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New glucocerebrosidase antibodies can advance research in the field of neurodegenerative disorders

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Neural Regeneration Research 2025年第4期20卷 1085-1086页

作者： Charis Ma Krystyna Rytel Yu chen Ellen Sidransky Medical Genetics Branch National Human Genome Research InstituteNational Institutes of HealthBethesdaMDUSA

In medical research,there are times when the introduction of a new tool can launch scientific discovery in new *** antibody development may be considered mundane,in the field of glucocerebrosidase(GCase)research,the dearth of validated antibodies for different applications has impeded progress in studies of disease pathogenesis and therapeutic *** recent introduction of new,rigorously evaluated antibodies can now propel research into the link between glucocerebrosidase and Parkinson’s disease(PD)as well as aspects of the pathobiology of Gaucher disease(Jong et al.,2024).

关键词： antibodies cerebro

PREPARATION OF A SINGLE PHASE R_(3)(Fe,Mo)_(29)(R=Ce,Nd,Sm,Gd,Tb,Dy AND Y)

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中国有色金属学会会刊：英文版 1998年第3期8卷 37-41页

作者： Pan Hongge chen Weixiang chen yun chen Changpin Department of Materials Science and Engineering Zhejiang UniversityHangzhou 310027P.R.China

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１ＩＮＴＲＯＤＵＣＴＩＯＮＩｎｒｅｃｅｎｔｙｅａｒｓ，ｒｅｓｅａｒｃｈｅｒｓｉｎｔｈｅｆｉｅｌｄｏｆｐｅｒｍａｎｅｎｔｍａｇｎｅｔｉｃｍａｔｅｒｉａｌｓｈａｖｅｐａｉｄｍｏｒｅａｔｔｅｎｔｉｏｎｔｏｔｈｅｎｅｗｔｙｐｅｏｆｒａｒｅｅａｒｔｈｉｒｏｎ...

关键词： 3:29 compounds preparation a single phase

Automatic search method for multiple differentials and its application on MANTIS

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Science China(Information Sciences) 2019年第3期62卷 145-159页

作者： Shiyao chen ru LIU Tingting CUI Meiqin WANG Key Laboratory of Cryptologic Technology and Information Security Ministry of EducationShandong University

Multiple differential cryptanalysis is one of the extensions of classic differential cryptanalysis. In this paper, we present a generic automatic search method for clustering multiple differentials on a target block cipher. Our search method has two steps. Firstly, the sets of input and output differences will be *** these sets, we get different multiple differentials. Then for each one of these multiple differentials, we enumerate and record all satisfied differential trails, which leads to a more accurate evaluation of the multiple differentials distinguisher. Among these different multiple differentials distinguishers, we can choose the best one for key recovery attack. We demonstrate our search method by applying it on the part of differentials of the block cipher MANTIS. As a result, we find a new 10-round multiple differentials distinguisher with probability 2;and an 11-round multiple differentials distinguisher with probability 2;, which is the longest distinguisher for MANTIS so far as we know. This new 10-round distinguisher can lead to a better signal-to-noise ratio, so we derive an improved key recovery attack on MANTIS-6 with the complexity of about 2;chosen-plaintext queries, 2;encryptions and data-time product 2;, which is better than the previous best one with data-time product 2;. Aiming at exploring the gap between the performance of multiple differential attack and the security margin on MANTIS, we also use the 11-round distinguisher to derive a key recovery attack on MANTIS-7 with the complexity of about 2;chosen-plaintext queries,2;encryptions and data-time product 2;. It does not threat the security of full version MANTIS（MANTIS-7） since the security bound of data-time product claimed by the designers is 2;.

