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Effect of vibration on seepage feeding during low-pressure casting of ZL205A alloy

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China Foundry 2019年第1期16卷 40-45页

作者： ru-jia wang Shi-ping Wu Wei Chen School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China

Appropriate vibration can promote the feeding capacity of gravity casting, but the effect of vibration on the feeding of low-pressure casting is not clear. The effect of vibration on the seepage feeding of ZL205A alloy was investigated by vibration casting experiment and physical simulation. The aqueous solution of sodium carboxymethyl cellulose(CMC) with the same rheological characteristic of metal melt was used. The results show that vibration can improve the feeding capacity and reduce shrinkage defects of ZL205A alloy in lowpressure casting. The orthogonal physical simulation experiments indicate that vibration with low frequency and great exerted force can significantly improve the seepage velocity of non-Newtonian fluid with solid particles in porous medium. The seepage phenomenon in CMC solution shows that vibration can change the structure of accumulated particles at the seepage entrance, and thus open the blocked feeding channel. The numerical simulation of one-dimensional semisolid fluid seepage reveals that vibration can form a wave field in the porous medium, which can reduce the adhesion force between fluid and capillary wall and destroy the boundary layer of fluid, and thus promote the seepage velocity.

关键词： mechanical vibration physical simulation seepage ZL205A alloy

Reduction of shrinkage porosities in aluminum alloy castings by external pressure fluctuation under gravity field

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China Foundry 2018年第5期15卷 372-377页

作者： Shi-ping Wu ru-jia wang Ye wang Wei Chen Ze-sheng Ji School of Materials Science and Engineering Harbin Institute of Technology School of Materials Science and Engineering Harbin University of Science and Technology

A novel method to improve the feeding capacity of ZL205 A alloy castings by pressure fluctuation during its solidification process under gravity field was proposed. The experiments were done in the graphite mould by applying the fluctuation pressure at the top of the riser. Results of the X-ray inspection of castings and simulations of flow velocity of alloy melt and temperature field show that the new method can effectively improve the feeding capacity and significantly reduce the shrinkage in the castings. The mechanism of improving the feeding capacity by pressure fluctuation is that the fluctuating pressure can make the ZL205 A alloy melt form a vibration wave in the melt. The vibration wave can intensify the convection of the melt, and therefore, break down the barrage from the feeding channel which forms during the solidification process of the ZL205 A alloy, improving the feeding capacity.

关键词： Fluctuation pressure shrinkage porosity ZL205A alloy gravity casting

Mechanism of burst feeding in ZL205A casting under mechanical vibration and low pressure

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Transactions of Nonferrous Metals Society of China 2018年第8期28卷 1514-1520页

作者： ru-jia wang Shi-ping WU Wei CHEN School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001China

The burst feeding behavior of ZL205 A casting under mechanical vibration and low pressure was investigated by casting experiment and physical model. Experimental results indicated that the burst feeding appeared repeatedly during solidification and left a shrinkage cavity with layered structure under mechanical vibration. The castings with less shrinkage and higher density could be achieved through the vibration. The calculation results of physical model showed that the burst feeding could perform spontaneously under vibration while difficultly without vibration in low-pressure die casting. The obstruction of a casting could be broken and the grains could be rearranged by the vibration. And the obstruction could be carried away due to the inner and outer pressure difference, causing a burst feeding.

关键词： burst feeding ZL205A alloy mechanical vibration low pressure physical model

Bioinformatics analysis of hepatic fibrosis based on hepatic stellate cells

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Precision Medicine Research 2020年第1期2卷 1-10页

作者： Yang Zheng jia-Hui wang jia-ru wang Tie-jian Zhao Department of Medicine Faculty of Chinese Medicine Science Guangxi University of Chinese MedicineNanning 530021China College of Nursing Guangdong Medical UniversityDongguan 523000China Department of Physiology College of Basic MedicineGuangxi University of Chinese MedicineNanning 530021China.

