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Genomic prediction of fruit texture a.d tra.ning popula.ion optimiza.ion towa.ds the a.plica.ion of genomic selection in a.ple

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Horticulture Resea.ch 2020年第1期7卷 889-902页

作者： Morga.e roth Hélène Mura.ty Ma.io Di Gua.do Wa.ter Guerra.a.drea.Pa.occhi Fa.rizio Costa Pla.t Breeding Resea.ch Division AgroscopeWädenswilZurichSwitzerland IRHS INRAEAgrocampus-OuestUniversitéd’AngersSFR 4207 QuaSaVBeaucouzéFrance Depa.tment of Genomics a.d Biology of Fruit Crops Research and Innovation CentreFondazione Edmund Mach(FEM)Via E.Mach 138010 San Michele all’AdigeItaly Depa.tment of a.riculture Food and Environment(Di3A)University of CataniaCataniaItaly Resea.ch Centre La.mburg Laimburg 639040 AuerItaly Center a.riculture Food Environment University of TrentoVia Mach 138010 San Michele all’AdigeItaly Present a.dress:Ga.L INRAE84140 MontfavetFrance

Texture is a.complex tra.t a.d a.ma.or component of fruit qua.ity in *** the ma.or effect of MdPG1,a.gene controlling firmness,ha. a.rea.y been exploited in elite cultiva.s,the genetic ba.is of crispness rema.ns poorly *** further improve fruit texture,ha.nessing loci with minor effects via.genomic selection is therefore *** this study,we mea.ured a.oustic a.d mecha.ica. fea.ures in 537 genotypes to dissect the firmness a.d crispness components of fruit *** of a.ross-yea. phenotypic va.ues for these components were ca.cula.ed using a.model ca.ibra.ed with 8,294 SNP *** best prediction a.cura.ies following cross-va.ida.ions within the tra.ning set of 259 genotypes were obta.ned for the a.oustic linea. dista.ce(0.64).Predictions for bipa.enta. fa.ilies using the entire tra.ning set va.ied from low to high a.cura.y,depending on the fa.ily *** a.ding siblings or ha.f-siblings into the tra.ning set did not clea.ly improve predictions,we performed a. optimiza.ion of the tra.ning set size a.d composition for ea.h va.ida.ion *** a.lowed us to increa.e prediction a.cura.ies by 0.17 on a.era.e,with a.ma.ima. a.cura.y of 0.81 when predicting firmness in the‘Ga.a.×‘Pink La.y’*** results therefore identified key genetic pa.a.eters to consider when deploying genomic selection for texture in *** pa.ticula.,we a.vise to rely on a.la.ge tra.ning popula.ion,with high phenotypic va.ia.ility from which a.ta.lored tra.ning popula.ion’ca. be extra.ted using a.priori informa.ion on genetic rela.edness,in order to predict a.specific ta.get popula.ion.

关键词： prediction optimiza.ion fir

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Dua. Ta.geting to Mitochondria.a.d Chloropla.ts： Cha.a.teriza.ion of Thr-tRNa.Syntheta.e Ta.geting Peptide

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Molecula. Pla.t 2009年第6期2卷 1298-1309页

作者： a.na.Ka.in Berglund Erika.Spa.ning Henrik Biversta.l Gia.luca.Ma.da.o Christia. Tellgren-roth Lena.Ma.er Elzbieta.Gla.er Depa.tment of Biochemistry a.d Biophysics Arrhenius Laboratories for Natural Science Stockholm University SF-10691 Stockholm Sweden Depa.tment of Genetics a.d Pa.hology Rudbecklaboratoriet Uppsala University SE-751 85 Uppsala Sweden

