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Science China Chemistry 2024年第9期67卷 3050-3062页

作者： Yanxi Yang Xinru kong Xueli Ren Yandai Lin Zhe Liu Academy of Medical Engineering and Translational Medicine Tianjin University Tianjin Key Laboratory of Brain Science and Neural Engineering Tianjin University

It is desirable but always challenging to develop a cutting-edge tumor treatment strategy with high therapeutic efficacy, lesiontargeted precision and mild accessibility. Compared to traditional treatment modalities, photodynamic therapy has been widely studied since the generation of reactive oxygen species（ROS） at cancerous lesions unprecedentedly offers a convenient approach for localized tumor eliminations. Nevertheless, the consumption of oxygen for ROS production in a hypoxic tumor microenvironment has dramatically limited its feasibility and efficacy. Herein, the engineered nanocomposites of BTO@PDA-ICGHA with photodynamic and pyroelectric performances have been fabricated and applied to the photodynamic-pyroelectric dynamic treatments. The continuing ROS production derived from intracellular oxygen（O2） and water（H2O） by laser irradiation contributed to the superb tumor cell apoptosis and significant tumor growth inhibition. Thus, this study has validated a new concept by depositing the engineered nanocomposites at the tumor just like Trojan horses, facilitating ROS release as killers and exerting the NIR-induced cell apoptosis and tumor growth inhibition with high therapeutic efficiency and expectable translational perspectives.

关键词： nanocomposites pyroelectric effect photodynamic therapy cell apoptosis tumor growth inhibition

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Pt/Mo chalcogenide composite deriving from Pt-Mo_(6)S_8 by high temperature shock for enhanced HER performance

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Chinese Chemical Letters 2024年第3期35卷 497-501页

作者： Meng Liu Guocheng Lv Hao Liu Tianming Liu Lingchang kong Libing Liao Engineering Research Center of Ministry of Education for Geological Carbon Storage and Low Carbon Utilization of Resources Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid WastesNational Laboratory of Mineral MaterialsSchool of Materials Science and TechnologyChina University of Geosciences(Beijing)Beijing 100083China School of Science China University of GeosciencesBeijing 100083China

Highly efficient catalysts for electrolysis of water are crucial to the development of hydrogen energy which is helpful to carbon ***,high temperature shock(HTS),with advantage of rapid speed,universality and scalable production,has been a promising method in synthesis of *** this paper,HST was used to treat low Pt loading Mo_(6)S_(8)for enhanced water splitting ***,the optimized MoS_(2)/MoO_(2)/Mo_(6)S_(8)nano-composite with low Pt mass loading(~4%)displays well hydrogen evolution reaction(HER)electrochemical *** overpotential is 124 mV to reach 10 mA/cm^(2)and the corresponding Tafel slope is 88 mV/dec in acidic *** mass activity is 6.2 mA/μg_(Pt)at-124 mV ***,which is almost 2 times relative to 20%Pt/***,it presents distinguished stability even after 2000 *** work will broaden the way of catalysts preparation and the application of hydrogen evolution.

关键词： HTS Low Pt loading Mo_(6)S_8 MoS_(2)/MoO_(2)/Mo_(6)S_8 composite HER

The Journey/DAO/TAO of Embodied Intelligence: From Large Models to Foundation Intelligence and Parallel Intelligence

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IEEE/CAA Journal of Automatica Sinica 2024年第6期11卷 1313-1316页

作者： Tianyu Shen Jinlin Sun Shihan kong Yutong Wang Juanjuan Li Xuan Li Fei-Yue Wang College of Information Science and Technology Beijing University of Chemical TechnologyBeijing 100029China School of Electrical and Information Engineering Jiangsu UniversityZhenjiang 212013China State Key Laboratory for Turbulence and Complex Systems Department of Advanced Manufacturing and RoboticsCollege of EngineeringPeking UniversityBeijing 100871China State Key Laboratory of Multimodal Artificial Intelligence Systems Institute of AutomationChinese Academy of SciencesBeijing 100190China Peng Cheng Laboratory Shenzhen 518000China State Key Laboratory for Management and Control of Complex Systems Chinese Academy of SciencesBeijing 100190 Faculty of Innovation Engineering Macao University of Science and TechnologyMacao 999078China IEEE