Objective:To analyze differentially expressed genes in human hepatic stellate cells(HSCs)based on data from the GEO database and to identify important target genes for hepatic fibrosis(HF).Methods:In GEO database,microarray GSE11954 of the GEO database was used to obtain data on differential gene expression in human HSCs and was analyzed using GEO2R,using a P value of<0.01 and log2FC value of≥2 for the *** genes were input into the DAVID database for enrichment analysis of genes and pathways,followed by protein interaction analysis and module *** results were compared with the results found through text ***:Two hundred sixty two differentially expressed genes(DEGs)were *** results of gene bulk enrichment showed that the functional molecules encoded by the DEGS were mainly located in the cytoplasm,extracellular matrix and nucleosome,while the molecular functions were mainly related to"regulating actin binding","protein kinase binding"and"kinase activity".The biological processes they were found to be involved in"regulating cell division","immune response"and"collagen decomposition reaction".KEGG signaling pathway analysis found that they were mainly involved in"cell cycle signaling pathway","ECM receptor interaction signaling pathway","p53 signaling pathway"and"FOXO signaling pathway".Text mining results suggested that MMP1 and ETV6 are potential molecular targets for HF ***:The results of bioinformatics analysis identified targets and signaling pathways involved in the pathogenesis of HF,but these require further experimental verification.

关键词： Hepatic stellate cells Liver fibrosis Bioinformatics Differentially expressed genes Gene enrichment analysis

Skyway:Accelerate Graph Applications with a Dual-Path Architecture and Fine-Grained Data Management

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Journal of Computer Science & Technology 2024年第4期39卷 871-894页

作者： Mo Zou Ming-Zhe Zhang ru-jia wang Xian-He Sun Xiao-Chun Ye Dong-rui Fan Zhi-Min Tang Institute of Computing Technology Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China Institute of Information Engineering Chinese Academy of SciencesBeijing 100045China Department of Computer Science Illinois Institute of TechnologyChicagoIL 60616U.S.A.

Graph processing is a vital component of many AI and big data ***,due to its poor locality and complex data access patterns,graph processing is also a known performance killer of AI and big data *** this work,we propose to enhance graph processing applications by leveraging fine-grained memory access patterns with a dual-path architecture on top of existing software-based graph *** first identify that memory accesses to the offset,edge,and state array have distinct locality and impact on *** then introduce the Skyway architecture,which consists of two primary components:1)a dedicated direct data path between the core and memory to transfer state array elements efficiently,and 2)a data-type aware fine-grained memory-side row buffer hardware for both the newly designed direct data path and the regular memory hierarchy data *** proposed Skyway architecture is able to improve the overall performance by reducing the memory access interference and improving data access efficiency with a minimal *** evaluate Skyway on a set of diverse algorithms using large real-world *** a simulated fourcore system,Skyway improves the performance by 23%on average over the best-performing graph-specialized hardware optimizations.

关键词： graph application computer architecture memory hierarchy

Antibodies against the C-terminal peptide of rabbit oviductin inhibit mouse early embryo development to pass 2-cell stage

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Cell Research 2002年第1期12卷 69-78页

作者： PAN YONG, ZHENG GU, JIN PING LUO, JUN ru wang, jia KE TSO National Laboratory of Contraceptives and Devices Research, Shanghai Institute of Planned Parenthood Research, 21.40 Xietu Road, Shanghai 200032, China National Laboratory of Contraceptives and Devices Research Shanghai Institute of Planned Parenthood Research China.

A full-length rabbit oviductin cDNA(1909bp) was cloned. It consists of a 5'-UTR of 52bp, an open reading frame (ORF) of 1374bp and a 3'-UTR of 483bp and has more than 80% homology with that of other mammal oviductins. N-terminal peptide (NTP) (384 residues) and C-terminal peptide (CTP) (73 residues) of deduced protein precursor has about 80% and 50% identity with that of other mammals respectively. Fusion proteins GST-NTP 368(1R-368N)and GST-CTP73 (369F-441A) were expressed and purified. NH2-terminal of CTP sequencing reveals that the purified protein is consistent with the deduced one. In order to study the function of NTP and CTP the mouse anti-NTP and rabbit anti-CTP antisera were prepared. Tissue-specific (skeleton muscle, oviduct, uterus, ovary, liver, heart and brain) analysis indicated that rabbit oviductin was only found in oviduct. The conditioned medium derived from the rabbit oviduct mucosa epithelial cells has a function of overcoming the early embryonic development block of Kunming mous e cultured in vitro. Anti-CTP antiserum could totally inhibit the early embryo development at 2-cell stage cultured in the conditioned culture medium, but anti-NTP antiserum couldn't. There was a positive relationship between the ratio of early embryos at development block and the dosage of anti-CTP antiserum added in the conditioned culture medium. These results suggest that oviductin has a function not only on fertilization, but also on the release of early embryonic development block, and the later function domain of rabbit oviductin may be situate in its C-terminal.