There is a.group of proteins tha. a.e encoded by a.single gene, expressed a. a.single precursor protein a.d dua.ly ta.geted to both mitochondria.a.d chloropla.ts using a. a.biguous ta.geting peptide. Sequence a.a.ysis of 43 dua. ta.geted proteins in compa.ison with 385 mitochondria. proteins a.d 567 chloropla.t proteins ofa.a.idopsis tha.ia.a.revea.ed a. overa.l significa.t increa.e in phenyla.a.ines, leucines, a.d serines a.d a.decrea.e in a.idic a.ino a.ids a.d glycine in dua. ta.geting peptides （dTPs）. The N-termina. portion of dTPs ha. significa.tly more serines tha. mTPs. The number of a.ginines is simila. to those in mTPs, but a.most twice a. high a. those in cTPs. We ha.e investiga.ed ta.geting determina.ts of the dua. ta.geting peptide of Thr-tRNa.syntheta.e （ThrRS-dTP） studying orga.ella. import of N- a.d C-termina. deletion constructs of ThrRS-dTP coupled to GFR These results show tha. the 23 a.ino a.id long N-termina. portion of ThrRS-dTP is crucia. but not sufficient for the orga.ella. import. The C-termina. deletions revea.ed tha. the shortest peptide tha. wa. ca.a.le of conferring dua. ta.geting wa. 60 a.ino a.ids long. We ha.e purified the ThrRS- dTP（2-60） to homogeneity a.ter its expression a. a.fusion construct with GST followed by CNBr clea.a.e a.d ion excha.ge chroma.ogra.hy. The purified ThrRS-dTP（2-60） inhibited import of pF1β into mitochondria.a.d of pSSU into chloropla.ts a. μM concentra.ions showing tha. dua. a.d orga.elle-specific proteins use the sa.e orga.ella. import pa.hwa.s. Furthermore, the CD spectra.of ThrRS-dTP（2-60） indica.ed tha. the peptide ha. the propensity for forming α-helica. structure in membra.e mimetic environments; however, the membra.e cha.ge wa. not importa.t for the a.ount of induced helica. structure. This is the first study in which a.dua. ta.geting peptide ha. been purified a.d investiga.ed by biochemica. a.d biophysica. mea.s.

关键词： Dua. ta.geting mitochondria chloropla.t ta.geting peptide a.inoa.yl-tRNa.syntheta.e

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Ta.te responsiveness to two steviol glycosides in three species of nonhuma. prima.es

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Current Zoology 2018年第1期64卷 63-68页

作者： Sa.dra.NICKLa.SON Desiree SJOSTROM Ma.s a.UNDIN Da.iel roth La.ra.Teresa.HERNa.DEZ Sa.a.a. ia.thia. La.KA IFM Biology Linkoping University Linkoping SE-581 83 Kolma.den Wildlife Pa.k Kolmarden SE-681 92 Bora. Zoo Boras SE-501 13 Sweden Instituto de Neuro-Etologia Universidad Veracruzana Xalapa Veracruz C.P. 91000 Mexico

Prima.es ha.e been found to differ widely in their ta.te perception a.d studies suggest tha. a.coevolution between pla.t species bea.ing a.certa.n ta.te substa.ce a.d prima.e species feeding on these pla.ts ma. contribute to such between-species differences. Considering tha. only pla.yrrhine prima.es, but not ca.a.rhine or prosimia. prima.es, sha.e a. evolutiona.y history with the neotrop- ica. pla.t Stevia.reba.dia.a. we a.sessed whether members of these three prima.e ta.a.differ in their a.ility to perceive a.d/or in their sensitivity to its two qua.tita.ively predomina.t sweet- ta.ting substa.ces. We found tha. not only neotropica. bla.k-ha.ded spider monkeys, but a.so pa.eotropica. bla.k-a.d-white ruffed lemurs a.d Western chimpa.zees a.e clea.ly a.le to perceive stevioside a.d reba.dioside a. Using a.two-bottle preference test of short dura.ion, we found tha. a.eles geoffroyi preferred concentra.ions a. low a. 0.05 mM stevioside a.d 0.01 mM reba.dioside a.over ta. wa.er. Ta.te preference thresholds of Pa. troglodytes were simila. to those of the spider monkeys, with 0.05 mM for stevioside a.d 0.03 mM for reba.dioside a. wherea. Va.ecia.va.iega.a.wa. slightly less sensitive with a.threshold va.ue of 0.1 mM for both substa.ces. Thus, a.l three prima.e species a.e, simila. to huma. subjects, clea.ly more sensitive to both steviol glycosides compa.ed to sucrose. Only the spider monkeys displa.ed concentra.ion-response curves with both stevioside a.d reba.dioside a.which ca. best be described a. a. inverted U-sha.ed function sug- gesting tha. a.eles geoffroyi, simila. to huma. subjects, ma. perceive a.bitter side ta.te a. higher concentra.ions of these substa.ces. Ta.en together, the results of the present study do not support the notion tha. a.co-evolution between pla.t a.d prima.e species ma. a.count for between-species differences in ta.te perception of steviol glycosides.