关键词： multiple di?erential cryptanalysis structure attack automatic search MANTIS MILP

Unleashing the Potential of Electroactive Hybrid Biomaterials and Self‑Powered Systems for Bone Therapeutics

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Nano-Micro Letters 2025年第2期17卷 463-497页

作者： Shichang Liu Farid Manshaii Jinmiao chen Xinfei Wang Shaolei Wang Junyi Yin Ming Yang Xuxu chen Xinhua Yin yunlei Zhou Honghui Hospital Xi’an Jiaotong UniversityXi’an 710018People’s Republic of China Department of Bioengineering Henry Samueli School of Engineering and Applied ScienceUniversity of California Los AngelesLos Angeles 90095USA Hangzhou Institute of Technology Xidian UniversityHangzhou 311231People’s Republic of China

The incidence of large bone defects caused by traumatic injury is increasing worldwide,and the tissue regeneration process requires a long recovery time due to limited self-healing *** bioelectrical phenomena have been well recognized as critical biophysical factors in bone remodeling and *** by bioelectricity,electrical stimulation has been widely considered an external intervention to induce the osteogenic lineage of cells and enhance the synthesis of the extracellular matrix,thereby accelerating bone *** ongoing advances in biomaterials and energy-harvesting techniques,electroactive biomaterials and self-powered systems have been considered biomimetic approaches to ensure functional recovery by recapitulating the natural electrophysiological microenvironment of healthy bone *** this review,we first introduce the role of bioelectricity and the endogenous electric field in bone tissue and summarize different techniques to electrically stimulate cells and ***,we highlight the latest progress in exploring electroactive hybrid biomaterials as well as self-powered systems such as triboelectric and piezoelectric-based nanogenerators and photovoltaic cell-based devices and their implementation in bone tissue ***,we emphasize the significance of simulating the target tissue’s electrophysiological microenvironment and propose the opportunities and challenges faced by electroactive hybrid biomaterials and self-powered bioelectronics for bone repair strategies.

关键词： Electroactive biomaterials Self-powered bioelectronics Bone regeneration Bone tissue

Surface modification of poly(vinyl chloride)by long-distance and direct argon RF plasma

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Chinese Science Bulletin 2006年第5期51卷 615-619页

作者： LI ru chen Jierong College of Environmental and Chemical Engineering Xi'an Jiaotong University Xi'an 710049 China College of Environmental and Chemical Engineering Xi'an University of Engineer Science &Technology Xi'an 710048 China

This paper reports the effects of long- distance and direct argon radio frequency (RF) plasma surface treatment on polyvinyl chloride (PVC) films in terms of changes in surface wettability and surface chemistry. The surface properties are char- acterized by the water contact angle measurement, X-ray photoelectron spectroscopy (XPS) and scan- ning electron microscopy (SEM). The mechanism is further analyzed and the role of all kinds of active species, e.g. electrons, ions and free radicals in- volved in plasma surface modification is further evaluated. Results show that the long-distance and direct RF plasma treatments modify the PVC surface in morphology and composition, and both modifica- tions cause surface oxidation of PVC films, in the forming of functional groups enhancing polymer wet- tability. The effect of the long-distance argon RF plasma is more notable. This suggests that long-distance argon RF plasma could restrain the ion and electron eroding effect and enhance free radical reaction.

关键词：聚氯乙烯表面改性远距离射频氩等离子体表面处理 X射线光电子光谱学扫描电子显微术

Theoretical Investigation of Detailed Thermodynamic Character of Possible Difunctional Adducts Model

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Chinese Journal of Structural Chemistry 2006年第5期25卷 533-542页

作者： CHANG Guan-ru ZHOU Li-Xin chen Dong Department of Chemistry Jinan University Guangzhou Guangdong 510632 China

The B3LYP/6-31G^＊ level of theory was used to optimize trans-[Pt（NH3）（Am）G-L], where Am = quinoline or thiazole and L is chosen as the model for functional groups of peptide side chains, and for adenine and guanine sites of DNA as the ultimate target of platinum anticancer drugs. Bond dissociating energy and stability energy of complexes are chosen to study detailedly thermodynamic character of possible difunctional adducts model. In order to investigate the influence of a polarizable environment on the energy of the Pt-L bond formation, we adopt a new bonding energy formula brought forward by Lippard and his coworkers： △H（Sol） = △H（SCF）＋ △G（Solv）, which is quite appropriate to compare with what is found in experimental studies. Our calculated results demonstrate that N-containing ligands are more favored in view of thermodynamics both in gas phrase and in solution. However, it is worthly to be noted that addition of solvation free energies result in moderate correction of bonding energy in relative ordering, and the largest ones both present in imidazole ligand, not in guanine ligand. Finally, the nature of bond is analyzed in terms of partial charges distribution based on NBO population.

