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Peptidomimetic-based antibody surrogate for HER2

Acta Pharmaceutica Sinica B 2021年第9期11卷 2645-2654页

作者： Mengmeng Zheng Chunpu li Mi Zhou ru Jia Fengyu She Lulu Wei Feng Cheng qi li Jianfeng Cai Yan Wang Department of Chemistry University of South FloridaTampaFL 33620USA Department of Medical Oncology&Cancer Institute of Medicine Shuguang HospitalShanghai University of Traditional Chinese MedicineShanghai 201203China Academy of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghai 201203China Department of Pharmaceutical Science College of PharmacyUniversity of South FloridaTampaFL 33612USA

Inhibition of human epidermal growth factor receptor 2 mediated cell signaling pathway is an important therapeutic strategy for HER2-positive *** monoclonal antibodies are currently used as marketed drugs,their large molecular weight,high cost of production and susceptibility to proteolysis could be a hurdle for long-term *** this study,we reported a strategy for the development of artificial antibody based on y-AApeptides to target HER2 extracellular domain(ECD).To achieve this,we synthesized a one-bead-two-compound(OBTC)library containing 320,000 cyclic y-AApeptides,from which we identified a y-AApeptide,M-3-6,that tightly binds to HER2 ***,we designed an antibody-like dimer of M-3-6,named M-3-6-D,which showed excellent binding affinity toward HER2 comparable to monoclonal ***,M-3-6-D was completely resistant toward enzymatic *** addition,it could effectively inhibit the phosphorylation of HER2,as well as the downstream signaling pathways of AKT and ***,M-3-6-D also efficiently inhibited cell proliferation in vitro,and suppressed tumor growth in SKBR3 xenograft model in vivo,implying its therapeutic potential for the treatment of *** small molecular weight,antibody-like property,resistance to proteolysis,may enable it a new generation of artificial antibody ***,our strategy of artificial antibody surrogate based on dimers of cyclicγ-AApeptides could be applied to a myriad of disease-related receptor targets in future.

关键词： HER2 Anti-cancer Peptidomimetics γ-AApeptides Antibody-surrogate

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Effect of Guanxin Danshen Dripping Pills on Coronary Heart Disease Comorbid with Depression or Anxiety: The ADECODE-Real World Study

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Chinese Journal of Integrative Medicine 2024年第5期30卷 443-448页

作者： WU Shi-hao SHI Wei-qi li Yu-hang liU ru-hui HU Da-yi ZHENG li-qiang MA Wen-lin Department of Geriatric Medicine Tongji HospitalSchool of MedicineTongji UniversityShanghai 200065China Department of Cardiology Tongji HospitalSchool of MedicineTongji UniversityShanghai 200065China Department of Cardiology Peking University People's HospitalBeijing 100044China School of Public Health Shanghai Jiao Tong UniversityShanghai 200030China

Objective: To evaluate the efficacy of Guanxin Danshen Dripping Pill(GXDSDP) in treating anxiety and depression in patients with coronary heart disease(CHD). Methods: A total of 1,428 patients diagnosed with CHD screened for anxiety, depression, and quality of life(QOL) at baseline received 0.4 g of GXDSDP treatment 3 times per day and returned for monthly reassessment. Patients were recruited after stable treatment for CHD and received assessment of General Anxiety Disorder-7(GAD-7), Patient Health Questionnaire-9(PHQ-9), and Seattle Angina Questionnaire(SAQ) for evaluating anxiety, depression, and *** were followed up 3 times, once every 4 weeks, during outpatient visits for 12 weeks. Results: At the third follow-up(F3), the anxiety symptom of 63.79%(673/1,055) of the patients improved to sub-clinical level, and the GAD-7 score improved significantly(8.11 vs. 3.87, Plinical level, with a significant improvement in PHQ-9 score(8.69 vs. 4.41, Pline(all Plimitation(31.17 vs. 34.14), anginal stability(2.74 vs. 4.14), anginal frequency(8.16vs. 9.10), treatment satisfaction(13.43 vs. 16.29), and disease perception(8.69 vs. 11.02). Conclusions: A fixed dosage of GXDSDP may be a potential treatment option for CHD patients comorbid with anxiety or depression.(Registration No. ChiCTR2100051523)

