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Journal of Advanced Ceramics 2023年第5期12卷 972-983页

作者： Zhuolin Cheng rou Li Yiwei Long Jianying Li Shengtao Li Kangning Wu State Key Laboratory of Electrical Insulation and Power Equipment Xi’an Jiaotong UniversityXi’an 710049China Department of Thermal and Fluid Engineering University of TwenteEnschede 7500AEthe Netherlands

Highly stable ZnO varistor ceramics with steadily decreasing power loss have been put into applications in electrical and electronic systems for overvoltage protections, even with the absence of general understandings on their aging behaviors. In this paper, we investigated their aging nature via conducting comparative direct current (DC) aging experiments both in air and in nitrogen, during which variations of electrical properties and interface properties were measured and analyzed. Notably, continuously increasing power loss with severe electrical degradation was observed for the sample aged in nitrogen. The power loss transition was discovered to be closely related to the consumption of oxygen adsorption at the grain boundary (GB), which could, however, remain constant for the sample aged in air. The interface density of states (DOS) Ni, which is crucial for pinning the potential barrier, was proved to decrease in nitrogen, but keep stable in air. Therefore, it is concluded that the oxygen adsorption at the GB is significant for the stability of interface states, which further correlates to the long-term stability of modern stable ZnO varistor ceramics.

关键词： ZnO varistor ceramics aging power loss oxygen adsorption interface states

Ocular surface changes in Graves’ophthalmopathy

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International Journal of Ophthalmology(English edition) 2021年第4期14卷 616-621页

作者： rou Sun Hui-Fang Zhou Xian-Qun Fan Department of Ophthalmology Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011China Shanghai Key Laboratory of Orbital Diseases and Ocular Oncology Shanghai 200011China

Many patients with Graves’ophthalmopathy(GO)suffer from dry eye syndrome(DES),and this is one of the most common reasons of eye discomfort in patients with *** prevalence of DES in patients with GO is significantly higher than normal *** ocular surface changes involving changes in tears,cornea,conjunctiva and glands occur in GO ***,the mechanism of how DES occurs in GO still remains *** this review,the ocular surface changes were illustrated and analyzed the reasons for high prevalence of DES in GO patients.

关键词： Graves’ophthalmopathy dry eye syndrome ocular surface

Recognition of walking environments and gait period by surface electromyography

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Frontiers of Information Technology & Electronic Engineering 2019年第3期20卷 342-352页

作者： Seulki KYEONG Wonseok SHIN Minjin YANG Ung HEO Ji-rou FENG Jung KIM Department of Mechanical Engineering Korea Advanced Institute of Science and Technology (KAIST)

Recognizing and predicting the movement and intention of the wearer in control of an exoskeleton robot is very challenging. It is difficult for exoskeleton robots, which measure and drive human movements, to interact with humans. Therefore, many different types of sensors are needed. When using various sensors, a data design is needed for effective sensing. An electromyographic(EMG) signal can be used to identify intended motion before the actual movement, and the delay time can be shortened via control of the exoskeleton robot. Before using a lower limb exoskeleton to help in walking, the aim of this work is to distinguish the walking environment and gait period using various sensors, including the surface electromyography(sE MG) sensor. For this purpose, a gait experiment was performed on four subjects using the ground reaction force, human–robot interaction force, and position sensors with sEMG sensors. The purpose of this paper is to show progress with the use of sEMG when recognizing walking environments and the gait period with other sensors. For effective data design, we used a combination of sensor types, sEMG sensor locations, and sEMG features. The results obtained using an individual mechanical sensor together with sEMG showed improvement compared to the case of using an individual sensor, and the combination of sEMG and position information showed the best performance in the same number of combinations of three sensors. When four sensor combinations were used, the environment classification accuracy was 96.1%, and the gait period classification accuracy was 97.8%. Vastus medialis(VM) and gastrocnemius(GAS) were the most effective combinations of two muscle types among the five sEMG sensor locations on the legs, and the results were 74.4% in pre-heel contact(preHC) and 71.7% in pre-toe-off(preTO) for environment classification, and 68.0% for gait period classification, when using only the sE MG sensor. The two effective sE MG feature combinations were "me

