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The Induction of Epstein-Barr Virus Early Antigen Expression in Raji Cells by GSM Mobile Phone Radiation

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Biomedical and Environmental Sciences 2013年第1期26卷 76-78页

作者： LIU Yang WANG Ming lian ZHONG ru Gang MA xue Mei WANG Qun ZENG Yi College of Life Sciences and Bioengineering Beijing University of Technology College of Materials Science and Engineering Beijing University of Technology

obile phones are widely used nowadays and there have been many reports suspecting mobile phone radiation-induced cancer during the past few years. But the results to date have given no consistent or convincing evidence of a causal relation between radiofrequency field exposure and cancer risks. On May 31, 2011, International Agency for Research on Cancer （IARC）, which is affiliated with World Health Organization （WHO）,

关键词： Mobile phone radiation EBV EA TPA Immunocytochemistry

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障碍物对轴流泵空化内部流场的影响

兰州理工大学学报 2024年第3期50卷 33-41页

作者：赵伟国张翠莲 ZAKIR Khan 寇相儒周忠亮罗云霞兰州理工大学能源与动力工程学院甘肃兰州730050 兰州理工大学甘肃省流体机械及系统重点实验室甘肃兰州730050

空化会影响泵的正常工作和稳定运行,为了探索能够有效抑制轴流泵内发生空化的策略,提出了将矩形流向障碍物布置在轴流泵叶片背面的方法.以比转数700的轴流泵作为研究对象,采用全流道非定常数值模拟,分析障碍物对轴流泵外特性空化性能的... 详细信息

空化会影响泵的正常工作和稳定运行,为了探索能够有效抑制轴流泵内发生空化的策略,提出了将矩形流向障碍物布置在轴流泵叶片背面的方法.以比转数700的轴流泵作为研究对象,采用全流道非定常数值模拟,分析障碍物对轴流泵外特性空化性能的影响.结果表明:在设计工况下布置障碍物的改进模型在空化各阶段均能有效减少空泡体积,尤其当空泡发展至障碍物位置时效果最好,空泡体积减少了72.5%;布置障碍物能够提高叶片背面出口压力,限制低压区向出口方向扩张,减小逆压梯度,阻挡轮毂侧发生偏流,梳理空化发展的流线,优化流场结构,抑制空化的发展,并将断裂扬程提升了10.19%.

关键词：轴流泵流向障碍物空化抑制非定常

区域创新体系视角下中央引导地方科技发展资金项目绩效评价

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冶金经济与管理 2024年第3期 53-56页

作者：喻海飞林群庚喻如钰王艺联东北大学工商管理学院辽宁沈阳110167 大连海事大学法学院辽宁大连116026

中央引导地方科技发展资金是地方政府贯彻落实国家创新驱动发展战略与科技改革发展政策的主要抓手。构建中央引导地方科技发展资金项目绩效评价体系,采用组合赋权-TOPSIS法,以辽宁省2022年中央引导地方科技发展资金项目为例进行绩效评... 详细信息

中央引导地方科技发展资金是地方政府贯彻落实国家创新驱动发展战略与科技改革发展政策的主要抓手。构建中央引导地方科技发展资金项目绩效评价体系,采用组合赋权-TOPSIS法,以辽宁省2022年中央引导地方科技发展资金项目为例进行绩效评价。结果表明:第一,创新产出和创新效益指标对引导资金绩效评价结果具有显著影响;第二,制造业综合得分位列第一,产出数量、产出质量、经济效益和社会效益等指标得分均位于前列;第三,各行业的综合得分情况呈现区域优势行业、高关注度行业得分明显优于区域劣势行业、低关注度行业得分的特点。根据研究结论,对区域创新体系的建设与发展提出推行绩效闭环管理体制、强化经费监督检查、强优势补短板挖潜力等建议。

关键词：区域创新体系中央引导地方科技发展资金绩效评价组合赋权-TOPSIS法

An epididymis-specific carboxyl esterase CES5A is required for sperm capacitation and male fertility in the rat

