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Downregulation of the circadian clock gene period 2 aggravates prognosis in breast cancer patients with obesity

Oncology and Translational Medicine 2024年第2期10卷 73-78页

作者： ru-xing wu Dan Hu Han-Wang Zhang Xiao-Yuan Huang Liang Zhuang Reproductive Medicine Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Cancer Biology Research Centre Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina Cancer Center Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanChina

Background:Obese individuals diagnosed with breast cancer often experience a less favorable prognosis;however,the underlying mechanisms linking obesity to breast cancer outcomes remain *** study aimed to identify and validate novel prognostic markers associated with breast cancer in patients with ***:We conducted a reanalysis of gene expression profiles from normal-weight,overweight,and obese breast cancer patients to identify candidate ***,we validated the protein levels of these candidates using ***,we investigated the association between candidate genes and breast cancer prognosis at Tongji Hospital,utilizing data from an 8-year follow-up through the Kaplan-Meier method and univariate and multivariate Cox regression ***:The fold change of the circadian clock gene period 2(PER2),which exhibited a declining trend with increasing body mass index,was 0.76 in obese patients compared with normal-weight *** expression rates of PER2 protein were 44.7%,51.5%,and 61.3%in normal-weight,overweight,and obese patients,*** 8-year recurrence-free survival rates were 75.9%,69.6%,and 64.1%,whereas the 8-year overall survival rates were 86.8%,83.0%,and 76.1%in normal-weight,overweight,and obese patients,respectively(P<0.05).Furthermore,the 8-year recurrence-free survival rates were 66.2%and 76.4%,and the 8-year overall survival rates were 79.9%and 86.3%in the low and high PER2 expression groups,respectively(P<0.05).The unadjusted hazard ratio for PER2 was 1.550(95%confidence interval,1.029–2.335),and the adjusted hazard ratio was 3.003(95%confidence interval,1.838–4.907).Conclusions:Our findings indicate that low PER2 expression serves as an independent risk factor for breast cancer prognosis and may contribute to the unfavorable outcomes observed in obese patients.

关键词： Breast cancer Obesity PER2 Prognosis

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基于能量法的轮对蛇行运动稳定性

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交通运输工程学报 2018年第2期18卷 82-89页

作者：孙建锋池茂儒吴兴文梁树林李伟西南交通大学牵引动力国家重点实验室四川成都610031

为了分析轮对蛇行运动的形成机理与能量传递机制,基于车辆系统动力学理论推导了轮对蛇行运动的能量表达式;借助轮对运动参数的相位关系和能量表达式,确定了轮对蛇行运动过程中各部分所做的功及其对应的能量传递路线;通过数值仿真计算不... 详细信息

为了分析轮对蛇行运动的形成机理与能量传递机制,基于车辆系统动力学理论推导了轮对蛇行运动的能量表达式;借助轮对运动参数的相位关系和能量表达式,确定了轮对蛇行运动过程中各部分所做的功及其对应的能量传递路线;通过数值仿真计算不同参数条件下的输入能量,对比了踏面等效锥度、轮对质量、一系悬挂刚度与重力刚度等参数对轮对稳定性的影响规律。研究结果表明:蠕滑力和锥形踏面的协同作用是轮对产生蛇行运动的根本原因,蠕滑力中的刚度项通过调节纵、横向蠕滑率向轮对系统横向运动输入能量,蠕滑力中的阻尼项耗散轮对系统的能量;当输入能量大于耗散能量时,轮对蛇行运动发散,当输入能量小于耗散能量时,蛇行运动收敛,当输入能量等于耗散能量时,轮对做等幅周期运动;增大轮对质量和车轮踏面等效锥度不利于轮对的稳定性,增大一系悬挂纵、横向刚度对轮对稳定性有利;踏面等效锥度对轮对稳定性的影响最大,当锥度由0.15增大到0.20时,输入能量增大了约9.5倍;一系悬挂刚度的影响次之,刚度由75kN·m^(-1)增大到100kN·m^(-1)时,输入能量减小了约60%;轮对质量影响最小,轮对质量由1 000kg增大到2 100kg时,输入能量增长了约1.1倍;在锥形踏面下,重力刚度对轮对稳定性的影响可以忽略。

