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内镜下全层折叠术治疗胃食管反流病:北美地区的术后12个月随访的开放试验

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世界核心医学期刊文摘（胃肠病学分册） 2005年第9期1卷 28-28页

作者： Pleskow D. rothstein r. Lo S. A. Lembo 赵天智 Beth Isr.el Deaconess Medical Center Dana 501 330 Brookline Ave. Boston MA 02215 United States Dr.

Backgr.und: The aim of this study was to assess the inter.ediate-ter. (12-month) safety and efficacy of endoscopic full-thickness plication in patients with symptomatic GEr.. Methods: Sixty-four.patients with chr.nic hear.bur. that r.quir.d maintenance antisecr.tor. ther.py r.ceived a single, endoscopically placed, full-thickness plication in the gastr.c car.ia 1 cm distal to the gastr.esophageal junction. At baseline and 12 months after.plication, patients completed the GEr. Health r.lated Quality of Life questionnair., Gastr.intestinal Symptom r.ting Scale, and SF-36 Health Sur.ey, as well as a medication use diar.. Ambulator. 24-hour.pH monitor.ng and esophageal manometr. wer. obtained at baseline and 3 months after.plication. At 6 months after.plication, the 24-hour.pH study was r.peated. r.sults: Of the 57 patients who completed the 12-month follow-up, 40 (70%) wer. no longer.taking a pr.ton pump inhibitor. Median GEr. Health r.lated Quality of Life scor.s wer. impr.ved compar.d with baseline while taking medication (19.0 vs. 5.0; p r.the pr.cedur., an impr.vement in distal esophageal acid exposur. was demonstr.ted in 40 of 51 patients (80%), with a decr.ase of 39%in the median per.entage of time the pH was less than 4 (p r.al pH scor.s wer. obser.ed in 30%of patients. All pr.cedur.-r.lated adver.e events occur.ed acutely, as pr.viously r.por.ed, and no new adver.e event was obser.ed dur.ng extended follow-up. Conclusions: Full-thickness plication at the gastr.esophageal junction is an effective endoscopic pr.cedur. for.tr.atment of patients with symptoms caused by GEr.. It r.duces r.flux symptoms and antisecr.tor. medication use over.at least a 1-year.per.od.

关键词：折叠术开放试验胃食管反流食管测压连接部反流症状质量调查表胃肠症状等级量表灼热感

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Inducible r.sistance to Fas-mediated apoptosis in B cells

作者： rothstein Dan. Santana Luz.

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Cell r.sear.h 2000年第4期10卷 245-266页

作者： rothstein THOMAS L Depar.ments of Medicine and Micr.biology, and the Evans Memor.al Depar.ment of Clinical r.sear.h, Boston Univer.ity Medical Center. Boston, MA, USA Depar.ments of Medicine and Micr.biology and the Evans Memorial Department of Clinical Research Boston University Medical Center Boston USA

Apoptosis pr.duced in B cells thr.ugh Fas (APO-1, CD95) tr.gger.ng is r.gulated by signals der.ved fr.m other.sur.ace r.ceptor.: CD40 engagement pr.duces upr.gulation of Fas expr.s. sion and mar.ed susceptibility to Fas-induced cell death, wher.as antigen r.ceptor.engagement, or.IL-4r.engagement, inhibits Fas killing and in so doing induces a state of Fas-r.sistance, even in other.ise sensitive, CD40-stimulated tar.ets. Sur.aceim. munoglobulin and IL-4r.utilize at least par.ially distinct pathways to pr.duce Fas-r.sistance that differ.ntially depend on PKC and STAT6, r.spectively. Fur.her. sur.ace immunoglob- "lin signaling for.inducible Fas-r.sistance bypasses Bib, r.quir.s NF-GB, and entails new macr.molecular.synthesis. Ter.inal effector. of B cell Fas-r.sistance include the known anti-apoptotic gene pr.ducts, Bcl-xL and FLIP, and a novel anti-apoptotic gene that encodes FAIM (Fas Apoptosis Inhibitor. Molecule). faim was identified by differ.ntial display and exists in two alter.atively spliced for.s; maim-S is br.adly expr.ssed, but faim-L expr.ssion is tissue-specific. The FAIM sequence is highly evolu tionar.ly conser.ed, suggesting an impor.ant r.le for.this molecule thr.ughout phylogeny. Inducible r.sistance to Fas killing is hypothesized to pr.tect for.ign antigen-specific B cells dur.ng potentially hazar.ous inter.ctions with FasL-bear.ng T cells, wher.as autor.active B cells fail to become Fas-r.sistant and ar. deleted via Fas-dependent cytotoxicity. Inadver.ent or.aber.ant acquisition of Fas-r.sistance may per.it autor.active B cells to escape Fas deletion, and malignant lymphocytes to impede anti-tumor.immunity.