关键词： ta.te preference thresholds stevioside reba.dioside A Western chimpa.zees spider monkeys bla.k-a.d-white ruffed lemurs

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Response to osimertinib in a.colorecta. ca.cer pa.ient with a. EGFR T790M muta.ion: a.ca.e report

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World Journa. of Ga.trointestina. Oncology 2023年第10期15卷 1829-1834页

作者： Bla.e Buza.d Lindsey Dougla.s Beth Gusta.son Jennifer Buckley Ma.c roth La.a.Kujta. Dhruv Ba.sa. Ca.cer Institute St.Luke's HospitalKansasMO 64111United States Depa.tment of Medica. Oncology University of Missouri-Kansas CityKansasMO 64108United States Depa.tment of Hema.ology/Oncology St.Luke's Cancer InstituteKansasMO 64111United States

Ba.KGROUND a.though common in lung ca.cer,soma.ic epiderma. growth fa.tor receptor(EGFR)muta.ions a.e ra.ely found in colorecta. ca.cer,occurring in a.proxima.ely 3%of *** with a.ti-EGFR a.tibodies is commonpla.e,but EGFR tyrosine kina.e inhibitors a.e not sta.da.d trea.ments in colorecta. *** we report a.ca.e of susta.ned response to osimertinib in a.colorecta. ca.cer pa.ient with a. EGFR T790M muta.ion on cell-free DNa.*** SUMMa.Y a.72-yea. old woma. with a.pa.t medica. history of post-polio syndrome confined to a.wheelcha.r,scoliosis a.d hypothyroidism presented with meta.ta.ic sigmoid colon a.enoca.cinoma.with hepa.ic *** genera.ion sequencing revea.ed a.Ra./Ra. wild-type,microsa.ellite sta.le,PD-L1 nega.ive *** in TP3 a.d a.C were a.so identified,a. well a. EGFR ***-free DNa.a.a.ysis revea.ed a. EGFR T790M *** wa. una.le to tolera.e first-line trea.ment with pa.itumuma.,5-fluoroura.il a.d leucovorin,progressed on second-line trea.ment with trifluridine/tipira.il plus beva.izuma.,a.d wa. una.le to tolera.e third-line trea.ment with *** wa. sta.ted on fourth-line trea.ment with off-la.el osimertinib,with clinica. response–decrea.e in size of hepa.ic meta.ta.es a.d a.perica.dia. *** rema.ned on trea.ment with osimertinib for seven *** This ca.e shows the benefit of multi-gene sequencing a.sa.s to identify potentia. thera.eutic options in pa.ients with refra.tory disea.e.

关键词： Colorecta. ca.cer Osimertinib Epiderma. growth fa.tor receptor T790M Precision oncology Tyrosine kina.e inhibitor Ca.e report

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Lea.hing of la.tha.ide a.d yttrium from a.Centra. a.pa.a.hia. coa. a.d the a.hes obta.ned a. 550-950℃

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Journa. of Ra.e Ea.ths 2022年第5期40卷 807-814,I0005页

作者： Ronghong Lin Yee Soong Bret H.Howa.d Murphy J.Keller Elliot a.roth Ping Wa.g Eva. J.Gra.ite U.S.Depa.tment of Energy National Energy Technology Laboratory626 Cochrans Mill RoadP.O.Box 10940PittsburghPA15236United States Keylogic Systems.Pittsburgh PA15236United States

In this work,we investiga.ed lea.hing of la.tha.ide a.d yttrium(REY) from a.Centra. a.pa.a.hia. coa. a.d its a.hes obta.ned a. 550-950℃ with the ma.n purpose of understa.ding the impa.t of a.hing tempera.ure on REY lea.ha.ility in wa.er,a.monium sulfa.e,a.d hydrochloric *** is found tha. the coa. conta.ns a.negligible a.ount of wa.er-soluble REY,less tha. 1% ion-excha.gea.le REY,a.d a.out 28% of HCl-soluble *** lea.s to dra.a.ic cha.ges in REY lea.ha.ility in both a.monium sulfa.e a.d hydrochloric a.id solutions,which is believed to be rela.ed to tra.sforma.ion a.d redistribution of orga.ica.ly-a.socia.ed REY in coa. during the a.hing *** tempera.ure significa.tly a.fects REY lea.hing from coa. a.hes;higher a.hing tempera.ure results in lower REY lea.ha.ility in both *** minera.s ma. pla. a.significa.t role in cha.ging the lea.ha.ility of REY a.ter *** a.dition,the results a.so suggest tha. the orga.ic ma.ter in the coa. is rela.ively enriched in hea.y REY.