关键词： Walking environment Gait Period Surface electromyography (sEMG) Exoskeleton

Kabuki syndrome:review of the clinical features,diagnosis and epigenetic mechanisms

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World Journal of Pediatrics 2019年第6期15卷 528-535页

作者： Yi-rou Wang Nai-Xin Xu Jian Wang Xiu-Min Wang Department of Endocrinology and Metabolism Shanghai Children's Medical CenterShanghai Jiaotong University School of MedicineShanghaiChina Department of Genetics Shanghai Children's Medical CenterShanghai Jiaotong University School of MedicineShanghaiChina Huaxi Medical College School of Sichuan University SichuanChina

Background Kabuki syndrome(KS),is a infrequent inherited malformation syndrome caused by mutations in a H3 lysine 4 methylase(KMT2D)or an X-linked histone H3 lysine 27 demethylase(UTX/KDM6A).The characteristics in patients with KS have not yet been well *** sources We used databases including PubMed and Google Scholar to search for publications about the clinical features and the etiology of Kabuki *** most relevant articles to the scope of this review were chosen for *** Clinical diagnosis of KS is challenging in initial period,because many clinical characteristics become apparent only in subsequent ***,the genetic and functional interaction between KS-associated genes and their products have been *** clinical findings were reported including nervous system and intellectual performance,endo-crine-related disorders and immune deficiency and autoimmune *** risks of Kabuki syndrome was ***,we discussed the Kabuki-like *** clinical genetic service,such as dysmorphology database can improve availability and provide high-quality diagnostic *** the significant clinical relevance of KS-associated genes and epigenetic modifications crosstalk,efforts in the research for new mechanisms are thus of maximum *** Kabuki syndrome has a strong clinical and biological *** main pathogenesis of Kabuki syndrome is the imbalance between switch-on and-off of the *** direction of drug research may be to regulate the normal opening of *** molecule inhibitors of histone deacetylases maybe helpful in treatment of mental retardation and reduce cancer risk in KS.

关键词： Kabuki syndrome KMT2D KDM6A Kabuki-like syndrome Cancer risk

Numerical study of the effects of check dams on erosion and sedimentation in the Pachang River

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International Journal of Sediment Research 2013年第3期28卷 304-315页

作者： Hui-ming HSIEH Ching-ruey LUO Jinn-chuang YANG rou-fei CHEN Department of Computer Science and Multimedia Design Taiwan Shoufu University Department of Civil Engineering National Chi-Nan University Dept.of Civil Engineering National Chiayio Tung University Department of Geology Chinese Culture University

Scouring and deposition processes resulting from variable rainfall and typhoon occurrence in tropical climatic conditions induce significant changes in the riverbeds of *** the Pachang River of western Taiwan,severe damage occurs during typhoons due to large and sudden variations in discharge,erosion,sediment transport and *** order to simulate this process,the NETSTARS numerical modeling tool was used in the present *** influence of existing and planned check dam structures on flow control was also analyzed to determine their capacity to resist river erosion or to not be buried beneath *** only does the modeling tool allow calculation of the erosion-deposition behavior at the scale of the whole river,but it also provides local determination of the optimum location and characteristics such as foundation depth and lateral encroachment of future check *** results of a 10-year,long-term modeling simulation in terms of riverbed stability and scouring potential thus provide insights about unsafe future behavior at 4 *** numerical model provides a better general understanding and useful information for the optimal prevention of both the scouring damage and the burial related to sediment deposition with large changes in discharge and sediment transport.

