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世界核心医学期刊文摘（皮肤病学分册） 2005年第7期1卷 34-35页

作者： Alam N.A. Barclay E. rowan a.j. I.P.M.Tomlinson 刘燕 Molec. and Pop. Genetics Laboratory Cancer Research UK Lincoln' s Inn Fields London WC2A 3PX United Kingdom Dr.

Objective: To investigate the clinical features of the multiple cutaneous and uterine leiomyomatosis (MCUL) syndrome, including the hereditary leiomyomatosis and renal cell cancer syndrome. Design: A case series of patients with multiple skin leiomyomas solicited via a circular letter to dermatologists. Setting: Research institute. Patients: A total of 108 affected individuals, including 46 probands and 62 affected relatives. Main Outcome Measures: The proportion of probands with underlying fumarate hydratase (FH) mutations, the penetrance of FH mutations, and clinicopathologic features of MCUL. Results: Forty-one (89% ) of 46 probands with multiple skin leiomyomas had evidence of germline FH mutations, which were highly penetrant. All 26 male mutation carriers had skin leiomyomas. Of 67 women with FH mutations, 46 (69% ) had both skin and uterine leiomyomas; 10 (15% ) had only skin leiomyomas;5(7% )had only uterine leiomyomas;and 6(9% )were clinically unaffected. Patients presented with skin leiomyomas at a mean age of 24 years and had a mean of 25 lesions. Forty-one individuals (89% ) reported painful lesions, particularly in response to cold or trauma. Fibroids were histologically unremarkable, highly symptomatic, and associated with a high risk of early hysterectomy. One individual had a very aggressive collecting duct renal cancer. The G354R FH mutation predisposed patients to uterine fibroids without skin leiomyomas (P=.03). Many patients with skin leiomyomas had not previously presented for medical attention. Fibroids were rarely recognized as cases of MCUL. Conclusions: Highly penetrant FH mutations underlie MCUL. Increased clinical awareness is important because of the associated risk of severe uterine fibroids and, in some cases, aggressive renal cancer.

关键词：子宫平滑肌瘤诊断标准子宫纤维瘤种系突变外显率组织学检查肾细胞癌延胡索酸水合酶先证者发病年龄

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The role of digital technologies in supporting and improving fishery and aquaculture across the supply chain-Quo Vadis?

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Aquaculture and Fisheries 2023年第4期8卷 365-374页

作者： Neil j.rowan Bioscience Research Institute Technological University of the ShannonMidlands Midwest(TUS)AthloneN37 HD68Ireland Empower Eco^(™)Innovation Hub TUSAthloneN37 HD68Ireland CURAM Research Centre NUIGalwayH91 TK33Ireland

Fish constitute important high protein products to meet the demands of an increasing global ***,the continued depletion of wild fish stocks is leading to increased strain on the aquaculture sector in terms of sustaining the supply of fish and seafood to global *** the fact that aquaculture is more diversified than other agriculture sectors,there are significant pressures on the industry to continue innovating in order to enable sustainability including increased fish production,improved appropriate selection of species,disease mitigation,reduced wastage,preventing environmental pollution and generating more employment *** viewpoint article addresses how digital transformation can help support and meet expansion needs of the fisheries/aquaculture industries that includes exploiting and harnessing ICT,IoT,Cloud-edge computing,AI,machine learning,immersive technologies and *** technologies are bringing significant operational benefits for global food chain,improving efficiencies and productivity,reducing waste,contamination and food *** focus on digital technologies has recently evolved to Industry 5.0 where AI and robotics are coupled with the human mind in order to advance human-centric *** viewpoint describes the role of Quadruple helix Hub(academic-industry-government and society)in delivering a convergent holistic approach to meeting the diversity of fishery industry needs by connecting and placing fisheries centrally in a defined ecosystem of *** includes specialist training,testing technologies,providing access to finance and fostering disruption through aquaculture accelerator initiatives such as that provided by Hatch *** digital Innovation Hubs trans-regionally,nationally and internationally will also help mitigate against significant risks for the fisheries and aquaculture industry including climate change,global pandemics and conflicts that can jeopardize fish an

关键词： Digital transformation Sustainability End-to-end monitoring Food processing Disruptive innovation

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Emerging concepts in the management of pancreatic ductal adenocarcinoma