关键词：车辆工程轮对能量法蛇行运动稳定性蠕滑力

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一种新的OFDM-PON子载波分配机制

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光通信研究 2016年第3期3期(25)卷 1-3页

作者：胡发泽李汝星伍仕宝上海大学特种光纤与光接入网重点实验室上海200072

OFDM-PON(正交频分复用无源光网络)技术受到越来越多的关注,而子载波分配是其关键技术之一。文章介绍了两种已有的OFDM-PON子载波分配机制,并在此基础上提出一种新的OFDM-PON上行传输的子载波分配机制,该机制主要分为求余法和凑数法两部... 详细信息

OFDM-PON(正交频分复用无源光网络)技术受到越来越多的关注,而子载波分配是其关键技术之一。文章介绍了两种已有的OFDM-PON子载波分配机制,并在此基础上提出一种新的OFDM-PON上行传输的子载波分配机制,该机制主要分为求余法和凑数法两部分,可以有效地减少用于保护间隔的带宽浪费。仿真结果表明,与已有的子载波分配机制相比,新的子载波分配机制可以获得更高的吞吐量。

关键词：正交频分复用无源光网络子载波分配吞吐量

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Resting-state brain network remodeling after different nerve reconstruction surgeries:a functional magnetic resonance imaging study in brachial plexus injury rats

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Neural Regeneration Research 2025年第5期20卷 1495-1504页

作者： Yunting Xiang Xiangxin xing Xuyun Hua Yuwen Zhang Xin Xue Jiajia wu Mouxiong Zheng He Wang Jianguang Xu School of Rehabilitation Science Shanghai University of Traditional Chinese MedicineShanghaiChina Engineering Research Center of Traditional Chinese Medicine Intelligent Rehabilitation Ministry of EducationShanghaiChina Department of Rehabilitation Medicine Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Department of Traumatology and Orthopedics Yueyang Hospital of Integrated Traditional Chinese and Western MedicineShanghai University of Traditional Chinese MedicineShanghaiChina Institute of Science and Technology for Brain-Inspired Intelligence Fudan UniversityShanghaiChina Key Laboratory of Computational Neuroscience and Brain-Inspired Intelligence(Fudan University) Ministry of EducationShanghaiChina Human Phenome Institute Fudan UniversityShanghaiChina

Distinct brain remodeling has been found after different nerve reconstruction strategies,including motor representation of the affected ***,differences among reconstruction strategies at the brain network level have not been *** study aimed to explore intranetwork changes related to altered peripheral neural pathways after different nerve reconstruction surgeries,including nerve repair,endto-end nerve transfer,and end-to-side nerve ***–Dawley rats underwent complete left brachial plexus transection and were divided into four equal groups of eight:no nerve repair,grafted nerve repair,phrenic nerve end-to-end transfer,and end-to-side transfer with a graft sutured to the anterior upper ***-state brain functional magnetic resonance imaging was obtained 7 months after *** independent component analysis algorithm was utilized to identify group-level network components of interest and extract resting-state functional connectivity values of each voxel within the *** in intra-network resting-state functional connectivity were compared among the *** muscle reinnervation was assessed by behavioral observation(elbow flexion)and *** results showed that alterations in the sensorimotor and interoception networks were mostly related to changes in the peripheral neural *** repair was related to enhanced connectivity within the sensorimotor network,while end-to-side nerve transfer might be more beneficial for restoring control over the affected limb by the original motor *** thalamic-cortical pathway was enhanced within the interoception network after nerve repair and end-to-end nerve *** areas related to cognition and emotion were enhanced after end-to-side nerve *** study revealed important brain networks related to different nerve *** networks may be potential targets for enhancing motor recovery.

关键词： brain functional networks end-to-end nerve transfer end-to-side nerve transfer independent component analysis nerve repair peripheral plexus injury resting-state functional connectivity

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Insights into spinal muscular atrophy from molecular biomarkers

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Neural Regeneration Research 2025年第7期20卷 1849-1863页

作者： Xiaodong xing Xinzhu Liu Xiandeng Li Mi Li Xian wu Xiaohui Huang Ajing Xu Yan Liu Jian Zhang Department of Clinical Pharmacy Xinhua HospitalShanghai Jiao Tong University School of MedicineShanghaiChina College of Pharmacy Chongqing Medical UniversityChongqingChina