关键词： Guanxin Danshen Dripping Pill coronary heart disease depression anxiety quality of life Chinese medicine

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A simple method to synthesize worm-like AlN nanowires and its field emission studies

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Chinese Physics B 2021年第8期30卷 469-474页

作者： qi liang Meng-qi Yang Chang-Hao Wang ru-Zhi Wang Institute of New Energy Materials and Devices of Faculty of Materials and Manufacturing Key Laboratory of Advanced Functional Materials of Education Ministry of ChinaBeijing University of TechnologyBeijing 100124China

The worm-like AlN nanowires are fabricated by the plasma-enhanced chemical vapor deposition(PECVD)on Si substrates through using Al powder and N2 as precursors,CaF2 as fluxing medium,Au as catalyst,*** as-grown worm-like AlN nanowires each have a polycrystalline and hexagonal wurtzite *** diameters are about 300 nm,and the lengths are over 10μ*** growth mechanism of worm-like AlN nanowires is *** plasma plays a very important role in forming the polycrystalline structure and rough surfaces of worm-like AlN *** worm-like AlN nanowires exhibit an excellent field-emission(FE)property with a low turn-on field of 4.5 V/μm at a current density of 0.01 mA/cm^(2) and low threshold field of 9.9 V/μm at 1 mA/cm^(2).The emission current densities of worm-like AlN nanowires each have a good *** enhanced FE properties of worm-like AlN nanowires may be due to their polycrystalline and rough structure with nanosize and high aspect *** excellent FE properties of worm-like AlN nanowires can be explained by a grain boundary conduction *** results demonstrate that the worm-like AlN nanowires prepared by the proposed simple and the PECVD method possesses the potential applications in photoelectric and field-emission devices.

关键词： worm-like aluminum nitride nanowires growth mechanism plasma enhanced chemical vapor deposition field-emission property

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Robustness Assessment of Asynchronous Advantage Actor-Critic Based on Dynamic Skewness and Sparseness Computation: A Parallel Computing View

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Journal of Computer Science & Technology 2021年第5期36卷 1002-1021页

作者： Tong Chen Ji-qiang liu He li Shuo-ru Wang Wen-Jia Niu En-Dong Tong liang Chang qi Alfred Chen Gang li Beijing Key Laboratory of Security and Privacy in Intelligent Transportation Beijing Jiaotong University Beijing 100044China Guangxi Key Laboratory of Trusted Software Guilin University of Electronic TechnologyGuilin 541004China Donald Bren School of Information and Computer Sciences University of CaliforniaIrvine 92697U.S.A. Centre for Cyber Security Research and Innovation Deakin UniversityGeelongVIC 3216Australia

Reinforcement learning as autonomous learning is greatly driving artificial intelligence(AI)development to practical *** demonstrated the potential to significantly improve synchronously parallel learning,the parallel computing based asynchronous advantage actor-critic(A3C)opens a new door for reinforcement ***,the acceleration's influence on A3C robustness has been largely *** this paper,we perform the first robustness assessment of A3C based on parallel *** perceiving the policy's action,we construct a global matrix of action probability deviation and define two novel measures of skewness and sparseness to form an integral robustness *** on such static assessment,we then develop a dynamic robustness assessing algorithm through situational whole-space state sampling of changing *** experiments with different combinations of agent number and learning rate are implemented on an A3C-based pathfinding application,demonstrating that our proposed robustness assessment can effectively measure the robustness of A3C,which can achieve an accuracy of 83.3%.

关键词： robustness assessment skewness sparseness asynchronous advantage actor-critic reinforcement learning

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Study on the performance of ceramic composite projectile penetrating into ceramic composite target

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Defence Technology（防务技术） 2017年第4期13卷 295-299页

作者： Rong-cheng Yi li-kui Yin Jian-ru Wang Zhi-gang Chen Di-qi Hu National Defense Key Laboratory of Underground Damage Technology North University of China Taiyuan 030051 China

In order to study the performance of ceramic composite projectile penetrating into ceramic composite target,the contrast test and numerical simulations of the penetration of standard projectile and the ceramic composite projectile into a ceramic composite target were *** results show that the penetration performance of ceramic composite projectile is obvious superior to that of standard projectile for ceramic composite *** ceramic nose of ceramic composite projectile fully destroys the ceramic panels anterior to its following armor-piercing projectile body,thus maintaining the penetration ability of the following armor-piercing projectile body.

