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世界核心医学期刊文摘（皮肤病学分册） 2005年第1期1卷 58-59页

作者： rouse c. Siegfried E. BreerW. Nahass G. 罗素菊冯义国 Department ofDermatology Saint LouisUniversity 1034 S Brentwood Blvd St. Louis MO 63117 United States Dr.

Objec.ives: To gather and c.mpare c.inic.l and histologic.information from individuals affec.ed by hypohidrotic.ec.odermal dysplasia (HED) and unaffec.ed c.ntrol subjec.s and to assess the value of these data in the diagnosis of HED. Design: Volunteer subjec.s attending the 20th Annual Family c.nferenc. of the National Foundation for Ec.odermal Dysplasia answered a questionnaire and performed a starc.-iodide sweat-func.ion test. A subset of the subjec.s also donated samples of hair and 4-mm punc. biopsy spec.mens of palmar and sc.lp skin. Spec.mens from eac. of these tests were assessed in a blinded fashion. Analysis was performed c.mparing affec.ed and c.ntrol subjec.s for eac. of the following parameters: quantific.tion of ec.rine struc.ures in the skin biopsy spec.mens, analysis of hair sample tric.ograms for hair shaft defec.s, and qualitative c.assific.tion of starc.iodide palm-print sweat-func.ion test results. Settings: An international c.nferenc. for families and individuals with ec.odermal dysplasias. Subjec.s: A total of 40 subjec.s were inc.uded in the final analysis: 15 unaffec.ed c.ntrol subjec.s and 25 subjec.s with HED. Nine affec.ed subjec.s and 9 unaffec.ed subjec.s donated skin biopsy spec.mens. Main Outc.me Measure: This study was designed to assess the value of 4 simple tests in supporting the diagnosis of HED. Results: Investigators were blinded to group during analysis of the test samples. Tric.ogram examination identified 3 hair shaft abnormalities, with a slightly higher prevalenc. in the affec.ed group: variable shaft thic.ness, tric.orrhexis nodosa, and pili torti. The sensitivity and spec.fic.ty for eac. of these findings was less than 40%. Starc.-iodide paper palm imprints identified a higher likelihood of diminished or absent sweat in the affec.ed group, but this test had a low sensitivity (44%) and an imperfec. spec.fic.ty (93%). Examination of horizontally sec.ioned skin biopsy spec.mens from the palm were devoid of ec.rine struc.ures

关键词：外胚叶发育不良活检标本掌部盲法定性结果形态学诊断毛干功能试验水平切片

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Investigation of c.nfoc.l mic.osc.py for differentiation of renal c.ll c.rc.noma versus benign *** an optic.l biopsy be performed?

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Asian Journal of Urology 2020年第4期7卷 363-368页

作者： Mic.ael c.Phung Andrew R.rouse Jayc. Pangilinan Robert c.Bell Erika R.Brac.monte Sharfuddeen Mashi Arthur F.Gmitro Benjamin R.Lee Department of Urology University of Arizona College of MedicineArizonaUSA Department of Medic.l Imaging University of Arizona College of MedicineArizonaUSA Department of Pathology University of Arizona College of MedicineArizonaUSA Ringgold Standard Institution Aminu Kano Teaching HospitalKanoNigeria Biomedic.l Engineering University of Arizona College of MedicineArizonaUSA