THE tremendous impact of large models represented by ChatGPT[1]-[3]makes it necessary to con-sider the practical applications of such models[4].However,for an artificial intelligence(AI)to truly evolve,it needs to possess a physical“body”to transition from the virtual world to the real world and evolve through interaction with the real *** this context,“embodied intelligence”has sparked a new wave of research and technology,leading AI beyond the digital realm into a new paradigm that can actively act and perceive in a physical environment through tangible entities such as robots and automated devices[5].

关键词： Intelligence DAO TAO

An improved particle filter indoor fusion positioning approach based on Wi-Fi/PDR/geomagnetic field

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Defence Technology（防务技术） 2024年第2期32卷 443-458页

作者： Tianfa Wang Litao Han Qiaoli kong Zeyu Li Changsong Li Jingwei Han Qi Bai Yanfei Chen College of Geodesy and Geomatics Shandong University of Science and TechnologyQingdao266590China Key Laboratory of Geomatics and Digital Technology of Shandong Province Shandong University of Science and TechnologyQingdao266590China

The existing indoor fusion positioning methods based on Pedestrian Dead Reckoning(PDR)and geomagnetic technology have the problems of large initial position error,low sensor accuracy,and geomagnetic *** this study,a novel indoor fusion positioning approach based on the improved particle filter algorithm by geomagnetic iterative matching is proposed,where Wi-Fi,PDR,and geomagnetic signals are integrated to improve indoor positioning *** important contribution is that geomagnetic iterative matching is firstly proposed based on the particle filter *** the positioning process,an iterative window and a constraint window are introduced to limit the particle generation range and the geomagnetic matching range *** position is corrected several times based on geomagnetic iterative matching in the location correction stage when the pedestrian movement is detected,which made up for the shortage of only one time of geomagnetic correction in the existing particle filter *** addition,this study also proposes a real-time step detection algorithm based on multi-threshold constraints to judge whether pedestrians are moving,which satisfies the real-time requirement of our fusion positioning *** experimental verification,the average positioning accuracy of the proposed approach reaches 1.59 m,which improves 33.2%compared with the existing particle filter fusion positioning algorithms.

关键词： Fusion positioning Particle filter Geomagnetic iterative matching Iterative window Constraint window

Microstructure and room temperature fracture toughness of Nb-Si-based alloys with Sr addition

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Rare Metals 2024年第8期43卷 3904-3912页

作者： Yong-Lin Huang Li-Na Jia Bin kong Yue-Ling Guo Na Wang School of Materials Science and Engineering Beihang University

Nb-Si-based alloys show great potential to surpass the widely used Ni-based *** element Sr is widely applied in aluminum and magnesium alloys,but reports about the effects of Sr on Nb-Si-based alloys are quite ***,Nb-Si-based alloys with nominal compositions of Nb-15Si-24Ti-4Cr-2Al-2Hf-0/0.05/0.15Sr（at%）were prepared by directional solidification and heat *** microstructural characterization and room temperature fracture toughness of Nb-Si-based alloy were systematically *** show that all these alloys consist of Nb5Si3phase embedded within Nb solid solution(Nbss) *** Nb5Si3phase becomes refined and more discontinuous after adding minor *** for the fracture toughness,0.05 at% and 0.15 at% Sr additions do not cause significant *** discontinuous and refining mechanism of Sr element was studied,and the analysis of toughness decreasing with Sr addition reveals that the size of Nbssphase plays a crucial role in determining the fracture toughness.

