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Intersections between innate immune response and gastric cancer development

World Journal of Gastroenterology 2023年第15期29卷 2222-2240页

作者： Franz Villarroel-Espindola Troy Ejsmentewicz roxana gonzalez-stegmaier Roddy A Jorquera Esteban Salinas Translational Medicine Unit Instituto Oncologico Fundacion Arturo Lopez PerezSantiago 7500000Metropolitan regionChile

Worldwide,gastric cancer(GC)is the fifth most commonly diagnosed *** has a reduced prevalence but has maintained its poor prognosis being the fourth leading cause of deaths related to *** highest mortality rates occur in Asian and Latin American countries,where cases are usually diagnosed at advanced ***,GC is viewed as the consequence of a multifactorial process,involving the virulence of the Helicobacter pylori(***)strains,as well as some environmental factors,dietary habits,and host intrinsic *** tumor microenvironment in GC appears to be chronically inflamed which promotes tumor progression and reduces the therapeutic *** has been suggested that inflammation assessment needs to be measured qualitatively and quantitatively,considering cell-infiltration types,availability of receptors to detect damage and pathogens,and presence or absence of aggressive *** *** epithelial cells express several Toll-like receptors and determine the first defensive line against pathogens,and have been also described as mediators of ***,other molecules,such as cytokines related to inflammation and innate immunity,including immune checkpoint molecules,interferon-gamma pathway and NETosis have been associated with an increased risk of ***,this review will explore innate immune activation in the context of premalignant lesions of the gastric epithelium and established gastric tumors.

关键词： Gastric cancer Toll-like receptor Helicobacter pylori Nuclear factor kappa B Neutrophils

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Use of a combination strategy to improve neuroprotection and neuroregeneration in a rat model of acute spinal cord injury

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Neural Regeneration Research 2019年第6期14卷 1060-1068页

作者： Elisa García roxana Rodríguez-Barrera Vinnitsa Buzoianu-Anguiano Adrian Flores-Romero Emanuel Malagón-Axotla Marco Guerrero-Godinez Estefanía De la Cruz-Castillo Laura Castillo-Carvajal Monserrat Rivas-gonzalez Paola Santiago-Tovar Ivis Morales Cesar Borlongan Antonio Ibarra Centro de Investigación en Ciencias de la Salud (CICSA) Facultad de Ciencias de la SaludUniversidad Anáhuac México Campus Norte Centro de Investigación del Proyecto CAMINA A.C. Unidad de Investigación Médica en Enfermedades Neurologicas Hospital Especialidades CMN Siglo XXI Unidad de Rehabilitación Osteoarticular.Instituto Nacional de Rehabilitación. Luis Guillermo Ibarra Ibarra Center of Excellence for Aging and Brain Repair Department of Neurosurgery and Brain RepairUniversity of South Florida Morsani College of Medicine

Spinal cord injury is a very common pathological event that has devastating functional consequences in patients. In recent years, several research groups are trying to find an effective therapy that could be applied in clinical practice. In this study, we analyzed the combination of different strategies as a potential therapy for spinal cord injury. Immunization with neural derived peptides(INDP), inhibition of glial scar formation(dipyridyl: DPY), as well as the use of biocompatible matrix(fibrin glue: FG) impregnated with bone marrow mesenchymal stem cells(MSCs) were combined and then its beneficial effects were evaluated in the induction of neuroprotection and neuroregeneration after acute SCI. Sprague-Dawley female rats were subjected to a moderate spinal cord injury and then randomly allocated into five groups: 1) phosphate buffered saline; 2) DPY; 3) INDP + DPY; 4) DPY+ FG; 5) INDP + DPY + FG + MSCs. In all rats, intervention was performed 72 hours after spinal cord injury. Locomotor and sensibility recovery was assessed in all rats. At 60 days after treatment, histological examinations of the spinal cord(hematoxylin-eosin and Bielschowsky staining) were performed. Our results showed that the combination therapy(DPY+ INDP + FG+ MSCs) was the best strategy to promote motor and sensibility recovery. In addition, significant increases in tissue preservation and axonal density were observed in the combination therapy group. Findings from this study suggest that the combination theapy(DPY+ INDP + FG + MSCs) exhibits potential effects on the protection and regeneration of neural tissue after acute spinal cord injury. All procedures were approved by the Animal Bioethics and Welfare Committee(approval No. 178544; CSNBTBIBAJ 090812960)on August 15, 2016.

关键词： fibrin glue mesenchymal stem cells glial scar protective autoimmunity neural derived peptides neural regeneration

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分子标记和尾孢菌素分析方法研究阿根廷大豆紫斑病菌遗传多样性

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大豆科技 2015年第1期 36-36页

作者：李雪光 Maria Cristina Lura Maria Gabriela Latorre Rapela Maria Celia Vaccari roxana Maumary Anabel Soldano Monica Mattio Ana Maria gonzalez Catedra de Microbiologla General Facultad de Bioqmmica y Ciencias Biologicas Universidad Nacional delLitoral Santa Fe Argentina Catedra de Fitopatologia Pacultad de Ciencias Agrarias Universidad National delLitoral Esperanza Argentina

在阿根廷由大豆紫斑病菌Cercospora kikuchii引起的叶斑和种子变紫是大豆上非常重要的病害。该研究主要进行了以下工作：1、采用内部简单序列重复（ISSR）标记和内转录间隔区r DNA序列信息方法,鉴定在圣达菲省不同大豆产区采集的大豆紫... 详细信息

在阿根廷由大豆紫斑病菌Cercospora kikuchii引起的叶斑和种子变紫是大豆上非常重要的病害。该研究主要进行了以下工作：1、采用内部简单序列重复（ISSR）标记和内转录间隔区r DNA序列信息方法,鉴定在圣达菲省不同大豆产区采集的大豆紫斑病菌不同菌株间的遗传变异;2、分析不同地区大豆紫斑病菌的尾孢菌素产品,以评价该地区菌株间分子分布和毒素产品是否有关系。

关键词：分子标记阿根廷尾孢菌遗传多样性大豆病菌内转录间隔区简单序列重复

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