MS, elemental analysis' and X-ray diffraction.

关键词： Amino AcidEster or Phosphonate Groups

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Effect of Bushen Qingre Yuyin Decoction on Salivary Secretion, Spleen Index, Submandibular Gland Index, Submandibular Gland Histomorphology, and aqp5 Expression in the Nonobese Diabetic Mouse Model

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World Journal of Traditional Chinese Medicine 2020年第4期6卷 508-514页

作者： Wan-ru Wang Huan-Yu Liu Zhi-Xiong Ren Lu Chen Sai Liu lian-Cun Shi Xiao-Ping Yan Feng Mi Department of Traditional Chinese Medicine Aviation General HospitalBeijing 100011China Department of Hematology and Oncology Dongzhimen Hospital of BeijingBeijing 100700China Department of Traditional Chinese Medicine Rheumatology China‑Japan Friendship HospitalBeijing 100029China Acupoint Acupuncture Clinic Tom Kristensens Vej 425 TV2300 S CopenhagenDenmark

Objective:The objective of this study was to observe the effect of Bushen Qingre Yuyin Decoction on the spleen index,submandibular gland index,salivary secretion,submandibular gland morphology,and aquaporin 5(AQP5)expression levels in the submandibular *** and Methods:Fifty 8-week-old nonobese diabetic(NOD)female mice were randomly divided into the following five groups:model;hydroxychloroquine;and high-,medium-,and low-dose Bushen Qingre Yuyin Decoction *** blank group consisted of ten 8-week-old Balb/C *** Yuyin Qingre Decoction was administered by gavage at 20,40,and 80 g/kg in the low-,medium-,and high-dose groups,*** hydroxychloroquine group was administered hydroxychloroquine at a dose of 80 mg/kg by *** normal and model groups were administered the same amount of *** the different administrations,the amount of salivary secretion in the mice was regularly *** 12 weeks,the mice were sacrificed,and their submandibular gland tissues were excised,stained with hematoxylin-eosin,and pathologically ***5 expression levels in the tissues were detected using real-time polymerase chain ***:The spleen index of mice in the high-dose group was higher than that in the model group(P<0.05),and the submandibular gland index of the hydroxychloroquine group and all the Bushen Qingre Yuyin Decoction prescription groups was higher than that in the model group(P<0.05).After 6 weeks,the salivary volume of the hydroxychloroquine group and all the Bushen Qingre Yuyin Decoction prescription groups was significantly higher than that of the model group(P<0.05);the amount of lymphocyte infiltration in mice among each administration group was significantly reduced(P<0.05);and the AQP5 expression levels in the submandibular glands of mice had significantly increased in the hydroxychloroquine and high-dose groups(P<0.05),with the high-dose group showing the best ***:Bushen Qingre Yuyin D

关键词： Aquaporin 5 Bushen Qingre Yuyin Decoction nonobese diabetic mouse Sjogren’s syndrome Submandibular gland histomorphology

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SYNTHESIS AND CHARACTERIZATION OF THE SOLID COMPLEXES OF Mn(Ⅱ), Co(Ⅱ), Cu(Ⅱ), Zn(Ⅱ), Ag(Ⅰ), Cd(Ⅱ) NITRATES WITH DISUBSTITUTED BENZO CROWN ETHERS

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Chinese Chemical Letters 1992年第10期3卷 811-812页

作者： Ai ru LU Yu Jie DAI You Ming ZHANG lian Xiang ZHANG Liu Fang WANG Department of Chemistry Northwest Normal UniversityLanzhou730070 Department of Chemistry Lanzhou University730000 Hebai Medical Institute

Nine new solid complexes of Mn(Ⅱ),Co(Ⅱ),Cu(Ⅱ),Zn(Ⅱ.),Ag(Ⅰ) nitrates with 4',5'-dibromobenzo-15—crown—5(L_A),Ag(Ⅰ),Cd(Ⅱ)nitrates with tetrabromodibenzo—18—crown—6(L_B)and Cu(Ⅱ), Ag(Ⅰ) nitrates with 4'—bromo—5'—nitrobenzo—15—crown-5(L_c),having the compositions of M(NO_2)_2·L·nH_2O(M=Mn,Co, Zn,L=L_A,n=2;M=Cu,L=L_A,n=1.5; M=Cd, L=L_B,n=0; M=Cu,L=Lc,n=2) and AgNO_·L·nCH_3CN(L=LA,n=0; L=L_B,n=1; L=Lc,n=1/2) have been synthesized in nonaqueous solvent. All the isolated complexes have been characterized by elementary analysis, IR and UV spectra, differential thermal and thermogravimetric analysis, X—ray powder diffraction analysis, molar conductance and measuremends of solubility in some general solvents.

关键词： Cd Zn NITRATES WITH DISUBSTITUTED BENZO CROWN ETHERS Ag Cu

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基于Levenberg-Marquardt算法的桥梁结构静力参数识别

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交通运输工程学报 2005年第3期5卷 56-59页

作者：谭冬莲肖汝诚同济大学桥梁系上海200092

为了提高桥梁结构状态评估中结构参数识别的精度和稳定性,克服Gauss-Newton法不能有效地处理奇异和非正定矩阵以及对初始点要求苛刻的缺点,利用Levenberg-Marquardt法,通过在Gauss-Newton法的迭代矩阵中添加阻尼项,对迭代矩阵加以修正,... 详细信息

为了提高桥梁结构状态评估中结构参数识别的精度和稳定性,克服Gauss-Newton法不能有效地处理奇异和非正定矩阵以及对初始点要求苛刻的缺点,利用Levenberg-Marquardt法,通过在Gauss-Newton法的迭代矩阵中添加阻尼项,对迭代矩阵加以修正,通过Matlab自编程序实现对实际结构参数的优化求解。对一连续梁的数值模拟计算表明,在Gauss-Newton法迭代发散的情况下,Levenberg-Marquardt法的识别结果相对误差在10%左右,Levenberg-Marquardt法基本能实现对真实结构参数的识别,为结构进一步的状态评估提供了结构模型最基本的量化信息。

关键词：桥梁工程桥梁结构参数识别 Levenberg—Marquardt算法静态应变静态位移

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