关键词： Ceramic Composite projectile Penetration Composite target Test

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一种新型压配式腰椎椎间融合器的机械性能

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中国组织工程研究 2025年第21期29卷 4492-4498页

作者：李世文于长水刘启王智博刘禹良祁全哈尔滨医科大学附属第一医院黑龙江省哈尔滨市150000

背景:行经皮微创椎间孔腰椎椎间融合置入椎间融合器时,由于入路操作范围狭窄,有牵拉神经根损伤或置入融合器位置不良等风险,为了解决以上问题作者课题组发明了一种新型机械结构可变形压配式cage(Press-fit cage,YP-cage)。目的:对新型... 详细信息

背景:行经皮微创椎间孔腰椎椎间融合置入椎间融合器时,由于入路操作范围狭窄,有牵拉神经根损伤或置入融合器位置不良等风险,为了解决以上问题作者课题组发明了一种新型机械结构可变形压配式cage(Press-fit cage,YP-cage)。目的:对新型腰椎融合器YP-cage的机械强度特性进行初步评估。方法:对不同尺寸9,11,13 mm高度的新型YP-cage(n=9)和聚醚醚酮-cage(n=9)进行了静态轴向压缩实验和静态轴向扭转实验,分别采集力-位移曲线计算屈服位移及载荷、极限载荷位移及刚度,屈服角位移及扭矩、极限载荷角位移扭矩及刚度,并进行对比分析。结果与结论:(1)在静态轴向压缩测试中,YP-cage在3组测试中(9,11,13 mm),其刚度、屈服载荷、极限位移和载荷极限方面均优于聚醚醚酮-cage(P <0.01),但YP-cage的屈服位移小于聚醚醚酮-cage(P <0.05);(2)在静态扭转测试中,除了9 mm组的YP-cage和聚醚醚酮-cage在极限扭转角度上差异无显著性意义,YP-cage在屈服扭矩、屈服扭转角度及极限扭矩均小于聚醚醚酮-cage(P <0.01),而YP-cage扭转刚度在9 mm组和11 mm组大于聚醚醚酮-ccage(P <0.01);(3)结果表明新型压配式机械结构椎间融合器相较于聚醚醚酮材质cage具有更高的抗压强度,但抗扭强度不如聚醚醚酮-cage。

关键词：椎间融合装置经孔椎体间融合术脊柱融合机械性能物理性质

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Technical Innovation of Land Treatment Systems for Municipal Wastewater in Northeast China

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Pedosphere 2006年第3期16卷 297-303页

作者： ZHOU qi-Xing ZHANG qian-ru SUN Tie-Heng Shenyang Key Laboratory of Environmental Engineering Shenyang University Shenyang 110010 （China） College of Environmental Science and Engineering Nankai University Tianjin 300071 （China） Key Laboratory of Terrestrial Ecological Process Institute of Applied Ecology Chinese Academy of Sciences Shenyang 110016 （China） Graduate School of the Chinese Academy of Sciences Beijing 100039 （China）

On the basis of ecological principles including holistic optimization, cycling and regeneration, and regional differentiation, land treatment systems (LTSs) for municipal wastewater were continuously explored and updated in the western Shenyang area and the Huolinhe area, China. Intensified pretreatment, addition of a man-made soil filtration layer, and use of an ecologically diversified secondary plant cover were proved to be technically feasible. Hydraulic loading was determined according to the assimilation capacity of soil ecosystems, thus ensuring safe operation of wastewater treatment. This modernized and alternative approach to wastewater treatment had been widely applied in middle-sized and small cities and towns of Northeast China, and these innovative systems in some areas had indicated favorable ecological, social, and economic benefits.