关键词： Nb–Si alloy Refinement Discontinuous Fracture toughness Nb ss

Immune checkpoint inhibitors:breakthroughs in cancer treatment

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Cancer Biology & Medicine 2024年第6期21卷 451-472页

作者： Xueqing kong Jinyi Zhang Shuwei Chen Xianyang Wang Qing Xi Han Shen Rongxin Zhang Laboratory of Immunology and Inflammation School of Life Sciences and BiopharmaceuticsGuangdong Pharmaceutical UniversityGuangzhou 510006China Department of Biology School of Life Sciences and BiopharmaceuticsGuangdong Pharmaceutical UniversityGuangzhou 510006China

Over the past two decades,immunotherapies have increasingly been considered as first-line treatments for most *** such treatment is immune checkpoint blockade(ICB),which has demonstrated promising results against various solid tumors in clinical *** antibodies(mAbs)are currently available as immune checkpoint inhibitors(ICIs).These ICIs target specific immune checkpoints,including cytotoxic T-lymphocyte-associated antigen-4(CTLA-4)and programmed cell death protein 1(PD-1).Clinical trial results strongly support the feasibility of this immunotherapeutic ***,a substantial proportion of patients with cancer develop resistance or tolerance to treatment,owing to tumor immune evasion mechanisms that counteract the host immune ***,substantial research focus has been aimed at identifying additional ICIs or synergistic inhibitory receptors to enhance the effectiveness of anti-PD-1,anti-programmed cell death ligand 1(anti-PD-L1),and anti-CTLA-4 ***,several immune checkpoint molecular targets have been identified,such as T cell immunoreceptor with Ig and ITIM domains(TIGIT),mucin domain containing-3(TIM-3),lymphocyte activation gene-3(LAG-3),V-domain immunoglobulin suppressor of T cell activation(VISTA),B and T lymphocyte attenuator(BTLA),and signal-regulatory proteinα(SIRPα).Functional m Abs targeting these molecules are under ***-4,PD-1/PD-L1,and other recently discovered immune checkpoint proteins with distinct structures are at the forefront of *** review discusses these structures,as well as clinical progress in m Abs targeting these immune checkpoint molecules and their potential applications.

关键词： Immunotherapy cancer ICIs PD-1 CTLA-4

Multi-agent distributed optimization based on the game theory and its application in automobile chassis

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Multi-agent distributed optimization based on the game theor...

Double Closed-Loop Control of High-Regulation of Electronically Controlled Air Suspension

第37届中国控制会议

作者： ru kong Niaona Zhang Xuanxuan Bao Xiaohui Lu Changchun University of Technology

Most problems in real life can be solved by optimizing a series of complex ***,most of the existing optimization theories are dependent on the specific application scenarios,and lack a systematized optimization *** most of the existing optimization algorithms are based on the global information to build a decision-making mechanism,it’s difficult to meet in *** this purpose this paper studies the multi-agent optimization problem of the hot research in the field of complex multi-objective optimization in the world in recent years,and proposes a multi-agent distributed optimization method based on the game *** paper achieves global optimization by analyzing the optimization target of each agent and determining the action strategy of multi-agent,finally,taking the automobile chassis as an example to to verify this method.

关键词： Multi-agent Distributed optimization Game theory Automobile chassis

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Double Closed-Loop Control of High-Regulation of Electronica...

Garnet and Zircon U-Pb Geochronology and Geochemistry Reveal Genesis of the Dafang Au-Pb-Zn-Ag Deposit,Southern Hunan

第36届中国控制会议

作者： Niaona Zhang Yanyang Li Xiaohui Lu ru kong School of Electrical & Electronic Engineering Changchun University of Technology School of Mechatronic Engineering Changchun University of Technology

Electronic control air suspension in the vehicle height adjustment process in the presence of time delay,over charging,over discharge and oscillation *** order to solve this problem,design a double closed-loop controller based on sliding mode control and PID control,through the neural network algorithm,dynamic adjustment of the controller structure parameters,in order to achieve the precise control of the body *** tracking control of neural network PID algorithm is used to control the height of outer ring *** the mathematical model of the suspension,the inner loop adopts sliding mode control to realize the optimal control force *** on Matlab/Simulink software,a simulation model of the vehicle body height control system is established to verify the reliability of the *** and analysis of the process of the vehicle static height and the tracking performance of the dynamic *** results show that the control system can effectively reduce the error in the adjustment process and meet the requirements of the control precision.

