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Determination of glycated hemoglobin in patients with advanced liver disease

World Journal of Gastroenterology 2004年第15期10卷 2284-2286页

作者： Theresa Lahousen Karin Hegenbarth rottraut ille Rainer W.Lipp Robert Krause Randie R. Little Wolfgang J.Schnedl Department of Psychiatry School of MedicineMedical University GrazAuenbruggerplatz 31A-8063 GrazAustria Department of Internal Medicine School of MedicineMedical University GrazAuenbruggerplatz 15A-8063 GrazAustria University of Missouri School of Medicine Department of Pathology and Child HealthOne Hospital DriveColumbiaMO 65212USA

AIM:To evaluate the glycated hemoglobin(HbA_(1c)) determination methods and to determine fructosamine in patients with chronic hepatitis,compensated cirrhosis and in patients with chronic hepatitis treated with ribavirin. METHODS:HbA_(1c) values were determined in 15 patients with compensated liver cirrhosis and in 20 patients with chronic hepatitis using the ion-exchange high performance liquid chromatography and the immunoassay methods. Fructosamine was determined using nitroblue tetrazolium. RESULTS:Forty percent of patients with liver cirrhosis had HbA_(1c) results below the non-diabetic reference range by at least one HbA_(1c)method,while fructosamine results were either within the reference range or *** percent of patients with chronic hepatitis(hepatic fibrosis) had HbA_(1c)results below the non-diabetic reference range by at least one HbA_(1c)*** patients with chronic hepatitis treated with ribavirin,50% of HbA_(1c)results were below the non-diabetic reference using at least one of the HbA_(1c)methods. CONCLUSION:Only evaluated in context with all liver function parameters as well as a red blood count including reticulocytes,HbA_(1c)results should be used in patients with advanced liver ***_(1c)and fructosamine measurements should be used with caution when evaluating long-term glucose control in patients with hepatic cirrhosis or in patients with chronic hepatitis and dbavidn treatment.

关键词： Antiviral Agents Fructosamine Hemoglobin A, Glycosylated Hepatitis C, Chronic Hepatitis, Chronic Humans Liver Cirrhosis Ribavirin

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Clinical outcome in patients with hilar malignant strictures type Ⅱ Bismuth-Corlette treated by minimally invasive unilateral versus bilateral endoscopic biliary drainage

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Hepatobiliary & Pancreatic Diseases International 2012年第2期11卷 209-214页

作者： Milutin Bulajic Nikola Panic Miodrag Radunovic Radisav Scepanovic Radoslav Perunovic Predrag Stevanovic Tatjana ille Maurizio Zilli Mirko Bulajic Faculty of Medicine University of BelgradeDr Subotica 811000 BelgradeSerbia University Clinical-Hospital Center "Dragisa MisovicDedinje" Milana Tepica 111000 BelgradeSerbia General Hospital "Danilo I-Cetinje" Vuka Micunovica b.b81250 CetinjeMontenegro Department of Surgery Medical Faculty of PodgoricaUniversity of PodgoricaKrusevac b.b81000 PodgoricaMontenegro Department of Gastroenterology University Clinical Hospital "Santa Maria della Misericordia di Udine"Piazzale S.Maria della Misericorida 1533100 UdineItaly

BACKGROUND:Stenting of malignant hilar strictures remains a standard endoscopic treatment in patients with unresectable *** aim of this two-center prospective study was to compare unilateral versus bilateral drainage in hilar malignant stenosis Bismuth-Corlette type ***:During a 3-year period,a total of 49 patients with hilar tumors(Bismuth-Corlette type II) were referred for endoscopic treatment,following the criteria of ***,computed tomography scan and magnetic resonance cholangiopancreatography(MRCP) were previously performed in all patients in order to facilitate endoscopic retrograde cholangiopancreatography(ERCP).The stricture was first passed by the hydrophilic guide-wire and then contrast medium was *** bile duct dilation was performed,followed by plastic stent placement only in the liver lobe which was previously *** procedures were performed under conscious *** patients were followed up for the next 12 months with a stent exchange every 3 *** outcome was assessed by patient survival in the first 12 months after the ***:All 49 patients were treated with ERCP while 39(79.59%) had successful stent *** these,32 had hilar cholangiocarcinoma(82%) and 7(18%) had gallbladder *** groups of patients had Bismuth II strictures:A,21 patients(54%) with unilateral contrast injection and drainage,and B,18(46%) with bilateral contrast injection and drainage.A total of 57 plastic stents were used(10 Fr,89%;11.5 Fr,11%).Group B showed a lower bilirubin level 7 days after the procedure(P=0.008).Early complications were cholangitis(3 patients,2 in group A and 1 in group B) and acute pancreatitis(2 patients,1 each in A and B) with no statistical difference between the *** complications were stent migration(5 patients,1 in A and 4 in B) and stent clogging(6 patients,2 in A and 4 in B) showing a significant difference between the groups(P<0.01).The first ste

