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Asian Pacific Journal of Tropical Medicine 2015年第7期8卷 518-523页

作者： Cedillo J Kholif AE Salem AZM Elghandour MMY Vázquez JF Alonso MU Barbabosa A Chagoyán JCV Reyna ag University center of UAEM-Temascaltepec Autonomous University of the Mexico State Dairy Science Department National Research Centre Faculty of Veterinary Medicine and Animal Science Autonomous University of the Mexico State Autonomous University of the Tamaulipas Faculty of Engineering and Science

Objective: To explore anthelmintic effects of oral administration of aqueous extract of Sauce llorón(Salix babylonica; SB) against gastrointestinal nematodes and Moniezia spp. Methods: Sixteen Pelibuey male lambs of 3-4 months of age and(23.7±3.3) kg body weight were used in a completely randomized design to be fed a total mixed ration(Control; SB0), or Control plus SB extract using 20(SB20), 40(SB40) and 60(SB60) mL/lamb/day for 45 days. Lambs had a natural gastrointestinal nematodes and Moniezia spp. infection and had never been treated with chemical anthelmintic drugs. Individual faecal samples were collected for ova counting using Mc Master procedure after 0, 7, 14, 21, 30 and 45 days post extract administration. Results: No extract dose×day interactions for both gastrointestinal nematodes and Monieziaspp. egg count were found. Administration of SB extract had a higher effect(quadratic effect, P=0.0064) at dose of 20 mL SB/lamb/day for gastrointestinal nematode eggs during the first 21 days; however, the dose of SB40 tended(linear effect, P=0.0897) to be more effective than the others for Moniezia spp. egg during the first 7 days. Sampling day had a linear(P=0.0436) effect on Moniezia spp. egg count. Conclusions: The aqueous extract of SB could be more effective against nematodes at 20 and at 40 mL/lamb/day for Moniezia spp. The use of the SB extract could represent a promising alternative to synthetic anthelmintics for the treatment of gastrointestinal nematodes and Moniezia spp. in small ruminants from organic and conventional production systems.

关键词： Anthelmintic Extract Moniezia spp. Nematodes

Tumor-stroma ratio as prognostic factor for survival in rectal adenocarcinoma: A retrospective cohort study

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World Journal of Gastrointestinal Oncology 2017年第12期9卷 466-474页

作者： René Scheer Alexi Baidoshvili Shorena Zoidze Marloes ag Elferink Annefleur EM Berkel Joost M Klaase Paul J van Diest Department of Surgery Medisch Spectrum Twente Laboratory for Pathology East-Netherlands Netherlands Comprehensive Cancer Organization Location Enschede Department of Pathology University Medical Center Utrecht

AIM To evaluate the prognostic value of the tumor-stroma ratio(TSR) in rectal *** TSR was determined on hematoxylin and eosin stained histological sections of 154 patients treated for rectal adenocarcinoma without prior neoadjuvant treatment in the period 1996-2006 by two observers to assessreproducibility. Patients were categorized into three categories: TSR-high [carcinoma percentage(CP) ≥ 70%], TSR-intermediate(CP 40%, 50% and 60%) and TSR-low(CP ≤ 30%). The relation between categorized TSR and survival was analyzed using Cox proportional hazards *** Thirty-six(23.4%) patients were scored as TSR-low, 70(45.4%) as TSR-intermediate and 48(31.2%) as TSRhigh. TSR had a good interobserver agreement(κ = 0.724, concordance 82.5%). Overall survival(OS) and disease free survival(DFS) were significantly better for patients with a high TSR(P = 0.01 and P = 0.02, respectively). A similar association existed for disease specific survival(P = 0.06). In multivariate analysis, patients without lymph node metastasis and an intermediate TSR had a higher risk of dying from rectal cancer(HR = 5.27, 95%CI: 1.54-18.10), compared to lymph node metastasis negative patients with a high TSR. This group also had a worse DFS(HR = 6.41, 95%CI: 1.84-22.28). An identical association was seen for OS. These relations were not seen in lymph node metastasis positive patients. CONCLUSION The TSR has potential as a prognostic factor for survival in surgically treated rectal cancer patients, especially in lymph node negative cases.