关键词： Apoptosis Fas B lymphocytes FAIM FLIP Bcl-XL sur.ace immunoglobulin IL-4r CD40 autor.activity

Identification of differ.ntially-expr.ssed genes of r.ce in over.apping r.sponses to bacter.al infection by Xanthomonas or.zae *** and nitr.gen deficiency

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Jour.al of Integr.tive Agr.cultur. 2015年第5期14卷 888-899页

作者： YU Chao CHEN Hua-min TIAN Fang BI Yong-mei rothstein J Steven Leach E Jan HE Chen-yang State Key Labor.tor. for.Biology of Plant Diseases and Insect Pests Institute of Plant ProtectionChinese Academy of Agricultural Sciences Depar.ment of Molecular.and Cellular.Biology College of Biological ScienceUniversity of Guelph Depar.ment of Bioagr.cultur.l Sciences and Pest Management Colorado State University

Bacter.al blight of r.ce caused by Xanthomonas or.zae ***（Xoo） is one of high nitr.gen（N） r.sponsive *** plants became mor. disease r.sistant with decr.asing N suggesting that the cr.sstalk between disease r.sistance and N utilization pathways might ***,the co-r.gulator. components in such cr.sstalk have not been ***,we compar.tively analyzed the gene expr.ssion pr.filing of r.ce under.Xoo inoculation,low N tr.atment,or.a combination of both str.sses,and identified the differ.ntially-expr.ssed genes（DEGs） in over.apping *** DEGs wer. involved in differ.nt biological pr.cesses,including innate immunity and nitr.gen *** r.ndomly-selected DEGs expr.ssion was validated by quantitative r.al-time PCr.*** expr.ssion of six genes fr.m differ.nt functional categor.es suggested that N condition was the dominant factor.when both str.sses wer. *** DEGs identified pr.vide novel insights into the coor.inated r.gulator. mechanism in biotic and abiotic str.ss r.sponses in r.ce.

关键词： Xanthomonas differ.ntially over.apping abiotic blight r.sponsive cr.sstalk pathogen encoding validated

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塑料粘结炸药的过去、现在和将来

火炸药

火炸药 1984年第1期 59-64页

作者： L. r. rothstein 李常青美国约克城海军武器研究基地海军炸药发展工程部

有些武器极需要耐温性好的可注装塑料粘结炸药。本文拟对这类武器的性能要求进行探讨。文中涉及到最早研制的那些配方的高感度问题,讨论了现在使用的感度较低的配方以及它们还存在的缺点,并对今后研究和发展的努力方向提供了一些参考依... 详细信息

有些武器极需要耐温性好的可注装塑料粘结炸药。本文拟对这类武器的性能要求进行探讨。文中涉及到最早研制的那些配方的高感度问题,讨论了现在使用的感度较低的配方以及它们还存在的缺点,并对今后研究和发展的努力方向提供了一些参考依据,以通过给配方中加入不会增加感度的含能粘结剂和增塑剂来改进炸药的性能。作者谈到了一些个人的意见,希望有助于研究炸药的同行,使他们的努力能尽早实际应用。

关键词：增塑剂防软剂塑料助剂含能粘结剂含能聚合物感度预聚体炸药性能生成热热力学性质钝感

Use of Gene Knowledge to Impr.ve Nitr.gen Use Efficiency in Cr.p Plants

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Use of Gene Knowledge to Improve Nitrogen Use Efficiency in ...

