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Midterm outcomes of penetrating keratoplasty following allogeneic cultivated limbal epithelial transplantation in patients with bilateral limbal stem cell deficiency

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International Journal of Ophthalmology(English edition) 2021年第11期14卷 1690-1699页

作者： Jun-Fa Xue Dong-Fang Li Ya-Ni Wang Chen Chen ru-fei yang Qing-Jun Zhou Ting Liu Li-Xin Xie Yan-Ling Dong School of Medicine and Life Sciences Shandong First Medical UniversityJinan 271016Shandong ProvinceChina State Key Laboratory Cultivation Base Shandong Province Key Laboratory of OphthalmologyShandong Eye InstituteShandong First Medical University&Shandong Academy of Medical SciencesQingdao 266071Shandong ProvinceChina Medical College Qingdao UniversityQingdao 266071Shandong ProvinceChina Department of Ophthalmology Shandong UniversityJinan 250100Shandong ProvinceChina Qingdao Eye Hospital of Shandong First Medical University Qingdao 266071Shandong ProvinceChina

AIM:To evaluate the midterm outcomes of penetrating keratoplasty(PK)following allogeneic cultivated limbal epithelial transplantation(CLET)for bilateral total limbal stem cell deficiency(LSCD).METHODS:Ten patients(10 eyes)with bilateral LSCD were enrolled in this prospective noncomparative case series *** participant underwent PK approximately 6 mo after a *** tacrolimus,topical and systemic steroids,and oral ciclosporin were administered ***-corrected visual acuity(BCVA),intraocular pressure(IOP),ocular surface grading scores(OSS),corneal graft epithelial rehabilitation,persistent epithelial defect(PED),immunological rejection,and graft survival rate were ***:The time interval between PK and allogeneic CLET was 6.90±1.29(6-10)*** improved from 2.46±0.32 log MAR preoperatively to 0.77±0.55 log MAR post-PK(P<0.001).Kaplan-Meier analysis of mean graft survival revealed graft survival rates of 100%at 12 and 24 mo and 80.0%at 36 *** appeared in 5 eyes at different periods post-PK,and graft rejection occurred in 4 *** total OSS decreased from 12.4±4.4 before allogeneic CLET to 1.4±1.51 after ***:A sequential therapy design of PK following allogeneic CLET can maintain a stable ocular surface with improved BCVA despite the relatively high graft rejection rate.

关键词： limbal stem cell deficiency allogeneic cultured limbal epithelial transplantation penetrating keratoplasty graft rejection

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miRNA-21-5p is an important contributor to the promotion of injured peripheral nerve regeneration using hypoxia-pretreated bone marrow-derived neural crest cells

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Neural Regeneration Research 2025年第1期20卷 277-290页

作者： Meng Cong Jing-Jing Hu Yan Yu Xiao-Li Li Xiao-Ting Sun Li-Ting Wang Xia Wu Ling-Jie Zhu Xiao-Jia yang Qian-ru He fei Ding Hai-Yan Shi School of Medicine Nantong UniversityNantongJiangsu ProvinceChina Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education and Coinnovation Center of Neuroregeneration Nantong UniversityNantongJiangsu ProvinceChina Department of Physiology Jiangsu Health Vocational CollegeNanjingJiangsu ProvinceChina Department of Pathology Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina Jiangsu Clinical Medicine Center of Tissue Engineering and Nerve Injury Repair Affiliated Hospital of Nantong UniversityNantongJiangsu ProvinceChina