关键词： Rectal cancer Adenocarcinoma Prognosis Recurrence Pathology Tumor-stroma ratio

What VW to do in China

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中国汽车（英文版） 1999年第4期 5-7,21页

作者： Interviewing with the officials of VW ag

Volkswagen ag took part in the ever-great auto exhibition of this century in China, Auto Shanghai ’99 held during July 15 to 20, with an unprecedented display space of more than 1,000 square meters and brought 14 passenger cars as well as the dissections of Lupo and Passat to the visitors. During the exhibition, reporters of CHINA AUTO interviewed with the officials of VW ag. Here are the records of the interview.

关键词： will What VW to do in China

Suppression of the External MitochondrialNADPH Dehydrogenase, NDB1, in Arabidopsisthaliana Affects Central Metabolism andVegetative Growth

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Molecular Plant 2014年第2期7卷 356-368页

作者： Wallström S Florez-Sarasa I Araújo WL Aidemark M Fernández-Fernández M Fernie AR Ribas-Carbó M Rasmusson ag Department of Biology Lund University Biology building Sölvegatan 35 SE-223 62 Lund Sweden

Ca2＋-dependent oxidation of cytosolic NADPH is mediated by NDB1, which is an external type II NADPHdehydrogenase in the plant mitochondrial electron transport chain. Using RNA interference, the NDB1 transcript wassuppressed by 80% in Arabidopsis thaliana plants, and external Ca2＋-dependent NADPH dehydrogenase activity becameundetectable in isolated mitochondria. This was linked to a decreased level of NADP＋ in rosettes of the transgenic ***-grown transgenic seedlings displayed decreased growth specifically on glucose, and respiratory metabolism of 14C-glucose was increased. On soil, NDBl-suppressing plants had a decreased vegetative biomass, but leaf maximumquantum efficiency of photosystem Ⅱ and CO2 assimilation rates, as well as total respiration, were similar to the wild-type. The in vivo alternative oxidase activity and capacity were also similar in all genotypes. Metabolic profiling revealeddecreased levels of sugars, citric acid cycle intermediates, and amino acids in the transgenic lines. The NDBl-suppressioninduced transcriptomic changes associated with protein synthesis and glucosinolate and jasmonate metabolism. Thetranscriptomic changes also overlapped with changes observed in a mutant lacking ABAINSENSITIVE4 and in A. thalianaoverexpressing stress tolerance genes from rice. The results thus indicate that A. thaliana NDB1 modulates NADP（H）reduction levels, which in turn affect central metabolism and growth, and interact with defense signaling.

关键词： citric acid cycle metabolic profiling mitochondrial respiration NADPH RNA interference type II NAD(P)Hdehydrogenase vegetative growth

铁螯合剂1-羟乙基-2-乙基-3-羟基吡啶-4-酮的合成

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中国医药工业杂志 1998年第5期29卷 203-204页

作者：吉爱国 Ji,ag 山东医科大学药学系

铁螯合剂１－羟乙基－２－乙基－３－羟基吡啶－４－酮的合成ＳＹＮＴＨＥＳＩＳＯＦ１┐ＨＹＤＲＯＸＹＥＴＨＹＬ┐２┐ＥＴＨＹＬ┐３┐ＨＹＤＲＯＸＹＰＹＲＩＤ┐４┐ＯＮＥＳＡＳＩＲＯＮＣＨＥＬＡＴＯＲＳ吉爱国（山东医科大学... 详细信息

铁螯合剂１－羟乙基－２－乙基－３－羟基吡啶－４－酮的合成ＳＹＮＴＨＥＳＩＳＯＦ１┐ＨＹＤＲＯＸＹＥＴＨＹＬ┐２┐ＥＴＨＹＬ┐３┐ＨＹＤＲＯＸＹＰＹＲＩＤ┐４┐ＯＮＥＳＡＳＩＲＯＮＣＨＥＬＡＴＯＲＳ吉爱国（山东医科大学药学系，济南２５００１２）ＪＩＡｉ...