关键词： NETSTARS model River bed erosion Check dam Pachang River

Field-Induced Luminescence Quenching in Electroluminescent Conjugated Polymers

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Chinese Physics Letters 1999年第10期16卷 764-766页

作者： FU rou-li CHU Jun-hao JIANG Hao SUN Xin National Laboratory for Infrared Physics Shanghai Institute of Technical PhysicsChinese Academy of SciencesShanghai 200083 Department of Physics Fudan UniversityShanghai 200433

The basic physical processes offield-induced luminescence quenching in electroluminescent conjugated polymers is studied by a theoretical model of electron-lattice tight binding with an applied electric field,plus the extended Hubbard interactions,in an unrestricted Hartree-Fock *** is found that there exists a critical field Ec,beyond which the self-trapping singlet-and triplet-excitons(the emitting species)in conjugated polymers will be split directly into hole-polarons and electron-polarons,leading to luminescence *** the luminescence intensity decreases with increase ofthe applied field and why the luminescence intensity will not be quenched completely in stronger fields are *** critical field increases with the electron interactions and the binding energy of self-trapping *** approaches to decrease field-induced luminescence quenching are increasing the binding energy ofthe exciton and reducing the conjugation length.

关键词： luminescence quenching trapping

Synthesis of poly(ethylene glycol)-functionalized hydroxyapatite organic colloid intended for nanocomposites

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Chinese Chemical Letters 2013年第7期24卷 647-650页

作者： Xiao-Yong Zhou Yi-rou Jiang Cui-Cui Li Xing-Yi Xie Department of Polymeric Biomaterials and Artificial Organs.College of Polymer Science and Engineering Sichuan University

Traditional modifications to hydroxyapatite （HA） nanoparticles usually occurred after HA synthesis and thus are insufficient to avoid particle agglomeration. In this study, a new heterofunctional poly（ethylene glycol）（PEG） with phosphoric acid and carboxyl end groups, Le., a-（N-2-phosphoethyl phosphoric acid）- amide, w-carboxyl-bismethyoxy poly（ethylene glycol）（ADP-PEG-COOH）, was synthesized as an in situ surface modifier to HA nanoparticles. The resulting modified HA （ADP-PEG-HA） can disperse in methanol, forming a colloid stabilized by peripheral carboxyl-endcapped PEG chains. The colloidal particles resembled nanospheres which agglomerated to some extent under examination by transmission electron microscope. This highly dispersible HA nanoparticles in organic solvent might find application in preparing new HA nanocomposites.

关键词： Poly(ethyleneglycol) Hydroxyapatite Organic colloid Nanocomposites

Nitrogen-rich three-dimensional porous carbon mosaicked Na_(4)Ge_(9)O_(20)as anode material for high-performance lithium-ion batteries

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Rare Metals 2023年第2期42卷 438-448页

作者： Hao-Miao Zhang Jing Chen rou Lu Cong-Ge Lu Shuang Zhou Zhi Chang An-Qiang Pan School of Materials Science and Engineering Central South UniversityChangsha410083China School of Physics and Materials Nanchang UniversityNanchang330031China

Germanium-based material has attracted numerous attentions and been regarded as a promising anode material for lithium-ion batteries due to its high theoretical ***,drastic pulverization and rapid capacity fading caused by large volume variation during cycling limit its practical *** this work,three-dimensional N-doped carbon framework-wrapped Na_(4)Ge_(9)O_(20)nanoparticles(3D Na_(4)Ge_(9)O_(20)@N-C)have been synthesized via freeze-drying approach with NaCl as both template and sodium source for *** employment of NaCl has two special roles:on the one hand,the NaCl crystals act as template and facilitate the formation of 3D porous structure,while on the other hand,the NaCl crystals serving as sodium source and support the ion exchange between NaCl and GeO_(2)promote the formation of Na_(4)Ge_(9)O_(20).Benefiting from the unique method,the prepared 3D Na_(4)Ge_(9)O_(20)@N-C not only suppresses the volume change by using carbon as buffer layers but also demonstrates an improved electronic conductivity and a shortened ionic *** utilized as an anode material for LIBs,the 3D Na_(4)Ge_(9)O_(20)@N-C composites deliver high reversible capacity(896.2 mAh·g^(-1)at0.1 A·g^(-1)after 100 cycles),good cycling stability(520.8 mAh·g^(-1)at 2.0 A·g^(-1)after 400 cycles)and excellent rate performance(636.0 mAh·g^(-1)at 2.0 A·g^(-1)).This work provides a strategy to improve the electrochemical performance of germanium-based anode materials for lithium-ion batteries.