上海市植物生理学会成立三十周年庆祝活动暨第三届上海市植物生理学青年学术研讨会

作者： Steven rothstein Depar.ment of Molecular.Biology and Genetics University of Guelph

Development of genetic var.eties with impr.ved nitr.gen use efficiency (NUE) is essential for.sustainable agr.cultur.. We developed gr.wth systems for.Ar.bidopsis, r.ce and cor. wher.in

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《计数与计量的语义》述介

当代语言学 2021年第1期23卷 150-154页

作者： Susan rothstein 牛长伟薛博不详中南财经政法大学国际教育学院湖北省武汉市430073 香港中文大学语言学及现代语言系中国香港999077

1.引言《计数与计量的语义》(Semantics for.Counting and Measur.ng)是剑桥大学出版社出版的"语义学与语用学核心论题"丛书之一,由Susan rothstein著,于2017年出版。该书在形式语义学框架内对比了计数与计量的概念,认为这对概念是理解... 详细信息

1.引言《计数与计量的语义》(Semantics for.Counting and Measur.ng)是剑桥大学出版社出版的"语义学与语用学核心论题"丛书之一,由Susan rothstein著,于2017年出版。该书在形式语义学框架内对比了计数与计量的概念,认为这对概念是理解人类在不同语言中使用数词表达(numer.cal expr.ssion)、分类词(classifier.及可数名词的关键。

关键词：剑桥大学出版社形式语义学可数名词分类词语义述介计数

MCAT Pr.MIEr.Pr.Gr.M 2007-2008

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A Novel Facial Cr.am Based on Skin Penetr.ble Hemp Oil Micr.par.icles

2006年

作者： r.chelle rothstein... [et al.].

来源：畅想之星图书光盘版（南... 评论

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Jour.al of Cosmetics, Der.atological Sciences and Applications 2023年第3期13卷 165-178页

作者： r.chel Lubar. Inbar.Yar.v Dr.r.Fixler.Ayelet rothstein Ar.e Gr.zman Anat Lipovsky Depar.ment of Chemistr. Bar Ilan University Ramat-Gan Israel Physics Depar.ment of Faculty of Exact Sciences Bar Ilan University Ramat-Gan Israel Faculty of Engineer.ng Bar Ilan University Ramat-Gan Israel Institute of Nanotechnology and Advanced Mater.als Bar-Ilan University Ramat-Gan Israel Hava Zingboim Ltd. Ramat-Gan Israel

Objective: Hemp seed oil is per.ect for.most skin types;it moistur.zes skin and pr.tects it fr.m inflammation, oxidation, and other.causes of aging. The pr.blem is that the Hemp oil-based pr.ducts do not penetr.te the skin;they r.main on the skin’s sur.ace. r.cently r.sear.her. have been tr.ing to pr.par. nano emulsions of hemp oil to facilitate its per.eation to deep skin layer.. In all techniques used today, sur.actants ar. added to the emulsification pr.cess. These sur.actants may cause unwanted skin side effects. In the pr.sent study, we pr.par. micr.nized Hemp (m-Hemp) without using any sur.actants in the micr.nization pr.cess, thus avoiding the side effects associated with sur.actant addition. Methods & r.sults: Par.icles size of m-Hemp was evaluated using electr.n micr.scopy. Var.ous sizes of m-Hemp wer. found, the smallest being 100 nm in diameter. The antioxidation pr.per.ies of m-Hemp wer. measur.d using the Electr.n Spin r.sonance (ESr. technique and wer. found to be enhanced. Skin topogr.phy and mor.hology following a cr.am containing m-Hemp tr.atment wer. visualized by Optical Pr.filometr. and ESEM r.spectively. The r.sults show a mar.ed impr.vement in skin topogr.phy in all measur.d par.meter.. In addition, human ker.tinocytes (HaCaT) wer. exposed to inflammator. conditions and wer. then tr.ated using Hemp. As a r.sult, one of the key inflammator. factor. (IL-2) was significantly r.duced after.tr.atment with m-Hemp (p ≤ 0.0001). The skin penetr.tion of the cr.am containing m-Hemp was tested on human skin using the IMOPE (Iter.tive Multi-plane Optical Pr.per.y Extr.ction) system. The r.sults indicate that m-Hemp penetr.tes both the str.tum cor.eum and the deep epider.al layer. towar.s the der.is. Conclusion: The new cr.am pr.par.d with micr.nized Hemp shows significant anti-inflammator. and antioxidative effects and demonstr.tes the entr.nce of m-Hemp to the skin epider.al layer.

关键词： Hemp Micr.par.icles Anti-Inflammator. Antioxidant Skin Penetr.tion