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Mass Spectrometry Imaging-Based Single-Cell Lipidomics Profiles Metabolic Signatures of Heart Failure

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Research 2023年第3期6卷 309-318页

作者： Jie Ren Hao-Wen Li Liang Chen Min Zhang Yan-Xiang Liu Bo-Wen Zhang rui Xu Yan-Yan Miao Xue-Mei Xu Xin Hua Xiao-Gang Sun ru-jia yu Yi-Tao Long Sheng-Shou Hu State Key Laboratory of Cardiovascular Disease Fuwai HospitalNational Center for Cardiovascular DiseaseChinese Academy of Medicine Science(CAMS)and Perking Union Medical College(PUMC)Beijing100037P.R.China Institute of Molecular Medicine Shanghai Key Laboratory for Nucleic Acid Chemistry and NanomedicineState Key Laboratory of Oncogenes and Related GenesRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai200127P.R.China School of Chemistry and Molecular Engineering East China University of Science and TechnologyShanghai200237P.R.China jiangsu Engineering Laboratory of Smart Carbon-Rich Materials and Device School of Chemistry and Chemical EngineeringSoutheast UniversityNanjing211189P.R.China State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry and Chemical EngineeringNanjing UniversityNanjing210023P.R.China

Heart failure(HF),leading as one of the main causes of mortality,has become a serious public health issue with high prevalence around the *** cardiomyocyte(CM)metabolomics promises to revolutionize the understanding of HF pathogenesis since the metabolic remodeling in the human hearts plays a vital role in the disease ***,current metabolic analysis is often limited by the dynamic features of metabolites and the critical needs for high-quality isolated ***,high-quality CMs were directly isolated from transgenic HF mice biopsies and further employed in the cellular metabolic *** lipids landscape in individual CMs was profiled with a delayed extraction mode in time-of-flight secondary ion mass *** metabolic signatures were identified to distinguish HF CMs from the control subjects,presenting as possible single-cell *** spatial distributions of these signatures were imaged in single cells,and those were further found to be strongly associated with lipoprotein metabolism,transmembrane transport,and signal *** together,we systematically studied the lipid metabolism of single CMs with a mass spectrometry imaging method,which directly benefited the identification of HF-associated signatures and a deeper understanding of HF-related metabolic pathways.

关键词： signature metabolism Profiles

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新型细长支杆振动抑制方法

东北大学学报（自然科学版） 2024年第10期45卷 1425-1434页

作者：贾如玉姚红良陈亚强唐陈伟东北大学机械工程与自动化学院辽宁沈阳110819

基于点阵结构比刚度高、轻质量和设计性强等优点,提出在点阵结构内部填充黏弹性阻尼材料,设计了新型细长支杆-阻尼填充点阵支杆,该结构在具有足够承载能力的基础上拥有较高的阻尼性能.利用有限元方法对点阵支杆和阻尼填充支杆进行动力... 详细信息

基于点阵结构比刚度高、轻质量和设计性强等优点,提出在点阵结构内部填充黏弹性阻尼材料,设计了新型细长支杆-阻尼填充点阵支杆,该结构在具有足够承载能力的基础上拥有较高的阻尼性能.利用有限元方法对点阵支杆和阻尼填充支杆进行动力学分析,并通过响应面方法建立了一阶共振频率对应的动刚度峰值的响应面近似模型,分析了结构参数对动力学特性的影响,使用遗传算法对动刚度峰值进行了优化,确定了在给定结构参数范围内减振性能最好的结构尺寸参数.最后实验证明阻尼填充点阵支杆的加速度响应幅值降低了57.14%,验证其优越的减振性能.

关键词：细长支杆振动抑制点阵结构黏弹性阻尼材料参数优化

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大学英语听力认知策略应用研究——以长治医学院为例

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长治学院学报 2019年第6期36卷 103-105页

作者：茹家玉长治医学院外语教学部

英语听力水平在一定程度上能够影响学生的职业发展。当前,在英语听力学习过程中,学生由于不善于使用听力策略而影响了对材料的理解,从而导致听力成绩提升非常缓慢。利用课堂教学资源,进行听力认知策略的科学实践,发现在英语教学过程中... 详细信息

英语听力水平在一定程度上能够影响学生的职业发展。当前,在英语听力学习过程中,学生由于不善于使用听力策略而影响了对材料的理解,从而导致听力成绩提升非常缓慢。利用课堂教学资源,进行听力认知策略的科学实践,发现在英语教学过程中运用合理的听力策略,能够有效提高学生的听力成绩。