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Asian Journal of Andrology 2015年第2期17卷 292-297,I0010,I0011页

作者： Yan-Fei ru Hai-Min xue Zi-Mei Ni Dong Xia Yu-Chuan Zhou Yong-lian Zhang Shanghai Key Laboratory of Molecular Andrology State Key Laboratory of Molecular Biology Institute of Biochemistry and Cell Biology Shanghai Institute for Biological Sciences Chinese Academy of Sciences Shanghai China University of Chinese Academy of Sciences Beijing China Institute of Animal Husbandry and Veterinary Sciences Shanghai Academy of Agricultural Sciences Shanghai China Shanghai Institute of Planned Parenthood Research Shanghai China.

Despite the fact that the phenomenon of capacitation was discovered over half century ago and much progress has been made in identifying sperm events involved in capacitation, few specific molecules of epididymal origin have been identified as being directly involved in this process in vivo. Previously, our group cloned and characterized a carboxyl esterase gene CesSa in the rat epididymis. The CES5A protein is mainly expressed in the corpus and cauda epididymidis and secreted into the corresponding lumens. Here, we report the function of CESSA in sperm maturation. By local injection of Lentivirus-mediated siRNA in the *** region of the rat epididymis, CesSa-knockdown animal models were created. These animals exhibited an inhibited sperm capacitation and a reduction in male fertility. These results suggest that CESSA plays an important role in sperm maturation and male fertility.

关键词： carboxylesterase CES5A epididymis male fertility sperm capacitation

Puerarin Up-regulates Methyl-CpG Binding Protein 2 Phosphorylation in Hippocampus of Vascular Dementia Rats

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Chinese Journal of Integrative Medicine 2018年第5期24卷 372-377页

作者： WANG Hu-qing ZHANG Meng ZHAO Jia-xin WU Hai-qin GAO Zhen ZHANG Gui-lian ZHANG ru Department of Neurology the Second Affiliated Hospital of Xi'anJiaotong University Xi'an (710004) China

Objective: To observe the effect of puerarin on methyl-CpG binding protein 2(MeCP2) phosphorylation(pMeCP2) in the hippocampus of a rat model of vascular dementia(VD). Methods: Thirty-six healthy Sprague-Dawley rats were randomly assigned to the sham-operated group, dementia group and puerarintreated group using a random number table(n=12 per group). The modified permanent bilateral common carotid artery occlusion method was used to establish the VD model. The sham-operated and dementia groups were given 2 m L/d of saline, while the puerarin-treated group was given 100 mg/(kg·d) of puerarin for 17 days. The learning and memory abilities were evaluated by the Morris water maze test. Hematoxylin-eosin staining, immunohistochemical(IHC) staining and Western blot analysis were carried out to observe changes in neuron morphology and in level of pMeCP2 in the hippocampus, respectively. Results: The morphologies of rat hippocampal neurons in the puerarintreated group were markedly improved compared with the dementia group. The escape latency of the dementia group was significantly longer than the sham-operated group(P0.05). The number of pMeCP2 positive cells in the CA1 region of hippocampus in the dementia group was significantly increased compared with the sham-operated group, and the puerarin-treated group was significantly increased compared with the dementia group(both P0.05). The expression of pMeCP2 in the dementia group was significantly increased compared wit

关键词： vascular dementia puerarin methyl-CpG binding protein 2 phosphorylation

2015—2020年广州市某医院医院感染调查与分析

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中国消毒学杂志 2024年第7期41卷 515-517页

作者：李雨静刘霞张如冯卫民谭妙莲中山大学附属第一医院广东广州510700

目的了解某医院医院感染现状,为医院感染的重点防控提供依据。方法通过回顾性调查分析,对医院住院患者医院感染分布情况和危险因素进行调查与分析。结果该医院连续6年医院感染平均发生率为2.7%,医院感染例次发生率为3.1%。该医院感染发... 详细信息