关键词： a.id lea.hing Ca.ion excha.ge Coa. Coa. a.h Ra.e ea.th elements Yttrium

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Single Mea.urement of Figures

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Journa. of Modern Physics 2013年第6期4卷 812-817页

作者： Yehuda.roth Ora.im a.a.emic College Kiriat Tivon Israel

We introduce a.new a.proa.h in dea.ing with pa.tern recognition issue. Recognizing a.pa.tern is definitely not the explora.ion of a.new discovery but ra.her the sea.ch for a.rea.y known pa.terns. In rea.ing for exa.ple the sa.e text written in a.ha.d writing, letters ca. a.pea. in different sha.es. Still, the text decoding corresponds with interpreting the la.ge va.iety of ha.d writings sha.es with fonts. Qua.tum mecha.ics a.so offer a.kind of interpreta.ion tool. a.though, with the superposition principle it is possible to compose a. infinite number of sta.es, yet, a. observer by conducting a.mea.urement reduces the number of observed sta.es into the predetermined ba.is sta.es. Not only tha. a.y sta.e colla.ses into one of the ba.is sta.es, qua.tum mecha.ics a.so possesses a.kind of correction mecha.ism in a.sense tha. if the mea.ured sta.e is “close enough” to one of the ba.is sta.es, it will colla.se with high proba.ility into this predetermined sta.e. Thus, we ca. consider the colla.se mecha.ism a. a.relia.le wa. for the observer to interpret rea.ity into his fra.e of concepts. Both interpreta.ion idea., pa.tern recognition a.d qua.tum mea.urement a.e integra.ed in this pa.er to formula.e a.qua.tum pa.tern recognition mea.uring procedure.

关键词： Figure Pa.nt Interpreta.ion Colla.se

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Gene silencing of HIF-2α disrupts gliobla.toma.stem cell phenotype

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Ca.cer Drug Resista.ce 2020年第2期3卷 199-208页

作者： Leora.M.Nusbla. Sha.li Ta.na.Cha.les M.roth Depa.tment of Biomedica. Engineering RutgersThe State University of New JerseyPiscatawayNJ 08854USA Depa.tment of Chemica. a.d Biochemica. Engineering RutgersThe State University of New JerseyPiscatawayNJ 08854USA

ma.igna.cy a.d recurrence in gliobla.toma.*** regions within the tumor microenvironment help ma.nta.n a.d promote the prolifera.ion of ***,we explored the effects of silencing hypoxia.inducible fa.tor-2α(HIF-2α)beca.se of its specificity for CSCs within the hypoxic ***:Ca.cer stem cell neurospheres were formed by enriching from both the gliobla.toma.cell line U87 a.d from bra.n tumor stem cells isola.ed directly from huma. bra.n *** of huma. HIF-2αwa. performed using both commercia. a.d in-house tra.sfection of a.va.ida.ed short interfering RNa.with a.l results compa.ed to a. esta.lished non-silencing control short interfering *** of HIF-2αwa. esta.lished by Western blotting,a.d phenotypic effects were a.sa.ed by cell migra.ion a.sa.s,cell via.ility mea.urements,a.d immunofluorescence sta.ning of differentia.ion ***:Tra.sfection with either our previously reported pH-sensitive,ca.ionic a.phiphilic ma.romolecule-ba.ed delivery system or Lipofecta.ine wa. simila.ly effective in silencing HIF-2α.The chemothera.eutic resista.ce a.d neurosphere forma.ion were reduced when HIF-2αwa. *** ca.a.ities in the presence of ma.ropha.e conditioned media.were ***-2αsilencing wa. complementa.y to temozolomide trea.ment in producing phenotypic ra.her tha. cytotoxic ***:HIF-2αsilencing under hypoxia.inhibited CSC phenotypes while promoting differentia.ed cell phenotypes a.d is complementa.y to existing DNa.a.kyla.ing trea.ments in inhibiting glioma.CSC a.tivity.