Spinal muscular atrophy is a devastating motor neuron disease characterized by severe cases of fatal muscle *** is one of the most common genetic causes of mortality among infants aged less than 2 *** research is currently receiving more attention,and new candidate biomarkers are constantly being *** review initially discusses the evaluation methods commonly used in clinical practice while briefly outlining their respective pros and *** also describe recent advancements in research and the clinical significance of molecular biomarkers for spinal muscular atrophy,which are classified as either specific or non-specific *** review provides new insights into the pathogenesis of spinal muscular atrophy,the mechanism of biomarkers in response to drug-modified therapies,the selection of biomarker candidates,and would promote the development of future ***,the successful utilization of biomarkers may facilitate the implementation of gene-targeting treatments for patients with spinal muscular atrophy.

关键词： biomarkers disease progression gene-targeting therapy neurofilaments Nusinersen spinal muscular atrophy(SMA) survival motor neuron therapeutic evaluation treatment outcomes

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Microstructural evolution and mechanical properties of 55NiCrMoV7 hot-work die steel during quenching and tempering treatments

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Advances in Manufacturing 2021年第4期9卷 520-537页

作者： xing-Sheng Yu Chuan wu ru-xing Shi Ya-Sha Yuan Luoyang CITIC HIC Casting&Forging Co. LtdLuoyang 471039HenanPeople’s Republic of China National-Local Joint Engineering Laboratory of Intelligent Manufacturing Oriented Automobile Die&Mould Tianjin University of Technology and EducationTianjin 300222People’s Republic of China CITIC Heavy Industries Co. LtdLuoyang 471039HenanPeople’s Republic of China

55NiCrMoV7 hot-work die steel is mainly used to manufacture heavy forgings in the fields of aerospace and *** study aims to clarify the effects of heat treatment on the microstructural evolution and mechanical properties of the steel,in order to find out an optimal heat treatment scheme to obtain an excellent balance of strength,ductility and *** steel was quenched at temperature from 790℃ to 910℃ followed by tempering treatments of 100–650℃ for 5 *** mechanical property tests were carried out by tensile,impact toughness and *** microscope(OM),scanning electron microscope(SEM)and transmission electron microscope(TEM)were used to observe the austenite grains,lath martensite,carbides and fracture *** results show that the quenching temperature mainly influences the austenite grain size and the volume fraction of undissolved carbides(UCs),while the tempering temperature mainly influences the size and morphology of the martensite with a body centered cubic(BCC)and the carbides with a face centered cubic(FCC).The mechanical properties of the steel,including yield and tensile strength,ductility,impact toughness and hardness,get an excellent balance at a quenching range of 850–870*** the tempering temperature increases,the yield and tensile strength and hardness decrease,while the ductility and impact toughness *** variation trends can be further verified by fracture SEM observation and *** with a macro-micro coupled finite element(MMFE)modeling technique,the cooling rate,microstructural evolution and yield strength of the steel were predicted and compared with the tested data.

关键词： Hot-work die steel Microstructural evolution Mechanical properties Heat treatment Macro-micro coupled modeling and simulation

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Single-cell omics: experimental workflow, data analyses and applications

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Science China Life Sciences 2025年第1期68卷 5-102页

作者： Fengying Sun Haoyan Li Dongqing Sun Shaliu Fu Lei Gu Xin Shao Qinqin Wang Xin Dong Bin Duan Feiyang xing Jun wu Minmin Xiao Fangqing Zhao Jing-Dong J.Han Qi Liu Xiaohui Fan Chen Li Chenfei Wang Tieliu Shi Department of Clinical Laboratory the Affiliated Wuhu Hospital of East China Normal University (The Second People's Hospital of Wuhu City) Pharmaceutical Informatics Institute College of Pharmaceutical SciencesZhejiang University Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration (Tongji University) Ministry of EducationOrthopaedic DepartmentTongji HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Frontier Science Center for Stem Cells School of Life Sciences and TechnologyTongji University Translational Medical Center for Stem Cell Therapy and Institute for Regenerative Medicine Shanghai East HospitalBioinformatics DepartmentSchool of Life Sciences and TechnologyTongji University Research Institute of Intelligent Computing Zhejiang Lab Shanghai Research Institute for Intelligent Autonomous Systems Center for Single-cell Omics School of Public HealthShanghai Jiao Tong University School of Medicine National Key Laboratory of Chinese Medicine Modernization Innovation Center of Yangtze River DeltaZhejiang University Center for Bioinformatics and Computational Biology Shanghai Key Laboratory of Regulatory Biologythe Institute of Biomedical Sciences and School of Life SciencesEast China Normal University Beijing Institutes of Life Science Chinese Academy of Sciences Peking-Tsinghua Center for Life Sciences Academy for Advanced Interdisciplinary StudiesCenter for Quantitative Biology (CQB)Peking University Zhejiang Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Women's HospitalZhejiang University School of Medicine Key Laboratory of Advanced Theory and Application in Statistics and Data Science-MOE School of StatisticsEast China Normal University