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Laparoscopic, Endoscopic and Robotic Surgery 2019年第4期2卷 83-88页

作者： Sanket Srinivasa rowan Parks HPB Surgery Royal Infirmary of EdinburghEdinburghUK Department of Clinical Surgery University of EdinburghEdinburghUK

Pancreatic ductal adenocarcinoma is characterised by poor oncological outcomes with curative treatment only possible for a *** are dependent on the stage of the disease and location within the pancreas with constitutional decline often *** require biochemical investigations and accurate imaging with CT to determine stage of disease and local ***-PET and endoscopic ultrasound are increasingly used *** remains the cornerstone of curative management and can be performed using minimally invasive *** resection and combination treatment with chemoradiotherapy are also utilised for suitable *** outcomes may be optimised using enhanced recovery *** standards have been defined for individual clinicians and units to benchmark their clinical *** developments described hold promise in improving outcomes from pancreatic ductal adenocarcinoma.

关键词： Pancreatic ductal adenocarcinoma Pancreatic resection Laparoscopic surgery Robotic surgery

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Does prophylactic antidepressant treatment boost interferon-alpha treatment completion in HCV?

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World journal of Virology 2013年第4期2卷 139-145页

作者： Paul j rowan Division of Management Policy and Community Health University of Texas Health Sciences Center at Houston School of Public HealthHouston TX 77030 United States

Depression is often a side effect of interferon-alpha treatment for hepatitis C, and is recognized as a cause for treatment discontinuation. When detected, antidepressant treatment begins promptly. In contrast to this rescue approach, prophylactic antidepressant treatment has been considered as a superior approach. While studies indicate that depression is lower with prophylaxis, no study has prospectively evaluated the degree that treatment completion might be boosted by the prophylactic strategy. A structured literature search was conducted to discover all trials of antidepressant prophylaxis for patients undergoing antiviral treatment for chronic hepatitis C. Selection criteria included: antidepressant prophylaxis study; report of depression treatment outcome; report of numbers discontinuing and reason for discontinuation(including any of the following: discontinuation data for medical side effects(i.e., thrombocytopenia); discontinuation due to lack of antiviral response; discontinuation due to lack of antidepressant effect; discontinuation due to antidepressant side effects; discontinuation due to patient preference; discontinuation due to loss to follow-up; or unspecified discontinuation). Across the studies, total enrollees were determined for the prophylaxis arms and the rescue arms, and then, again across studies,those discontinuing for reasons other than lack of antiviral response or medical side effect were summed for each of these two arms. Twelve studies were discovered. One was a retrospective chart review, one was an uncontrolled trial, and ten were controlled trials. Discontinuation of antiviral therapy was not less common in the prophylaxis arms: of the 396 patients treated by the prophylaxis strategy, 47(11.9%) discontinued; of the 380 patients in the rescue strategy, 45(11.8%) discontinued. While the prophylaxis strategy seems to manage depression symptoms, it does not seem to boost treatment completion. Rescue was a very successful strategy when

关键词： Depression Therapy Clinical Psychiatry

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Assessing parameter sensitivity in a university campus COVID-19 model with vaccinations

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Infectious Disease Modelling 2023年第2期8卷 374-389页

作者： Meghan rowan Childs Tony E.Wong Rochester Institute of Technology 1 Lomb Memorial DrRochesterNY14623USA

From the beginning of the COVID-19 pandemic,universities have experienced unique challenges due to their dual nature as a place of education and *** research has explored non-pharmaceutical approaches to combating COVID-19,including representing in models different categories such as age *** key area not currently well represented in models is the effect of pharmaceutical preventative measures,specifically vaccinations,on COVID-19 spread on college *** remain key questions on the sensitivity of COVID-19 infection rates on college campuses to potentially time-varying vaccine *** we introduce a compartment model that decomposes a campus population into constituent subpopulations and implements vaccinations with timevarying *** use this model to represent a campus population with both vaccinated and unvaccinated individuals,and we analyze this model using two metrics of interest:maximum isolation population and symptomatic *** demonstrate a decrease in symptomatic infections occurs for vaccinated individuals when the frequency of testing for unvaccinated individuals is *** find that the number of symptomatic infections is insensitive to the frequency of testing of the unvaccinated subpopulation once about 80%or more of the population is *** a Sobol’global sensitivity analysis,we characterize the sensitivity of modeled infection rates to these uncertain *** find that in order to manage symptomatic infections and the maximum isolation population campuses must minimize contact between infected and uninfected individuals,promote high vaccine protection at the beginning of the semester,and minimize the number of individuals developing symptoms.