关键词： land treatment system municipal wastewater soil ecosystem soil purification

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Powerful CMD:a tool for color-magnitude diagram studies

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Research in Astronomy and Astrophysics 2017年第7期17卷 77-88页

作者： Zhong-Mu li Cai-Yan Mao qi-Ping Luo Zhou Fan Wen-Chang Zhao li Chen ru-Xi li Jian-Po Guo Institute for Astronomy and History of Science and Technology Dali University Key Laboratory for Optical Astronomy National Astronomical ObservatoriesChinese Academy of Sciences College of Science and Technology Puer University

We present a new tool for color-magnitude diagram（CMD） studies, Powerful CMD. This tool is built based on the advanced stellar population synthesis（ASPS） model, in which single stars, binary stars, rotating stars and star formation history have been taken into account. Via Powerful CMD, the distance modulus, color excess, metallicity, age, binary fraction, rotating star fraction and star formation history of star clusters can be determined simultaneously from observed CMDs. The new tool is tested via both simulated and real star clusters. Five parameters of clusters NGC 6362, NGC 6652, NGC 6838 and M67 are determined and compared to other works. It is shown that this tool is useful for CMD studies, in particular for those utilizing data from the Hubble Space Telescope（HST）. Moreover, we find that inclusion of binaries in theoretical stellar population models may lead to smaller color excess compared to the case of single-star population models.

关键词： (stars:) Hertzsprung-russell and C-M diagrams - (Galaxy:) globular clusters general -galaxies clusters general

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A binary study of color-magnitude diagrams of 12 globular clusters

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Research in Astronomy and Astrophysics 2010年第2期10卷 135-141页

作者： Zhong-Mu li Cai-Yan Mao ru-Heng li ru-Xi li Mao-Cai li College of Physics and Electronic Information Dali University Dali 671003 China National Astronomical Observatories Chinese Academy of Sciences Beijing 100012 China

Binary stars are common in star clusters and galaxies, but the detailed ef- fects of binary evolution are not taken into account in some color-magnitude diagram （CMD） studies. This paper studies the CMDs of twelve globular clusters via binary- star stellar populations. The observational CMDs of the star clusters are compared to those of binary-star populations, and then the stellar metallicities, ages, distances and reddenings of these star clusters are obtained. The paper also tests the different effects of binary and single stars on CMD studies. It is shown that binaries can better fit the observational CMDs of the sample globular clusters compared to single stars. This suggests that the effects of binary evolution should be considered when modeling the CMDs and stellar populations of star clusters and galaxies.

关键词： (Galaxy:) globular clusters: general -- galaxies: star clusters

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高光谱预处理方法与多模型在分类判别中的对比研究

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光谱学与光谱分析 2025年第1期45卷 125-132页

作者：居雷于洁吴炎淼李丽卢天丁亚萍束茹欣上海烟草集团有限责任公司技术中心上海200082 上海大学化学系上海200444 上海数之微信息科技有限公司上海200444

高光谱技术能够快速、无损地获取丰富的信息,在植物研究和监测中已成为一种广泛应用的工具。茄科植物作为一种重要的经济农作物,与高光谱技术结合进行研究具有巨大的应用潜力。本研究采用高光谱技术对茄科植物的初烤后不同部位叶片进行... 详细信息

高光谱技术能够快速、无损地获取丰富的信息,在植物研究和监测中已成为一种广泛应用的工具。茄科植物作为一种重要的经济农作物,与高光谱技术结合进行研究具有巨大的应用潜力。本研究采用高光谱技术对茄科植物的初烤后不同部位叶片进行分类研究。采用Field Spec 3光谱辐射仪对293份不同部位的茄科植物粉末样本进行高光谱采样,采用S-G平滑以及一阶导数和二阶导数的方法对数据进行预处理,用于信息增强和去除噪声,并通过偏最小二乘法对数据进行降维,以减少冗余特征。基于降维数据,采样支持向量机、逻辑回归、K近邻、决策树、随机森林和梯度提升决策树这六种机器学习算法建立分类模型。结果显示,在分类任务中,经过一阶导数处理后,支持向量机模型最佳,在训练集和测试集上分别实现了100.0%和84.7%的准确率。经网格参数优化后确定最优参数为:最大深度不限制,最小样本分割数为4,估计器数量为200。参数优化后五折交叉验证准确率为88.1%,训练集准确率为100%,测试集准确率为86.4%。研究结果表明,预处理方法结合降维方法能够增强数据信息使得分类模型能够更好地捕捉茄科植物样本的特征。该研究对于快速、准确、无损地区分茄科植物的部位具有重要意义。

关键词：高光谱部位分类机器学习

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