目的了解某医院医院感染现状,为医院感染的重点防控提供依据。方法通过回顾性调查分析,对医院住院患者医院感染分布情况和危险因素进行调查与分析。结果该医院连续6年医院感染平均发生率为2.7%,医院感染例次发生率为3.1%。该医院感染发生率排前5位的科室主要是重症医学科、神经外科、神经科重症监护室、普通儿科和心脏科监护室。医院感染部位居前3位的分别是下呼吸道、上呼吸道和泌尿道,感染率构成比依次为27.8%、18.1%和14.7%。共分离病原菌2290株,革兰阴性菌和革兰阳性菌分别占60.8%和19.9%,真菌占11.3%。高龄患者、住院时间长、插管留置、动静脉插管、营养不良和免疫抑制药使用等因素为主要危险因素。结论该院医院感染发生率在可控范围内,重点关注感染高发科室和高发部位,采取有针对性的防控措施。

关键词：医院感染感染分布危险因素防控措施

原子层沉积钌/氧化铝复合纳米薄膜的制备与电阻调控

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表面技术 2024年第14期53卷 173-180页

作者：廉卓禧朱香平王丹李相鑫西安交通大学微电子学院西安710049 西安中科原子精密制造科技有限公司西安710119 中国科学院西安光学精密机械研究所西安710119 西安市微纳电子与系统集成重点实验室西安710049

目的针对目前微通道板(MCP)导电层电阻可调范围窄、性能稳定性差等问题,提出一种新的MCP导电层的制备方法。方法应用原子层沉积(ALD)工艺在硅片上沉积不同厚度的Al_(2)O_(3)和ru薄膜,以获得较优的纳米薄膜制备工艺参数,应用扫描电子显微... 详细信息

目的针对目前微通道板(MCP)导电层电阻可调范围窄、性能稳定性差等问题,提出一种新的MCP导电层的制备方法。方法应用原子层沉积(ALD)工艺在硅片上沉积不同厚度的Al_(2)O_(3)和ru薄膜,以获得较优的纳米薄膜制备工艺参数,应用扫描电子显微镜(SEM)得到薄膜的截面厚度及成膜质量,应用能量色散X射线光谱(EDS)表征了薄膜的元素组成。基于获得的优选工艺参数,在MCP基板上应用ALD工艺交替沉积Al_(2)O_(3)和ru 2种材料,并且改变ru与Al_(2)O_(3)的ALD循环比例,制备了一系列ru/Al_(2)O_(3)复合纳米薄膜作为MCP导电层。对制备的一系列MCP导电层进行体电阻测试,并在不同偏压下进行体电阻稳定性测试。结果由SEM与EDS结果可知,利用ALD制备的Al_(2)O_(3)和ru纳米薄膜成膜特性良好,且薄膜沉积速率稳定。对于镀覆于MCP内表面的ru/Al_(2)O_(3)导电层,体电阻测试结果显示,随着复合薄膜中ru的ALD循环次数增加,MCP体电阻明显降低,适用于MCP导电层制备的工艺参数为:ru的ALD循环数为28~40,Al_(2)O_(3)的ALD循环数为10。在导电层制备过程中延长吹扫时间并在烘烤后随炉冷却,MCP导电层体电阻在不同偏压下具有良好的稳定性。结论利用ALD制备ru/Al_(2)O_(3)复合纳米薄膜作为MCP导电层,实现了体电阻从几至几百兆欧的调控,工艺优化后的导电层体电阻具有良好的稳定性,对扩展导电层可选材料范围,提升MCP器件性能具有工程应用价值。

关键词：微通道板原子层沉积导电层钌氧化铝体电阻

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Microarray gene expression analysis of chemosensitivity for docetaxel,cisplatin and 5-fluorouracil(TPF)combined chemotherapeutic regimen in hypopharyngeal squamous cell carcinoma