Cells are the fundamental units of biological systems and exhibit unique development trajectories and molecular features. Our exploration of how the genomes orchestrate the formation and maintenance of each cell, and control the cellular phenotypes of various organismsis, is both captivating and intricate. Since the inception of the first single-cell RNA technology, technologies related to single-cell sequencing have experienced rapid advancements in recent years. These technologies have expanded horizontally to include single-cell genome, epigenome,proteome, and metabolome, while vertically, they have progressed to integrate multiple omics data and incorporate additional information such as spatial sc RNA-seq and CRISPR screening. Single-cell omics represent a groundbreaking advancement in the biomedical field,offering profound insights into the understanding of complex diseases, including cancers. Here, we comprehensively summarize recent advances in single-cell omics technologies, with a specific focus on the methodology section. This overview aims to guide researchers in selecting appropriate methods for single-cell sequencing and related data analysis.

关键词： single-cell sequencing genome epigenome proteomics metabolomics multimodal spatial transcriptomics CRISPR screening

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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia wu Ling-Jie Zhu Xiao-Jia Yang Qian-ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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Information fusion diagnosis and early-warning method for monitoring the long-term service safety of high dams

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2012年第9期13卷 687-699页

作者： xing LIU Zhong-ru wu Yang YANG Jiang HU Bo XU State Key Laboratory of Hydrology-Water'Resources and Hydraulic Engineering Hohai UniversityNanjing 210098China National Engineering Research Center of Water Resources Efficient Utilization and Engineering Safety Hohai UniversityNanjing 210098China College of Water-Conservancy and Hydropower Hohai UniversityNanjing 210098China

Analyzing the service behavior of high dams and establishing early-warning systems for them have become increasingly important in ensuring their long-term *** analysis methods used to obtain safety monitoring data are suited only to single survey point *** or even paradoxical results are inevitably obtained when processing large amounts of monitoring data,thereby causing difficulty in acquiring precise ***,we have developed a new method based on multi-source information fusion for conducting a comprehensive analysis of prototype monitoring data of high *** addition,we propose the use of decision information entropy analysis for building a diagnosis and early-warning system for the long-term service of high *** metrics reduction is achieved using information fusion at the data level.A Bayesian information fusion is then conducted at the decision level to obtain a comprehensive ***-warning outcomes can be released after sorting analysis results from multi-positions in the dam according to importance.A case study indicates that the new method can effectively handle large amounts of monitoring data from numerous survey *** can likewise obtain precise real-time results and export comprehensive early-warning outcomes from multi-positions of high dams.

关键词： Dam monitoring Diagnosis Early-warning Multi-source information fusion Information entropy

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Complex Behaviors of a Simple Traffic Model

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Communications in Theoretical Physics 2006年第5X期46卷 952-960页

作者： GAO xing-ru Department of Physics and Institute of Theoretical Physics Beijing Normal University Beijing 100875 China Fundamental Teaching Department Beijing Union University Beijing 100101 China

In this paper, we propose a modified traffic model in which a single car moves through a sequence of traffic lights controlled by a step function instead of a sine function. In contrast to the previous work [Phys. Rev. E 70 （2004） 016107], we have investigated in detail the dependence of the behavior on four parameters, ω,α,η and α1, and given three kinds of bifurcation diagrams, which show three kinds of complex behaviors. We have found that in this model there are chaotic and complex periodic motions, as well as special singularities. We have also analyzed the characteristic of the complex period motion and the essential feature of the singularity.

关键词： traffic model complex behavior chaos bifurcation diagram singularity

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