Our previous study found that rat bone marrow–derived neural crest cells(acting as Schwann cell progenitors)have the potential to promote long-distance nerve ***-based therapy can enhance peripheral nerve repair and regeneration through paracrine bioactive factors and intercellular ***,the complex contributions of various types of soluble cytokines and extracellular vesicle cargos to the secretome remain *** investigate the role of the secretome and extracellular vesicles in repairing damaged peripheral nerves,we collected conditioned culture medium from hypoxia-pretreated neural crest cells,and found that it significantly promoted the repair of sensory neurons damaged by oxygen-glucose *** mRNA expression of trophic factors was highly expressed in hypoxia-pretreated neural crest *** performed RNA sequencing and bioinformatics analysis and found that miR-21-5p was enriched in hypoxia-pretreated extracellular vesicles of neural crest ***,to further clarify the role of hypoxia-pretreated neural crest cell extracellular vesicles rich in miR-21-5p in axonal growth and regeneration of sensory neurons,we used a microfluidic axonal dissociation model of sensory neurons in vitro,and found that hypoxia-pretreated neural crest cell extracellular vesicles promoted axonal growth and regeneration of sensory neurons,which was greatly dependent on loaded ***,we constructed a miR-21-5p-loaded neural conduit to repair the sciatic nerve defect in rats and found that the motor and sensory functions of injured rat hind limb,as well as muscle tissue morphology of the hind limbs,were obviously *** findings suggest that hypoxia-pretreated neural crest extracellular vesicles are natural nanoparticles rich in ***-21-5p is one of the main contributors to promoting nerve regeneration by the neural crest cell *** helps to explain the mechanism of action of the secretome and e

关键词： axotomy cell-free therapy conditioned medium extracellular vesicles hypoxic preconditioning microRNA oxygen-glucose deprivation peripheral nerve injury Schwann cell precursors

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microRNA-155在原发性开角型青光眼发病机制中的作用

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国际眼科杂志 2018年第5期18卷 836-839页

作者：杨茹菲苏颖蒋鑫王峰哈尔滨医科大学附属第一医院眼科分院中国黑龙江省哈尔滨市150001

microRNA在眼部组织有特定表达,对眼部组织发挥独特作用。microRNA-155可调控多种信号通路,影响相应蛋白的表达,导致细胞、组织的形态和功能等异常。原发性开角型青光眼的产生机制尚不完全明确,现认为小梁网的形态功能异常是引起眼内压... 详细信息

microRNA在眼部组织有特定表达,对眼部组织发挥独特作用。microRNA-155可调控多种信号通路,影响相应蛋白的表达,导致细胞、组织的形态和功能等异常。原发性开角型青光眼的产生机制尚不完全明确,现认为小梁网的形态功能异常是引起眼内压升高的主要原因。研究microRNA-155对原发性开角型青光眼发生发展的影响,可以为原发性开角型青光眼的发病机制和诊治提供新的思路。

关键词： microRNA-155 原发性开角型青光眼小梁网细胞外基质

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High-dose dexamethasone regulates microglial polarization via the GR/JAK1/STAT3 signaling pathway after traumatic brain injury

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Neural Regeneration Research 2025年第9期20卷 2611-2623页

作者： Mengshi yang Miao Bai Yuan Zhuang Shenghua Lu Qianqian Ge Hao Li Yu Deng Hongbin Wu Xiaojian Xu fei Niu Xinlong Dong Bin Zhang Baiyun Liu Beijing Tiantan Hospital Capital Medical UniversityBeijingChina Department of Neurology The First Hospital of Tsinghua UniversityBeijingChina Department of Neurotrauma and Beijing Key Laboratory of Central Nervous System Injury Beijing Neurosurgical InstituteCapital Medical UniversityBeijingChina Department of Critical Care Medicine Beijing Tiantan HospitalCapital Medical UniversityBeijingChina Center for Nerve Injury and Repair Beijing Institute of Brain DisordersChina National Clinical Research Center for Neurological DiseasesBeijingChina

Although microglial polarization and neuroinflammation are crucial cellular responses after traumatic brain injury,the fundamental regulatory and functional mechanisms remain insufficiently *** potent anti-inflammato ry agents,the use of glucoco rticoids in traumatic brain injury is still controversial,and their regulatory effects on microglial polarization are not yet *** the present study,we sought to determine whether exacerbation of traumatic brain injury caused by high-dose dexamethasone is related to its regulatory effects on microglial polarization and its mechanisms of *** vitro cultured BV2 cells and primary microglia and a controlled cortical impact mouse model were used to investigate the effects of dexamethasone on microglial ***,dexamethasone,ru486(a glucocorticoid receptor antagonist),and ruxolitinib(a Janus kinase 1 antagonist)were ***-sequencing data obtained from a C57BL/6 mouse model of traumatic brain injury were used to identify potential targets of *** Morris water maze,quantitative reverse transcription-polymerase chain reaction,western blotting,immunofluorescence and confocal microscopy analysis,and TUNEL,Nissl,and Golgi staining were performed to investigate our ***-throughput sequencing results showed that arginase 1,a marker of M2 microglia,was significantly downregulated in the dexamethasone group compared with the traumatic brain injury group at3 days post-traumatic brain *** dexamethasone inhibited M1 and M2 microglia,with a more pronounced inhibitory effect on M2microglia in vitro and in *** receptor plays an indispensable role in microglial polarization after dexamethasone treatment following traumatic brain ***,glucocorticoid receptor activation increased the number of apoptotic cells and neuronal death,and also decreased the density of dendritic spines.A possible downstream receptor signaling mechanism is th