关键词：大学英语教学听力策略

从归化和异化两种翻译策略角度看《上党钩沉》的英译

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长治学院学报 2021年第1期38卷 61-65页

作者：茹家玉长治医学院公共外语教学部山西长治046011

中国神话故事民族特性鲜明,为了让外国读者更好地了解中国的传统文化,神话故事翻译工作显得尤为重要。作者以归化和异化策略为指导原则,以《上党钩沉》这本书为载体,探讨了文化负载词、古诗句、成语等相关信息的不同翻译策略;通过对书... 详细信息

中国神话故事民族特性鲜明,为了让外国读者更好地了解中国的传统文化,神话故事翻译工作显得尤为重要。作者以归化和异化策略为指导原则,以《上党钩沉》这本书为载体,探讨了文化负载词、古诗句、成语等相关信息的不同翻译策略;通过对书中例子进行分析,论述了归化异化的翻译理论对神话故事翻译的适用性。

关键词：归化异化翻译策略《上党钩沉》

miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu Xiao-jia Yang Qian-ru He Fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

Integration of Electrical Properties and Polarization Loss Modulation on Atomic Fe–N‑RGO for Boosting Electromagnetic Wave Absorption

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Nano-Micro Letters 2025年第2期17卷 517-532页

作者： Kaili Zhang yuefeng Yan Zhen Wang Guansheng Ma Dechang jia Xiaoxiao Huang yu Zhou State Key Laboratory of Precision Welding&Joining of Materials and Structures Harbin Institute of TechnologyHarbin 150001People’s Republic of China School of Materials Science and Engineering Harbin Institute of TechnologyHarbin 150001People’s Republic of China MIIT Key Laboratory of Advanced Structural‑Functional Integration Materials&Green Manufacturing Technology Harbin Institute of TechnologyHarbin 150001People’s Republic of China

Developing effective strategies to regulate graphene’s conduction loss and polarization has become a key to expanding its application in the electromagnetic wave absorption(EMWA)*** on the unique energy band structure of graphene,regulating its bandgap and electrical properties by introducing heteroatoms is considered a feasible ***,metal-nitrogen doping reduced graphene oxide(M–N-RGO)was prepared by embedding a series of single metal atoms M–N_(4) sites(M=Mn,Fe,Co,Ni,Cu,Zn,Nb,Cd,and Sn)in RGO using an N-coordination atom-assisted *** composites had adjustable conductivity and polarization to optimize dielectric loss and impedance matching for efficient EMWA *** results showed that the minimum reflection loss(RL_(min))of Fe–N-RGO reaches−74.05 dB(2.0 mm)and the maximum effective absorption bandwidth(EAB_(max))is 7.05 GHz(1.89 mm)even with a low filler loading of only 1 wt%.Combined with X-ray absorption spectra(XAFS),atomic force microscopy,and density functional theory calculation analysis,the Fe–N_(4) can be used as the polarization center to increase dipole polarization,interface polarization and defect-induced polarization due to d-p orbital hybridization and structural ***,electron migration within the Fe further leads to conduction loss,thereby synergistically promoting energy *** study demonstrates the effectiveness of metal-nitrogen doping in regulating the graphene′s dielectric properties,which provides an important basis for further investigation of the loss mechanism.

关键词： Electromagnetic wave absorption Fe-N-RGO Dipole polarization Conduction loss Impedance matching

火针配合圆利针治疗原发性三叉神经痛疗效观察

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上海针灸杂志 2017年第2期36卷 154-156页

作者：吕婷婷赵军贾儒玉黑龙江中医药大学哈尔滨150040 黑龙江中医药大学附属第一医院哈尔滨150040

目的观察火针配合圆利针治疗原发性三叉神经痛的临床疗效。方法将62例原发性三叉神经痛患者随机分为治疗组和对照组,每组31例。治疗组先用火针点刺扳机点,然后用圆利针深刺下关穴,并远端取合谷、内庭。对照组选穴同治疗组,并采用常规针... 详细信息