关键词： nonclassical transplatin antitumor drug difunctional adduct DFT

Intelligent Traffic Scheduling for Mobile Edge Computing in IoT via Deep Learning

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Computer Modeling in Engineering & Sciences 2023年第3期134卷 1815-1835页

作者： Shaoxuan yun Ying chen School of Computing Science Beijing Information Science and Technology UniversityBeijing100101China

Nowadays,with the widespread application of the Internet of Things(IoT),mobile devices are renovating our *** data generated by mobile devices has reached a massive *** traditional centralized processing is not suitable for processing the data due to limited computing power and transmission *** Edge Computing(MEC)has been proposed to solve these *** of limited computation ability and battery capacity,tasks can be executed in the MEC ***,how to schedule those tasks becomes a challenge,and is the main topic of this *** this paper,we design an efficient intelligent algorithm to jointly optimize energy cost and computing resource allocation in *** view of the advantages of deep learning,we propose a Deep Learning-Based Traffic Scheduling Approach(DLTSA).We translate the scheduling problem into a classification *** demonstrates that our DLTSA approach can reduce energy cost and have better performance compared to traditional scheduling algorithms.

关键词： Mobile Edge Computing(MEC) traffic scheduling deep learning Internet of Things(IoT)

Hierarchically Crosslinked Gels Containing Hydrophobic Ionic Liquids towards Reliable Sensing Applications

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Chinese Journal of Polymer Science 2020年第4期38卷 332-341,I0005页

作者： Xia-Chao chen Pei-ru Sun Hong-Liang Liu Laboratory of Bio-inspired Smart Interface Science Technical Institute of Physics and ChemistryChinese Academy of SciencesBeijing 100190China Key Laboratory of Bio-inspired Smart Interfadal Science and Technology of Ministry of Education and Beijing Advanced Innovation Center for Biomedical Engineering Beihang UniversityBeijing 100191China School of Metallurgy and Materials Engineering Chongqing University of Science and TechnologyChongqing 401331China

Human skin can function steadily regardless of surrounding circumstarices(dry or wet),while it is still a challenge for artificial ionic skins,which tend to release solvents in dry air and leach electrolytes in wetted ***,a series of hierarchically crosslinked ionogels containing hydrophobic ionic liquids(ILs)is fabricated by combining a crystalline fluorinated copolymer with hydrophobic *** a reasonable combination of nonvolatility,transparency,stretchablility,and sensitivity,such ionogels can work as reliable sensors for real-time monitoring huma n motions and operate steadily in complex environments as human skin does,which can contribute to the developme nt of durable sen sing devices with a simple design.

关键词： Ionogels Conductivity Hydrophobicity Strain sensors

A Novel Indoor Positioning Framework

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Computer Modeling in Engineering & Sciences 2022年第3期130卷 1459-1477页

作者： Ming-Chih chen Yin-Ting cheng ru-Wei chen Department of Electronic Engineering National Kaohsiung University of Science and Technology(First Campus)Kaohsiung City82445Taiwan

Current positioning systems are primarily based on the Global Positioning System(GPS).Although the GPS is accurate within 10 m,it is mainly used for outdoor positioning services(Location-Based Service;LBS).However,since satellite signals cannot penetrate buildings,indoor positioning has always been a blind spot for satellite *** indoor positioning applications are extensive with high commercial values,they have created a competitive niche in *** indoor positioning technologies are unable to achieve less than 10 cmaccuracy except for the UltraWide Band(UWB)*** the other hand,the Bluetooth protocol achieves an accuracy of 1 to *** this work,we use Bluetooth wireless signals to build a novel indoor positioning framework to avoid the high manufacturing costs involved in the UWB *** Bluetooth signals are combined with the results from artificial intelligence algorithms to improve *** laboratory indoor location tracking,the accuracy rate is 96%,which provides effective indoor tracking for the movement of people.

关键词： Indoor positioning Bluetooth protocol artificial intelligence