关键词： COVID-19 Vaccination Subpopulation Modeling Sensitivity analysis University

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What psychiatric screening and monitoring might be needed with the new generation of hepatitis C treatments?

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World journal of Virology 2015年第1期4卷 13-16页

作者： Paul j rowan University of Texas Health Sciences Center at Houston School of Public Health

Psychiatric difficulties, including depression and alcohol use disorders, pose a challenge to treatment decisionmaking for chronic hepatitis C. This is especially made worse because interferon-alpha, as part of the standard of care, may exacerbate depressive symptoms and cause suicidal symptoms to appear. This requires a treatment setting that has the capacity to carry out psychiatric assessment and monitoring, and the capability to deliver patient education regarding these aspects of care. Psychiatric comorbidities create a challenging decisionmaking situation, especially since success rates for the most common hepatitis C genotype, genotype 1, hover around 40%. In recent years, new treatmentshave emerged. These significantly boost the likelihood of sustained viral response, including for genotype 1, and do not seem to have the side effects of interferonalpha or ribavirin. Relevant data are reviewed to assess the degree that these new treatments might reduce the portion not eligible for treatment due to psychiatric comorbidities, and might reduce the emergence of psychiatric symptoms during treatment. Several organizations have recently released evidence-based treatment recommendation guidelines. It is apparent that interferon-alpha continues to be a standard of care, with the new drugs added to this recognized regimen in order to shorten treatment and to boost efficacy. Clinical settings must continue to assess appropriateness for treatment, including current or recent psychiatric comorbidities, and must continue to closely monitor patients for the emergence of psychiatric side effects. The newly developed hepatitis C treatments may affect the metabolism of several categories of psychiatric drugs, and so drug-drug interactions must also be considered and monitored. With many promising drugs under development, an all-pill regimen, with no interferon-alpha and no ribavirin, may emerge in the near future. This will greatly change the challenge of treatment decision-m

关键词： Depression Therapy Psychiatry Review Clinical

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Do tau-synaptic long-term depression interactions in the hippocampus play a pivotal role in the progression of Alzheimer’s disease?

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Neural Regeneration Research 2023年第6期18卷 1213-1219页

作者： Zhengtao Hu Tomas Ondrejcak Pengpeng Yu Yangyang Zhang Yin Yang Igor Klyubin Sean P.Kennelly Michael j.rowan Neng-Wei Hu Department of Physiology and Neurobiology School of Basic Medical SciencesZhengzhou UniversityZhengzhouHenan ProvinceChina Department of Gerontology The First Affiliated Hospital of Wannan Medical CollegeWuhuAnhui ProvinceChina Department of Pharmacology&Therapeutics and Institute of Neuroscience Trinity CollegeDublinIreland Department of Age-Related Healthcare Tallaght University HospitalDublinIreland Department of Medical Gerontology Trinity CollegeDublinIreland

Cognitive decline in Alzheimer’s disease correlates with the extent of tau pathology,in particular tau hyperphosphorylation that initially appears in the transentorhinal and related regions of the brain including the *** evidence indicates that tau hyperphosphorylation caused by either amyloid-βor long-term depression,a form of synaptic weakening involved in learning and memory,share similar *** from our group and others demonstrate that long-term depression-inducing low-frequency stimulation triggers tau phosphorylation at different residues in the hippocampus under different experimental conditions including ***,certain forms of long-term depression at hippocampal glutamatergic synapses require endogenous tau,in particular,phosphorylation at residue *** the exact mechanisms of interaction between tau and long-term depression may help our understanding of the physiological and pathological functions of tau/tau(hyper)*** first summarize experimental evidence regarding tau-long-term depression interactions,followed by a discussion of possible mechanisms by which this interplay may influence the pathogenesis of Alzheimer’s ***,we conclude with some thoughts and perspectives on future research about these interactions.