关键词： apoptosis BV2 microglia dexamethasone glucocorticoid receptor glucocorticoids innate immune system microglial polarization neuroinflammation primary microglia traumatic brain injury

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Novel method for improving iron recovery from electric arc furnace slag: on-site hot modification

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Journal of Iron and Steel Research International 2022年第8期29卷 1224-1235页

作者： Xiang Lu Xiao-li Huang ru-fei Wei Wen Chen Da-qiang Cang fei-hua yang Chun-lei Pu Changsha Research Institute of Mining&Metallurgy Co. Ltd.Changsha 410012HunanChina School of Metallurgy and Ecological Engineering University of Science and Technology BeijingBeijing 100083China Technological Institute of Development and Strategy Studies Panzhihua 617000SichuanChina School of Metallurgical Engineering Anhui University of TechnologyMa’anshan 243000AnhuiChina State Key Laboratory of Solid Waste Reuse for Building Materials(SKL-SWR) Beijing Building Materials Academy of Sciences Research(BBMA)Beijing 100083China Iron and Steel Technology Research Institute HUATIAN Engineering&Technology CorporationMCCNanjing 210019JiangsuChina

The iron element in electric arc furnace(EAF)slag is extremely difficult to recycle due to the low specific magnetic susceptibility of the RO phase(a solid solution of FeO,MgO,CaO,and MnO).Landfilling EAF slag is strictly forbidden for environmental consideration because of poisonous Cr^(6+) *** original RO phase could be transformed to a spinel structure,whose specific magnetic susceptibility is much higher than that of other minerals,through hot modification,resulting in significantly increased iron recovery by magnetic *** of spinel crystals encloses chromium,such that iron and chromium could be recovered *** chromium in obtained iron concentrates is considerably useful for stainless steel making rather than polluting the *** a result,recovering iron and chromium is truly beneficial for cleaner *** modification of EAF slag should be conducted at 1500-1600ºC for at least 60 min to guarantee homogeneous liquid *** liquid slag was poured onto an iron mold to obtain modified slag(MS)through air *** was characterized by thermodynamic analysis,X-ray diffraction,and scanning electron microscopy combined with energy-dispersive spectroscopy to correlate the relationship between mineral structures and iron *** iron recovery rate of MS first increased and then decreased with increasing *** was less than 10%when the modifier addition amount was below 12 wt.%,but it increased rapidly as the modifier addition amount increased from 16 to 24 wt.%,mainly due to spinel *** highest iron recovery rate was 81.9%when the modifier amount reached 20 wt.%.Meanwhile,Cr^(6+) was enriched in the spinel phase but was not observed in other *** tests were performed on-site with the modifier ranging from 12 to 18 wt.%because additional heat was not provided during the *** showed that MS with 18 wt.%modifier addition exhibited an iron recovery rate of 61.0%,much h

关键词： EAF slag On-site hot modification Iron recovery Chromium recovery Spinel Industrial test

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Rapid identification of Dendrobium officinale using Loop-Mediated Isothermal Amplification (LAMP) method

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Chinese Journal of Natural Medicines 2019年第5期17卷 337-345页

作者： yang Lu WU Wen-ru ZHOU Hua LAI Hui-Li FU fei School of Pharmaceutical Sciences Guangzhou University of Chinese Medicine Faculty of Chinese Medicine Macao University of Science and Technology State Key Laboratory of Quality Research in Chinese Medicine Macao University of Science and Technology School of Nursing Guangdong Food and Drug Vocational College