关键词： Electronically Controlled air Suspension Vehicle High Regulation Neural Network PID Sliding Mode Control

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Acta Geologica Sinica(English Edition) 2024年第3期98卷 717-735页

作者： JIANG Hua kong Hua LIU Biao TAN Fucheng QIN Yixue HUANG Jingang ZHU Yu Key Laboratory of Metallogenic Prediction of Nonferrous Metals and Geological Environment Monitoring Ministry of EducationSchool of Geosciences and Info-PhysicsCentral South UniversityChangsha 410083China School of Geosciences and Info-Physics Central South UniversityChangsha 410083China Hunan Baoshan Nonferrous Metals and Minerals Co. Ltd.ChenzhouHunan 424402China

Garnet is a primary mineral in skarn deposits and plays a significant role in recording copious mineralization and metallogenic *** study systematically investigates the geochemistry and geochronology of garnet and zircon in the Dafang Au-Pb-Zn-Ag deposit,which represents prominent gold mineralization in southern Hunan,*** samples with distinct zoning patterns and compositional variations were identified using various analytical techniques,including Backscattered Electron(BSE)imaging,Cathodoluminescence(CL)response,textural characterization,and analysis of rare-earth elements(REE),major contents,and trace element *** garnet was dated U-Pb dating,which yielded a lower intercept age of 161.06±1.93 *** age is older than the underlying granodiorite porphyry,which has a concordia age of 155.13±0.95 Ma determined by zircon U-Pb *** results suggest that the gold mineralization may be related to the concealed *** groups of garnet changed from depleted Al garnet to enriched Al garnet,and the rare earth element(REE)patterns of these groups were converted from light REE(LREE)-enriched and heavy REE(HREE)-depleted with positive europium(Eu)anomalies to medium REE(MREE)-enriched from core to rim *** different REE patterns of garnet in various zones may be attributed to changes in the fluid environment and late superposition *** development of distal skarn in the southern Hunan could be a significant indicator for identifying gold mineralization.

关键词： garnet and zircon U-Pb dating LA-ICP-MS mapping Dafang Southern Hunan

Spatial compartmentalization and temporal stability of associated microbiota in Pacific oyster Crassostrea gigas

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Journal of Oceanology and Limnology 2024年第4期42卷 1348-1358页

作者： Qiang FU Zichao YU Junyan ZHAO Lei GAO Ning kong Lingling WANG Linsheng SONG Liaoning Key Laboratory of Marine Animal Immunology and Disease Control Dalian Ocean UniversityDalian 116023China Functional Laboratory of Marine Fisheries Science and Food Production Processes Qingdao National Laboratory for Marine Science and TechnologyQingdao 266237China Southern Marine Science and Engineering Guangdong Laboratory(Zhuhai) Zhuhai 519000China Dalian Key Laboratory of Aquatic Animal Disease Prevention and Control Dalian Ocean UniversityDalian 116023China

The Pacific oyster Crassostrea gigas,one of the most exploited molluscs in the world,has suffered from massive mortality in recent decades,and the occurrence mechanisms have not been well *** this study,to reveal the relationship of associated microbiota to the fitness of oysters,temporal dynamics of microbiota in the gill,hemolymph,and hepatopancreas of *** during April 2018-January 2019 were investigated by 16 S rRNA gene *** microbiota in *** exhibited tissue heterogeneity,of which Spirochaetaceae was dominant in the gill and hemolymph while Mycoplasmataceae enriched in the ***-occurrence network demonstrated that the gill microbiota exhibited higher inter-taxon connectivity while the hemolymph microbiota had more *** richness(Chao 1 index)and diversity(Shannon index)of microbial community in each tissue showed no significant seasonal variations,except for the hepatopancreas having a higher richness in the ***,beta diversity analysis indicated a relatively stable microbiota in each tissue during the sampling period,showing relative abundance of the dominant taxa exhibiting temporal *** indicate that the microbial community in *** showed a tissue-specific stability with temporal dynamics in the composition,which might be essential for the tissue functioning and environmental adaption in *** work provides a baseline microbiota in *** and is helpful for the understanding of host-microbiota interaction in oysters.

关键词： Pacific oyster associated microbiota spatial compartmentalization temporal stability