关键词： aging Alzheimer’s disease amyloid-β Aβoligomers hippocampus long-term depression long-term potentiation LTD LTP metabotropic glutamate receptor N-methyl-D-aspartate receptor tau hyperphosphorylation tau phosphorylation tau

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Surgical management of pancreatic neuroendocrine neoplasms

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Laparoscopic, Endoscopic and Robotic Surgery 2023年第3期6卷 83-90页

作者： Piero Alberti David Martin Georgios Gemenetzis rowan Parks General Surgery(Hepatopancreatobiliary Surgery) Royal Infirmary of EdinburghEdinburghUK Department of Visceral Surgery and Transplantation University Hospital CHUVUniversity of Lausanne(UNIL)LausanneSwitzerland Ninewells Hospital and Medical School DundeeUK University of Edinburgh Medical SchoolEdinburghUK

Pancreatic neuroendocrine neoplasms are a rare and complex group of neoplastic lesions that develop from pancreatic islet *** incidence has dramatically increased during the last two *** to its complex nature and pathophysiological behaviour,surgical management continues to *** remains the cornerstone of treatment for most non-functional and functional pancreatic neuroendocrine tumours,while lymphadenectomy remains a controversial *** techniques,such as pancreas-preserving and minimally invasive approaches,continue to evolve and offer the same overall outcomes as open *** comprehensive review describes in detail the current and most up-todate classification and staging of pancreatic neuroendocrine tumours,explores the rationale for nonsurgical and surgical management,and focuses on surgical treatment and more specifically,on minimally invasive approaches.

关键词： Pancreatic neuroendocrine neoplasms Non-functional pancreatic neuroendocrine tumours Functional pancreatic neuroendocrine tumours Lymphadenectomy Minimally invasive surgery Pancreas preserving techniques

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Nanoscale electron tomography and atomic scale high-resolution electron microscopy of nanoparticles and nanoclusters:A short survey

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Progress in Natural Science:Materials International 2013年第3期23卷 222-234页

作者： john Meurig Thomas Paul A.Midgley Caterina Ducati rowan K.Leary Department of Materials Science and Metallurgy University of CambridgePembroke StreetCambridgeCB2 3QZUK

The outstanding merits of scanning transmission electron tomography as a technique for the investigation of the internal structure and morphology of nanoparticle and nanocluster materials are summarized with the aid of numerous typical *** is made also to the significant advances that have arisen in probing ultrastructural characteristics of nanoscale solids using aberrationcorrected(AC) electron microscopy(EM).Information of a unique kind may be retrieved by combining the imaging and analytical power of ACEM.

关键词： Nanoclusters Nanoparticles Atomic structure Electron tomography Aberration-corrected electron microscopy

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Psychosocial assessment and monitoring in the new era of non-interferon-alpha hepatitis C virus treatments

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World journal of Hepatology 2015年第19期7卷 2209-2213页

作者： Paul j rowan Nizar Bhulani University of Texas School of Public Health Houston

Chronic hepatitis C virus(HCV) is a global concern. With the 2014 Food and Drug Administration approvals of two direct-acting antiviral(DAA) regimens, ledipasvir/sofosbuvir regimen and the ombitasvir/paritaprevir/ritonavir and dasabuvir regimen, we may now be in the era of all-pill regimens for HCV. Until this development, interferon-alpha along with Ribavirin has remained part of the standard of care for HCV patients. That regimen necessitates psychosocial assessment of factors affecting treatment eligibility, including interferon-alpharelated depressive symptoms, confounding psychiatric conditions, and social aspects such as homelessness affecting treatment eligibility. These factors have delayed as much as 70% of otherwise eligible candidates from interferon-based treatment, and have required treating physicians to monitor psychiatric as well as medical side effects throughout treatment. Allpill DAA regimens with the efficaciousness that would preclude reliance upon interferon-alpha or ribavirin have been anticipated for years. Efficacy studies for these recently approved DAA regimens provide evidence to assess the degree that psychosocial assessment and monitoring will be required. With shorter treatment timelines, greatly reduced side effect profiles, and easier regimens, psychosocial contraindications are greatly reduced. However, current or recent psychiatric comorbidity, and drug-drug interactions with psychiatric drugs, will require some level of clinical attention. Evidence from these efficacy studies tentatively demonstrate that the era of needing significant psychosocial assessment and monitoring may be at an end, as long as a manageable handful of clinical issues are managed.

关键词： Depression Therapy Psychiatry Clinical Direct-acti

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