关键词： Rabbit oviductin C-terminal peptide early embryo development loss of function.

Application of network pharmacology in uncovering the biological basis of using the Banxia Baizhu Tianma decoction for hypertension treatment

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TMR Pharmacology Research 2022年第4期2卷 31-39页

作者： Yong Yang jia-ru wang rui-Zhu jiang Yang Zheng Tie-jian Zhao Ying Zhang College of Nursing Guangxi University of Chinese MedicineNanning 530200China Faculty of Chinese Medicine Science Guangxi University of Chinese MedicineNanning 530222China Department of Physiology College of Basic MedicineGuangxi University of Chinese MedicineNanning 530200China

Background:The Banxia Baizhu Tianma decoction(BBTD)is widely used in the clinical treatment of hypertension and has definite curative ***,its active ingredients and mechanism of action in hypertension treatment are still *** this study,network pharmacology was used to elucidate the potential antihypertensive mechanism of ***:The active ingredients and targets of BBTD were screened in the pharmacological database of the Chinese medicine *** targets that are related to hypertension were obtained from the Online Mendelian Inheritance in Man(OMIM),Drugbank,and Genecards *** String database was used to analyze the prevention and treatment of hypertension by *** interaction of important targets was assessed,and the related network data was visualized using the Cytoscape *** OmicShare platform was employed in conducting enrichment analyses of gene functions and pathways of important targets,in addition to evaluating the relationship between important targets and the phenotype of *** docking of the main active ingredients with important targets was also ***:In this study,194 main active ingredients and 616 targets of BBTD were screened,and 5,819 related targets that are closely related to hypertension were unearthed.A total of 445 BBTD key targets for the treatment of hypertension were obtained,along with 73 core targets from performed network topology and module analysis on the key *** enrichment analyses of GO and KEGG showed that oxidative stress,HIF-1 signal,IL-17 signal,and TNF signal play a vital role in *** docking studies have revealed that the main biologically active components can be combined with key targets quite ***:The potential mechanism of BBTD in treating hypertension involves many components,targets,and *** of the potential targets for the prevention and treatment of hypertension are ESR1,MAPK,TP53,TNF,and ***

关键词： Banxia Baizhu Tianma decoction hypertension network pharmacology oxidative stress

Enhanced post-combustion CO2 capture and direct air capture by plasma surface functionalization of graphene adsorbent

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Journal of Energy Chemistry 2025年第1期100卷 653-664页

作者： Rahul Navik Eryu wang Xiao Ding Huang Yunyi Yiyu Liu jia Li Guangdong-Hong Kong Joint Laboratory for Carbon Neutrality Jiangmen Laboratory of Carbon and Science and Technology Guangzhou HKUST Fok Ying Tung Research Institute The Hong Kong University of Science and Technology (Guangzhou) Carbon Neutrality and Climate Change Thrust Society Hub The Hong Kong University of Science and Technology (Guangzhou) Stoddart Institute of Molecular Science Department of Chemistry Zhejiang University

Graphene has enormous potential to capture CO2due to its unique properties and ***,graphene-based adsorbents have drawbacks of lower CO2adsorption capacity and poor *** work demonstrates a one-step rapid and sustainable N2/H2plasma treatment process to prepare graphene-based sorbent material with enhanced CO2adsorption *** treatment directly enriches amine species,increases surface area,and improves textural *** CO2adsorption capacity increases from 1.6 to 3.3 mmol/g for capturing flue gas,and from 0.14 to 1.3 mmol/g for direct air capture （DAC）.Importantly,the electrothermal property of the plasma-modified aerogels has been significantly improved,resulting in faster heating rates and significantly reducing energy consumption compared to conventional external heating for regeneration of *** aerogels display improved selectivity of 42 and 87 after plasma modification for 5 and 10 min,*** plasma-treated aerogels display minimal loss between 17%and 19% in capacity after 40 adsorption/desorption cycles,rendering excellent *** N2/H2plasma treatment of adsorbent materials would lower energy expenses and prevent negative effects on the global economy caused by climate change.

关键词： Carbon neutrality CO 2 capture Climate change Plasma treatment Graphene aerogel

Impact of Clinical Pharmacist Led Guidance Team on Cancer Pain Therapy in China:A Prospective Multicenter Cohort Study

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Impact of Clinical Pharmacist Led Guidance Team on Cancer Pa...