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Chinese Journal of Cancer Research 2017年第3期29卷 204-212页

作者： Meng lian Haizhou Wang Jugao Fang Jie Zhai ru Wang Xixi Shen Yifan Yang Zhihong Ma Honggang Liu Department of Otorhinolaryngology Head and Neck Surgery Beijing Tongren HospitalCapital Medical UniversityBeijing 100730China Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology Beijing 100730China

Objective: To screen out a set of candidate genes which could help to determine whether patients with hypopharyngeal squamous cell carcinoma (HSCC) could benefit from docetaxel, cisplatin and 5-fluorouracil (TPF) induction chemotherapy. Methods: Gene-expression profiles in 12 TPF-sensitive patients were compared to 9 resistant controls by microarray analysis. Subsequently, expression levels of potential biomarkers in chemosensitive cell line FaDu after TPF treatment were observed by quantitative real-time polymerase chain reaction (qRT-PCR). Results: Through microarray analysis, 1,579 differentially expressed genes were identified, of which 815 were up-regulated in TPF chemotherapy-responsive tissues whereas 764 were down-regulated. Gene ontology (GO) analysis suggested these genes participating in physiological processes including transcription and its regulation, cellular signal transduction and metabolic process. Additionally, Kyoto Encyclopedia of Genes and Genomes (KEGG) database revealed that MAPK and Jat/STAT signaling pathways occupied important roles in TPF chemotherapeutic sensitivity. Moreover, in vitro cell culture experiments revealed the expression alternations of IL-6, MAPK14, JUN, CDK5 and CAMK2A exposed to TPF treatment by qRT-PCR, whilst providing an insight into the mechanism underlying TPF chemotherapeutic response in HSCC. Conclusions: These results provided a battery of genes related to TPF chemotherapeutic sensitivity and might act as molecular targets in HSCC treatment. Moreover, these candidate biomarkers could contribute to HSCC individualized treatment.

关键词： Microarray HSCC induction chemotherapy MAPK

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咽痒咳合剂质量评价

中成药 2024年第6期46卷 1781-1787页

作者：梁晓莲桂雄斌陈勇杨正腾马家宝赵凤仙宋海梅冯家茹广西中医药大学广西南宁530200 梧州市中医医院广西梧州543000 广西中医药大学第一附属医院广西南宁530200

目的评价咽痒咳合剂质量。方法建立HPLC指纹图谱,进行聚类分析、主成分分析和偏最小二乘判别分析。测定甘草苷、射干苷、迷迭香酸、异甘草苷、野鸢尾黄素、甘草酸单铵盐、次野鸢尾黄素、和厚朴酚、厚朴酚的含量,分析采用Agilent ZORBAX ... 详细信息

目的评价咽痒咳合剂质量。方法建立HPLC指纹图谱,进行聚类分析、主成分分析和偏最小二乘判别分析。测定甘草苷、射干苷、迷迭香酸、异甘草苷、野鸢尾黄素、甘草酸单铵盐、次野鸢尾黄素、和厚朴酚、厚朴酚的含量,分析采用Agilent ZORBAX SB-C_(18)色谱柱(5μm,250 mm×4.6 mm);流动相0.1%磷酸-乙腈,梯度洗脱;体积流量1 mL/min;柱温35℃;多波长检测。结果12批样品指纹图谱中有10个共有峰,相似度均大于0.9。各批样品聚为3类,3种主成分累积方差贡献率达87.448%,峰5、14(和厚朴酚)、3(甘草苷)、11(甘草酸单铵盐)、15(细辛脂素)为质量标志物。9种成分在各自范围内线性关系良好(r=0.9999),平均加样回收率98.23%~101.63%,RSD 1.05%~2.92%。结论该方法稳定可靠,可为咽痒咳合剂质量控制提供依据。

关键词：咽痒咳合剂质量评价 HPLC指纹图谱聚类分析主成分分析偏最小二乘判别分析含量测定