关键词：铁螯合剂羟乙基羟基吡啶酮合成

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葡萄霜霉病人工生活模型构建

浙江农业大学学报 1998年第5期24卷 509-516页

作者： Cost.,JO Rosa,ag Evolutionary Systems and Biomedical Engineering Laboratory 葡萄牙

对葡萄霜霉病无性态的生活与流行模型进行了研究。本模型模仿了人工环境条件下病菌群体的演化。病原菌人工群体包括病菌无性态阶段各种生活型；生活型之间属浙进发育关系；根据环境因素及生活型本身的特性的变化，不同生活型则存活，繁... 详细信息

对葡萄霜霉病无性态的生活与流行模型进行了研究。本模型模仿了人工环境条件下病菌群体的演化。病原菌人工群体包括病菌无性态阶段各种生活型；生活型之间属浙进发育关系；根据环境因素及生活型本身的特性的变化，不同生活型则存活，繁殖或死亡。每个生活型的酶主要依据已有文献及该型个体对环境的反应特性的不同。

关键词：葡萄霜霉病生活史模型

Study on incisional implantation of tumor cells by carbon dioxide pneumoperitoneum in gastric cancer of a murine model

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World Journal of Gastroenterology 1999年第6期5卷 544-546页

作者： Wang H Zheng MH Zhang HB Zhu J He JR Lu ag Ji YB Zhang MJ Jiang Y Yu BM Li HW Shanghai Second Med Univ Ruijin Hosp Dept Surg Shanghai 200025 Peoples R China Shanghai Inst Digest Surg Shanghai 200025 Peoples R China

INTRODUCTIONPort-site recurrence after laparoscopic tumor surgery is a frequent complication in cancer operations, such as gallbladder, stomach, ovary and colon[1-5]. The incidence of port-site recurrence after laparoscopic colectomy ranged from 1.1% to 6.3%, in contrast to a 0.68% tumor wound recurrence rate in patients undergoing curative open colectomy[6-8]. The possible mechanisms proposed were: ① contaminated laparoscopic instruments passing in and out of the port frequently; ② increased exfoliated cancer cells from laparoscopic manipulation; ③ adhered tumor cells by pneumoperitoneum[9-12]. Some experiments reported that desufflation related to seeding of port wounds via a stable suspension of tumor cells in CO2 gas was an unlikely cause of port tumors, some supported a direct intraperitoneal seeding of exfoliated tumor cells as its etiology and the instruments passing in and out of the port may play an important role in local recurrence[13-15]. The colon tumor cells were more common since laparoscopic colectomy was wildly performed.

关键词： stomach neoplasms colonic neoplasms cell movement carbon dioxide pneumoperitoneum murine model

Plyometric exercise and bone health in children and adolescents: a systematic review

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World Journal of Pediatrics 2017年第2期13卷 112-121页

作者： Alejandro Gómez-Bruton (A)ngel Matute-Llorente Alejandro González-agüero JoséA.Casajús Germán Vicente-Rodríguez Growth ExerciseNutrition and Development(GENUD)Research GroupUniversity of ZaragozaZaragozaSpain Faculty of Health and Sport Sciences(FCSD) Department of Physiatry and NursingUniversity of ZaragozaRonda Misericordia 522001-HuescaSpain Growth ExerciseNutrition and Development(GENUD)Research GroupUniversity of ZaragozaZaragozaSpain

Background:Many jumping interventions have been performed in children and adolescents in order to improve bone-related variables and thus,ensure a healthy bone development during these periods and later in *** systematic review aims to summarize and update present knowledge regarding the effects that jumping interventions may have on bone mass,structure and metabolism in order to ascertain the efficacy and durability (duration of the effects caused by the intervention) of the *** sources:Identification of studies was performed by searching in the database MEDLINE/PubMed and *** studies were identified by contacting clinical experts and searching bibliographies and *** terms included 'bone and bones','jump*','weight-bearing','resistance training' and 'school intervention'.The search was conducted up to October *** studies that had performed a specific jumping intervention in under 18-year olds and had measured bone mass were *** extraction of articles was done by 2 authors using predefined data ***:A total of 26 studies were included in this ***-four studies found positive results as subjects included in the intervention groups showed higher bone mineral density,bone mineral content and bone structure improvements than *** two studies found no effects on bone mass after a 10-week and 9-month ***,those studies that evaluated the durability of the effects found that some of the increases in the intervention groups were maintained after several ***:Jumping interventions during childhood and adolescence improve bone mineral content,density and structural properties without side *** type of interventions should be therefore implemented when possible in order to increase bone mass in early stages of life,which may have a direct preventive effect on bone diseases like osteoporosis later in fife.

关键词： adolescents bone mineral density intervention jumping osteoporosis

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动能弹的槽和螺纺所增加的阻力

弹箭技术 1992年第4期7卷 26-38页

作者： Mikh.,ag 王青