关键词： endoscopic retrograde cholangiopancreatography biliary tree stenosis stenting

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Baseline Clinical Profile of a “Normal Popu-lation” of HIV Exposed Sero-Negative (HESN) Partners May Impact HIV Biomedical Prevention Studies Negatively

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World Journal of AIDS 2015年第4期5卷 299-307页

作者： Pam Datong Evaezi Okpokoro Sophia Osawe Ruth Datiri Grace Choji Felicia Okolo Rebecca Abimiku ille Mamman Alash’le Abimiku Plateau State Specialist Hospital Jos Nigeria Plateau State Human Virology Research Centre Jos Nigeria Institute of Human Virology Abuja Nigeria Institute of Human Virology University of Maryland School of Medicine Baltimore USA

The burden and viral diversity of HIV in Nigeria makes it suitable to evaluate biomedical prevention strategies including HIV vaccines. We document baseline clinical characteristics of a cohort of HIV Exposed Sero-Negative (HESN) partners to highlight background morbidities that might impact the interpretation of research findings especially in low income countries where “normal control” is based on physical appearance and self-reporting. We established a 2-year prospective cohort of HESN, and obtained, at baseline medical history, general physical examination findings and safety laboratory tests results. Among 534 participants with a mean age of 37 ± 9 years, the commonest symptoms were headache (25.5%) and fever (20%), which occurred more among females. Also, 13% reported a history of urethral/vaginal discharge and genital ulcer. High blood pressure (HBP) (i.e. blood pressure ≥ 140/90 mmhg) was a major abnormal examination finding, which occurred more among males (53.2% vs 26.2%, p < 0.01). More female participants had abnormal laboratory results with 31% having low hemoglobin concentration (<12 g/dl, p = 0.021);30% with elevated alanine transaminase level (p = 0.019) and 28% with abnormal blood urea nitrogen level (p = 0.093). HBP and abnormal safety laboratory are significant findings among so called “normal population” that could affect interpretation of research findings of HIV biomedical prevention studies in Nigeria.

关键词： Clinical Characteristics Discordant Couple Developing Country HIV Vaccine Trial Nigeria

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Etiologies of the Hearing Loss and Their Impacts at the Patients Worn Hearing Aid in the International Center of Hearing Correction in Abidjan (ICHC)

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International Journal of Otolaryngology and Head & Neck Surgery 2018年第6期7卷 359-366页

作者： Mobio N’kan Max Ange ille Salha Yavo-Dosso Nadine Yotio Ayekpa D. Nasser Yapo Assi Romaric Evrand V. Koffi-Aka Service d’ORL et de Chirurgie Cervicofacial (CC-F) CHU Treichville Abidjan C&ocirc te d’Ivoire

Objective: Determine the etiologies and their impacts of hearing loss at the patients’ worn hearing aid in the international center of hearing correction in Abidjan (ICHC). Material and Method: The study is of transverse and analytical type realized in the ICHC from July 1999 to June 2010. It concerned the files of patients’ worn hearing aid in the center. The patients worn initially in another center but followed in the ICHC were excluded. Data were collected from medical files of patients and concerned etiologies, age, type, degree of hearing loss as well as the prosthetic gains and the satisfaction. Results: Fifteen etiologies were listed with in first three rows the meningitis (17.9%) the presbyacusis (17.5%) and chronic otitis media (12.1%). The degrees of hearing loss in the seven etiologies most frequent were severe and profound in 87.6% of cases to the right and 82.8% to the left. The prosthetic pure tonal gain was significant in case of sound trauma and sudden hearing loss. The prosthetic speech reception threshold gain was only significant in case of presbyacusis and sudden hearing loss. The satisfaction of hearing aids was significant in case of presbyacusis, sudden hearing loss and the sound trauma. Conclusion: The main clauses etiologies were the meningitis and the presbyacusis. The tonal and speech prosthetic gain were significant in case of sudden hearing loss.

关键词： Etiologies Hearing Loss Hearing Aid Satisfaction

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