目的观察火针配合圆利针治疗原发性三叉神经痛的临床疗效。方法将62例原发性三叉神经痛患者随机分为治疗组和对照组,每组31例。治疗组先用火针点刺扳机点,然后用圆利针深刺下关穴,并远端取合谷、内庭。对照组选穴同治疗组,并采用常规针刺法。治疗2个疗程后对两组的临床疗效进行评价。结果治疗组总有效率为93.5%(29/31),对照组为77.4%(24/31),两组比较差异有统计学意义(P<0.05)。结论火针配合圆利针是一种治疗原发性三叉神经痛的有效方法。

关键词：火针疗法针刺圆利针三叉神经痛

Inhibition of the NLRP3 inflammasome attenuates spiral ganglion neuron degeneration in aminoglycoside-induced hearing loss

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Neural Regeneration Research 2025年第10期20卷 3025-3039页

作者： jia Fang Zhuangzhuang Li Pengjun Wang Xiaoxu Zhang Song Mao Yini Li Dongzhen yu Xiaoyan Li Yazhi Xing Haibo Shi Shankai Yin Department of Otolaryngology Head and Neck Surgery Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of MedicineOtolaryngology Institute of Shanghai Jiao Tong UniversityShanghai Key Laboratory of Sleep Disordered BreathingShanghaiChina Department of Otorhinolaryngology-Head and Neck Surgery Shanghai Children’s HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghaiChina

Aminoglycosides are a widely used class of antibacterials renowned for their effectiveness and broad antimicrobial ***,their use leads to irreversible hearing damage by causing apoptosis of hair cells as their direct *** addition,the hearing damage caused by aminoglycosides involves damage of spiral ganglion neurons upon *** investigate the mechanisms underlying spiral ganglion neuron degeneration induced by aminoglycosides,we used a C57BL/6J mouse model treated with *** found that the mice exhibited auditory deficits following the acute loss of outer hair *** ganglion neurons displayed hallmarks of pyroptosis and exhibited progressive degeneration over *** profiling of these neurons showed significant upregulation of genes associated with inflammation and immune response,particularly those related to the NLRP3 *** of the canonical pyroptotic pathway in spiral ganglion neurons was observed,accompanied by infiltration of macrophages and the release of proinflammatory *** intervention targeting NLRP3 using Mcc950 and genetic intervention using NLRP3 knockout ameliorated spiral ganglion neuron degeneration in the injury *** findings suggest that NLRP3 inflammasome-mediated pyroptosis plays a role in aminoglycoside-induced spiral ganglion neuron *** of this pathway may offer a potential therapeutic strategy for treating sensorineural hearing loss by reducing spiral ganglion neuron degeneration.

关键词： degeneration hearing loss macrophages Mcc950 neuroinflammation NLRP3 inflammasome ototoxicity pyroptosis sensorineural hearing loss spiral ganglion neuron

Sine oculis homeobox homolog family function in gastrointestinal cancer:Progression and comprehensive analysis

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World Journal of Clinical Oncology 2025年第1期16卷 10-24页

作者： Yang-Zheng Lan Zheng Wu Wen-jia Chen Xin-Ning yu Hua-Tao Wu Jing Liu Department of The Breast Center Cancer Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina Department of General Surgery First Affiliated Hospital of Shantou University Medical CollegeShantou 515041Guangdong ProvinceChina

The sine oculis homeobox homolog(SIX)family,a group of transcription factors characterized by a conserved DNA-binding homology domain,plays a critical role in orchestrating embryonic development and organogenesis across various organisms,including *** six distinct members,from SIX1 to SIX6,each member contributes uniquely to the development and differentiation of diverse tissues and organs,underscoring the versatility of the SIX *** or mutations in SIX genes have been implicated in a spectrum of developmental disorders,as well as in tumor initiation and progression,highlighting their pivotal role in maintaining normal developmental trajectories and cellular *** to target the transcriptional complex of the SIX gene family have emerged as a promising strategy to inhibit tumor *** the development of inhibitors targeting this gene family is still in its early stages,the significant potential of such interventions holds promise for future therapeutic ***,this review aimed to comprehensively explore the advancements in understanding the SIX family within gastrointestinal cancers,focusing on its critical role in normal organ development and its implications in gastrointestinal cancers,including gastric,pancreatic,colorectal cancer,and hepatocellular *** conclusion,this review deepened the understanding of the functional roles of the SIX family and explored the potential of utilizing this gene family for the diagnosis,prognosis,and treatment of gastrointestinal cancers.

关键词： Sine oculis homeobox homolog Gastrointestinal cancer Transcription factor Development Regulation Diagnosis Therapeutics