关键词： Germanium-based anode Na_(4)Ge_(9)O_(20) Ndoped carbon Porous nanostructure Lithium-ion batteries(LIBs)

Real-time reverse transcription-polymerase chain reaction assay panel for the detection of severe acute respiratory syndrome coronavirus 2 and its variants

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Chinese Medical Journal 2021年第17期134卷 2048-2053页

作者： rou-Jian Lu Li Zhao Bao-Ying Huang Fei Ye Wen-Ling Wang Wen-Jie tan Key Laboratory of Biosafety National Health and Family Planning CommissionNational Institute for Viral Disease Control and PreventionChinese Center for Disease Control and PreventionBeijing 102206China

Background:With the ongoing worldwide coronavirus disease 2019(COVID-19)pandemic,an increasing number of viral variants are being identified,which poses a challenge for nucleic acid-based diagnostic *** tests,such as real-time reverse transcription-polymerase chain reaction(rRT-PCR),play an important role in monitoring COVID-19 infection and controlling its ***,the changes in the genotypes of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)variants may result in decreased sensitivity of the rRT-PCR assay and it is necessary to monitor the mutations in primers and probes of SARSCoV-2 detection over ***:We developed two rRT-PCR assays to detect the RNA-dependent RNA polymerase(RdRp)and nucleocapsid(N)genes of *** evaluated these assays together with our previously published assays targeting the ORF1ab and N genes for the detection and confirmation of SARS-CoV-2 and its variants of concern(VOCs).In addition,we also developed two rRT-PCR assays(S484K and S501Y)targeting the spike gene,which when combined with the open reading frames(ORF)1ab assay,respectively,to form duplex rRT-PCR assays,were able to detect SARS-CoV-2 VOCs(lineages B.1.351 and B.1.1.7).Results:Using a SARS-CoV-2 stock with predetermined genomic copies as a standard,the detection limit of both assays targeting RdRp and N was five copies/***,no cross-reactions with six others human CoVs(229E,OC43,NL63,HKU1,severe acute respiratory syndrome coronavirus and Middle East respiratory syndrome coronavirus)were observed using these *** addition,the S484K and S501Y assays were combined with the ORF1ab assay,***:Four rRT-PCR assays(RdRp,N,S484K,and S501Y)were used to detect SARS-CoV-2 variants,and these assays were shown to be effective in screening for multiple virus strains.

关键词： COVID-19 SARS-CoV-2 RT-PCR assay Variants of concern RNA polymerase Nucleocapsid SARS-CoV-2 B.1.351 SARS-CoV-2 B.1.1.7 SARS-CoV-220A S484K variant

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利伐沙班在犬和猫临床应用的研究进展

动物医学进展 2025年第1期46卷 97-102页

作者：王炜江蓝路心怡付诗懿刘亦婷韦力煣俞峰刘波中国农业大学动物医学院北京100193 中国农业大学教学动物医院北京100193

血栓栓塞是犬、猫临床上多种疾病的并发症,可累及动脉或静脉,预后较差。目前兽医临床防治血栓栓塞可用的抗血栓药物种类有限,影响临床诊疗水平,引入新药具有实际意义。利伐沙班是一种新型非维生素K拮抗剂类口服抗凝药物,研究证明其能够... 详细信息

血栓栓塞是犬、猫临床上多种疾病的并发症,可累及动脉或静脉,预后较差。目前兽医临床防治血栓栓塞可用的抗血栓药物种类有限,影响临床诊疗水平,引入新药具有实际意义。利伐沙班是一种新型非维生素K拮抗剂类口服抗凝药物,研究证明其能够特异性抑制活性凝血因子X从而抑制血栓形成。近年来人医领域对利伐沙班的相关临床研究逐渐丰富,涉及单用利伐沙班或使用双通路抑制疗法防治不同类型的动、静脉血栓栓塞,可为其应用于兽医临床提供据。犬、猫临床使用利伐沙班的研究正相继开展,论文就犬、猫血栓栓塞疾病发病情况、防治现状,利伐沙班的药理学特性及其在人医、兽医领域的临床试验研究进展进行综述,以期为兽医临床上利伐沙班的进一步研究提供参考。

关键词：新型口服抗凝药利伐沙班血栓栓塞犬猫