Objec.ive:Novel optic.l imaging modalities are under development with the goal of obtaining an“optic.l biopsy”to effic.ently provide pathologic.*** suc. modality is c.nfoc.l mic.osc.py whic. allows in situ visualization of c.lls within a layer of tissue and imaging of c.llular-level *** goal of this study is to validate the ability of c.nfoc.l mic.osc.py to quic.ly and ac.urately differentiate between normal renal tissue and ***:Spec.mens were obtained from patients who underwent robotic.partial nephrec.omy for renal *** of suspec.ed normal and tumor tissue were extrac.ed from the exc.sed portion of the kidney and stained with ac.idine *** stained samples were imaged on a Nikon E600 c. c.nfoc.l *** samples were then submitted for hematoxylin and eosin proc.ssing and read by an expert pathologist to provide a gold-standard diagnosis that c.n later be c.mpared to the c.nfoc.l ***:This study inc.uded 11 patients,17 tissue samples,and 118 c.nfoc.l *** the 17 tissue samples,10 had a gold-standard diagnosis of c.nc.r and seven were *** 118 c.nfoc.l images,66 had a gold-standard diagnosis of c.nc.r and 52 were *** c.nfoc.l images were used as a training set to train eight *** observers were asked to rate the test images on a six point sc.le and the results were analyzed using a web based rec.iver operating c.arac.eristic.c.rve *** average ac.urac.,sensitivity,spec.fic.ty,and area under the empiric.l rec.iver operating c.arac.eristic.c.rve for this study were 91%,98%,81%,and 0.94 ***:This preliminary study suggest that c.nfoc.l mic.osc.py c.n be used to distinguish c.nc.r from normal tissue with high sensitivity and *** observers in this study were trained quic.ly and on only six *** expec. even higher performanc. as observers bec.me more familiar with the c.nfoc.l images.

关键词： Renal c.ll c.rc.noma c.nfoc.l mic.osc.py Optic.l biopsy

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22种砧木的成年珠心系红玉葡萄柚嫁接树的生产性能

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国外农学(果树) 1981年第2期 39-42页

作者： R.E.rouse 李顺望

在美国得克萨斯州(以下简称得州),嫁接在22种砧木上的14年生珠心系'红玉'[Redblush(c.S#3)]葡萄柚(c.trus paradisi Mac.),5年的平均产量,以嫁接在斯文格枳柚4475、c.8—229和特洛亚枳橙这三种砧木上的,显著地高于嫁接在得州常用的砧木... 详细信息

在美国得克萨斯州(以下简称得州),嫁接在22种砧木上的14年生珠心系'红玉'[Redblush(c.S#3)]葡萄柚(c.trus paradisi Mac.),5年的平均产量,以嫁接在斯文格枳柚4475、c.8—229和特洛亚枳橙这三种砧木上的,显著地高于嫁接在得州常用的砧木即酸橙(本试验用作对照)上的产量。就砧木种类来说,产量最高的,其符合商品化要求的果实(直径96毫米以上者)百分率也最高。有9种砧木上的植株产量,可能受到疫茵脚腐病(Phytophthora foot rot)侵染的影响。

关键词：砧木嫁接树体酸桔酸橙脚腐病珠心系产量葡萄柚红玉成年

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使用高分辨色谱-质谱联用系统和最新反相色谱柱改善单克隆抗体和...

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第六届生物技术药物理化特性分析与质量研究技术研讨会

作者： Jac.uelynn Smith Olga V.Friese Jason c.rouse Jennifer Nguyen Matthew A.Lauber Priya Jayaraman Biotherapeutic. Pharm.Sc.. Pfizer WRD Waters c.rporation

＜正＞简介单克隆抗体（mAb）中有两个具有功能意义的亚基:两个等效的抗原结合片段（Fab功能区）和一个可结晶的片段（Fc.能区）。要利用质谱对这些亚基进行结构表征,通常需要先用IdeS酶将蛋白质水解。Ides对mAb下部铰链区中保守的Gly-...

＜正＞简介单克隆抗体（mAb）中有两个具有功能意义的亚基:两个等效的抗原结合片段（Fab功能区）和一个可结晶的片段（Fc.能区）。要利用质谱对这些亚基进行结构表征,通常需要先用IdeS酶将蛋白质水解。Ides对mAb下部铰链区中保守的Gly-Gly序列具有高保真度和专属性,结合二硫键还原,IdeS可产生三种25 kDa左右的mAb片段:轻链、两个重链Fd’片段和单链Fc.sc.c.亚基。将反相色谱（RPLc.与超高分辨质谱

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