Dendrobium officinale is not only an ornamental plant, but also a valuable medicinal herb that is widely used in traditional Chinese medicine. However, distinguishing D. officinale from other Dendrobium species is usually a difficult task. In this study,we developed a rapid identification protocol for D. officinale using the loop-mediated isothermal amplification(LAMP) method. A set of primers were specifically designed to detect a modified internal transcribed spacer region of D. officinale at 65 ℃ within 40 min after adding SYBR~? Green I, which was used for the detection of D. officinale. Unlike commonly used adulterants, reaction mixtures containing D. officinale DNA changed from orange to green, and this color change was easily observed with the naked eye. Thus, this methodology can be used to accurately differentiate D. officinale from other Dendrobium species, is quick as all D. officinale samples were amplified within 40 min, and specific as samples of the adulterants were not amplified. The specificity of this LAMP-based method was confirmed by testing 17 samples of D. officinale and 32 adulterant samples from other Dendrobium species. This LAMP-based rapid identification method does not require expensive equipment or specialized techniques and can be used in field surveys for accurate and fast on-site identification.

关键词： Dendrobium officinale ITS Loop-mediated isothermal amplification Identification

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Influences of CeO_(2)morphology on enhanced performance of electro-Fenton for wastewater treatment

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Journal of Rare Earths 2022年第12期40卷 1870-1877,I0002页

作者： Jingjing Hu Bei Wu Lei Chen Chengcheng Song Huifang yang fei Long Jie Sun ru'an Chi Hubei Novel Reactor&Green Chemical Technology Key Laboratory Key Laboratory for Green Chemical Process of Ministry of EducationXingfa School of Mining EngineeringWuhan Institute of TechnologyWuhan 430073China Key Laboratory of Catalysis and Materials Science of the State Ethnic Affairs Commission&Ministry of Education Hubei ProvinceCollege of Resource and Environmental ScienceSouth-Central University for NationalitiesWuhan 430074China

As a kind of rare-earth oxide,CeO_(2)has been considered as a great potential material for its abundant oxygen vacancies and catalysis activity in wastewater *** this study,three ceria samples with different morphological structure were prepared,and their effect on contaminates degradation in electro-Fenton(E-Fenton)system was *** is found that the morphology of CeO_(2)has great influence on promoting the performance of E-Fenton *** rod-like CeO_(2)(R-CeO_(2))induced EFenton system shows higher azo dye X3 B removal and mineralization rates than cubs(C-CeO_(2))and octahedrons(O-CeO_(2)),and the degradation kinetic rate constants are 0.28,0.169 and 0.181 min^(-1)respectively,already surpass that of the blank one(0.120 min^(-1)).The H_(2)O_(2)generation capacity of R-CeO_(2)induced E-Fenton system is also superior to the others,and the corresponding Faraday current efficiency even increases to 166.2%at 2.5 *** by scanning-transmission electron microscopy(STEM),X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS),electron spin resonance(ESR),Raman spectroscopy were conducted to disclose the mystery behind this *** results indicate that the difference of surface oxygen vacancy density in different shaped CeO_(2)acts as a magic driving force for the accelerated oxygen reduction,and then leads to the enhanced degradation efficiency of E-Fenton *** work provides a new insight into the development and application of rare-earth elements based catalyst in E-Fenton technology.

关键词： CeO_(2) Electro-Fenton Current efficiency Exposed facets H_(2)O_(2) Morphology

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Knowledge-based detection method for SAR targets

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Journal of Systems Engineering and Electronics 2014年第4期25卷 573-579页

作者： fei Gao Achang ru Jun Wang Shiyi Mao School of Electronic and Information Engineering Beihang University

When the classical constant false-alarm rate （CFAR） combined with fuzzy C-means （FCM） algorithm is applied to target detection in synthetic aperture radar （SAR） images with complex background, CFAR requires block-by-block estimation of clutter models and FCM clustering converges to local optimum. To address these problems, this paper pro-poses a new detection algorithm： knowledge-based combined with improved genetic algorithm-fuzzy C-means （GA-FCM） algorithm. Firstly, the algorithm takes target region＇s maximum and average intensity, area, length of long axis and long-to-short axis ratio of the external ellipse as factors which influence the target appearing probabil- ity. The knowledge-based detection algorithm can produce preprocess results without the need of estimation of clutter models as CFAR does. Afterward the GA-FCM algorithm is improved to cluster pre-process results. It has advantages of incorporating global optimizing ability of GA and local optimizing ability of FCM, which will further eliminate false alarms and get better results. The effectiveness of the proposed technique is experimentally validated with real SAR images.