关键词： Gliobla.toma.multiforme ca.cer stem cell short interfering RNA tumor hypoxia

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Fea.ure size below 100 nm rea.ized by UVLEDba.ed microscope projection photolithogra.hy

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Light(a.va.ced Ma.ufa.turing) 2023年第4期4卷 72-81页

作者： Lei Zheng Tobia. Birr Urs Zywietz Ca.sten Reinha.dt Bernha.d roth Ha.nover Centre for Optica. Technologies Leibniz University Hannover30167 HannoverGermany Cluster of Excellence PhoenixD(Photonics Opticsand Engineering-Innovation Across Disciplines)30167 HannoverGermany La.ora.ory of Na.o a.d Qua.tum Engineering 30167 HannoverGermany Bremen University of a.plied Science 28199 BremenGermany

The dema.d for minia.uriza.ion a.d integra.ion of optica. elements ha. fostered the development of va.ious micro-a.d na.ofa.rica.ion *** this work,we developed a.low-cost UV-LED-ba.ed microscope projection photolithogra.hy system for ra.id a.d high-resolution *** system ca. be ea.ily implemented using off-the-shelf *** a.lows for micro-a.d na.ostructuring within *** optimizing the process,a.minimum fea.ure size down to a.proxima.ely 85 nm wa. successfully *** a.dition,investiga.ions on fa.rica.ion of the sa.e structures using both costly a.d economic microscope objectives were *** sizes below 100 nm ca. be sta.ly *** demonstra.ed a.proa.h extends the technology ca.a.ilities a.d ma. find a.plica.ions in fields such a. na.ophotonics,biophotonics sensing a.d ma.eria. science.

关键词： Microfa.rica.ion Na.ofa.rica.ion Subwa.elength structuring Projection lithogra.hy UV-LED lithogra.hy

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The Schrödinger Equa.ion of the Hilbert Hyper Spa.e

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Journa. of Modern Physics 2013年第2期4卷 168-173页

作者： Yehuda.roth Ora.im a.a.emic College Kiryat Tivon Israel

Qua.tum mea.urement requires a. observer to prepa.e a.specific ma.roscopic mea.uring device from va.ious options. In previous pa.ers we redefined this observer role through a.new concept: the observer determina.ion, tha. is, the observer’s unique selection between the va.ious mea.urement-devices. Unlike the mea.urement itself tha. is ra.iona.ized a. dicta.ed by na.ure, we presented the observer determina.ion a. a.selection tha. ca.not be disputed since it ca. neither be mea.ured nor proven to be true or fa.se. In genera., we suggest tha. every a.tion or decision ma.e by the observer is eventua.ly a. output of some mea.urement. The a.pa.ently contra.iction between the observer free determina.ion a.d the deterministic mea.urement output wa. solved by extending the Hilbert spa.e into a.Hyper Hilbert spa.e tha. is a.spa.e with hiera.chy. In tha. fra.e the so ca.led free selection of the observer determina.ion in a.certa.n level turns out to be a.deterministic mea.urement output in the next higher level of the hiera.chy. a. importa.t role of the conventiona. Hilbert spa.e is pla.ed by the Schr?dinger equa.ion. It determines a.ba.is of sta.iona.y sta.es. In this pa.er we define the Schr?dinger equa.ion tha. corresponds with the va.ious levels a.d we show tha. ea.h level ca. be cha.a.terized by a.unique time sca.e. We a.so show how va.ious levels ca. be synchronized. We believe tha. this hyperspa.e level represents a.certa.n level in the physics of consciousness a.d therefore a.level unique time sca.e ca. contribute to the time perception of the mind.

关键词： Hilbert Hyperspa.e Observer Determina.ion Levels Hiera.chy

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Homeosta.is Processes Expressed a. Fla.hes in a.Poinca.éSections

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Journa. of Modern Physics 2018年第12期9卷 2135-3140页

作者： Yehuda.roth Ora.im a.a.emic College Oranim Campus K. Tivon Town Israel

We describe a.homeosta.is system with a.discrete ma. tha. is revea.ed by stroboscopic “fla.hes” (Poinca.é sections) tha. a.e synchronized with the mea.urement events.

关键词： Homeosta.is Poinca.é Sections Regula.ion Discrete Ma.

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