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Adjuvant chemotherapy after radical cystectomy:Do all patients who need chemotherapy after surgery actually receive it?

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当代泌尿学（英文） 2023年第2期17卷 109-112页

作者： roy croock Jonathan Modai Yuval Avda Igal Shpunt Morad Jaber Yamit Peretz Yaniv Shilo Dan Leibovici Department of Urology Kaplan Medical CenterRehovotIsrael

Background:Compliance with the guideline recommendations for neoadjuvant chemotherapyin patients with muscle-invasive bladder cancer is *** adjuvant chemotherapy approach has the advantage of pathology-based decision-making,allowing for pa-tient *** addition,radical surgery is not delayed and treatment-related toxicity does not impair surgical *** proportion of patients who completed chemotherapy after cystectomy among those who were fit and in need of treatment were *** rea-sons for not completing adjuvant chemotherapy were determined.Materials and methods:We retrospectively evaluated all patients who had undergone radical cystectomy at our center over thelast 7 *** for adjuvant chemotherapy included pathological T＞2,any node+,or surgical margin *** patients who were fit for chemotherapy before surgery were included in the study.Results:Of the 52 patients with muscle-invasive bladder cancer,14 received neoadjuvant chemotherapy or unfit for chemotherapy were *** the remaining 38 patients,14(37％)had bladder-confined cancers and did not require additional *** the 24 patients who needed chemotherapy and were fit to receive it,8 patients completed treatment(33％),and 3 discontinued treatment due to *** patients(50％)declined chemotherapy,whereas 1 patient became unfit for chemotherapy after surgery.Conclusions:While the adjuvant chemotherapy approach could save unnecessary treatment in 37％of patients,two-thirds of those who needed chemotherapy did not complete *** refusal was the primary reason for not receiving treatment.

关键词： Adjuvant chemotherapy Muscle-invasive bladder cancer Neoadjuvant chemotherapy

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