关键词： synthetic aperture radar (SAR) target detection,knowledge-based improved genetic algorithm-fuzzy C-means(GA-FCM) algorithm.

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3D nitrogen and boron dual-doped carbon quantum dots/reduced graphene oxide aerogel for advanced aqueous and flexible quasi-solid-state zinc-ion hybrid capacitors

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Rare Metals 2023年第7期42卷 2307-2323页

作者： Jun-Jun Yao Chang Liu Jing-Ying Li Zhong-Liang Hu ru-Yi Zhou Chen-Chen Guo Xin-ru Liu fei-Fan yang Yi-Rong Zhu Hunan Key Laboratory of Green Metallurgy and New Energy Materials College of Materials and Advanced ManufacturingHunan University of TechnologyZhuzhou412007China School of Chemistry and Chemical Engineering Hunan Institute of EngineeringXiangtan411104China National&Local Joint Engineering Research Center for Advanced Packaging Material and Technology Hunan University of TechnologyZhuzhou412007China

As prospective energy storage devices,zinc-ion hybrid capacitors(ZHCs)still suffer from unsatisfactory cathode ***,the three dimensional(3D)N,B dual-doped carbon quantum dots/reduced graphene oxide(N,B-CQDs/rGO)composite aerogel is prepared via a onepot hydrothermal *** to the synergism of CQDs modification and N,B dual-doping,the resultant N,B-CQDs/rGO composite aerogel delivers superior electrochemical ***,the as-obtained N,B-CQDs/rGO composite aerogel is served as a cathode for aqueous and flexible quasi-solid-state ZHCs for the first ***,the aqueous N,B-CQDs/rGO//Zn ZHC manifests a large energy density of 96.2 Wh·kg^(-1)at80 W·kg^(-1)and still remains a high energy density of 54.7Wh·kg^(-1)at a superb power density of 80 kW·kg^(-1).Meanwhile,kinetic analyses are employed to elucidate the prominent power performance,and various ex situ tests are undertaken to explore the energy storage mechanism of aqueous *** notably,the flexible quasi-solid-state N,B-CQDs/rGO//Zn ZHC displays a desirable energy density(89.1μWh·cm^(-2)),a superior power density(96,000μW·cm^(-2))and exceptional flexible *** present study offers a valuable reference for designing and developing advanced cathode materials for aqueous and flexible quasi-solid-state ZHCs.

关键词： Carbon quantum dots(CQDs) Graphene aerogel Heteroatom dual-doping Energy storage mechanism Zinc-ion hybrid capacitors(ZHCs)

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Hydrochloric acid-enhanced radiofrequency ablation for treating a large hepatocellular carcinoma with spontaneous rapture:a case report

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Chinese Journal of Cancer 2017年第1期36卷 44-49页

作者： ru-Hai Zou yang-Kui Gu fei Gao Tian-Qi Zhang Wang Yao Xiong-Ying Jiang Yan-yang Zhang Department of Minimally Invasive Interventional Therapy Sun Yat-sen University Cancer Center State Key Laboratory of Oncology in South ChinaCollaborative Innovation Center for Cancer Medicine Department of Oncologic Interventional Therapy The First Affiliated Hospital Sun Yat-sen University Department of Radiology Intervention Sun Yat-sen Memorial Hospital Sun Yat-sen University Department of Intervention The Third Affiliated Hospital Sun Yat-sen University

Background:A ruptured hepatocellular carcinoma(HCC)is often *** addition to surgery and transarterial embo?lization,radiofrequency ablation(RFA)might be another option for treating a ruptured ***,conven?tional RFA has a limited ablation zone;as such,it is rarely used to treat ruptured *** presentation:This case was a 60?year?old man who had a large,ruptured HCC in which hydrochloric acid(HCl)?enhanced RFA successfully controlled the bleeding and made the tumor completely ***:Considering the effectiveness of HCl?enhanced RFA in achieving hemostasis and tumor ablation,it might be a new option for treating large,ruptured HCCs.

关键词： Hydrochloric acid Radiofrequency ablation Spontaneous rupture Hepatocellular carcinoma

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